Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q68D06

- SLN13_HUMAN

UniProt

Q68D06 - SLN13_HUMAN

Protein

Schlafen family member 13

Gene

SLFN13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi599 – 6068ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Schlafen family member 13
    Gene namesi
    Name:SLFN13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:26481. SLFN13.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: LIFEdb

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA144596360.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 897897Schlafen family member 13PRO_0000282985Add
    BLAST

    Proteomic databases

    MaxQBiQ68D06.
    PaxDbiQ68D06.
    PRIDEiQ68D06.

    PTM databases

    PhosphoSiteiQ68D06.

    Expressioni

    Gene expression databases

    ArrayExpressiQ68D06.
    BgeeiQ68D06.
    CleanExiHS_SLFN13.
    GenevestigatoriQ68D06.

    Organism-specific databases

    HPAiHPA022532.
    HPA023064.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000285013.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68D06.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Schlafen family.Curated

    Phylogenomic databases

    eggNOGiNOG25289.
    HOGENOMiHOG000049135.
    HOVERGENiHBG056880.
    InParanoidiQ68D06.
    OMAiEKIRNMF.
    OrthoDBiEOG712TVN.
    PhylomeDBiQ68D06.
    TreeFamiTF337168.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR007421. ATPase_AAA-4.
    IPR018647. DUF2075.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF04326. AAA_4. 1 hit.
    PF09848. DUF2075. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q68D06-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEANHCSLGV YPSYPDLVID VGEVTLGEEN RKKLQKTQRD QERARVIRAA    50
    CALLNSGGGV IQMEMANRDE RPTEMGLDLE ESLRKLIQYP YLQAFFETKQ 100
    HGRCFYIFVK SWSGDPFLKD GSFNSRICSL SSSLYCRSGT SVLHMNSRQA 150
    FDFLKTKERQ SKYNLINEGS PPSKIMKAVY QNISESNPAY EVFQTDTIEY 200
    GEILSFPESP SIEFKQFSTK HIQQYVENII PEYISAFANT EGGYLFIGVD 250
    DKSRKVLGCA KEQVDPDSLK NVIARAISKL PIVHFCSSKP RVEYSTKIVE 300
    VFCGKELYGY LCVIKVKAFC CVVFSEAPKS WMVREKYIRP LTTEEWVEKM 350
    MDADPEFPPD FAEAFESQLS LSDSPSLCRP VYSKKGLEHK ADLQQHLFPV 400
    PPGHLECTPE SLWKELSLQH EGLKELIHKQ MRPFSQGIVI LSRSWAVDLN 450
    LQEKPGVICD ALLIAQNSTP ILYTILREQD AEGQDYCTRT AFTLKQKLVN 500
    MGGYTGKVCV RAKVLCLSPE SSAEALEAAV SPMDYPASYS LAGTQHMEAL 550
    LQSLVIVLLG FRSLLSDQLG CEVLNLLTAQ QYEIFSRSLR KNRELFVHGL 600
    PGSGKTIMAM KIMEKIRNVF HCEAHRILYV CENQPLRNFI SDRNICRAET 650
    RETFLREKFE HIQHIVIDEA QNFRTEDGDW YRKAKTITQR EKDCPGVLWI 700
    FLDYFQTSHL GHSGLPPLSA QYPREELTRV VRNADEIAEY IQQEMQLIIE 750
    NPPINIPHGY LAILSEAKWV PGVPGNTKII KNFTLEQIVT YVADTCRCFF 800
    ERGYSPKDVA VLVSTVTEVE QYQSKLLKAM RKKMVVQLSD ACDMLGVHIV 850
    LDSVRRFSGL ERSIVFGIHP RTADPAILPN ILICLASRAK QHLYIFL 897
    Length:897
    Mass (Da):102,045
    Last modified:October 11, 2004 - v1
    Checksum:i2D516123F44121D0
    GO
    Isoform 2 (identifier: Q68D06-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         9-326: Missing.

    Show »
    Length:579
    Mass (Da):65,949
    Checksum:i195AEFB2F4235C84
    GO

    Sequence cautioni

    The sequence AK127728 differs from that shown. Reason: Frameshift at position 261.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41N → S.
    Corresponds to variant rs12943866 [ dbSNP | Ensembl ].
    VAR_031449
    Natural varianti50 – 501A → T.
    Corresponds to variant rs7216628 [ dbSNP | Ensembl ].
    VAR_031450
    Natural varianti433 – 4331P → L.
    Corresponds to variant rs16970912 [ dbSNP | Ensembl ].
    VAR_053878
    Natural varianti642 – 6421D → V.
    Corresponds to variant rs11657183 [ dbSNP | Ensembl ].
    VAR_053879
    Natural varianti652 – 6521E → K.
    Corresponds to variant rs3744371 [ dbSNP | Ensembl ].
    VAR_031451

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei9 – 326318Missing in isoform 2. 1 PublicationVSP_024273Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056514 mRNA. Translation: BAB71201.1.
    AK127728 mRNA. No translation available.
    CR749630 mRNA. Translation: CAH18424.1.
    AL833747 mRNA. Translation: CAH56227.1.
    CH471147 Genomic DNA. Translation: EAW80150.1.
    CH471147 Genomic DNA. Translation: EAW80152.1.
    CCDSiCCDS32620.1. [Q68D06-1]
    RefSeqiNP_653283.3. NM_144682.5. [Q68D06-1]
    XP_005257979.1. XM_005257922.1. [Q68D06-1]
    XP_005257980.1. XM_005257923.1. [Q68D06-1]
    XP_006721783.1. XM_006721720.1. [Q68D06-1]
    UniGeneiHs.462833.

    Genome annotation databases

    EnsembliENST00000285013; ENSP00000285013; ENSG00000154760. [Q68D06-1]
    ENST00000526861; ENSP00000434439; ENSG00000154760. [Q68D06-1]
    ENST00000533791; ENSP00000467426; ENSG00000154760. [Q68D06-1]
    ENST00000534689; ENSP00000435442; ENSG00000154760. [Q68D06-2]
    ENST00000542635; ENSP00000444016; ENSG00000154760. [Q68D06-1]
    GeneIDi146857.
    KEGGihsa:146857.
    UCSCiuc002hjk.1. human. [Q68D06-1]
    uc010ctt.2. human. [Q68D06-2]

    Polymorphism databases

    DMDMi74708791.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056514 mRNA. Translation: BAB71201.1 .
    AK127728 mRNA. No translation available.
    CR749630 mRNA. Translation: CAH18424.1 .
    AL833747 mRNA. Translation: CAH56227.1 .
    CH471147 Genomic DNA. Translation: EAW80150.1 .
    CH471147 Genomic DNA. Translation: EAW80152.1 .
    CCDSi CCDS32620.1. [Q68D06-1 ]
    RefSeqi NP_653283.3. NM_144682.5. [Q68D06-1 ]
    XP_005257979.1. XM_005257922.1. [Q68D06-1 ]
    XP_005257980.1. XM_005257923.1. [Q68D06-1 ]
    XP_006721783.1. XM_006721720.1. [Q68D06-1 ]
    UniGenei Hs.462833.

    3D structure databases

    ProteinModelPortali Q68D06.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000285013.

    PTM databases

    PhosphoSitei Q68D06.

    Polymorphism databases

    DMDMi 74708791.

    Proteomic databases

    MaxQBi Q68D06.
    PaxDbi Q68D06.
    PRIDEi Q68D06.

    Protocols and materials databases

    DNASUi 146857.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000285013 ; ENSP00000285013 ; ENSG00000154760 . [Q68D06-1 ]
    ENST00000526861 ; ENSP00000434439 ; ENSG00000154760 . [Q68D06-1 ]
    ENST00000533791 ; ENSP00000467426 ; ENSG00000154760 . [Q68D06-1 ]
    ENST00000534689 ; ENSP00000435442 ; ENSG00000154760 . [Q68D06-2 ]
    ENST00000542635 ; ENSP00000444016 ; ENSG00000154760 . [Q68D06-1 ]
    GeneIDi 146857.
    KEGGi hsa:146857.
    UCSCi uc002hjk.1. human. [Q68D06-1 ]
    uc010ctt.2. human. [Q68D06-2 ]

    Organism-specific databases

    CTDi 146857.
    GeneCardsi GC17M033762.
    H-InvDB HIX0020218.
    HGNCi HGNC:26481. SLFN13.
    HPAi HPA022532.
    HPA023064.
    MIMi 614957. gene.
    neXtProti NX_Q68D06.
    PharmGKBi PA144596360.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25289.
    HOGENOMi HOG000049135.
    HOVERGENi HBG056880.
    InParanoidi Q68D06.
    OMAi EKIRNMF.
    OrthoDBi EOG712TVN.
    PhylomeDBi Q68D06.
    TreeFami TF337168.

    Miscellaneous databases

    GenomeRNAii 146857.
    NextBioi 85487.
    PROi Q68D06.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q68D06.
    Bgeei Q68D06.
    CleanExi HS_SLFN13.
    Genevestigatori Q68D06.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR007421. ATPase_AAA-4.
    IPR018647. DUF2075.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF04326. AAA_4. 1 hit.
    PF09848. DUF2075. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cervix and Stomach.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSLN13_HUMAN
    AccessioniPrimary (citable) accession number: Q68D06
    Secondary accession number(s): E1P645
    , Q658M1, Q6ZS51, Q96A81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3