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Q68D06 (SLN13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Schlafen family member 13
Gene names
Name:SLFN13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length897 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the Schlafen family.

Sequence caution

The sequence AK127728 differs from that shown. Reason: Frameshift at position 261.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintracellular

Inferred from direct assay. Source: LIFEdb

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q68D06-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q68D06-2)

The sequence of this isoform differs from the canonical sequence as follows:
     9-326: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 897897Schlafen family member 13
PRO_0000282985

Regions

Nucleotide binding599 – 6068ATP Potential

Natural variations

Alternative sequence9 – 326318Missing in isoform 2.
VSP_024273
Natural variant41N → S.
Corresponds to variant rs12943866 [ dbSNP | Ensembl ].
VAR_031449
Natural variant501A → T.
Corresponds to variant rs7216628 [ dbSNP | Ensembl ].
VAR_031450
Natural variant4331P → L.
Corresponds to variant rs16970912 [ dbSNP | Ensembl ].
VAR_053878
Natural variant6421D → V.
Corresponds to variant rs11657183 [ dbSNP | Ensembl ].
VAR_053879
Natural variant6521E → K.
Corresponds to variant rs3744371 [ dbSNP | Ensembl ].
VAR_031451

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 2D516123F44121D0

FASTA897102,045
        10         20         30         40         50         60 
MEANHCSLGV YPSYPDLVID VGEVTLGEEN RKKLQKTQRD QERARVIRAA CALLNSGGGV 

        70         80         90        100        110        120 
IQMEMANRDE RPTEMGLDLE ESLRKLIQYP YLQAFFETKQ HGRCFYIFVK SWSGDPFLKD 

       130        140        150        160        170        180 
GSFNSRICSL SSSLYCRSGT SVLHMNSRQA FDFLKTKERQ SKYNLINEGS PPSKIMKAVY 

       190        200        210        220        230        240 
QNISESNPAY EVFQTDTIEY GEILSFPESP SIEFKQFSTK HIQQYVENII PEYISAFANT 

       250        260        270        280        290        300 
EGGYLFIGVD DKSRKVLGCA KEQVDPDSLK NVIARAISKL PIVHFCSSKP RVEYSTKIVE 

       310        320        330        340        350        360 
VFCGKELYGY LCVIKVKAFC CVVFSEAPKS WMVREKYIRP LTTEEWVEKM MDADPEFPPD 

       370        380        390        400        410        420 
FAEAFESQLS LSDSPSLCRP VYSKKGLEHK ADLQQHLFPV PPGHLECTPE SLWKELSLQH 

       430        440        450        460        470        480 
EGLKELIHKQ MRPFSQGIVI LSRSWAVDLN LQEKPGVICD ALLIAQNSTP ILYTILREQD 

       490        500        510        520        530        540 
AEGQDYCTRT AFTLKQKLVN MGGYTGKVCV RAKVLCLSPE SSAEALEAAV SPMDYPASYS 

       550        560        570        580        590        600 
LAGTQHMEAL LQSLVIVLLG FRSLLSDQLG CEVLNLLTAQ QYEIFSRSLR KNRELFVHGL 

       610        620        630        640        650        660 
PGSGKTIMAM KIMEKIRNVF HCEAHRILYV CENQPLRNFI SDRNICRAET RETFLREKFE 

       670        680        690        700        710        720 
HIQHIVIDEA QNFRTEDGDW YRKAKTITQR EKDCPGVLWI FLDYFQTSHL GHSGLPPLSA 

       730        740        750        760        770        780 
QYPREELTRV VRNADEIAEY IQQEMQLIIE NPPINIPHGY LAILSEAKWV PGVPGNTKII 

       790        800        810        820        830        840 
KNFTLEQIVT YVADTCRCFF ERGYSPKDVA VLVSTVTEVE QYQSKLLKAM RKKMVVQLSD 

       850        860        870        880        890 
ACDMLGVHIV LDSVRRFSGL ERSIVFGIHP RTADPAILPN ILICLASRAK QHLYIFL 

« Hide

Isoform 2 [UniParc].

Checksum: 195AEFB2F4235C84
Show »

FASTA57965,949

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Cervix and Stomach.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK056514 mRNA. Translation: BAB71201.1.
AK127728 mRNA. No translation available.
CR749630 mRNA. Translation: CAH18424.1.
AL833747 mRNA. Translation: CAH56227.1.
CH471147 Genomic DNA. Translation: EAW80150.1.
CH471147 Genomic DNA. Translation: EAW80152.1.
RefSeqNP_653283.3. NM_144682.5.
XP_005257979.1. XM_005257922.1.
XP_005257980.1. XM_005257923.1.
UniGeneHs.462833.

3D structure databases

ProteinModelPortalQ68D06.
SMRQ68D06. Positions 580-639.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000285013.

PTM databases

PhosphoSiteQ68D06.

Polymorphism databases

DMDM74708791.

Proteomic databases

PaxDbQ68D06.
PRIDEQ68D06.

Protocols and materials databases

DNASU146857.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000285013; ENSP00000285013; ENSG00000154760. [Q68D06-1]
ENST00000360502; ENSP00000353692; ENSG00000154760. [Q68D06-2]
ENST00000526861; ENSP00000434439; ENSG00000154760. [Q68D06-1]
ENST00000533791; ENSP00000467426; ENSG00000154760. [Q68D06-1]
ENST00000534689; ENSP00000435442; ENSG00000154760. [Q68D06-2]
ENST00000542635; ENSP00000444016; ENSG00000154760. [Q68D06-1]
GeneID146857.
KEGGhsa:146857.
UCSCuc002hjk.1. human. [Q68D06-1]
uc010ctt.2. human. [Q68D06-2]

Organism-specific databases

CTD146857.
GeneCardsGC17M033762.
H-InvDBHIX0020218.
HGNCHGNC:26481. SLFN13.
HPAHPA022532.
HPA023064.
MIM614957. gene.
neXtProtNX_Q68D06.
PharmGKBPA144596360.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG25289.
HOGENOMHOG000049135.
HOVERGENHBG056880.
InParanoidQ68D06.
OMATEVEQYQ.
OrthoDBEOG712TVN.
PhylomeDBQ68D06.
TreeFamTF337168.

Gene expression databases

ArrayExpressQ68D06.
BgeeQ68D06.
CleanExHS_SLFN13.
GenevestigatorQ68D06.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR007421. ATPase_AAA-4.
IPR018647. DUF2075.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF04326. AAA_4. 1 hit.
PF09848. DUF2075. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi146857.
NextBio85487.
PROQ68D06.
SOURCESearch...

Entry information

Entry nameSLN13_HUMAN
AccessionPrimary (citable) accession number: Q68D06
Secondary accession number(s): E1P645 expand/collapse secondary AC list , Q658M1, Q6ZS51, Q96A81
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM