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Protein

HAUS augmin-like complex subunit 3

Gene

HAUS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.2 Publications

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • centrosome organization Source: UniProtKB
  • mitotic nuclear division Source: UniProtKB-KW
  • spindle assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
HAUS augmin-like complex subunit 3
Gene namesi
Name:HAUS3
Synonyms:C4orf15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:28719. HAUS3.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • HAUS complex Source: UniProtKB
  • microtubule Source: UniProtKB-KW
  • microtubule cytoskeleton Source: HPA
  • mitochondrion Source: HPA
  • nucleoplasm Source: HPA
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165664132.

Polymorphism and mutation databases

BioMutaiHAUS3.
DMDMi74708788.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 603602HAUS augmin-like complex subunit 3PRO_0000301951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ68CZ6.
MaxQBiQ68CZ6.
PaxDbiQ68CZ6.
PeptideAtlasiQ68CZ6.
PRIDEiQ68CZ6.

PTM databases

iPTMnetiQ68CZ6.
PhosphoSiteiQ68CZ6.

Expressioni

Gene expression databases

BgeeiQ68CZ6.
CleanExiHS_C4orf15.
ExpressionAtlasiQ68CZ6. baseline and differential.
GenevisibleiQ68CZ6. HS.

Organism-specific databases

HPAiHPA048190.

Interactioni

Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
C19orf57Q0VDD73EBI-2558217,EBI-741210
DKFZp451B226Q5HYH73EBI-2558217,EBI-10173842
TXLNAP402223EBI-2558217,EBI-359793

Protein-protein interaction databases

BioGridi122667. 44 interactions.
DIPiDIP-48832N.
IntActiQ68CZ6. 43 interactions.
STRINGi9606.ENSP00000243706.

Structurei

3D structure databases

ProteinModelPortaliQ68CZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili93 – 17785Sequence analysisAdd
BLAST
Coiled coili305 – 33632Sequence analysisAdd
BLAST
Coiled coili389 – 42638Sequence analysisAdd
BLAST
Coiled coili458 – 49538Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the HAUS3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG8W. Eukaryota.
ENOG4111N2F. LUCA.
GeneTreeiENSGT00390000011904.
HOGENOMiHOG000054217.
HOVERGENiHBG060746.
InParanoidiQ68CZ6.
KOiK16586.
OMAiEQFHQVE.
OrthoDBiEOG71P2C7.
PhylomeDBiQ68CZ6.
TreeFamiTF331151.

Family and domain databases

InterProiIPR026206. HAUS3.
IPR032733. HAUS3_N.
[Graphical view]
PANTHERiPTHR19378. PTHR19378. 1 hit.
PfamiPF14932. HAUS-augmin3. 1 hit.
[Graphical view]
PRINTSiPR02089. HAUSAUGMINL3.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q68CZ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCGNEFVET LKKIGYPKAD NLNGEDFDWL FEGVEDESFL KWFCGNVNEQ
60 70 80 90 100
NVLSERELEA FSILQKSGKP ILEGAALDEA LKTCKTSDLK TPRLDDKELE
110 120 130 140 150
KLEDEVQTLL KLKNLKIQRR NKCQLMASVT SHKSLRLNAK EEEATKKLKQ
160 170 180 190 200
SQGILNAMIT KISNELQALT DEVTQLMMFF RHSNLGQGTN PLVFLSQFSL
210 220 230 240 250
EKYLSQEEQS TAALTLYTKK QFFQGIHEVV ESSNEDNFQL LDIQTPSICD
260 270 280 290 300
NQEILEERRL EMARLQLAYI CAQHQLIHLK ASNSSMKSSI KWAEESLHSL
310 320 330 340 350
TSKAVDKENL DAKISSLTSE IMKLEKEVTQ IKDRSLPAVV RENAQLLNMP
360 370 380 390 400
VVKGDFDLQI AKQDYYTARQ ELVLNQLIKQ KASFELLQLS YEIELRKHRD
410 420 430 440 450
IYRQLENLVQ ELSQSNMMLY KQLEMLTDPS VSQQINPRNT IDTKDYSTHR
460 470 480 490 500
LYQVLEGENK KKELFLTHGN LEEVAEKLKQ NISLVQDQLA VSAQEHSFFL
510 520 530 540 550
SKRNKDVDML CDTLYQGGNQ LLLSDQELTE QFHKVESQLN KLNHLLTDIL
560 570 580 590 600
ADVKTKRKTL ANNKLHQMER EFYVYFLKDE DYLKDIVENL ETQSKIKAVS

LED
Length:603
Mass (Da):69,650
Last modified:October 11, 2004 - v1
Checksum:iC65B80CC58F326E9
GO
Isoform 2 (identifier: Q68CZ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     477-489: KLKQNISLVQDQL → AGEWHEPRRRGLQ
     490-603: Missing.

Note: No experimental confirmation available.
Show »
Length:489
Mass (Da):56,384
Checksum:i5538DA1354A2E7C9
GO

Sequence cautioni

The sequence AAB97010.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH03648.1 differs from that shown. Reason: Frameshift at position 12. Curated
The sequence AAH03648.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH25356.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti586 – 5861I → T.
Corresponds to variant rs11937432 [ dbSNP | Ensembl ].
VAR_034912

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei477 – 48913KLKQN…VQDQL → AGEWHEPRRRGLQ in isoform 2. 1 PublicationVSP_057022Add
BLAST
Alternative sequencei490 – 603114Missing in isoform 2. 1 PublicationVSP_057023Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040964 mRNA. Translation: AAB97010.1. Different initiation.
AK293948 mRNA. Translation: BAG57325.1.
CR749640 mRNA. Translation: CAH18434.1.
AL158068 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82537.1.
BC003648 mRNA. Translation: AAH03648.1. Frameshift.
BC025356 mRNA. Translation: AAH25356.1. Different initiation.
CCDSiCCDS33941.1. [Q68CZ6-1]
RefSeqiNP_001290072.1. NM_001303143.1. [Q68CZ6-1]
NP_078787.2. NM_024511.6. [Q68CZ6-1]
UniGeneiHs.665869.

Genome annotation databases

EnsembliENST00000243706; ENSP00000243706; ENSG00000214367. [Q68CZ6-1]
ENST00000443786; ENSP00000392903; ENSG00000214367. [Q68CZ6-1]
ENST00000506763; ENSP00000427350; ENSG00000214367. [Q68CZ6-2]
GeneIDi79441.
KEGGihsa:79441.
UCSCiuc003ges.2. human. [Q68CZ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040964 mRNA. Translation: AAB97010.1. Different initiation.
AK293948 mRNA. Translation: BAG57325.1.
CR749640 mRNA. Translation: CAH18434.1.
AL158068 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82537.1.
BC003648 mRNA. Translation: AAH03648.1. Frameshift.
BC025356 mRNA. Translation: AAH25356.1. Different initiation.
CCDSiCCDS33941.1. [Q68CZ6-1]
RefSeqiNP_001290072.1. NM_001303143.1. [Q68CZ6-1]
NP_078787.2. NM_024511.6. [Q68CZ6-1]
UniGeneiHs.665869.

3D structure databases

ProteinModelPortaliQ68CZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122667. 44 interactions.
DIPiDIP-48832N.
IntActiQ68CZ6. 43 interactions.
STRINGi9606.ENSP00000243706.

PTM databases

iPTMnetiQ68CZ6.
PhosphoSiteiQ68CZ6.

Polymorphism and mutation databases

BioMutaiHAUS3.
DMDMi74708788.

Proteomic databases

EPDiQ68CZ6.
MaxQBiQ68CZ6.
PaxDbiQ68CZ6.
PeptideAtlasiQ68CZ6.
PRIDEiQ68CZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243706; ENSP00000243706; ENSG00000214367. [Q68CZ6-1]
ENST00000443786; ENSP00000392903; ENSG00000214367. [Q68CZ6-1]
ENST00000506763; ENSP00000427350; ENSG00000214367. [Q68CZ6-2]
GeneIDi79441.
KEGGihsa:79441.
UCSCiuc003ges.2. human. [Q68CZ6-1]

Organism-specific databases

CTDi79441.
GeneCardsiHAUS3.
HGNCiHGNC:28719. HAUS3.
HPAiHPA048190.
MIMi613430. gene.
neXtProtiNX_Q68CZ6.
PharmGKBiPA165664132.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG8W. Eukaryota.
ENOG4111N2F. LUCA.
GeneTreeiENSGT00390000011904.
HOGENOMiHOG000054217.
HOVERGENiHBG060746.
InParanoidiQ68CZ6.
KOiK16586.
OMAiEQFHQVE.
OrthoDBiEOG71P2C7.
PhylomeDBiQ68CZ6.
TreeFamiTF331151.

Miscellaneous databases

GeneWikiiHAUS3.
GenomeRNAii79441.
NextBioi35471416.
PROiQ68CZ6.
SOURCEiSearch...

Gene expression databases

BgeeiQ68CZ6.
CleanExiHS_C4orf15.
ExpressionAtlasiQ68CZ6. baseline and differential.
GenevisibleiQ68CZ6. HS.

Family and domain databases

InterProiIPR026206. HAUS3.
IPR032733. HAUS3_N.
[Graphical view]
PANTHERiPTHR19378. PTHR19378. 1 hit.
PfamiPF14932. HAUS-augmin3. 1 hit.
[Graphical view]
PRINTSiPR02089. HAUSAUGMINL3.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comparison of exon trapping and sequence-based methods of gene finding."
    Pribill I., Barnes G.T., Chen J., Church D., Buckler A., Baxendale S., Bates G.P., Lehrach H., Gusella M.J., Duyao M.P., Ambrose C.M., MacDonald M.E., Gusella J.F.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Endometrial adenocarcinoma.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung carcinoma and Rhabdomyosarcoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION IN THE HAUS AUGMIN-LIKE COMPLEX, FUNCTION.
  9. "The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells."
    Uehara R., Nozawa R.-S., Tomioka A., Petry S., Vale R.D., Obuse C., Goshima G.
    Proc. Natl. Acad. Sci. U.S.A. 106:6998-7003(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE HAUS AUGMIN-LIKE COMPLEX, FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiHAUS3_HUMAN
AccessioniPrimary (citable) accession number: Q68CZ6
Secondary accession number(s): B4DF64
, O43606, Q8TAZ5, Q9BTJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2004
Last modified: May 11, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.