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Protein

Mothers against decapentaplegic homolog

Gene

DKFZp781O1323

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mothers against decapentaplegic homologUniRule annotation
Short name:
MAD homologUniRule annotation
Short name:
Mothers against DPP homologUniRule annotation
Alternative name(s):
SMAD family memberUniRule annotation
Gene namesi
Name:DKFZp781O1323Imported
Synonyms:DKFZp781C1895Imported, SMAD5Imported
ORF Names:hCG_41402Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000113658.16.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30528.

Expressioni

Gene expression databases

BgeeiENSG00000113658.

Structurei

3D structure databases

SMRiQ68DB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 137MH1InterPro annotationAdd BLAST125
Domaini271 – 465MH2InterPro annotationAdd BLAST195

Sequence similaritiesi

Belongs to the dwarfin/SMAD family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3701. Eukaryota.
ENOG410XQKU. LUCA.
HOGENOMiHOG000286018.
HOVERGENiHBG053353.
KOiK16790.
OMAiDVQPVEY.
OrthoDBiEOG091G082C.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProiView protein in InterPro
IPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD-like_dom_sf.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_dom_sf.
IPR036578. SMAD_MH1_sf.
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiView protein in Pfam
PF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
SMARTiView protein in SMART
SM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEiView protein in PROSITE
PS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68DB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSMASLFSF TSPAVKRLLG WKQGDEEEKW AEKAVDALVK KLKKKKGAME
60 70 80 90 100
ELEKALSSPG QPSKCVTIPR SLDGRLQVSH RKGLPHVIYC RVWRWPDLQS
110 120 130 140 150
HHELKPLDIC EFPFGSKQKE VCINPYHYKR VESPVLPPVL VPRHNEFNPQ
160 170 180 190 200
HSLLVQFRNL SHNEPHMPQN ATFPDSFHQP NNTPFPLSPN SPYPPSPASS
210 220 230 240 250
TYPNSPASSG PGSPFQLPAD TPPPAYMPPD DQMGQDNSQP MDTSNNMIPQ
260 270 280 290 300
IMPSISSRDV QPVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT
310 320 330 340 350
DPSNNKSRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD
360 370 380 390 400
SSIFVQSRNC NFHHGFHPTT VCKIPSSCSL KIFNNQEFAQ LLAQSVNHGF
410 420 430 440 450
EAVYELTKMC TIRMSFVKGW GAEYHRQDVT STPCWIEIHL HGPLQWLDKV
460
LTQMGSPLNP ISSVS
Length:465
Mass (Da):52,258
Last modified:May 10, 2005 - v1
Checksum:i4A1FD7EC7BD06728
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313397 mRNA. Translation: BAG36195.1.
CR749366 mRNA. Translation: CAH18219.1.
CR749473 mRNA. Translation: CAH18303.1.
CH471062 Genomic DNA. Translation: EAW62195.1.
CH471062 Genomic DNA. Translation: EAW62196.1.
RefSeqiNP_001001419.1. NM_001001419.2.
NP_001001420.1. NM_001001420.2.
NP_005894.3. NM_005903.6.
XP_016864959.1. XM_017009470.1.
UniGeneiHs.167700.

Genome annotation databases

GeneIDi4090.
KEGGihsa:4090.

Similar proteinsi

Entry informationi

Entry nameiQ68DB7_HUMAN
AccessioniPrimary (citable) accession number: Q68DB7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 22, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.