Q68D06 (SLN13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Schlafen family member 13

Gene names

Name:

SLFN13

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	897 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the Schlafen family.
Sequence caution	The sequence AK127728 differs from that shown. Reason: Frameshift at position 261.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	intracellular Inferred from direct assay. Source: LIFEdb
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q68D06-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q68D06-2)

The sequence of this isoform differs from the canonical sequence as follows:
     9-326: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 897	897	Schlafen family member 13		PRO_0000282985
Regions
	Nucleotide binding	599 – 606	8	ATP Potential
Natural variations
	Alternative sequence	9 – 326	318	Missing in isoform 2.		VSP_024273
	Natural variant	4	1	N → S. Corresponds to variant rs12943866 [ dbSNP | Ensembl ].		VAR_031449
	Natural variant	50	1	A → T. Corresponds to variant rs7216628 [ dbSNP | Ensembl ].		VAR_031450
	Natural variant	433	1	P → L. Corresponds to variant rs16970912 [ dbSNP | Ensembl ].		VAR_053878
	Natural variant	642	1	D → V. Corresponds to variant rs11657183 [ dbSNP | Ensembl ].		VAR_053879
	Natural variant	652	1	E → K. Corresponds to variant rs3744371 [ dbSNP | Ensembl ].		VAR_031451

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 2D516123F44121D0	FASTA	897	102,045
	10 20 30 40 50 60 MEANHCSLGV YPSYPDLVID VGEVTLGEEN RKKLQKTQRD QERARVIRAA CALLNSGGGV 70 80 90 100 110 120 IQMEMANRDE RPTEMGLDLE ESLRKLIQYP YLQAFFETKQ HGRCFYIFVK SWSGDPFLKD 130 140 150 160 170 180 GSFNSRICSL SSSLYCRSGT SVLHMNSRQA FDFLKTKERQ SKYNLINEGS PPSKIMKAVY 190 200 210 220 230 240 QNISESNPAY EVFQTDTIEY GEILSFPESP SIEFKQFSTK HIQQYVENII PEYISAFANT 250 260 270 280 290 300 EGGYLFIGVD DKSRKVLGCA KEQVDPDSLK NVIARAISKL PIVHFCSSKP RVEYSTKIVE 310 320 330 340 350 360 VFCGKELYGY LCVIKVKAFC CVVFSEAPKS WMVREKYIRP LTTEEWVEKM MDADPEFPPD 370 380 390 400 410 420 FAEAFESQLS LSDSPSLCRP VYSKKGLEHK ADLQQHLFPV PPGHLECTPE SLWKELSLQH 430 440 450 460 470 480 EGLKELIHKQ MRPFSQGIVI LSRSWAVDLN LQEKPGVICD ALLIAQNSTP ILYTILREQD 490 500 510 520 530 540 AEGQDYCTRT AFTLKQKLVN MGGYTGKVCV RAKVLCLSPE SSAEALEAAV SPMDYPASYS 550 560 570 580 590 600 LAGTQHMEAL LQSLVIVLLG FRSLLSDQLG CEVLNLLTAQ QYEIFSRSLR KNRELFVHGL 610 620 630 640 650 660 PGSGKTIMAM KIMEKIRNVF HCEAHRILYV CENQPLRNFI SDRNICRAET RETFLREKFE 670 680 690 700 710 720 HIQHIVIDEA QNFRTEDGDW YRKAKTITQR EKDCPGVLWI FLDYFQTSHL GHSGLPPLSA 730 740 750 760 770 780 QYPREELTRV VRNADEIAEY IQQEMQLIIE NPPINIPHGY LAILSEAKWV PGVPGNTKII 790 800 810 820 830 840 KNFTLEQIVT YVADTCRCFF ERGYSPKDVA VLVSTVTEVE QYQSKLLKAM RKKMVVQLSD 850 860 870 880 890 ACDMLGVHIV LDSVRRFSGL ERSIVFGIHP RTADPAILPN ILICLASRAK QHLYIFL
	Isoform 2 [UniParc]. Checksum: 195AEFB2F4235C84	FASTA	579	65,949
	10 20 30 40 50 60 MEANHCSLAP KSWMVREKYI RPLTTEEWVE KMMDADPEFP PDFAEAFESQ LSLSDSPSLC 70 80 90 100 110 120 RPVYSKKGLE HKADLQQHLF PVPPGHLECT PESLWKELSL QHEGLKELIH KQMRPFSQGI 130 140 150 160 170 180 VILSRSWAVD LNLQEKPGVI CDALLIAQNS TPILYTILRE QDAEGQDYCT RTAFTLKQKL 190 200 210 220 230 240 VNMGGYTGKV CVRAKVLCLS PESSAEALEA AVSPMDYPAS YSLAGTQHME ALLQSLVIVL 250 260 270 280 290 300 LGFRSLLSDQ LGCEVLNLLT AQQYEIFSRS LRKNRELFVH GLPGSGKTIM AMKIMEKIRN 310 320 330 340 350 360 VFHCEAHRIL YVCENQPLRN FISDRNICRA ETRETFLREK FEHIQHIVID EAQNFRTEDG 370 380 390 400 410 420 DWYRKAKTIT QREKDCPGVL WIFLDYFQTS HLGHSGLPPL SAQYPREELT RVVRNADEIA 430 440 450 460 470 480 EYIQQEMQLI IENPPINIPH GYLAILSEAK WVPGVPGNTK IIKNFTLEQI VTYVADTCRC 490 500 510 520 530 540 FFERGYSPKD VAVLVSTVTE VEQYQSKLLK AMRKKMVVQL SDACDMLGVH IVLDSVRRFS 550 560 570 GLERSIVFGI HPRTADPAIL PNILICLASR AKQHLYIFL

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Cervix and Stomach.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK056514 mRNA. Translation: BAB71201.1. AK127728 mRNA. No translation available. CR749630 mRNA. Translation: CAH18424.1. AL833747 mRNA. Translation: CAH56227.1. CH471147 Genomic DNA. Translation: EAW80150.1. CH471147 Genomic DNA. Translation: EAW80152.1.
IPI	IPI00470806. IPI00477650.
RefSeq	NP_653283.3. NM_144682.5.
UniGene	Hs.462833.
3D structure databases
ProteinModelPortal	Q68D06.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000285013.
PTM databases
PhosphoSite	Q68D06.
Polymorphism databases
DMDM	74708791.
Proteomic databases
PaxDb	Q68D06.
PRIDE	Q68D06.
Protocols and materials databases
DNASU	146857.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000285013; ENSP00000285013; ENSG00000154760. ENST00000360502; ENSP00000353692; ENSG00000154760. ENST00000526861; ENSP00000434439; ENSG00000154760. ENST00000533791; ENSP00000467426; ENSG00000154760. ENST00000534689; ENSP00000435442; ENSG00000154760. ENST00000542635; ENSP00000444016; ENSG00000154760.
GeneID	146857.
KEGG	hsa:146857.
UCSC	uc002hjk.1. human. uc010ctt.2. human.
Organism-specific databases
CTD	146857.
GeneCards	GC17M033762.
H-InvDB	HIX0020218.
HGNC	HGNC:26481. SLFN13.
HPA	HPA022532. HPA023064.
MIM	614957. gene.
neXtProt	NX_Q68D06.
PharmGKB	PA144596360.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG25289.
HOGENOM	HOG000049135.
HOVERGEN	HBG056880.
InParanoid	Q68D06.
OMA	YQNISES.
Gene expression databases
ArrayExpress	Q68D06.
Bgee	Q68D06.
CleanEx	HS_SLFN13.
Genevestigator	Q68D06.
Family and domain databases
InterPro	IPR007421. ATPase_AAA-4. IPR018647. DUF2075. [Graphical view]
Pfam	PF04326. AAA_4. 1 hit. PF09848. DUF2075. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	146857.
NextBio	85487.
SOURCE	Search...

Entry information

Entry name

SLN13_HUMAN

Accession

Primary (citable) accession number: Q68D06
Secondary accession number(s): E1P645 , Q658M1, Q6ZS51, Q96A81

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.