Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q68D86

- C102B_HUMAN

UniProt

Q68D86 - C102B_HUMAN

Protein

Coiled-coil domain-containing protein 102B

Gene

CCDC102B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 4 (25 Nov 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 102B
    Gene namesi
    Name:CCDC102B
    Synonyms:C18orf14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:26295. CCDC102B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134948675.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Coiled-coil domain-containing protein 102BPRO_0000079308Add
    BLAST

    Proteomic databases

    PaxDbiQ68D86.
    PRIDEiQ68D86.

    PTM databases

    PhosphoSiteiQ68D86.

    Expressioni

    Gene expression databases

    ArrayExpressiQ68D86.
    BgeeiQ68D86.
    CleanExiHS_CCDC102B.
    GenevestigatoriQ68D86.

    Organism-specific databases

    HPAiHPA040623.

    Interactioni

    Protein-protein interaction databases

    BioGridi122930. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68D86.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili72 – 14271Sequence AnalysisAdd
    BLAST
    Coiled coili268 – 33770Sequence AnalysisAdd
    BLAST
    Coiled coili363 – 513151Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG131045.
    HOGENOMiHOG000008304.
    HOVERGENiHBG080941.
    InParanoidiQ68D86.
    OMAiQSHAAHN.
    PhylomeDBiQ68D86.
    TreeFamiTF320856.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q68D86-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNLDSIHRLI EETQIFQMQQ SSIKSRGDMV APASPPRDTC NTCFPLHGLQ    50
    SHAAHNFCAH SYNTNKWDIC EELRLRELEE VKARAAQMEK TMRWWSDCTA 100
    NWREKWSKVR AERNSAREEG RQLRIKLEMA MKELSTLKKK QSLPPQKEAL 150
    EAKVTQDLKL PGFVEESCEH TDQFQLSSQM HESIREYLVK RQFSTKEDTN 200
    NKEQGVVIDS LKLSEEMKPN LDGVDLFNNG GSGNGETKTG LRLKAINLPL 250
    ENEVTEISAL QVHLDEFQKI LWKEREMRTA LEKEIERLES ALSLWKWKYE 300
    ELKESKPKNV KEFDILLGQH NDEMQELSGN IKEESKSQNS KDRVICELRA 350
    ELERLQAENT SEWDKREILE REKQGLEREN RRLKIQVKEM EELLDKKNRL 400
    SANSQSPDFK MSQIDLQEKN QELLNLQHAY YKLNRQYQAN IAELTHANNR 450
    VDQNEAEVKK LRLRVEELKQ GLNQKEDELD DSLNQIRKLQ RSLDEEKERN 500
    ENLETELRHL QNW 513

    Note: No experimental confirmation available.

    Length:513
    Mass (Da):60,448
    Last modified:November 25, 2008 - v4
    Checksum:i450D36A80D6D88C8
    GO
    Isoform 2 (identifier: Q68D86-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         479-483: LDDSL → VLLYE
         484-513: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:483
    Mass (Da):56,720
    Checksum:i58CB338DE6B55098
    GO

    Sequence cautioni

    The sequence AAH56269.1 differs from that shown. Reason: wrong intron-exon boundaries.
    The sequence CAD38721.2 differs from that shown. Reason: Frameshift at position 200.
    The sequence BAB15706.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAD38721.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti131 – 1311M → T in CAH18334. (PubMed:17974005)Curated
    Sequence conflicti382 – 3821R → G in CAH18334. (PubMed:17974005)Curated
    Sequence conflicti469 – 4691K → R in CAH18334. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti153 – 1531K → N.1 Publication
    Corresponds to variant rs572020 [ dbSNP | Ensembl ].
    VAR_047331
    Natural varianti298 – 2981K → R.1 Publication
    Corresponds to variant rs2187094 [ dbSNP | Ensembl ].
    VAR_047332
    Natural varianti346 – 3461C → F.
    Corresponds to variant rs745894 [ dbSNP | Ensembl ].
    VAR_022893
    Natural varianti370 – 3701E → G.
    Corresponds to variant rs34102373 [ dbSNP | Ensembl ].
    VAR_047333
    Natural varianti425 – 4251N → K.
    Corresponds to variant rs17080065 [ dbSNP | Ensembl ].
    VAR_047334
    Natural varianti429 – 4291A → P.
    Corresponds to variant rs9963788 [ dbSNP | Ensembl ].
    VAR_022894

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei479 – 4835LDDSL → VLLYE in isoform 2. 1 PublicationVSP_014688
    Alternative sequencei484 – 51330Missing in isoform 2. 1 PublicationVSP_014689Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR749520 mRNA. Translation: CAH18334.2.
    AL833863 mRNA. Translation: CAD38721.2. Sequence problems.
    AC022035 Genomic DNA. No translation available.
    AC096708 Genomic DNA. No translation available.
    AC011087 Genomic DNA. No translation available.
    BC056269 mRNA. Translation: AAH56269.1. Sequence problems.
    AK027247 mRNA. Translation: BAB15706.1. Different initiation.
    CCDSiCCDS11996.2. [Q68D86-1]
    RefSeqiNP_079057.2. NM_024781.2.
    XP_005266821.1. XM_005266764.1. [Q68D86-1]
    XP_005266822.1. XM_005266765.1. [Q68D86-1]
    XP_006722605.1. XM_006722542.1. [Q68D86-1]
    XP_006722606.1. XM_006722543.1. [Q68D86-1]
    XP_006722607.1. XM_006722544.1. [Q68D86-1]
    UniGeneiHs.280781.

    Genome annotation databases

    EnsembliENST00000319445; ENSP00000316237; ENSG00000150636. [Q68D86-1]
    ENST00000360242; ENSP00000353377; ENSG00000150636. [Q68D86-1]
    ENST00000584156; ENSP00000463111; ENSG00000150636. [Q68D86-2]
    GeneIDi79839.
    KEGGihsa:79839.
    UCSCiuc002lki.2. human. [Q68D86-1]

    Polymorphism databases

    DMDMi215274243.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR749520 mRNA. Translation: CAH18334.2 .
    AL833863 mRNA. Translation: CAD38721.2 . Sequence problems.
    AC022035 Genomic DNA. No translation available.
    AC096708 Genomic DNA. No translation available.
    AC011087 Genomic DNA. No translation available.
    BC056269 mRNA. Translation: AAH56269.1 . Sequence problems.
    AK027247 mRNA. Translation: BAB15706.1 . Different initiation.
    CCDSi CCDS11996.2. [Q68D86-1 ]
    RefSeqi NP_079057.2. NM_024781.2.
    XP_005266821.1. XM_005266764.1. [Q68D86-1 ]
    XP_005266822.1. XM_005266765.1. [Q68D86-1 ]
    XP_006722605.1. XM_006722542.1. [Q68D86-1 ]
    XP_006722606.1. XM_006722543.1. [Q68D86-1 ]
    XP_006722607.1. XM_006722544.1. [Q68D86-1 ]
    UniGenei Hs.280781.

    3D structure databases

    ProteinModelPortali Q68D86.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122930. 1 interaction.

    PTM databases

    PhosphoSitei Q68D86.

    Polymorphism databases

    DMDMi 215274243.

    Proteomic databases

    PaxDbi Q68D86.
    PRIDEi Q68D86.

    Protocols and materials databases

    DNASUi 79839.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319445 ; ENSP00000316237 ; ENSG00000150636 . [Q68D86-1 ]
    ENST00000360242 ; ENSP00000353377 ; ENSG00000150636 . [Q68D86-1 ]
    ENST00000584156 ; ENSP00000463111 ; ENSG00000150636 . [Q68D86-2 ]
    GeneIDi 79839.
    KEGGi hsa:79839.
    UCSCi uc002lki.2. human. [Q68D86-1 ]

    Organism-specific databases

    CTDi 79839.
    GeneCardsi GC18P066382.
    HGNCi HGNC:26295. CCDC102B.
    HPAi HPA040623.
    neXtProti NX_Q68D86.
    PharmGKBi PA134948675.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG131045.
    HOGENOMi HOG000008304.
    HOVERGENi HBG080941.
    InParanoidi Q68D86.
    OMAi QSHAAHN.
    PhylomeDBi Q68D86.
    TreeFami TF320856.

    Miscellaneous databases

    GenomeRNAii 79839.
    NextBioi 69510.
    PROi Q68D86.

    Gene expression databases

    ArrayExpressi Q68D86.
    Bgeei Q68D86.
    CleanExi HS_CCDC102B.
    Genevestigatori Q68D86.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 189-513 (ISOFORM 2), VARIANTS ASN-153 AND ARG-298.
      Tissue: Salivary gland and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 199-513 (ISOFORM 1).
      Tissue: Lung.

    Entry informationi

    Entry nameiC102B_HUMAN
    AccessioniPrimary (citable) accession number: Q68D86
    Secondary accession number(s): Q7Z467, Q8NDK7, Q9H5C1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 79 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3