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Protein

Tensin-3

Gene

TNS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-8875513. MET interacts with TNS proteins.
SignaLinkiQ68CZ2.
SIGNORiQ68CZ2.

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin-3
Alternative name(s):
Tensin-like SH2 domain-containing protein 1
Tumor endothelial marker 6
Gene namesi
Name:TNS3
Synonyms:TEM6, TENS1, TPP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21616. TNS3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • focal adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi64759.
OpenTargetsiENSG00000136205.
PharmGKBiPA134888115.

Polymorphism and mutation databases

BioMutaiTNS3.
DMDMi156637424.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002959151 – 1445Tensin-3Add BLAST1445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei332PhosphoserineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1
Modified residuei571PhosphoserineBy similarity1
Modified residuei632PhosphothreonineCombined sources1
Modified residuei649PhosphoserineCombined sources1
Modified residuei660PhosphoserineCombined sources1
Modified residuei687PhosphoserineBy similarity1
Modified residuei690PhosphoserineBy similarity1
Modified residuei735PhosphoserineCombined sources1
Modified residuei776PhosphoserineCombined sources1
Modified residuei780PhosphotyrosineCombined sources1
Modified residuei811PhosphoserineCombined sources1
Modified residuei866PhosphoserineCombined sources1
Modified residuei901PhosphoserineCombined sources1
Modified residuei1149PhosphoserineCombined sources1
Modified residuei1154PhosphoserineCombined sources1
Modified residuei1293PhosphoserineCombined sources1
Modified residuei1441PhosphoserineCombined sources1

Post-translational modificationi

EGF/epidermal growth factor induces tyrosine phosphorylation in a time- and dose-dependent manner.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ68CZ2.
MaxQBiQ68CZ2.
PaxDbiQ68CZ2.
PeptideAtlasiQ68CZ2.
PRIDEiQ68CZ2.

PTM databases

iPTMnetiQ68CZ2.
PhosphoSitePlusiQ68CZ2.

Expressioni

Tissue specificityi

Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.3 Publications

Inductioni

Down-regulated by EGF.2 Publications

Gene expression databases

BgeeiENSG00000136205.
CleanExiHS_TNS3.
ExpressionAtlasiQ68CZ2. baseline and differential.
GenevisibleiQ68CZ2. HS.

Organism-specific databases

HPAiHPA055338.
HPA056015.

Interactioni

Subunit structurei

EGF promotes the interaction with EGFR. Interacts with PTK2/FAK1 and BCAR1. Tyrosine phosphorylation is critical for these interactions.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BCAR1P569458EBI-1220488,EBI-702093
CDH1P128302EBI-1220488,EBI-727477
EGFRP005334EBI-1220488,EBI-297353
ERBB2P046262EBI-1220488,EBI-641062
ERBB3P218602EBI-1220488,EBI-720706
KITP107215EBI-1220488,EBI-1379503
METP085813EBI-1220488,EBI-1039152
PTK2Q053973EBI-1220488,EBI-702142
SRCP1293113EBI-1220488,EBI-621482

Protein-protein interaction databases

BioGridi122272. 14 interactors.
IntActiQ68CZ2. 21 interactors.
MINTiMINT-1494711.
STRINGi9606.ENSP00000312143.

Structurei

3D structure databases

ProteinModelPortaliQ68CZ2.
SMRiQ68CZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 170Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST170
Domaini175 – 301C2 tensin-typePROSITE-ProRule annotationAdd BLAST127
Domaini1172 – 1282SH2PROSITE-ProRule annotationAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi941 – 944Poly-Ser4

Sequence similaritiesi

Contains 1 C2 tensin-type domain.PROSITE-ProRule annotation
Contains 1 phosphatase tensin-type domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG1930. Eukaryota.
KOG2283. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000119113.
HOVERGENiHBG060186.
InParanoidiQ68CZ2.
KOiK18080.
OMAiIPERDPL.
OrthoDBiEOG091G0G8Y.
PhylomeDBiQ68CZ2.
TreeFamiTF315996.

Family and domain databases

CDDicd01213. PTB_tensin. 1 hit.
Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR033929. Tensin_PTB.
IPR003595. Tyr_Pase_cat.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM01326. PTEN_C2. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q68CZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEGHGLDLT YITERIIAVS FPAGCSEESY LHNLQEVTRM LKSKHGDNYL
60 70 80 90 100
VLNLSEKRYD LTKLNPKIMD VGWPELHAPP LDKMCTICKA QESWLNSNLQ
110 120 130 140 150
HVVVIHCRGG KGRIGVVISS YMHFTNVSAS ADQALDRFAM KKFYDDKVSA
160 170 180 190 200
LMQPSQKRYV QFLSGLLSGS VKMNASPLFL HFVILHGTPN FDTGGVCRPF
210 220 230 240 250
LKLYQAMQPV YTSGIYNVGP ENPSRICIVI EPAQLLKGDV MVKCYHKKYR
260 270 280 290 300
SATRDVIFRL QFHTGAVQGY GLVFGKEDLD NASKDDRFPD YGKVELVFSA
310 320 330 340 350
TPEKIQGSEH LYNDHGVIVD YNTTDPLIRW DSYENLSADG EVLHTQGPVD
360 370 380 390 400
GSLYAKVRKK SSSDPGIPGG PQAIPATNSP DHSDHTLSVS SDSGHSTASA
410 420 430 440 450
RTDKTEERLA PGTRRGLSAQ EKAELDQLLS GFGLEDPGSS LKEMTDARSK
460 470 480 490 500
YSGTRHVVPA QVHVNGDAAL KDRETDILDD EMPHHDLHSV DSLGTLSSSE
510 520 530 540 550
GPQSAHLGPF TCHKSSQNSL LSDGFGSNVG EDPQGTLVPD LGLGMDGPYE
560 570 580 590 600
RERTFGSREP KQPQPLLRKP SVSAQMQAYG QSSYSTQTWV RQQQMVVAHQ
610 620 630 640 650
YSFAPDGEAR LVSRCPADNP GLVQAQPRVP LTPTRGTSSR VAVQRGVGSG
660 670 680 690 700
PHPPDTQQPS PSKAFKPRFP GDQVVNGAGP ELSTGPSPGS PTLDIDQSIE
710 720 730 740 750
QLNRLILELD PTFEPIPTHM NALGSQANGS VSPDSVGGGL RASSRLPDTG
760 770 780 790 800
EGPSRATGRQ GSSAEQPLGG RLRKLSLGQY DNDAGGQLPF SKCAWGKAGV
810 820 830 840 850
DYAPNLPPFP SPADVKETMT PGYPQDLDII DGRILSSKES MCSTPAFPVS
860 870 880 890 900
PETPYVKTAL RHPPFSPPEP PLSSPASQHK GGREPRSCPE TLTHAVGMSE
910 920 930 940 950
SPIGPKSTML RADASSTPSF QQAFASSCTI SSNGPGQRRE SSSSAERQWV
960 970 980 990 1000
ESSPKPMVSL LGSGRPTGSP LSAEFSGTRK DSPVLSCFPP SELQAPFHSH
1010 1020 1030 1040 1050
ELSLAEPPDS LAPPSSQAFL GFGTAPVGSG LPPEEDLGAL LANSHGASPT
1060 1070 1080 1090 1100
PSIPLTATGA ADNGFLSHNF LTVAPGHSSH HSPGLQGQGV TLPGQPPLPE
1110 1120 1130 1140 1150
KKRASEGDRS LGSVSPSSSG FSSPHSGSTI SIPFPNVLPD FSKASEAASP
1160 1170 1180 1190 1200
LPDSPGDKLV IVKFVQDTSK FWYKADISRE QAIAMLKDKE PGSFIVRDSH
1210 1220 1230 1240 1250
SFRGAYGLAM KVATPPPSVL QLNKKAGDLA NELVRHFLIE CTPKGVRLKG
1260 1270 1280 1290 1300
CSNEPYFGSL TALVCQHSIT PLALPCKLLI PERDPLEEIA ESSPQTAANS
1310 1320 1330 1340 1350
AAELLKQGAA CNVWYLNSVE MESLTGHQAI QKALSITLVQ EPPPVSTVVH
1360 1370 1380 1390 1400
FKVSAQGITL TDNQRKLFFR RHYPVNSVIF CALDPQDRKW IKDGPSSKVF
1410 1420 1430 1440
GFVARKQGSA TDNVCHLFAE HDPEQPASAI VNFVSKVMIG SPKKV
Length:1,445
Mass (Da):155,266
Last modified:July 24, 2007 - v2
Checksum:i40B02C6269899320
GO
Isoform 2 (identifier: Q68CZ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-480: Missing.

Show »
Length:1,205
Mass (Da):129,066
Checksum:i7E02E291D5DF030D
GO
Isoform 3 (identifier: Q68CZ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     381-391: DHSDHTLSVSS → ANVLFELIGQV
     392-1445: Missing.

Show »
Length:391
Mass (Da):43,549
Checksum:iB35A18476C52C6F3
GO
Isoform 4 (identifier: Q68CZ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-250: KCYHKKYR → MNYNIANI
     251-1445: Missing.

Show »
Length:250
Mass (Da):28,043
Checksum:i35E9ABB42FF739A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31L → P in AAN32667 (PubMed:15140944).Curated1
Sequence conflicti458V → A in CAH18438 (PubMed:11230166).Curated1
Sequence conflicti505A → V in AAN32667 (PubMed:15140944).Curated1
Sequence conflicti917T → A in CAH18438 (PubMed:11230166).Curated1
Sequence conflicti1047A → T in CAH18438 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034593600Q → H.Corresponds to variant rs2293362dbSNPEnsembl.1
Natural variantiVAR_034594679G → S.Corresponds to variant rs7808646dbSNPEnsembl.1
Natural variantiVAR_0525481034E → K.Corresponds to variant rs3807590dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027123241 – 480Missing in isoform 2. 1 PublicationAdd BLAST240
Alternative sequenceiVSP_027124243 – 250KCYHKKYR → MNYNIANI in isoform 4. 1 Publication8
Alternative sequenceiVSP_027125251 – 1445Missing in isoform 4. 1 PublicationAdd BLAST1195
Alternative sequenceiVSP_027126381 – 391DHSDHTLSVSS → ANVLFELIGQV in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_027127392 – 1445Missing in isoform 3. 1 PublicationAdd BLAST1054

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378756 mRNA. Translation: AAL11993.1.
AF417489 mRNA. Translation: AAN32667.1.
AK092864 mRNA. Translation: BAC03993.1.
CR749644 mRNA. Translation: CAH18438.1.
AC073341 Genomic DNA. Translation: AAQ96841.1.
CH471128 Genomic DNA. Translation: EAW61011.1.
BC071791 mRNA. Translation: AAH71791.1.
BC137133 mRNA. Translation: AAI37134.1.
BC137134 mRNA. Translation: AAI37135.1.
AB062750 mRNA. Translation: BAB60681.1.
CCDSiCCDS5506.2. [Q68CZ2-1]
RefSeqiNP_073585.8. NM_022748.11. [Q68CZ2-1]
XP_011513782.1. XM_011515480.2. [Q68CZ2-1]
XP_011513783.1. XM_011515481.2. [Q68CZ2-1]
XP_011513784.1. XM_011515482.2. [Q68CZ2-1]
XP_011513785.1. XM_011515483.2. [Q68CZ2-1]
XP_016868028.1. XM_017012539.1. [Q68CZ2-1]
UniGeneiHs.520814.

Genome annotation databases

EnsembliENST00000311160; ENSP00000312143; ENSG00000136205. [Q68CZ2-1]
ENST00000442536; ENSP00000389285; ENSG00000136205. [Q68CZ2-4]
ENST00000458317; ENSP00000388318; ENSG00000136205. [Q68CZ2-4]
GeneIDi64759.
KEGGihsa:64759.
UCSCiuc003tnw.3. human. [Q68CZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378756 mRNA. Translation: AAL11993.1.
AF417489 mRNA. Translation: AAN32667.1.
AK092864 mRNA. Translation: BAC03993.1.
CR749644 mRNA. Translation: CAH18438.1.
AC073341 Genomic DNA. Translation: AAQ96841.1.
CH471128 Genomic DNA. Translation: EAW61011.1.
BC071791 mRNA. Translation: AAH71791.1.
BC137133 mRNA. Translation: AAI37134.1.
BC137134 mRNA. Translation: AAI37135.1.
AB062750 mRNA. Translation: BAB60681.1.
CCDSiCCDS5506.2. [Q68CZ2-1]
RefSeqiNP_073585.8. NM_022748.11. [Q68CZ2-1]
XP_011513782.1. XM_011515480.2. [Q68CZ2-1]
XP_011513783.1. XM_011515481.2. [Q68CZ2-1]
XP_011513784.1. XM_011515482.2. [Q68CZ2-1]
XP_011513785.1. XM_011515483.2. [Q68CZ2-1]
XP_016868028.1. XM_017012539.1. [Q68CZ2-1]
UniGeneiHs.520814.

3D structure databases

ProteinModelPortaliQ68CZ2.
SMRiQ68CZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122272. 14 interactors.
IntActiQ68CZ2. 21 interactors.
MINTiMINT-1494711.
STRINGi9606.ENSP00000312143.

PTM databases

iPTMnetiQ68CZ2.
PhosphoSitePlusiQ68CZ2.

Polymorphism and mutation databases

BioMutaiTNS3.
DMDMi156637424.

Proteomic databases

EPDiQ68CZ2.
MaxQBiQ68CZ2.
PaxDbiQ68CZ2.
PeptideAtlasiQ68CZ2.
PRIDEiQ68CZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311160; ENSP00000312143; ENSG00000136205. [Q68CZ2-1]
ENST00000442536; ENSP00000389285; ENSG00000136205. [Q68CZ2-4]
ENST00000458317; ENSP00000388318; ENSG00000136205. [Q68CZ2-4]
GeneIDi64759.
KEGGihsa:64759.
UCSCiuc003tnw.3. human. [Q68CZ2-1]

Organism-specific databases

CTDi64759.
DisGeNETi64759.
GeneCardsiTNS3.
HGNCiHGNC:21616. TNS3.
HPAiHPA055338.
HPA056015.
MIMi606825. gene.
neXtProtiNX_Q68CZ2.
OpenTargetsiENSG00000136205.
PharmGKBiPA134888115.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1930. Eukaryota.
KOG2283. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000119113.
HOVERGENiHBG060186.
InParanoidiQ68CZ2.
KOiK18080.
OMAiIPERDPL.
OrthoDBiEOG091G0G8Y.
PhylomeDBiQ68CZ2.
TreeFamiTF315996.

Enzyme and pathway databases

ReactomeiR-HSA-8875513. MET interacts with TNS proteins.
SignaLinkiQ68CZ2.
SIGNORiQ68CZ2.

Miscellaneous databases

ChiTaRSiTNS3. human.
GenomeRNAii64759.
PROiQ68CZ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136205.
CleanExiHS_TNS3.
ExpressionAtlasiQ68CZ2. baseline and differential.
GenevisibleiQ68CZ2. HS.

Family and domain databases

CDDicd01213. PTB_tensin. 1 hit.
Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR033929. Tensin_PTB.
IPR003595. Tyr_Pase_cat.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM01326. PTEN_C2. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTENS3_HUMAN
AccessioniPrimary (citable) accession number: Q68CZ2
Secondary accession number(s): B2RNV1
, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.