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Protein

Schlafen family member 13

Gene

SLFN13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi599 – 6068ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Schlafen family member 13
Gene namesi
Name:SLFN13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26481. SLFN13.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: LIFEdb
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596360.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 897897Schlafen family member 13PRO_0000282985Add
BLAST

Proteomic databases

MaxQBiQ68D06.
PaxDbiQ68D06.
PRIDEiQ68D06.

PTM databases

PhosphoSiteiQ68D06.

Expressioni

Gene expression databases

BgeeiQ68D06.
CleanExiHS_SLFN13.
ExpressionAtlasiQ68D06. baseline and differential.
GenevestigatoriQ68D06.

Organism-specific databases

HPAiHPA022532.
HPA023064.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000285013.

Structurei

3D structure databases

ProteinModelPortaliQ68D06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Schlafen family.Curated

Phylogenomic databases

eggNOGiNOG25289.
GeneTreeiENSGT00410000025651.
HOGENOMiHOG000049135.
HOVERGENiHBG056880.
InParanoidiQ68D06.
OMAiQQLHILW.
OrthoDBiEOG712TVN.
PhylomeDBiQ68D06.
TreeFamiTF337168.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR007421. ATPase_AAA-4.
IPR018647. DUF2075.
IPR027417. P-loop_NTPase.
IPR029684. Schlafen.
IPR029679. SLFN13.
[Graphical view]
PANTHERiPTHR12155. PTHR12155. 1 hit.
PTHR12155:SF21. PTHR12155:SF21. 1 hit.
PfamiPF04326. AAA_4. 1 hit.
PF09848. DUF2075. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q68D06-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEANHCSLGV YPSYPDLVID VGEVTLGEEN RKKLQKTQRD QERARVIRAA
60 70 80 90 100
CALLNSGGGV IQMEMANRDE RPTEMGLDLE ESLRKLIQYP YLQAFFETKQ
110 120 130 140 150
HGRCFYIFVK SWSGDPFLKD GSFNSRICSL SSSLYCRSGT SVLHMNSRQA
160 170 180 190 200
FDFLKTKERQ SKYNLINEGS PPSKIMKAVY QNISESNPAY EVFQTDTIEY
210 220 230 240 250
GEILSFPESP SIEFKQFSTK HIQQYVENII PEYISAFANT EGGYLFIGVD
260 270 280 290 300
DKSRKVLGCA KEQVDPDSLK NVIARAISKL PIVHFCSSKP RVEYSTKIVE
310 320 330 340 350
VFCGKELYGY LCVIKVKAFC CVVFSEAPKS WMVREKYIRP LTTEEWVEKM
360 370 380 390 400
MDADPEFPPD FAEAFESQLS LSDSPSLCRP VYSKKGLEHK ADLQQHLFPV
410 420 430 440 450
PPGHLECTPE SLWKELSLQH EGLKELIHKQ MRPFSQGIVI LSRSWAVDLN
460 470 480 490 500
LQEKPGVICD ALLIAQNSTP ILYTILREQD AEGQDYCTRT AFTLKQKLVN
510 520 530 540 550
MGGYTGKVCV RAKVLCLSPE SSAEALEAAV SPMDYPASYS LAGTQHMEAL
560 570 580 590 600
LQSLVIVLLG FRSLLSDQLG CEVLNLLTAQ QYEIFSRSLR KNRELFVHGL
610 620 630 640 650
PGSGKTIMAM KIMEKIRNVF HCEAHRILYV CENQPLRNFI SDRNICRAET
660 670 680 690 700
RETFLREKFE HIQHIVIDEA QNFRTEDGDW YRKAKTITQR EKDCPGVLWI
710 720 730 740 750
FLDYFQTSHL GHSGLPPLSA QYPREELTRV VRNADEIAEY IQQEMQLIIE
760 770 780 790 800
NPPINIPHGY LAILSEAKWV PGVPGNTKII KNFTLEQIVT YVADTCRCFF
810 820 830 840 850
ERGYSPKDVA VLVSTVTEVE QYQSKLLKAM RKKMVVQLSD ACDMLGVHIV
860 870 880 890
LDSVRRFSGL ERSIVFGIHP RTADPAILPN ILICLASRAK QHLYIFL
Length:897
Mass (Da):102,045
Last modified:October 10, 2004 - v1
Checksum:i2D516123F44121D0
GO
Isoform 2 (identifier: Q68D06-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-326: Missing.

Show »
Length:579
Mass (Da):65,949
Checksum:i195AEFB2F4235C84
GO

Sequence cautioni

The sequence AK127728 differs from that shown. Reason: Frameshift at position 261. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41N → S.
Corresponds to variant rs12943866 [ dbSNP | Ensembl ].
VAR_031449
Natural varianti50 – 501A → T.
Corresponds to variant rs7216628 [ dbSNP | Ensembl ].
VAR_031450
Natural varianti433 – 4331P → L.
Corresponds to variant rs16970912 [ dbSNP | Ensembl ].
VAR_053878
Natural varianti642 – 6421D → V.
Corresponds to variant rs11657183 [ dbSNP | Ensembl ].
VAR_053879
Natural varianti652 – 6521E → K.
Corresponds to variant rs3744371 [ dbSNP | Ensembl ].
VAR_031451

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei9 – 326318Missing in isoform 2. 1 PublicationVSP_024273Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056514 mRNA. Translation: BAB71201.1.
AK127728 mRNA. No translation available.
CR749630 mRNA. Translation: CAH18424.1.
AL833747 mRNA. Translation: CAH56227.1.
CH471147 Genomic DNA. Translation: EAW80150.1.
CH471147 Genomic DNA. Translation: EAW80152.1.
CCDSiCCDS32620.1. [Q68D06-1]
RefSeqiNP_653283.3. NM_144682.5. [Q68D06-1]
XP_005257979.1. XM_005257922.1. [Q68D06-1]
XP_005257980.1. XM_005257923.1. [Q68D06-1]
XP_006721783.1. XM_006721720.1. [Q68D06-1]
UniGeneiHs.462833.

Genome annotation databases

EnsembliENST00000285013; ENSP00000285013; ENSG00000154760. [Q68D06-1]
ENST00000526861; ENSP00000434439; ENSG00000154760. [Q68D06-1]
ENST00000533791; ENSP00000467426; ENSG00000154760. [Q68D06-1]
ENST00000534689; ENSP00000435442; ENSG00000154760. [Q68D06-2]
ENST00000542635; ENSP00000444016; ENSG00000154760. [Q68D06-1]
GeneIDi146857.
KEGGihsa:146857.
UCSCiuc002hjk.1. human. [Q68D06-1]
uc010ctt.2. human. [Q68D06-2]

Polymorphism databases

DMDMi74708791.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056514 mRNA. Translation: BAB71201.1.
AK127728 mRNA. No translation available.
CR749630 mRNA. Translation: CAH18424.1.
AL833747 mRNA. Translation: CAH56227.1.
CH471147 Genomic DNA. Translation: EAW80150.1.
CH471147 Genomic DNA. Translation: EAW80152.1.
CCDSiCCDS32620.1. [Q68D06-1]
RefSeqiNP_653283.3. NM_144682.5. [Q68D06-1]
XP_005257979.1. XM_005257922.1. [Q68D06-1]
XP_005257980.1. XM_005257923.1. [Q68D06-1]
XP_006721783.1. XM_006721720.1. [Q68D06-1]
UniGeneiHs.462833.

3D structure databases

ProteinModelPortaliQ68D06.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000285013.

PTM databases

PhosphoSiteiQ68D06.

Polymorphism databases

DMDMi74708791.

Proteomic databases

MaxQBiQ68D06.
PaxDbiQ68D06.
PRIDEiQ68D06.

Protocols and materials databases

DNASUi146857.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285013; ENSP00000285013; ENSG00000154760. [Q68D06-1]
ENST00000526861; ENSP00000434439; ENSG00000154760. [Q68D06-1]
ENST00000533791; ENSP00000467426; ENSG00000154760. [Q68D06-1]
ENST00000534689; ENSP00000435442; ENSG00000154760. [Q68D06-2]
ENST00000542635; ENSP00000444016; ENSG00000154760. [Q68D06-1]
GeneIDi146857.
KEGGihsa:146857.
UCSCiuc002hjk.1. human. [Q68D06-1]
uc010ctt.2. human. [Q68D06-2]

Organism-specific databases

CTDi146857.
GeneCardsiGC17M033762.
H-InvDBHIX0020218.
HGNCiHGNC:26481. SLFN13.
HPAiHPA022532.
HPA023064.
MIMi614957. gene.
neXtProtiNX_Q68D06.
PharmGKBiPA144596360.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG25289.
GeneTreeiENSGT00410000025651.
HOGENOMiHOG000049135.
HOVERGENiHBG056880.
InParanoidiQ68D06.
OMAiQQLHILW.
OrthoDBiEOG712TVN.
PhylomeDBiQ68D06.
TreeFamiTF337168.

Miscellaneous databases

GenomeRNAii146857.
NextBioi85487.
PROiQ68D06.
SOURCEiSearch...

Gene expression databases

BgeeiQ68D06.
CleanExiHS_SLFN13.
ExpressionAtlasiQ68D06. baseline and differential.
GenevestigatoriQ68D06.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR007421. ATPase_AAA-4.
IPR018647. DUF2075.
IPR027417. P-loop_NTPase.
IPR029684. Schlafen.
IPR029679. SLFN13.
[Graphical view]
PANTHERiPTHR12155. PTHR12155. 1 hit.
PTHR12155:SF21. PTHR12155:SF21. 1 hit.
PfamiPF04326. AAA_4. 1 hit.
PF09848. DUF2075. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix and Stomach.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSLN13_HUMAN
AccessioniPrimary (citable) accession number: Q68D06
Secondary accession number(s): E1P645
, Q658M1, Q6ZS51, Q96A81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 2, 2007
Last sequence update: October 10, 2004
Last modified: January 6, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.