Q68CZ2 (TENS3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tensin-3

Alternative name(s):
Tensin-like SH2 domain-containing protein 1
Tumor endothelial marker 6

Gene names

Name:	TNS3
Synonyms:	TEM6, TENS1, TPP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1445 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development By similarity. Ref.9
Subunit structure	EGF promotes the interaction with EGFR. Interacts with PTK2/FAK1 and BCAR1. Tyrosine phosphorylation is critical for these interactions. Ref.2
Subcellular location	Cell junction › focal adhesion Ref.2 Ref.9.
Tissue specificity	Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas. Ref.1 Ref.2 Ref.8
Induction	Down-regulated by EGF. Ref.2 Ref.9
Post-translational modification	EGF/epidermal growth factor induces tyrosine phosphorylation in a time- and dose-dependent manner.
Sequence similarities	Contains 1 C2 tensin-type domain. Contains 1 phosphatase tensin-type domain. Contains 1 SH2 domain.

Ontologies

Keywords
Cellular component	Cell junction
Coding sequence diversity	Alternative splicing Polymorphism
Domain	SH2 domain
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell migration Inferred from electronic annotation. Source: Compara lung alveolus development Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara
Cellular_component	focal adhesion Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BCAR1	P56945	8	EBI-1220488,EBI-702093
CDH1	P12830	2	EBI-1220488,EBI-727477
PTK2	Q05397	3	EBI-1220488,EBI-702142
SRC	P12931	13	EBI-1220488,EBI-621482

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q68CZ2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q68CZ2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     241-480: Missing.

Isoform 3 (identifier: Q68CZ2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     381-391: DHSDHTLSVSS → ANVLFELIGQV
     392-1445: Missing.

Isoform 4 (identifier: Q68CZ2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     243-250: KCYHKKYR → MNYNIANI
     251-1445: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1445	1445	Tensin-3		PRO_0000295915
Regions
	Domain	1 – 170	170	Phosphatase tensin-type
	Domain	175 – 301	127	C2 tensin-type
	Domain	1172 – 1282	111	SH2
	Compositional bias	941 – 944	4	Poly-Ser
Amino acid modifications
	Modified residue	332	1	Phosphoserine Ref.11
	Modified residue	333	1	Phosphotyrosine By similarity
	Modified residue	632	1	Phosphothreonine Ref.11
	Modified residue	649	1	Phosphoserine Ref.12
	Modified residue	660	1	Phosphoserine Ref.11 Ref.12
	Modified residue	735	1	Phosphoserine Ref.12
	Modified residue	776	1	Phosphoserine Ref.11 Ref.12
	Modified residue	780	1	Phosphotyrosine Ref.12
	Modified residue	811	1	Phosphoserine Ref.12
	Modified residue	866	1	Phosphoserine Ref.11
	Modified residue	901	1	Phosphoserine Ref.11
	Modified residue	941	1	Phosphoserine By similarity
	Modified residue	1149	1	Phosphoserine Ref.11 Ref.12
	Modified residue	1154	1	Phosphoserine Ref.11 Ref.12
	Modified residue	1293	1	Phosphoserine Ref.11
	Modified residue	1441	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	241 – 480	240	Missing in isoform 2.		VSP_027123
	Alternative sequence	243 – 250	8	KCYHKKYR → MNYNIANI in isoform 4.		VSP_027124
	Alternative sequence	251 – 1445	1195	Missing in isoform 4.		VSP_027125
	Alternative sequence	381 – 391	11	DHSDHTLSVSS → ANVLFELIGQV in isoform 3.		VSP_027126
	Alternative sequence	392 – 1445	1054	Missing in isoform 3.		VSP_027127
	Natural variant	600	1	Q → H. Corresponds to variant rs2293362 [ dbSNP | Ensembl ].		VAR_034593
	Natural variant	679	1	G → S. Corresponds to variant rs7808646 [ dbSNP | Ensembl ].		VAR_034594
	Natural variant	1034	1	E → K. Corresponds to variant rs3807590 [ dbSNP | Ensembl ].		VAR_052548
Experimental info
	Sequence conflict	31	1	L → P in AAN32667. Ref.2
	Sequence conflict	458	1	V → A in CAH18438. Ref.4
	Sequence conflict	505	1	A → V in AAN32667. Ref.2
	Sequence conflict	917	1	T → A in CAH18438. Ref.4
	Sequence conflict	1047	1	A → T in CAH18438. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 24, 2007. Version 2. Checksum: 40B02C6269899320	FASTA	1,445	155,266
	10 20 30 40 50 60 MEEGHGLDLT YITERIIAVS FPAGCSEESY LHNLQEVTRM LKSKHGDNYL VLNLSEKRYD 70 80 90 100 110 120 LTKLNPKIMD VGWPELHAPP LDKMCTICKA QESWLNSNLQ HVVVIHCRGG KGRIGVVISS 130 140 150 160 170 180 YMHFTNVSAS ADQALDRFAM KKFYDDKVSA LMQPSQKRYV QFLSGLLSGS VKMNASPLFL 190 200 210 220 230 240 HFVILHGTPN FDTGGVCRPF LKLYQAMQPV YTSGIYNVGP ENPSRICIVI EPAQLLKGDV 250 260 270 280 290 300 MVKCYHKKYR SATRDVIFRL QFHTGAVQGY GLVFGKEDLD NASKDDRFPD YGKVELVFSA 310 320 330 340 350 360 TPEKIQGSEH LYNDHGVIVD YNTTDPLIRW DSYENLSADG EVLHTQGPVD GSLYAKVRKK 370 380 390 400 410 420 SSSDPGIPGG PQAIPATNSP DHSDHTLSVS SDSGHSTASA RTDKTEERLA PGTRRGLSAQ 430 440 450 460 470 480 EKAELDQLLS GFGLEDPGSS LKEMTDARSK YSGTRHVVPA QVHVNGDAAL KDRETDILDD 490 500 510 520 530 540 EMPHHDLHSV DSLGTLSSSE GPQSAHLGPF TCHKSSQNSL LSDGFGSNVG EDPQGTLVPD 550 560 570 580 590 600 LGLGMDGPYE RERTFGSREP KQPQPLLRKP SVSAQMQAYG QSSYSTQTWV RQQQMVVAHQ 610 620 630 640 650 660 YSFAPDGEAR LVSRCPADNP GLVQAQPRVP LTPTRGTSSR VAVQRGVGSG PHPPDTQQPS 670 680 690 700 710 720 PSKAFKPRFP GDQVVNGAGP ELSTGPSPGS PTLDIDQSIE QLNRLILELD PTFEPIPTHM 730 740 750 760 770 780 NALGSQANGS VSPDSVGGGL RASSRLPDTG EGPSRATGRQ GSSAEQPLGG RLRKLSLGQY 790 800 810 820 830 840 DNDAGGQLPF SKCAWGKAGV DYAPNLPPFP SPADVKETMT PGYPQDLDII DGRILSSKES 850 860 870 880 890 900 MCSTPAFPVS PETPYVKTAL RHPPFSPPEP PLSSPASQHK GGREPRSCPE TLTHAVGMSE 910 920 930 940 950 960 SPIGPKSTML RADASSTPSF QQAFASSCTI SSNGPGQRRE SSSSAERQWV ESSPKPMVSL 970 980 990 1000 1010 1020 LGSGRPTGSP LSAEFSGTRK DSPVLSCFPP SELQAPFHSH ELSLAEPPDS LAPPSSQAFL 1030 1040 1050 1060 1070 1080 GFGTAPVGSG LPPEEDLGAL LANSHGASPT PSIPLTATGA ADNGFLSHNF LTVAPGHSSH 1090 1100 1110 1120 1130 1140 HSPGLQGQGV TLPGQPPLPE KKRASEGDRS LGSVSPSSSG FSSPHSGSTI SIPFPNVLPD 1150 1160 1170 1180 1190 1200 FSKASEAASP LPDSPGDKLV IVKFVQDTSK FWYKADISRE QAIAMLKDKE PGSFIVRDSH 1210 1220 1230 1240 1250 1260 SFRGAYGLAM KVATPPPSVL QLNKKAGDLA NELVRHFLIE CTPKGVRLKG CSNEPYFGSL 1270 1280 1290 1300 1310 1320 TALVCQHSIT PLALPCKLLI PERDPLEEIA ESSPQTAANS AAELLKQGAA CNVWYLNSVE 1330 1340 1350 1360 1370 1380 MESLTGHQAI QKALSITLVQ EPPPVSTVVH FKVSAQGITL TDNQRKLFFR RHYPVNSVIF 1390 1400 1410 1420 1430 1440 CALDPQDRKW IKDGPSSKVF GFVARKQGSA TDNVCHLFAE HDPEQPASAI VNFVSKVMIG SPKKV
	Isoform 2 [UniParc]. Checksum: 7E02E291D5DF030D	FASTA	1,205	129,066
	10 20 30 40 50 60 MEEGHGLDLT YITERIIAVS FPAGCSEESY LHNLQEVTRM LKSKHGDNYL VLNLSEKRYD 70 80 90 100 110 120 LTKLNPKIMD VGWPELHAPP LDKMCTICKA QESWLNSNLQ HVVVIHCRGG KGRIGVVISS 130 140 150 160 170 180 YMHFTNVSAS ADQALDRFAM KKFYDDKVSA LMQPSQKRYV QFLSGLLSGS VKMNASPLFL 190 200 210 220 230 240 HFVILHGTPN FDTGGVCRPF LKLYQAMQPV YTSGIYNVGP ENPSRICIVI EPAQLLKGDV 250 260 270 280 290 300 EMPHHDLHSV DSLGTLSSSE GPQSAHLGPF TCHKSSQNSL LSDGFGSNVG EDPQGTLVPD 310 320 330 340 350 360 LGLGMDGPYE RERTFGSREP KQPQPLLRKP SVSAQMQAYG QSSYSTQTWV RQQQMVVAHQ 370 380 390 400 410 420 YSFAPDGEAR LVSRCPADNP GLVQAQPRVP LTPTRGTSSR VAVQRGVGSG PHPPDTQQPS 430 440 450 460 470 480 PSKAFKPRFP GDQVVNGAGP ELSTGPSPGS PTLDIDQSIE QLNRLILELD PTFEPIPTHM 490 500 510 520 530 540 NALGSQANGS VSPDSVGGGL RASSRLPDTG EGPSRATGRQ GSSAEQPLGG RLRKLSLGQY 550 560 570 580 590 600 DNDAGGQLPF SKCAWGKAGV DYAPNLPPFP SPADVKETMT PGYPQDLDII DGRILSSKES 610 620 630 640 650 660 MCSTPAFPVS PETPYVKTAL RHPPFSPPEP PLSSPASQHK GGREPRSCPE TLTHAVGMSE 670 680 690 700 710 720 SPIGPKSTML RADASSTPSF QQAFASSCTI SSNGPGQRRE SSSSAERQWV ESSPKPMVSL 730 740 750 760 770 780 LGSGRPTGSP LSAEFSGTRK DSPVLSCFPP SELQAPFHSH ELSLAEPPDS LAPPSSQAFL 790 800 810 820 830 840 GFGTAPVGSG LPPEEDLGAL LANSHGASPT PSIPLTATGA ADNGFLSHNF LTVAPGHSSH 850 860 870 880 890 900 HSPGLQGQGV TLPGQPPLPE KKRASEGDRS LGSVSPSSSG FSSPHSGSTI SIPFPNVLPD 910 920 930 940 950 960 FSKASEAASP LPDSPGDKLV IVKFVQDTSK FWYKADISRE QAIAMLKDKE PGSFIVRDSH 970 980 990 1000 1010 1020 SFRGAYGLAM KVATPPPSVL QLNKKAGDLA NELVRHFLIE CTPKGVRLKG CSNEPYFGSL 1030 1040 1050 1060 1070 1080 TALVCQHSIT PLALPCKLLI PERDPLEEIA ESSPQTAANS AAELLKQGAA CNVWYLNSVE 1090 1100 1110 1120 1130 1140 MESLTGHQAI QKALSITLVQ EPPPVSTVVH FKVSAQGITL TDNQRKLFFR RHYPVNSVIF 1150 1160 1170 1180 1190 1200 CALDPQDRKW IKDGPSSKVF GFVARKQGSA TDNVCHLFAE HDPEQPASAI VNFVSKVMIG SPKKV
	Isoform 3 [UniParc]. Checksum: B35A18476C52C6F3	FASTA	391	43,549
	10 20 30 40 50 60 MEEGHGLDLT YITERIIAVS FPAGCSEESY LHNLQEVTRM LKSKHGDNYL VLNLSEKRYD 70 80 90 100 110 120 LTKLNPKIMD VGWPELHAPP LDKMCTICKA QESWLNSNLQ HVVVIHCRGG KGRIGVVISS 130 140 150 160 170 180 YMHFTNVSAS ADQALDRFAM KKFYDDKVSA LMQPSQKRYV QFLSGLLSGS VKMNASPLFL 190 200 210 220 230 240 HFVILHGTPN FDTGGVCRPF LKLYQAMQPV YTSGIYNVGP ENPSRICIVI EPAQLLKGDV 250 260 270 280 290 300 MVKCYHKKYR SATRDVIFRL QFHTGAVQGY GLVFGKEDLD NASKDDRFPD YGKVELVFSA 310 320 330 340 350 360 TPEKIQGSEH LYNDHGVIVD YNTTDPLIRW DSYENLSADG EVLHTQGPVD GSLYAKVRKK 370 380 390 SSSDPGIPGG PQAIPATNSP ANVLFELIGQ V
	Isoform 4 [UniParc]. Checksum: 35E9ABB42FF739A5	FASTA	250	28,043
	10 20 30 40 50 60 MEEGHGLDLT YITERIIAVS FPAGCSEESY LHNLQEVTRM LKSKHGDNYL VLNLSEKRYD 70 80 90 100 110 120 LTKLNPKIMD VGWPELHAPP LDKMCTICKA QESWLNSNLQ HVVVIHCRGG KGRIGVVISS 130 140 150 160 170 180 YMHFTNVSAS ADQALDRFAM KKFYDDKVSA LMQPSQKRYV QFLSGLLSGS VKMNASPLFL 190 200 210 220 230 240 HFVILHGTPN FDTGGVCRPF LKLYQAMQPV YTSGIYNVGP ENPSRICIVI EPAQLLKGDV 250 MVMNYNIANI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cell surface tumor endothelial markers are conserved in mice and humans." Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W., St Croix B. Cancer Res. 61:6649-6655(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
[2]	"Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3." Cui Y., Liao Y.-C., Lo S.H. Mol. Cancer Res. 2:225-232(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, INTERACTION WITH EGFR; PTK2/FAK1 AND BCAR1.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Spleen.
[4]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Amygdala.
[5]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Brain and Kidney.
[8]	"Tensin3 is a novel thyroid-specific gene." Maeda I., Takano T., Yoshida H., Matsuzuka F., Amino N., Miyauchi A. J. Mol. Endocrinol. 36:R1-R8(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 749-1445, TISSUE SPECIFICITY.
[9]	"A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration." Katz M., Amit I., Citri A., Shay T., Carvalho S., Lavi S., Milanezi F., Lyass L., Amariglio N., Jacob-Hirsch J., Ben-Chetrit N., Tarcic G., Lindzen M., Avraham R., Liao Y.C., Trusk P., Lyass A., Rechavi G. , Spector N.L., Lo S.H., Schmitt F., Bacus S.S., Yarden Y. Nat. Cell Biol. 9:961-969(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION, KNOCKDOWN IN MCF10A CELLS.
[10]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332; THR-632; SER-660; SER-776; SER-866; SER-901; SER-1149; SER-1154 AND SER-1293, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-649; SER-660; SER-735; SER-776; TYR-780; SER-811; SER-1149 AND SER-1154, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF378756 mRNA. Translation: AAL11993.1. AF417489 mRNA. Translation: AAN32667.1. AK092864 mRNA. Translation: BAC03993.1. CR749644 mRNA. Translation: CAH18438.1. AC073341 Genomic DNA. Translation: AAQ96841.1. CH471128 Genomic DNA. Translation: EAW61011.1. BC071791 mRNA. Translation: AAH71791.1. BC137133 mRNA. Translation: AAI37134.1. BC137134 mRNA. Translation: AAI37135.1. AB062750 mRNA. Translation: BAB60681.1.
IPI	IPI00658152. IPI00854760. IPI00854817. IPI00854869.
RefSeq	NP_073585.8. NM_022748.11.
UniGene	Hs.520814.
3D structure databases
ProteinModelPortal	Q68CZ2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q68CZ2. 11 interactions.
MINT	MINT-1494711.
STRING	9606.ENSP00000312143.
PTM databases
PhosphoSite	Q68CZ2.
Polymorphism databases
DMDM	156637424.
Proteomic databases
PaxDb	Q68CZ2.
PRIDE	Q68CZ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000311160; ENSP00000312143; ENSG00000136205. ENST00000398879; ENSP00000381854; ENSG00000136205. ENST00000442536; ENSP00000389285; ENSG00000136205. ENST00000458317; ENSP00000388318; ENSG00000136205.
GeneID	64759.
KEGG	hsa:64759.
UCSC	uc003tnw.3. human. uc010kyo.1. human.
Organism-specific databases
CTD	64759.
GeneCards	GC07M047281.
HGNC	HGNC:21616. TNS3.
MIM	606825. gene.
neXtProt	NX_Q68CZ2.
PharmGKB	PA134888115.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2453.
HOVERGEN	HBG060186.
InParanoid	Q68CZ2.
OMA	KWIKDGP.
OrthoDB	EOG4NCMBW.
Enzyme and pathway databases
SignaLink	Q68CZ2.
Gene expression databases
ArrayExpress	Q68CZ2.
Bgee	Q68CZ2.
CleanEx	HS_TNS3.
Genevestigator	Q68CZ2.
Family and domain databases
Gene3D	2.30.29.30. 1 hit. 3.30.505.10. 1 hit.
InterPro	IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR011993. PH_like_dom. IPR014019. Phosphatase_tensin-typ. IPR013625. PTB. IPR006020. PTyr_interaction_dom. IPR000980. SH2. IPR014020. Tensin_phosphatase_C2-dom. [Graphical view]
Pfam	PF08416. PTB. 1 hit. PF10409. PTEN_C2. 1 hit. PF00017. SH2. 1 hit. [Graphical view]
SMART	SM00462. PTB. 1 hit. SM00252. SH2. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit.
PROSITE	PS51182. C2_TENSIN. 1 hit. PS51181. PPASE_TENSIN. 1 hit. PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TNS3. human.
GenomeRNAi	64759.
NextBio	66735.
SOURCE	Search...

Entry information

Entry name

TENS3_HUMAN

Accession

Primary (citable) accession number: Q68CZ2
Secondary accession number(s): B2RNV1 , Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	May 29, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.