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Protein

Schlafen family member 13

Gene

SLFN13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi599 – 606ATPSequence analysis8

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Schlafen family member 13
Gene namesi
Name:SLFN13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000154760.13
HGNCiHGNC:26481 SLFN13
MIMi614957 gene
neXtProtiNX_Q68D06

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000154760
PharmGKBiPA144596360

Polymorphism and mutation databases

BioMutaiSLFN13
DMDMi74708791

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002829851 – 897Schlafen family member 13Add BLAST897

Proteomic databases

EPDiQ68D06
MaxQBiQ68D06
PaxDbiQ68D06
PeptideAtlasiQ68D06
PRIDEiQ68D06

PTM databases

iPTMnetiQ68D06
PhosphoSitePlusiQ68D06

Expressioni

Gene expression databases

BgeeiENSG00000154760
CleanExiHS_SLFN13
ExpressionAtlasiQ68D06 baseline and differential
GenevisibleiQ68D06 HS

Organism-specific databases

HPAiHPA022532
HPA023064

Structurei

3D structure databases

ProteinModelPortaliQ68D06
SMRiQ68D06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Schlafen family.Curated

Phylogenomic databases

eggNOGiENOG410IJEW Eukaryota
ENOG410Z5MV LUCA
GeneTreeiENSGT00410000025651
HOGENOMiHOG000049135
HOVERGENiHBG056880
InParanoidiQ68D06
OMAiKLPIVHF
OrthoDBiEOG091G01HZ
PhylomeDBiQ68D06
TreeFamiTF337168

Family and domain databases

Gene3Di3.30.950.30, 1 hit
InterProiView protein in InterPro
IPR018647 DUF2075
IPR027417 P-loop_NTPase
IPR029684 Schlafen
IPR007421 Schlafen_AAA_dom
IPR038461 Schlafen_AAA_dom_sf
IPR029679 SLFN13
PANTHERiPTHR12155 PTHR12155, 1 hit
PTHR12155:SF21 PTHR12155:SF21, 1 hit
PfamiView protein in Pfam
PF04326 AlbA_2, 1 hit
PF09848 DUF2075, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q68D06-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEANHCSLGV YPSYPDLVID VGEVTLGEEN RKKLQKTQRD QERARVIRAA
60 70 80 90 100
CALLNSGGGV IQMEMANRDE RPTEMGLDLE ESLRKLIQYP YLQAFFETKQ
110 120 130 140 150
HGRCFYIFVK SWSGDPFLKD GSFNSRICSL SSSLYCRSGT SVLHMNSRQA
160 170 180 190 200
FDFLKTKERQ SKYNLINEGS PPSKIMKAVY QNISESNPAY EVFQTDTIEY
210 220 230 240 250
GEILSFPESP SIEFKQFSTK HIQQYVENII PEYISAFANT EGGYLFIGVD
260 270 280 290 300
DKSRKVLGCA KEQVDPDSLK NVIARAISKL PIVHFCSSKP RVEYSTKIVE
310 320 330 340 350
VFCGKELYGY LCVIKVKAFC CVVFSEAPKS WMVREKYIRP LTTEEWVEKM
360 370 380 390 400
MDADPEFPPD FAEAFESQLS LSDSPSLCRP VYSKKGLEHK ADLQQHLFPV
410 420 430 440 450
PPGHLECTPE SLWKELSLQH EGLKELIHKQ MRPFSQGIVI LSRSWAVDLN
460 470 480 490 500
LQEKPGVICD ALLIAQNSTP ILYTILREQD AEGQDYCTRT AFTLKQKLVN
510 520 530 540 550
MGGYTGKVCV RAKVLCLSPE SSAEALEAAV SPMDYPASYS LAGTQHMEAL
560 570 580 590 600
LQSLVIVLLG FRSLLSDQLG CEVLNLLTAQ QYEIFSRSLR KNRELFVHGL
610 620 630 640 650
PGSGKTIMAM KIMEKIRNVF HCEAHRILYV CENQPLRNFI SDRNICRAET
660 670 680 690 700
RETFLREKFE HIQHIVIDEA QNFRTEDGDW YRKAKTITQR EKDCPGVLWI
710 720 730 740 750
FLDYFQTSHL GHSGLPPLSA QYPREELTRV VRNADEIAEY IQQEMQLIIE
760 770 780 790 800
NPPINIPHGY LAILSEAKWV PGVPGNTKII KNFTLEQIVT YVADTCRCFF
810 820 830 840 850
ERGYSPKDVA VLVSTVTEVE QYQSKLLKAM RKKMVVQLSD ACDMLGVHIV
860 870 880 890
LDSVRRFSGL ERSIVFGIHP RTADPAILPN ILICLASRAK QHLYIFL
Length:897
Mass (Da):102,045
Last modified:October 11, 2004 - v1
Checksum:i2D516123F44121D0
GO
Isoform 2 (identifier: Q68D06-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-326: Missing.

Show »
Length:579
Mass (Da):65,949
Checksum:i195AEFB2F4235C84
GO

Sequence cautioni

The sequence AK127728 differs from that shown. Reason: Frameshift at position 261.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0314494N → S. Corresponds to variant dbSNP:rs12943866Ensembl.1
Natural variantiVAR_03145050A → T. Corresponds to variant dbSNP:rs7216628Ensembl.1
Natural variantiVAR_053878433P → L. Corresponds to variant dbSNP:rs16970912Ensembl.1
Natural variantiVAR_053879642D → V. Corresponds to variant dbSNP:rs11657183Ensembl.1
Natural variantiVAR_031451652E → K. Corresponds to variant dbSNP:rs3744371Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0242739 – 326Missing in isoform 2. 1 PublicationAdd BLAST318

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056514 mRNA Translation: BAB71201.1
AK127728 mRNA No translation available.
CR749630 mRNA Translation: CAH18424.1
AL833747 mRNA Translation: CAH56227.1
CH471147 Genomic DNA Translation: EAW80150.1
CH471147 Genomic DNA Translation: EAW80152.1
CCDSiCCDS32620.1 [Q68D06-1]
RefSeqiNP_653283.3, NM_144682.5 [Q68D06-1]
XP_005257979.1, XM_005257922.2 [Q68D06-1]
XP_016879721.1, XM_017024232.1 [Q68D06-1]
XP_016879722.1, XM_017024233.1 [Q68D06-1]
UniGeneiHs.462833

Genome annotation databases

EnsembliENST00000285013; ENSP00000285013; ENSG00000154760 [Q68D06-1]
ENST00000526861; ENSP00000434439; ENSG00000154760 [Q68D06-1]
ENST00000533791; ENSP00000467426; ENSG00000154760 [Q68D06-1]
ENST00000534689; ENSP00000435442; ENSG00000154760 [Q68D06-2]
ENST00000542635; ENSP00000444016; ENSG00000154760 [Q68D06-1]
GeneIDi146857
KEGGihsa:146857
UCSCiuc002hjk.2 human [Q68D06-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSLN13_HUMAN
AccessioniPrimary (citable) accession number: Q68D06
Secondary accession number(s): E1P645
, Q658M1, Q6ZS51, Q96A81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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