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Q68CZ2

- TENS3_HUMAN

UniProt

Q68CZ2 - TENS3_HUMAN

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Protein

Tensin-3

Gene

TNS3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity).By similarity

GO - Biological processi

  1. cell migration Source: Ensembl
  2. lung alveolus development Source: Ensembl
  3. positive regulation of cell proliferation Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ68CZ2.

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin-3
Alternative name(s):
Tensin-like SH2 domain-containing protein 1
Tumor endothelial marker 6
Gene namesi
Name:TNS3
Synonyms:TEM6, TENS1, TPP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21616. TNS3.

Subcellular locationi

Cell junctionfocal adhesion 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. focal adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134888115.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14451445Tensin-3PRO_0000295915Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei332 – 3321Phosphoserine1 Publication
Modified residuei632 – 6321Phosphothreonine1 Publication
Modified residuei649 – 6491Phosphoserine1 Publication
Modified residuei660 – 6601Phosphoserine2 Publications
Modified residuei687 – 6871PhosphoserineBy similarity
Modified residuei690 – 6901PhosphoserineBy similarity
Modified residuei735 – 7351Phosphoserine1 Publication
Modified residuei776 – 7761Phosphoserine2 Publications
Modified residuei780 – 7801Phosphotyrosine1 Publication
Modified residuei811 – 8111Phosphoserine1 Publication
Modified residuei866 – 8661Phosphoserine1 Publication
Modified residuei901 – 9011Phosphoserine1 Publication
Modified residuei1149 – 11491Phosphoserine2 Publications
Modified residuei1154 – 11541Phosphoserine2 Publications
Modified residuei1293 – 12931Phosphoserine1 Publication

Post-translational modificationi

EGF/epidermal growth factor induces tyrosine phosphorylation in a time- and dose-dependent manner.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ68CZ2.
PaxDbiQ68CZ2.
PRIDEiQ68CZ2.

PTM databases

PhosphoSiteiQ68CZ2.

Expressioni

Tissue specificityi

Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.3 Publications

Inductioni

Down-regulated by EGF.2 Publications

Gene expression databases

BgeeiQ68CZ2.
CleanExiHS_TNS3.
ExpressionAtlasiQ68CZ2. baseline and differential.
GenevestigatoriQ68CZ2.

Organism-specific databases

HPAiHPA055338.
HPA056015.

Interactioni

Subunit structurei

EGF promotes the interaction with EGFR. Interacts with PTK2/FAK1 and BCAR1. Tyrosine phosphorylation is critical for these interactions.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BCAR1P569458EBI-1220488,EBI-702093
CDH1P128302EBI-1220488,EBI-727477
EGFRP005334EBI-1220488,EBI-297353
ERBB2P046262EBI-1220488,EBI-641062
ERBB3P218602EBI-1220488,EBI-720706
KITP107215EBI-1220488,EBI-1379503
METP085813EBI-1220488,EBI-1039152
PTK2Q053973EBI-1220488,EBI-702142
SRCP1293113EBI-1220488,EBI-621482

Protein-protein interaction databases

BioGridi122272. 10 interactions.
IntActiQ68CZ2. 17 interactions.
MINTiMINT-1494711.
STRINGi9606.ENSP00000312143.

Structurei

3D structure databases

ProteinModelPortaliQ68CZ2.
SMRiQ68CZ2. Positions 2-301, 1167-1284, 1309-1439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 170170Phosphatase tensin-typePROSITE-ProRule annotationAdd
BLAST
Domaini175 – 301127C2 tensin-typePROSITE-ProRule annotationAdd
BLAST
Domaini1172 – 1282111SH2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi941 – 9444Poly-Ser

Sequence similaritiesi

Contains 1 C2 tensin-type domain.PROSITE-ProRule annotation
Contains 1 phosphatase tensin-type domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00760000119113.
HOVERGENiHBG060186.
InParanoidiQ68CZ2.
KOiK18080.
OMAiKWIKDGP.
PhylomeDBiQ68CZ2.
TreeFamiTF315996.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q68CZ2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEGHGLDLT YITERIIAVS FPAGCSEESY LHNLQEVTRM LKSKHGDNYL
60 70 80 90 100
VLNLSEKRYD LTKLNPKIMD VGWPELHAPP LDKMCTICKA QESWLNSNLQ
110 120 130 140 150
HVVVIHCRGG KGRIGVVISS YMHFTNVSAS ADQALDRFAM KKFYDDKVSA
160 170 180 190 200
LMQPSQKRYV QFLSGLLSGS VKMNASPLFL HFVILHGTPN FDTGGVCRPF
210 220 230 240 250
LKLYQAMQPV YTSGIYNVGP ENPSRICIVI EPAQLLKGDV MVKCYHKKYR
260 270 280 290 300
SATRDVIFRL QFHTGAVQGY GLVFGKEDLD NASKDDRFPD YGKVELVFSA
310 320 330 340 350
TPEKIQGSEH LYNDHGVIVD YNTTDPLIRW DSYENLSADG EVLHTQGPVD
360 370 380 390 400
GSLYAKVRKK SSSDPGIPGG PQAIPATNSP DHSDHTLSVS SDSGHSTASA
410 420 430 440 450
RTDKTEERLA PGTRRGLSAQ EKAELDQLLS GFGLEDPGSS LKEMTDARSK
460 470 480 490 500
YSGTRHVVPA QVHVNGDAAL KDRETDILDD EMPHHDLHSV DSLGTLSSSE
510 520 530 540 550
GPQSAHLGPF TCHKSSQNSL LSDGFGSNVG EDPQGTLVPD LGLGMDGPYE
560 570 580 590 600
RERTFGSREP KQPQPLLRKP SVSAQMQAYG QSSYSTQTWV RQQQMVVAHQ
610 620 630 640 650
YSFAPDGEAR LVSRCPADNP GLVQAQPRVP LTPTRGTSSR VAVQRGVGSG
660 670 680 690 700
PHPPDTQQPS PSKAFKPRFP GDQVVNGAGP ELSTGPSPGS PTLDIDQSIE
710 720 730 740 750
QLNRLILELD PTFEPIPTHM NALGSQANGS VSPDSVGGGL RASSRLPDTG
760 770 780 790 800
EGPSRATGRQ GSSAEQPLGG RLRKLSLGQY DNDAGGQLPF SKCAWGKAGV
810 820 830 840 850
DYAPNLPPFP SPADVKETMT PGYPQDLDII DGRILSSKES MCSTPAFPVS
860 870 880 890 900
PETPYVKTAL RHPPFSPPEP PLSSPASQHK GGREPRSCPE TLTHAVGMSE
910 920 930 940 950
SPIGPKSTML RADASSTPSF QQAFASSCTI SSNGPGQRRE SSSSAERQWV
960 970 980 990 1000
ESSPKPMVSL LGSGRPTGSP LSAEFSGTRK DSPVLSCFPP SELQAPFHSH
1010 1020 1030 1040 1050
ELSLAEPPDS LAPPSSQAFL GFGTAPVGSG LPPEEDLGAL LANSHGASPT
1060 1070 1080 1090 1100
PSIPLTATGA ADNGFLSHNF LTVAPGHSSH HSPGLQGQGV TLPGQPPLPE
1110 1120 1130 1140 1150
KKRASEGDRS LGSVSPSSSG FSSPHSGSTI SIPFPNVLPD FSKASEAASP
1160 1170 1180 1190 1200
LPDSPGDKLV IVKFVQDTSK FWYKADISRE QAIAMLKDKE PGSFIVRDSH
1210 1220 1230 1240 1250
SFRGAYGLAM KVATPPPSVL QLNKKAGDLA NELVRHFLIE CTPKGVRLKG
1260 1270 1280 1290 1300
CSNEPYFGSL TALVCQHSIT PLALPCKLLI PERDPLEEIA ESSPQTAANS
1310 1320 1330 1340 1350
AAELLKQGAA CNVWYLNSVE MESLTGHQAI QKALSITLVQ EPPPVSTVVH
1360 1370 1380 1390 1400
FKVSAQGITL TDNQRKLFFR RHYPVNSVIF CALDPQDRKW IKDGPSSKVF
1410 1420 1430 1440
GFVARKQGSA TDNVCHLFAE HDPEQPASAI VNFVSKVMIG SPKKV
Length:1,445
Mass (Da):155,266
Last modified:July 24, 2007 - v2
Checksum:i40B02C6269899320
GO
Isoform 2 (identifier: Q68CZ2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-480: Missing.

Show »
Length:1,205
Mass (Da):129,066
Checksum:i7E02E291D5DF030D
GO
Isoform 3 (identifier: Q68CZ2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     381-391: DHSDHTLSVSS → ANVLFELIGQV
     392-1445: Missing.

Show »
Length:391
Mass (Da):43,549
Checksum:iB35A18476C52C6F3
GO
Isoform 4 (identifier: Q68CZ2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-250: KCYHKKYR → MNYNIANI
     251-1445: Missing.

Show »
Length:250
Mass (Da):28,043
Checksum:i35E9ABB42FF739A5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311L → P in AAN32667. (PubMed:15140944)Curated
Sequence conflicti458 – 4581V → A in CAH18438. (PubMed:11230166)Curated
Sequence conflicti505 – 5051A → V in AAN32667. (PubMed:15140944)Curated
Sequence conflicti917 – 9171T → A in CAH18438. (PubMed:11230166)Curated
Sequence conflicti1047 – 10471A → T in CAH18438. (PubMed:11230166)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti600 – 6001Q → H.
Corresponds to variant rs2293362 [ dbSNP | Ensembl ].
VAR_034593
Natural varianti679 – 6791G → S.
Corresponds to variant rs7808646 [ dbSNP | Ensembl ].
VAR_034594
Natural varianti1034 – 10341E → K.
Corresponds to variant rs3807590 [ dbSNP | Ensembl ].
VAR_052548

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei241 – 480240Missing in isoform 2. 1 PublicationVSP_027123Add
BLAST
Alternative sequencei243 – 2508KCYHKKYR → MNYNIANI in isoform 4. 1 PublicationVSP_027124
Alternative sequencei251 – 14451195Missing in isoform 4. 1 PublicationVSP_027125Add
BLAST
Alternative sequencei381 – 39111DHSDHTLSVSS → ANVLFELIGQV in isoform 3. 1 PublicationVSP_027126Add
BLAST
Alternative sequencei392 – 14451054Missing in isoform 3. 1 PublicationVSP_027127Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF378756 mRNA. Translation: AAL11993.1.
AF417489 mRNA. Translation: AAN32667.1.
AK092864 mRNA. Translation: BAC03993.1.
CR749644 mRNA. Translation: CAH18438.1.
AC073341 Genomic DNA. Translation: AAQ96841.1.
CH471128 Genomic DNA. Translation: EAW61011.1.
BC071791 mRNA. Translation: AAH71791.1.
BC137133 mRNA. Translation: AAI37134.1.
BC137134 mRNA. Translation: AAI37135.1.
AB062750 mRNA. Translation: BAB60681.1.
CCDSiCCDS5506.2. [Q68CZ2-1]
RefSeqiNP_073585.8. NM_022748.11. [Q68CZ2-1]
UniGeneiHs.520814.

Genome annotation databases

EnsembliENST00000311160; ENSP00000312143; ENSG00000136205. [Q68CZ2-1]
ENST00000442536; ENSP00000389285; ENSG00000136205. [Q68CZ2-4]
ENST00000458317; ENSP00000388318; ENSG00000136205. [Q68CZ2-4]
GeneIDi64759.
KEGGihsa:64759.
UCSCiuc003tnw.3. human. [Q68CZ2-1]
uc010kyo.1. human. [Q68CZ2-4]

Polymorphism databases

DMDMi156637424.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF378756 mRNA. Translation: AAL11993.1 .
AF417489 mRNA. Translation: AAN32667.1 .
AK092864 mRNA. Translation: BAC03993.1 .
CR749644 mRNA. Translation: CAH18438.1 .
AC073341 Genomic DNA. Translation: AAQ96841.1 .
CH471128 Genomic DNA. Translation: EAW61011.1 .
BC071791 mRNA. Translation: AAH71791.1 .
BC137133 mRNA. Translation: AAI37134.1 .
BC137134 mRNA. Translation: AAI37135.1 .
AB062750 mRNA. Translation: BAB60681.1 .
CCDSi CCDS5506.2. [Q68CZ2-1 ]
RefSeqi NP_073585.8. NM_022748.11. [Q68CZ2-1 ]
UniGenei Hs.520814.

3D structure databases

ProteinModelPortali Q68CZ2.
SMRi Q68CZ2. Positions 2-301, 1167-1284, 1309-1439.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122272. 10 interactions.
IntActi Q68CZ2. 17 interactions.
MINTi MINT-1494711.
STRINGi 9606.ENSP00000312143.

PTM databases

PhosphoSitei Q68CZ2.

Polymorphism databases

DMDMi 156637424.

Proteomic databases

MaxQBi Q68CZ2.
PaxDbi Q68CZ2.
PRIDEi Q68CZ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311160 ; ENSP00000312143 ; ENSG00000136205 . [Q68CZ2-1 ]
ENST00000442536 ; ENSP00000389285 ; ENSG00000136205 . [Q68CZ2-4 ]
ENST00000458317 ; ENSP00000388318 ; ENSG00000136205 . [Q68CZ2-4 ]
GeneIDi 64759.
KEGGi hsa:64759.
UCSCi uc003tnw.3. human. [Q68CZ2-1 ]
uc010kyo.1. human. [Q68CZ2-4 ]

Organism-specific databases

CTDi 64759.
GeneCardsi GC07M047281.
HGNCi HGNC:21616. TNS3.
HPAi HPA055338.
HPA056015.
MIMi 606825. gene.
neXtProti NX_Q68CZ2.
PharmGKBi PA134888115.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00760000119113.
HOVERGENi HBG060186.
InParanoidi Q68CZ2.
KOi K18080.
OMAi KWIKDGP.
PhylomeDBi Q68CZ2.
TreeFami TF315996.

Enzyme and pathway databases

SignaLinki Q68CZ2.

Miscellaneous databases

ChiTaRSi TNS3. human.
GenomeRNAii 64759.
NextBioi 66735.
PROi Q68CZ2.
SOURCEi Search...

Gene expression databases

Bgeei Q68CZ2.
CleanExi HS_TNS3.
ExpressionAtlasi Q68CZ2. baseline and differential.
Genevestigatori Q68CZ2.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR000008. C2_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
[Graphical view ]
Pfami PF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view ]
SMARTi SM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cell surface tumor endothelial markers are conserved in mice and humans."
    Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W., St Croix B.
    Cancer Res. 61:6649-6655(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. "Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3."
    Cui Y., Liao Y.-C., Lo S.H.
    Mol. Cancer Res. 2:225-232(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, INTERACTION WITH EGFR; PTK2/FAK1 AND BCAR1.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Spleen.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Brain and Kidney.
  8. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 749-1445, TISSUE SPECIFICITY.
  9. Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION, KNOCKDOWN IN MCF10A CELLS.
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332; THR-632; SER-660; SER-776; SER-866; SER-901; SER-1149; SER-1154 AND SER-1293, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-649; SER-660; SER-735; SER-776; TYR-780; SER-811; SER-1149 AND SER-1154, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTENS3_HUMAN
AccessioniPrimary (citable) accession number: Q68CZ2
Secondary accession number(s): B2RNV1
, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3