Q68DA7 (FMN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formin-1

Alternative name(s):
Limb deformity protein homolog

Gene names

Name:	FMN1
Synonyms:	FMN, LD

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1419 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a role in the formation of adherens junction and the polymerization of linear actin cables By similarity.
Subunit structure	Interacts with alpha-catenin and may interact with tubulin By similarity.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity. Cell junction › adherens junction By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note: Localization to the adherens junctions is alpha-catenin-dependent. Also localizes to F-actin bundles originating from adherens junctions and to microtubules By similarity.
Developmental stage	Expressed in fetal kidney and fetal lung. Ref.5
Post-translational modification	Phosphorylated on serine and possibly threonine residues By similarity.
Sequence similarities	Belongs to the formin homology family. Cappuccino subfamily. Contains 1 FH1 (formin homology 1) domain. Contains 1 FH2 (formin homology 2) domain.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Cytoplasm Membrane Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	Actin-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro forelimb morphogenesis Inferred from electronic annotation. Source: Compara gene expression Inferred from electronic annotation. Source: Compara hindlimb morphogenesis Inferred from electronic annotation. Source: Compara positive regulation of actin filament polymerization Inferred from electronic annotation. Source: Compara positive regulation of actin nucleation Inferred from electronic annotation. Source: Compara skeletal system morphogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	actin cytoskeleton Inferred from electronic annotation. Source: InterPro adherens junction Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q68DA7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q68DA7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     623-662: GISSEGFPWD...GYRAGPACPF → AFHWDLQQHF...AGKGKESRSG
     663-1419: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q68DA7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-680: Missing.
     681-681: H → MENVDNSLDG...PADGPSDSKS
     721-726: EYQAAI → GNVKGS
     727-1419: Missing.

Isoform 5 (identifier: Q68DA7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-680: Missing.
     681-681: H → MENVDNSLDG...PADGPSDSKS

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1419	1419	Formin-1		PRO_0000296361
Regions
	Domain	870 – 957	88	FH1
	Domain	972 – 1388	417	FH2
	Region	1 – 622	622	Microtubule-binding By similarity
	Region	456 – 842	387	Mediates interaction with alpha-catenin By similarity
	Coiled coil	720 – 774	55	Potential
	Compositional bias	869 – 984	116	Pro-rich
Amino acid modifications
	Modified residue	235	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 680	680	Missing in isoform 3 and isoform 5.		VSP_027208
	Alternative sequence	623 – 662	40	GISSE…PACPF → AFHWDLQQHFQEPVIRTVSI SCASNLIKEEAGKGKESRSG in isoform 2.		VSP_027209
	Alternative sequence	663 – 1419	757	Missing in isoform 2.		VSP_027210
	Alternative sequence	681	1	H → MENVDNSLDGSDVSEPAKPE AGLEVAQSILSKFSMKSLFG FTSKLESVNPEEEDAVLKAF HSLDVNPTSQQDDSSNGLDP QEAGSRVSPDLGNDEKIASV ETESEGSQRKEAGTSLLAQE LLPLSTLKGTKDDVICVRGT LVHTTSDSDSDDGGQEPEEG SSTNGPKSPSGVLSEPSQES KENPGGFRENTVTGEMNGAE LCAEDPQRIPPEMSSKLEAG NGGLQTERRPSQDQVGEEGS QDLPAVTNQNSSVGITESAS SKKEVSGEKSFQLPAFFSGL RVLKKGATAEGGETITEIKP KDGDLALLKLTQPVQKSLVQ AGLQTVKSEKKATDPKATPT LLEQLSLLLNIDMPKTEPKG ADPESPRREEMGCNADQESQ SGPGVPQTQGGEVKPKSPET ALEAFKALFIRPPRKGTTAD TSELEALKRKMRHEKESLRA VFERSNSKPADGPSDSKS in isoform 3 and isoform 5.		VSP_027211
	Alternative sequence	721 – 726	6	EYQAAI → GNVKGS in isoform 3.		VSP_027212
	Alternative sequence	727 – 1419	693	Missing in isoform 3.		VSP_027213
	Natural variant	686	1	L → P. Ref.3 Ref.4 Corresponds to variant rs2306277 [ dbSNP | Ensembl ].		VAR_034630
Experimental info
	Sequence conflict	57	1	S → A in CAH18313. Ref.1
	Sequence conflict	221	1	L → P in CAH18313. Ref.1
Isoform 3:
	Sequence conflict	171	1	G → V in AAI03693. Ref.3
	Sequence conflict	171	1	G → V in AAI07594. Ref.3
	Sequence conflict	239	1	G → E in AAI07594. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 5, 2011. Version 3. Checksum: 6ED2783FC8151A43	FASTA	1,419	157,578
	10 20 30 40 50 60 MEGTHCTLQL HKPITELCYI SFCLPKGEVR GFSYKGTVTL DRSNKGFHNC YQVREESDII 70 80 90 100 110 120 SLSQEPDEHP GDIFFKQTPT KDILTELYKL TTERERLLTN LLSSDHILGI TMGNQEGKLQ 130 140 150 160 170 180 ELSVSLAPED DCFQSAGDWQ GELPVGPLNK RSTHGNKKPR RSSGRRESFG ALPQKRTKRK 190 200 210 220 230 240 GRGGRESAPL MGKDKICSSH SLPLSRTRPN LWVLEEKGNL LPNGALACSL QRRESCPPDI 250 260 270 280 290 300 PKTPDTDLGF GSFETAFKDT GLGREVLPPD CSSTEAGGDG IRRPPSGLEH QQTGLSESHQ 310 320 330 340 350 360 DPEKHPEAEK DEMEKPAKRT CKQKPVSKVV AKVQDLSSQV QRVVKTHSKG KETIAIRPAA 370 380 390 400 410 420 HAEFVPKADL LTLPGAEAGA HGSRRQGKER QGDRSSQSPA GETASISSVS ASAEGAVNKV 430 440 450 460 470 480 PLKVIESEKL DEAPEGKRLG FPVHTSVPHT RPETRNKRRA GLPLGGHKSL FLDLPHKVGP 490 500 510 520 530 540 DSSQPRGDKK KPSPPAPAAL GKVFNNSASQ SSTHKQTSPV PSPLSPRLPS PQQHHRILRL 550 560 570 580 590 600 PALPGEREAA LNDSPCRKSR VFSGCVSADT LEPPSSAKVT ETKGASPAFL RAGQPRLVPG 610 620 630 640 650 660 ETLEKSLGPG KTTAEPQHQS PPGISSEGFP WDGFNEQTPK DLPNRDGGAW VLGYRAGPAC 670 680 690 700 710 720 PFLLHEEREK SNRSELYLDL HPDHSLTEQD DRTPGRLQAV WPPPKTKDTE EKVGLKYTEA 730 740 750 760 770 780 EYQAAILHLK REHKEEIENL QAQFELRAFH IRGEHAMITA RLEETIENLK HELEHRWRGG 790 800 810 820 830 840 CEERKDVCIS TDDDCPPKTF RNVCVQTDRE TFLKPCESES KTTRSNQLVP KKLNISSLSQ 850 860 870 880 890 900 LSPPNDHKDI HAALQPMEGM ASNQQKALPP PPASIPPPPP LPSGLGSLSP APPMPPVSAG 910 920 930 940 950 960 PPLPPPPPPP PPLPPPSSAG PPPPPPPPPL PNSPAPPNPG GPPPAPPPPG LAPPPPPGLF 970 980 990 1000 1010 1020 FGLGSSSSQC PRKPAIEPSC PMKPLYWTRI QISDRSQNAT PTLWDSLEEP DIRDPSEFEY 1030 1040 1050 1060 1070 1080 LFSKDTTQQK KKPLSETYEK KNKVKKIIKL LDGKRSQTVG ILISSLHLEM KDIQQAIFNV 1090 1100 1110 1120 1130 1140 DDSVVDLETL AALYENRAQE DELVKIRKYY ETSKEEELKL LDKPEQFLHE LAQIPNFAER 1150 1160 1170 1180 1190 1200 AQCIIFRSVF SEGITSLHRK VEIITRASKD LLHVKSVKDI LALILAFGNY MNGGNRTRGQ 1210 1220 1230 1240 1250 1260 ADGYSLEILP KLKDVKSRDN GINLVDYVVK YYLRYYDQEA GTEKSVFPLP EPQDFFLASQ 1270 1280 1290 1300 1310 1320 VKFEDLIKDL RKLKRQLEAS EKQMVVVCKE SPKEYLQPFK DKLEEFFQKA KKEHKMEESH 1330 1340 1350 1360 1370 1380 LENAQKSFET TVRYFGMKPK SGEKEITPSY VFMVWYEFCS DFKTIWKRES KNISKERLKM 1390 1400 1410 AQESVSKLTS EKKVETKKIN PTASLKERLR QKEASVTTN
	Isoform 2 [UniParc]. Checksum: C119E228B5F717DE	FASTA	662	71,892
	10 20 30 40 50 60 MEGTHCTLQL HKPITELCYI SFCLPKGEVR GFSYKGTVTL DRSNKGFHNC YQVREESDII 70 80 90 100 110 120 SLSQEPDEHP GDIFFKQTPT KDILTELYKL TTERERLLTN LLSSDHILGI TMGNQEGKLQ 130 140 150 160 170 180 ELSVSLAPED DCFQSAGDWQ GELPVGPLNK RSTHGNKKPR RSSGRRESFG ALPQKRTKRK 190 200 210 220 230 240 GRGGRESAPL MGKDKICSSH SLPLSRTRPN LWVLEEKGNL LPNGALACSL QRRESCPPDI 250 260 270 280 290 300 PKTPDTDLGF GSFETAFKDT GLGREVLPPD CSSTEAGGDG IRRPPSGLEH QQTGLSESHQ 310 320 330 340 350 360 DPEKHPEAEK DEMEKPAKRT CKQKPVSKVV AKVQDLSSQV QRVVKTHSKG KETIAIRPAA 370 380 390 400 410 420 HAEFVPKADL LTLPGAEAGA HGSRRQGKER QGDRSSQSPA GETASISSVS ASAEGAVNKV 430 440 450 460 470 480 PLKVIESEKL DEAPEGKRLG FPVHTSVPHT RPETRNKRRA GLPLGGHKSL FLDLPHKVGP 490 500 510 520 530 540 DSSQPRGDKK KPSPPAPAAL GKVFNNSASQ SSTHKQTSPV PSPLSPRLPS PQQHHRILRL 550 560 570 580 590 600 PALPGEREAA LNDSPCRKSR VFSGCVSADT LEPPSSAKVT ETKGASPAFL RAGQPRLVPG 610 620 630 640 650 660 ETLEKSLGPG KTTAEPQHQS PPAFHWDLQQ HFQEPVIRTV SISCASNLIK EEAGKGKESR SG
	Isoform 3 [UniParc]. Checksum: 0636873ED8470DF0	FASTA	503	53,619
	10 20 30 40 50 60 MENVDNSLDG SDVSEPAKPE AGLEVAQSIL SKFSMKSLFG FTSKLESVNP EEEDAVLKAF 70 80 90 100 110 120 HSLDVNPTSQ QDDSSNGLDP QEAGSRVSPD LGNDEKIASV ETESEGSQRK EAGTSLLAQE 130 140 150 160 170 180 LLPLSTLKGT KDDVICVRGT LVHTTSDSDS DDGGQEPEEG SSTNGPKSPS GVLSEPSQES 190 200 210 220 230 240 KENPGGFREN TVTGEMNGAE LCAEDPQRIP PEMSSKLEAG NGGLQTERRP SQDQVGEEGS 250 260 270 280 290 300 QDLPAVTNQN SSVGITESAS SKKEVSGEKS FQLPAFFSGL RVLKKGATAE GGETITEIKP 310 320 330 340 350 360 KDGDLALLKL TQPVQKSLVQ AGLQTVKSEK KATDPKATPT LLEQLSLLLN IDMPKTEPKG 370 380 390 400 410 420 ADPESPRREE MGCNADQESQ SGPGVPQTQG GEVKPKSPET ALEAFKALFI RPPRKGTTAD 430 440 450 460 470 480 TSELEALKRK MRHEKESLRA VFERSNSKPA DGPSDSKSPD HSLTEQDDRT PGRLQAVWPP 490 500 PKTKDTEEKV GLKYTEAGNV KGS
	Isoform 5 [UniParc]. Checksum: 29D19AC2C4245CD9	FASTA	1,196	132,156
	10 20 30 40 50 60 MENVDNSLDG SDVSEPAKPE AGLEVAQSIL SKFSMKSLFG FTSKLESVNP EEEDAVLKAF 70 80 90 100 110 120 HSLDVNPTSQ QDDSSNGLDP QEAGSRVSPD LGNDEKIASV ETESEGSQRK EAGTSLLAQE 130 140 150 160 170 180 LLPLSTLKGT KDDVICVRGT LVHTTSDSDS DDGGQEPEEG SSTNGPKSPS GVLSEPSQES 190 200 210 220 230 240 KENPGGFREN TVTGEMNGAE LCAEDPQRIP PEMSSKLEAG NGGLQTERRP SQDQVGEEGS 250 260 270 280 290 300 QDLPAVTNQN SSVGITESAS SKKEVSGEKS FQLPAFFSGL RVLKKGATAE GGETITEIKP 310 320 330 340 350 360 KDGDLALLKL TQPVQKSLVQ AGLQTVKSEK KATDPKATPT LLEQLSLLLN IDMPKTEPKG 370 380 390 400 410 420 ADPESPRREE MGCNADQESQ SGPGVPQTQG GEVKPKSPET ALEAFKALFI RPPRKGTTAD 430 440 450 460 470 480 TSELEALKRK MRHEKESLRA VFERSNSKPA DGPSDSKSPD HSLTEQDDRT PGRLQAVWPP 490 500 510 520 530 540 PKTKDTEEKV GLKYTEAEYQ AAILHLKREH KEEIENLQAQ FELRAFHIRG EHAMITARLE 550 560 570 580 590 600 ETIENLKHEL EHRWRGGCEE RKDVCISTDD DCPPKTFRNV CVQTDRETFL KPCESESKTT 610 620 630 640 650 660 RSNQLVPKKL NISSLSQLSP PNDHKDIHAA LQPMEGMASN QQKALPPPPA SIPPPPPLPS 670 680 690 700 710 720 GLGSLSPAPP MPPVSAGPPL PPPPPPPPPL PPPSSAGPPP PPPPPPLPNS PAPPNPGGPP 730 740 750 760 770 780 PAPPPPGLAP PPPPGLFFGL GSSSSQCPRK PAIEPSCPMK PLYWTRIQIS DRSQNATPTL 790 800 810 820 830 840 WDSLEEPDIR DPSEFEYLFS KDTTQQKKKP LSETYEKKNK VKKIIKLLDG KRSQTVGILI 850 860 870 880 890 900 SSLHLEMKDI QQAIFNVDDS VVDLETLAAL YENRAQEDEL VKIRKYYETS KEEELKLLDK 910 920 930 940 950 960 PEQFLHELAQ IPNFAERAQC IIFRSVFSEG ITSLHRKVEI ITRASKDLLH VKSVKDILAL 970 980 990 1000 1010 1020 ILAFGNYMNG GNRTRGQADG YSLEILPKLK DVKSRDNGIN LVDYVVKYYL RYYDQEAGTE 1030 1040 1050 1060 1070 1080 KSVFPLPEPQ DFFLASQVKF EDLIKDLRKL KRQLEASEKQ MVVVCKESPK EYLQPFKDKL 1090 1100 1110 1120 1130 1140 EEFFQKAKKE HKMEESHLEN AQKSFETTVR YFGMKPKSGE KEITPSYVFM VWYEFCSDFK 1150 1160 1170 1180 1190 TIWKRESKNI SKERLKMAQE SVSKLTSEKK VETKKINPTA SLKERLRQKE ASVTTN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Retina.
[2]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT PRO-686.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANT PRO-686. Tissue: Brain.
[5]	"A human gene homologous to the formin gene residing at the murine limb deformity locus: chromosomal location and RFLPs." Maas R.L., Jepeal L.I., Elfering S.L., Holcombe R.F., Morton C.C., Eddy R.L., Byers M.G., Shows T.B., Leder P. Am. J. Hum. Genet. 48:687-695(1991) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, DEVELOPMENTAL STAGE.
[6]	"Identification and characterization of the human FMN1 gene in silico." Katoh M., Katoh M. Int. J. Mol. Med. 14:121-126(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR749487 mRNA. Translation: CAH18313.1. AC090098 Genomic DNA. No translation available. AC090877 Genomic DNA. No translation available. AC090982 Genomic DNA. No translation available. AC018515 Genomic DNA. No translation available. AC019278 Genomic DNA. No translation available. BC103692 mRNA. Translation: AAI03693.1. BC107593 mRNA. Translation: AAI07594.1. AK127078 mRNA. No translation available.
IPI	IPI00470874. IPI00740336. IPI00854651. IPI00889693.
RefSeq	NP_001096654.1. NM_001103184.2. XP_003959994.1. XM_003959945.1. XP_003960634.1. XM_003960585.1. XP_003960927.1. XM_003960878.1.
UniGene	Hs.657649.
3D structure databases
ProteinModelPortal	Q68DA7.
SMR	Q68DA7. Positions 973-1399.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q68DA7. 1 interaction.
STRING	9606.ENSP00000333950.
PTM databases
PhosphoSite	Q68DA7.
Polymorphism databases
DMDM	158564317.
Proteomic databases
PaxDb	Q68DA7.
PRIDE	Q68DA7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000320930; ENSP00000325166; ENSG00000248905. ENST00000334528; ENSP00000333950; ENSG00000248905. ENST00000558197; ENSP00000452984; ENSG00000248905. ENST00000559047; ENSP00000454047; ENSG00000248905.
GeneID	101059984. 342184.
KEGG	hsa:101059984. hsa:342184.
UCSC	uc001zhf.4. human. uc001zhg.2. human.
Organism-specific databases
CTD	342184.
GeneCards	GC15M033059.
H-InvDB	HIX0012079.
HGNC	HGNC:3768. FMN1.
HPA	HPA005465. HPA046786.
MIM	136535. gene.
neXtProt	NX_Q68DA7.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG149898.
HOGENOM	HOG000112617.
HOVERGEN	HBG107922.
KO	K10367.
OMA	DSKSPDH.
OrthoDB	EOG4KWJSD.
Gene expression databases
ArrayExpress	Q68DA7.
Bgee	Q68DA7.
CleanEx	HS_FMN1.
Genevestigator	Q68DA7.
Family and domain databases
InterPro	IPR003104. Actin-bd_FH2/DRF_autoreg. IPR015425. FH2_actin-bd. IPR001265. Formin. [Graphical view]
Pfam	PF02181. FH2. 1 hit. [Graphical view]
PRINTS	PR00828. FORMIN.
SMART	SM00498. FH2. 1 hit. [Graphical view]
SUPFAM	SSF101447. FH2_actin_bd. 1 hit.
PROSITE	PS51444. FH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	98243.
SOURCE	Search...

Entry information

Entry name

FMN1_HUMAN

Accession

Primary (citable) accession number: Q68DA7
Secondary accession number(s): Q3B7I6, Q3ZAR4, Q6ZSY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 71 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.