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Protein

Mothers against decapentaplegic homolog

Gene

DKFZp781O1323

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mothers against decapentaplegic homologUniRule annotation
Short name:
MAD homologUniRule annotation
Short name:
Mothers against DPP homologUniRule annotation
Alternative name(s):
SMAD family memberUniRule annotation
Gene namesi
Name:DKFZp781O1323Imported
Synonyms:DKFZp781C1895Imported, SMAD5Imported
ORF Names:hCG_41402Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation
  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30528.

Expressioni

Gene expression databases

BgeeiENSG00000113658.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000441954.

Structurei

3D structure databases

SMRiQ68DB7. Positions 10-133, 270-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 137125MH1 (MAD homology 1)InterPro annotationAdd
BLAST
Domaini271 – 465195MH2 (MAD homology 2)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the dwarfin/SMAD family.UniRule annotation
Contains 1 MH1 (MAD homology 1) domain.UniRule annotation
Contains 1 MH2 (MAD homology 2) domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG3701. Eukaryota.
ENOG410XQKU. LUCA.
HOGENOMiHOG000286018.
HOVERGENiHBG053353.
KOiK16790.
OMAiDVQPVEY.
OrthoDBiEOG091G082C.
PhylomeDBiQ68DB7.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProiIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiPF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEiPS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68DB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSMASLFSF TSPAVKRLLG WKQGDEEEKW AEKAVDALVK KLKKKKGAME
60 70 80 90 100
ELEKALSSPG QPSKCVTIPR SLDGRLQVSH RKGLPHVIYC RVWRWPDLQS
110 120 130 140 150
HHELKPLDIC EFPFGSKQKE VCINPYHYKR VESPVLPPVL VPRHNEFNPQ
160 170 180 190 200
HSLLVQFRNL SHNEPHMPQN ATFPDSFHQP NNTPFPLSPN SPYPPSPASS
210 220 230 240 250
TYPNSPASSG PGSPFQLPAD TPPPAYMPPD DQMGQDNSQP MDTSNNMIPQ
260 270 280 290 300
IMPSISSRDV QPVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT
310 320 330 340 350
DPSNNKSRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD
360 370 380 390 400
SSIFVQSRNC NFHHGFHPTT VCKIPSSCSL KIFNNQEFAQ LLAQSVNHGF
410 420 430 440 450
EAVYELTKMC TIRMSFVKGW GAEYHRQDVT STPCWIEIHL HGPLQWLDKV
460
LTQMGSPLNP ISSVS
Length:465
Mass (Da):52,258
Last modified:May 10, 2005 - v1
Checksum:i4A1FD7EC7BD06728
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313397 mRNA. Translation: BAG36195.1.
CR749366 mRNA. Translation: CAH18219.1.
CR749473 mRNA. Translation: CAH18303.1.
CH471062 Genomic DNA. Translation: EAW62195.1.
CH471062 Genomic DNA. Translation: EAW62196.1.
RefSeqiNP_001001419.1. NM_001001419.2.
NP_001001420.1. NM_001001420.2.
NP_005894.3. NM_005903.6.
UniGeneiHs.167700.

Genome annotation databases

GeneIDi4090.
KEGGihsa:4090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313397 mRNA. Translation: BAG36195.1.
CR749366 mRNA. Translation: CAH18219.1.
CR749473 mRNA. Translation: CAH18303.1.
CH471062 Genomic DNA. Translation: EAW62195.1.
CH471062 Genomic DNA. Translation: EAW62196.1.
RefSeqiNP_001001419.1. NM_001001419.2.
NP_001001420.1. NM_001001420.2.
NP_005894.3. NM_005903.6.
UniGeneiHs.167700.

3D structure databases

SMRiQ68DB7. Positions 10-133, 270-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000441954.

Protocols and materials databases

DNASUi4090.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4090.
KEGGihsa:4090.

Organism-specific databases

CTDi4090.
PharmGKBiPA30528.

Phylogenomic databases

eggNOGiKOG3701. Eukaryota.
ENOG410XQKU. LUCA.
HOGENOMiHOG000286018.
HOVERGENiHBG053353.
KOiK16790.
OMAiDVQPVEY.
OrthoDBiEOG091G082C.
PhylomeDBiQ68DB7.

Miscellaneous databases

ChiTaRSiSMAD5. human.
GenomeRNAii4090.

Gene expression databases

BgeeiENSG00000113658.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProiIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiPF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEiPS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ68DB7_HUMAN
AccessioniPrimary (citable) accession number: Q68DB7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.