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Protein

Coiled-coil domain-containing protein 102B

Gene

CCDC102B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 102B
Gene namesi
Name:CCDC102B
Synonyms:C18orf14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000150636.15.
HGNCiHGNC:26295. CCDC102B.

Pathology & Biotechi

Organism-specific databases

DisGeNETi79839.
OpenTargetsiENSG00000150636.
PharmGKBiPA134948675.

Polymorphism and mutation databases

BioMutaiCCDC102B.
DMDMi215274243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793081 – 513Coiled-coil domain-containing protein 102BAdd BLAST513

Proteomic databases

PaxDbiQ68D86.
PeptideAtlasiQ68D86.
PRIDEiQ68D86.

PTM databases

iPTMnetiQ68D86.
PhosphoSitePlusiQ68D86.

Expressioni

Gene expression databases

BgeeiENSG00000150636.
CleanExiHS_CCDC102B.
ExpressionAtlasiQ68D86. baseline and differential.
GenevisibleiQ68D86. HS.

Organism-specific databases

HPAiHPA040623.
HPA048194.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB93EBI-10171570,EBI-743598
AK8Q96MA63EBI-10171570,EBI-8466265
ARL4AP406173EBI-10171570,EBI-2875746
ARL4DP497034EBI-10171570,EBI-711726
BYSLQ138955EBI-10171570,EBI-358049
CCDC120Q96HB54EBI-10171570,EBI-744556
CCDC120Q96HB5-43EBI-10171570,EBI-10185348
CCHCR1Q8TD31-35EBI-10171570,EBI-10175300
CDK18Q070023EBI-10171570,EBI-746238
CEP19Q96LK05EBI-10171570,EBI-741885
CEP57L1Q8IYX8-23EBI-10171570,EBI-10181988
EHHADHQ084263EBI-10171570,EBI-2339219
ENKD1Q9H0I25EBI-10171570,EBI-744099
EXOC5O004713EBI-10171570,EBI-949824
FAM161AQ3B8205EBI-10171570,EBI-719941
FBF1Q8TES7-63EBI-10171570,EBI-10244131
FNDC11Q9BVV23EBI-10171570,EBI-744935
GEMP550403EBI-10171570,EBI-744104
GOPCQ9HD263EBI-10171570,EBI-349832
HMG20BQ9P0W25EBI-10171570,EBI-713401
KIFC3Q9BVG83EBI-10171570,EBI-2125614
LENG1Q96BZ83EBI-10171570,EBI-726510
LMO4P619687EBI-10171570,EBI-2798728
LNX1Q8TBB13EBI-10171570,EBI-739832
MAB21L2Q9Y5863EBI-10171570,EBI-6659161
MAGOHBQ96A725EBI-10171570,EBI-746778
MCM7P339933EBI-10171570,EBI-355924
MEOX1P502214EBI-10171570,EBI-2864512
MOSP005403EBI-10171570,EBI-1757866
NIF3L1Q9GZT83EBI-10171570,EBI-740897
NXT2Q9NPJ83EBI-10171570,EBI-752122
PNMA5Q96PV47EBI-10171570,EBI-10171633
POMCP011894EBI-10171570,EBI-12219503
POP5Q969H65EBI-10171570,EBI-366525
PPP1R18Q6NYC85EBI-10171570,EBI-2557469
PSMA1P257863EBI-10171570,EBI-359352
RCOR3Q9P2K33EBI-10171570,EBI-743428
RSPH14Q9UHP65EBI-10171570,EBI-748350
RTL8AQ9BWD33EBI-10171570,EBI-741643
RTL8BQ17RB03EBI-10171570,EBI-10238588
SDCBPO005603EBI-10171570,EBI-727004
SFNP319473EBI-10171570,EBI-476295
SGF29Q96ES73EBI-10171570,EBI-743117
SLIRPQ9GZT33EBI-10171570,EBI-1050793
SPG21Q9NZD83EBI-10171570,EBI-742688
SYCE1Q8N0S23EBI-10171570,EBI-6872807
TPM3Q5VU623EBI-10171570,EBI-10184033
TRIM27P143735EBI-10171570,EBI-719493
TRIM54Q9BYV25EBI-10171570,EBI-2130429
WDYHV1Q96HA83EBI-10171570,EBI-741158
ZNF20P170245EBI-10171570,EBI-717634
ZNF250P15622-33EBI-10171570,EBI-10177272
ZNF572Q7Z3I76EBI-10171570,EBI-10172590

Protein-protein interaction databases

BioGridi122930. 102 interactors.
IntActiQ68D86. 84 interactors.
STRINGi9606.ENSP00000316237.

Structurei

3D structure databases

ProteinModelPortaliQ68D86.
SMRiQ68D86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili72 – 142Sequence analysisAdd BLAST71
Coiled coili268 – 337Sequence analysisAdd BLAST70
Coiled coili363 – 513Sequence analysisAdd BLAST151

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II1J. Eukaryota.
ENOG410XRGB. LUCA.
GeneTreeiENSGT00730000110960.
HOGENOMiHOG000008304.
HOVERGENiHBG080941.
InParanoidiQ68D86.
OMAiWDICEEL.
OrthoDBiEOG091G0CDO.
PhylomeDBiQ68D86.
TreeFamiTF320856.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q68D86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLDSIHRLI EETQIFQMQQ SSIKSRGDMV APASPPRDTC NTCFPLHGLQ
60 70 80 90 100
SHAAHNFCAH SYNTNKWDIC EELRLRELEE VKARAAQMEK TMRWWSDCTA
110 120 130 140 150
NWREKWSKVR AERNSAREEG RQLRIKLEMA MKELSTLKKK QSLPPQKEAL
160 170 180 190 200
EAKVTQDLKL PGFVEESCEH TDQFQLSSQM HESIREYLVK RQFSTKEDTN
210 220 230 240 250
NKEQGVVIDS LKLSEEMKPN LDGVDLFNNG GSGNGETKTG LRLKAINLPL
260 270 280 290 300
ENEVTEISAL QVHLDEFQKI LWKEREMRTA LEKEIERLES ALSLWKWKYE
310 320 330 340 350
ELKESKPKNV KEFDILLGQH NDEMQELSGN IKEESKSQNS KDRVICELRA
360 370 380 390 400
ELERLQAENT SEWDKREILE REKQGLEREN RRLKIQVKEM EELLDKKNRL
410 420 430 440 450
SANSQSPDFK MSQIDLQEKN QELLNLQHAY YKLNRQYQAN IAELTHANNR
460 470 480 490 500
VDQNEAEVKK LRLRVEELKQ GLNQKEDELD DSLNQIRKLQ RSLDEEKERN
510
ENLETELRHL QNW
Note: No experimental confirmation available.
Length:513
Mass (Da):60,448
Last modified:November 25, 2008 - v4
Checksum:i450D36A80D6D88C8
GO
Isoform 2 (identifier: Q68D86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     479-483: LDDSL → VLLYE
     484-513: Missing.

Note: No experimental confirmation available.
Show »
Length:483
Mass (Da):56,720
Checksum:i58CB338DE6B55098
GO

Sequence cautioni

The sequence AAH56269 differs from that shown. wrong intron-exon boundaries.Curated
The sequence AAI26449 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI26451 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15706 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD38721 differs from that shown. Reason: Frameshift at position 200.Curated
The sequence CAD38721 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131M → T in CAH18334 (PubMed:17974005).Curated1
Sequence conflicti382R → G in CAH18334 (PubMed:17974005).Curated1
Sequence conflicti469K → R in CAH18334 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047331153K → N1 PublicationCorresponds to variant dbSNP:rs572020Ensembl.1
Natural variantiVAR_047332298K → R1 PublicationCorresponds to variant dbSNP:rs2187094Ensembl.1
Natural variantiVAR_022893346C → F. Corresponds to variant dbSNP:rs745894Ensembl.1
Natural variantiVAR_047333370E → G. Corresponds to variant dbSNP:rs34102373Ensembl.1
Natural variantiVAR_047334425N → K. Corresponds to variant dbSNP:rs17080065Ensembl.1
Natural variantiVAR_022894429A → P. Corresponds to variant dbSNP:rs9963788Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014688479 – 483LDDSL → VLLYE in isoform 2. 1 Publication5
Alternative sequenceiVSP_014689484 – 513Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749520 mRNA. Translation: CAH18334.2.
AL833863 mRNA. Translation: CAD38721.2. Sequence problems.
AC022035 Genomic DNA. No translation available.
AC096708 Genomic DNA. No translation available.
AC011087 Genomic DNA. No translation available.
BC056269 mRNA. Translation: AAH56269.1. Sequence problems.
BC126448 mRNA. Translation: AAI26449.1. Different initiation.
BC126450 mRNA. Translation: AAI26451.1. Different initiation.
AK027247 mRNA. Translation: BAB15706.1. Different initiation.
CCDSiCCDS11996.2. [Q68D86-1]
RefSeqiNP_001087198.1. NM_001093729.1.
NP_079057.2. NM_024781.2.
XP_016881464.1. XM_017025975.1. [Q68D86-1]
UniGeneiHs.280781.
Hs.540997.

Genome annotation databases

EnsembliENST00000360242; ENSP00000353377; ENSG00000150636. [Q68D86-1]
ENST00000584156; ENSP00000463111; ENSG00000150636. [Q68D86-2]
GeneIDi79839.
KEGGihsa:79839.
UCSCiuc002lki.2. human. [Q68D86-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiC102B_HUMAN
AccessioniPrimary (citable) accession number: Q68D86
Secondary accession number(s): A1A4H1
, Q7Z467, Q8NDK7, Q9H5C1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 25, 2008
Last modified: October 25, 2017
This is version 108 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations