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Q68D06

- SLN13_HUMAN

UniProt

Q68D06 - SLN13_HUMAN

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Protein

Schlafen family member 13

Gene

SLFN13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi599 – 6068ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Schlafen family member 13
Gene namesi
Name:SLFN13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:26481. SLFN13.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: LIFEdb
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596360.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 897897Schlafen family member 13PRO_0000282985Add
BLAST

Proteomic databases

MaxQBiQ68D06.
PaxDbiQ68D06.
PRIDEiQ68D06.

PTM databases

PhosphoSiteiQ68D06.

Expressioni

Gene expression databases

BgeeiQ68D06.
CleanExiHS_SLFN13.
ExpressionAtlasiQ68D06. baseline and differential.
GenevestigatoriQ68D06.

Organism-specific databases

HPAiHPA022532.
HPA023064.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000285013.

Structurei

3D structure databases

ProteinModelPortaliQ68D06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Schlafen family.Curated

Phylogenomic databases

eggNOGiNOG25289.
GeneTreeiENSGT00410000025651.
HOGENOMiHOG000049135.
HOVERGENiHBG056880.
InParanoidiQ68D06.
OMAiEKIRNMF.
OrthoDBiEOG712TVN.
PhylomeDBiQ68D06.
TreeFamiTF337168.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR007421. ATPase_AAA-4.
IPR018647. DUF2075.
IPR027417. P-loop_NTPase.
IPR029684. Schlafen.
IPR029679. SLFN13.
[Graphical view]
PANTHERiPTHR12155. PTHR12155. 1 hit.
PTHR12155:SF21. PTHR12155:SF21. 1 hit.
PfamiPF04326. AAA_4. 1 hit.
PF09848. DUF2075. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q68D06-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEANHCSLGV YPSYPDLVID VGEVTLGEEN RKKLQKTQRD QERARVIRAA
60 70 80 90 100
CALLNSGGGV IQMEMANRDE RPTEMGLDLE ESLRKLIQYP YLQAFFETKQ
110 120 130 140 150
HGRCFYIFVK SWSGDPFLKD GSFNSRICSL SSSLYCRSGT SVLHMNSRQA
160 170 180 190 200
FDFLKTKERQ SKYNLINEGS PPSKIMKAVY QNISESNPAY EVFQTDTIEY
210 220 230 240 250
GEILSFPESP SIEFKQFSTK HIQQYVENII PEYISAFANT EGGYLFIGVD
260 270 280 290 300
DKSRKVLGCA KEQVDPDSLK NVIARAISKL PIVHFCSSKP RVEYSTKIVE
310 320 330 340 350
VFCGKELYGY LCVIKVKAFC CVVFSEAPKS WMVREKYIRP LTTEEWVEKM
360 370 380 390 400
MDADPEFPPD FAEAFESQLS LSDSPSLCRP VYSKKGLEHK ADLQQHLFPV
410 420 430 440 450
PPGHLECTPE SLWKELSLQH EGLKELIHKQ MRPFSQGIVI LSRSWAVDLN
460 470 480 490 500
LQEKPGVICD ALLIAQNSTP ILYTILREQD AEGQDYCTRT AFTLKQKLVN
510 520 530 540 550
MGGYTGKVCV RAKVLCLSPE SSAEALEAAV SPMDYPASYS LAGTQHMEAL
560 570 580 590 600
LQSLVIVLLG FRSLLSDQLG CEVLNLLTAQ QYEIFSRSLR KNRELFVHGL
610 620 630 640 650
PGSGKTIMAM KIMEKIRNVF HCEAHRILYV CENQPLRNFI SDRNICRAET
660 670 680 690 700
RETFLREKFE HIQHIVIDEA QNFRTEDGDW YRKAKTITQR EKDCPGVLWI
710 720 730 740 750
FLDYFQTSHL GHSGLPPLSA QYPREELTRV VRNADEIAEY IQQEMQLIIE
760 770 780 790 800
NPPINIPHGY LAILSEAKWV PGVPGNTKII KNFTLEQIVT YVADTCRCFF
810 820 830 840 850
ERGYSPKDVA VLVSTVTEVE QYQSKLLKAM RKKMVVQLSD ACDMLGVHIV
860 870 880 890
LDSVRRFSGL ERSIVFGIHP RTADPAILPN ILICLASRAK QHLYIFL
Length:897
Mass (Da):102,045
Last modified:October 11, 2004 - v1
Checksum:i2D516123F44121D0
GO
Isoform 2 (identifier: Q68D06-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-326: Missing.

Show »
Length:579
Mass (Da):65,949
Checksum:i195AEFB2F4235C84
GO

Sequence cautioni

The sequence AK127728 differs from that shown. Reason: Frameshift at position 261. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41N → S.
Corresponds to variant rs12943866 [ dbSNP | Ensembl ].
VAR_031449
Natural varianti50 – 501A → T.
Corresponds to variant rs7216628 [ dbSNP | Ensembl ].
VAR_031450
Natural varianti433 – 4331P → L.
Corresponds to variant rs16970912 [ dbSNP | Ensembl ].
VAR_053878
Natural varianti642 – 6421D → V.
Corresponds to variant rs11657183 [ dbSNP | Ensembl ].
VAR_053879
Natural varianti652 – 6521E → K.
Corresponds to variant rs3744371 [ dbSNP | Ensembl ].
VAR_031451

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei9 – 326318Missing in isoform 2. 1 PublicationVSP_024273Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056514 mRNA. Translation: BAB71201.1.
AK127728 mRNA. No translation available.
CR749630 mRNA. Translation: CAH18424.1.
AL833747 mRNA. Translation: CAH56227.1.
CH471147 Genomic DNA. Translation: EAW80150.1.
CH471147 Genomic DNA. Translation: EAW80152.1.
CCDSiCCDS32620.1. [Q68D06-1]
RefSeqiNP_653283.3. NM_144682.5. [Q68D06-1]
XP_005257979.1. XM_005257922.1. [Q68D06-1]
XP_005257980.1. XM_005257923.1. [Q68D06-1]
XP_006721783.1. XM_006721720.1. [Q68D06-1]
UniGeneiHs.462833.

Genome annotation databases

EnsembliENST00000285013; ENSP00000285013; ENSG00000154760. [Q68D06-1]
ENST00000526861; ENSP00000434439; ENSG00000154760. [Q68D06-1]
ENST00000533791; ENSP00000467426; ENSG00000154760. [Q68D06-1]
ENST00000534689; ENSP00000435442; ENSG00000154760. [Q68D06-2]
ENST00000542635; ENSP00000444016; ENSG00000154760. [Q68D06-1]
GeneIDi146857.
KEGGihsa:146857.
UCSCiuc002hjk.1. human. [Q68D06-1]
uc010ctt.2. human. [Q68D06-2]

Polymorphism databases

DMDMi74708791.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056514 mRNA. Translation: BAB71201.1 .
AK127728 mRNA. No translation available.
CR749630 mRNA. Translation: CAH18424.1 .
AL833747 mRNA. Translation: CAH56227.1 .
CH471147 Genomic DNA. Translation: EAW80150.1 .
CH471147 Genomic DNA. Translation: EAW80152.1 .
CCDSi CCDS32620.1. [Q68D06-1 ]
RefSeqi NP_653283.3. NM_144682.5. [Q68D06-1 ]
XP_005257979.1. XM_005257922.1. [Q68D06-1 ]
XP_005257980.1. XM_005257923.1. [Q68D06-1 ]
XP_006721783.1. XM_006721720.1. [Q68D06-1 ]
UniGenei Hs.462833.

3D structure databases

ProteinModelPortali Q68D06.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000285013.

PTM databases

PhosphoSitei Q68D06.

Polymorphism databases

DMDMi 74708791.

Proteomic databases

MaxQBi Q68D06.
PaxDbi Q68D06.
PRIDEi Q68D06.

Protocols and materials databases

DNASUi 146857.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000285013 ; ENSP00000285013 ; ENSG00000154760 . [Q68D06-1 ]
ENST00000526861 ; ENSP00000434439 ; ENSG00000154760 . [Q68D06-1 ]
ENST00000533791 ; ENSP00000467426 ; ENSG00000154760 . [Q68D06-1 ]
ENST00000534689 ; ENSP00000435442 ; ENSG00000154760 . [Q68D06-2 ]
ENST00000542635 ; ENSP00000444016 ; ENSG00000154760 . [Q68D06-1 ]
GeneIDi 146857.
KEGGi hsa:146857.
UCSCi uc002hjk.1. human. [Q68D06-1 ]
uc010ctt.2. human. [Q68D06-2 ]

Organism-specific databases

CTDi 146857.
GeneCardsi GC17M033762.
H-InvDB HIX0020218.
HGNCi HGNC:26481. SLFN13.
HPAi HPA022532.
HPA023064.
MIMi 614957. gene.
neXtProti NX_Q68D06.
PharmGKBi PA144596360.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25289.
GeneTreei ENSGT00410000025651.
HOGENOMi HOG000049135.
HOVERGENi HBG056880.
InParanoidi Q68D06.
OMAi EKIRNMF.
OrthoDBi EOG712TVN.
PhylomeDBi Q68D06.
TreeFami TF337168.

Miscellaneous databases

GenomeRNAii 146857.
NextBioi 85487.
PROi Q68D06.
SOURCEi Search...

Gene expression databases

Bgeei Q68D06.
CleanExi HS_SLFN13.
ExpressionAtlasi Q68D06. baseline and differential.
Genevestigatori Q68D06.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR007421. ATPase_AAA-4.
IPR018647. DUF2075.
IPR027417. P-loop_NTPase.
IPR029684. Schlafen.
IPR029679. SLFN13.
[Graphical view ]
PANTHERi PTHR12155. PTHR12155. 1 hit.
PTHR12155:SF21. PTHR12155:SF21. 1 hit.
Pfami PF04326. AAA_4. 1 hit.
PF09848. DUF2075. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix and Stomach.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSLN13_HUMAN
AccessioniPrimary (citable) accession number: Q68D06
Secondary accession number(s): E1P645
, Q658M1, Q6ZS51, Q96A81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3