Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

AT-rich interactive domain-containing protein 2

Gene

ARID2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi524 – 603RFX-type winged-helixPROSITE-ProRule annotationAdd BLAST80
Zinc fingeri1632 – 1657C2H2-typeAdd BLAST26

GO - Molecular functioni

  • DNA binding Source: GDB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • chromatin modification Source: UniProtKB-KW
  • negative regulation of cell migration Source: BHF-UCL
  • negative regulation of cell proliferation Source: BHF-UCL
  • nucleosome disassembly Source: BHF-UCL
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-31096-MONOMER.
ReactomeiR-HSA-3214858. RMTs methylate histone arginines.
SIGNORiQ68CP9.

Names & Taxonomyi

Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 2
Short name:
ARID domain-containing protein 2
Alternative name(s):
BRG1-associated factor 200
Short name:
BAF200
Zinc finger protein with activation potential
Zipzap/p200
Gene namesi
Name:ARID2
Synonyms:KIAA1557
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:18037. ARID2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi196528.
OpenTargetsiENSG00000189079.
PharmGKBiPA134916396.

Polymorphism and mutation databases

BioMutaiARID2.
DMDMi73921721.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002005772 – 1835AT-rich interactive domain-containing protein 2Add BLAST1834

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei635PhosphoserineCombined sources1
Modified residuei653PhosphothreonineCombined sources1
Modified residuei689PhosphoserineCombined sources1
Modified residuei692PhosphothreonineCombined sources1
Modified residuei1300PhosphoserineCombined sources1
Modified residuei1391PhosphoserineCombined sources1
Modified residuei1496PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ68CP9.
MaxQBiQ68CP9.
PaxDbiQ68CP9.
PeptideAtlasiQ68CP9.
PRIDEiQ68CP9.

PTM databases

iPTMnetiQ68CP9.
PhosphoSitePlusiQ68CP9.

Miscellaneous databases

PMAP-CutDBQ68CP9.

Expressioni

Tissue specificityi

Highly expressed in heart and testis.1 Publication

Developmental stagei

Up-regulated in adult heart (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000189079.
ExpressionAtlasiQ68CP9. baseline and differential.
GenevisibleiQ68CP9. HS.

Organism-specific databases

HPAiHPA063044.

Interactioni

Subunit structurei

Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PB1/BAF180, ARID2/BAF200, ARID1A/BAF250A or ARID1B/BAF250B and actin. Interacts with SRF. Forms complexes with SRF and SRF cofactors MYOCD, NKX2-5 and SRFBP1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PBRM1Q86U865EBI-637818,EBI-637807
SMARCA4P515326EBI-637818,EBI-302489
SMARCB1Q128243EBI-637818,EBI-358419
SMARCE1Q969G34EBI-637818,EBI-455078

Protein-protein interaction databases

BioGridi128219. 31 interactors.
DIPiDIP-33391N.
IntActiQ68CP9. 22 interactors.
STRINGi9606.ENSP00000335044.

Structurei

3D structure databases

ProteinModelPortaliQ68CP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 105ARIDPROSITE-ProRule annotationAdd BLAST93

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi313 – 317LXXLL5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi793 – 1128Gln-richAdd BLAST336

Sequence similaritiesi

Contains 1 ARID domain.PROSITE-ProRule annotation
Contains 1 C2H2-type zinc finger.Curated
Contains 1 RFX-type winged-helix DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1632 – 1657C2H2-typeAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2312. Eukaryota.
KOG2744. Eukaryota.
ENOG410XT3H. LUCA.
GeneTreeiENSGT00390000016138.
HOVERGENiHBG068777.
InParanoidiQ68CP9.
KOiK11765.
OMAiLKQYYLR.
OrthoDBiEOG091G169Y.
PhylomeDBiQ68CP9.
TreeFamiTF106406.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.60. 1 hit.
InterProiIPR001606. ARID_dom.
IPR016024. ARM-type_fold.
IPR003150. DNA-bd_RFX.
IPR011991. WHTH_DNA-bd_dom.
IPR007087. Znf_C2H2.
[Graphical view]
PfamiPF01388. ARID. 1 hit.
PF02257. RFX_DNA_binding. 1 hit.
[Graphical view]
SMARTiSM00501. BRIGHT. 1 hit.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
SSF46785. SSF46785. 1 hit.
SSF48371. SSF48371. 2 hits.
PROSITEiPS51011. ARID. 1 hit.
PS51526. RFX_DBD. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q68CP9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANSTGKAPP DERRKGLAFL DELRQFHHSR GSPFKKIPAV GGKELDLHGL
60 70 80 90 100
YTRVTTLGGF AKVSEKNQWG EIVEEFNFPR SCSNAAFALK QYYLRYLEKY
110 120 130 140 150
EKVHHFGEDD DEVPPGNPKP QLPIGAIPSS YNYQQHSVSD YLRQSYGLSM
160 170 180 190 200
DFNSPNDYNK LVLSLLSGLP NEVDFAINVC TLLSNESKHV MQLEKDPKII
210 220 230 240 250
TLLLANAGVF DDTLGSFSTV FGEEWKEKTD RDFVKFWKDI VDDNEVRDLI
260 270 280 290 300
SDRNKSHEGT SGEWIWESLF HPPRKLGIND IEGQRVLQIA VILRNLSFEE
310 320 330 340 350
GNVKLLAANR TCLRFLLLSA HSHFISLRQL GLDTLGNIAA ELLLDPVDFK
360 370 380 390 400
TTHLMFHTVT KCLMSRDRFL KMRGMEILGN LCKAEDNGVL ICEYVDQDSY
410 420 430 440 450
REIICHLTLP DVLLVISTLE VLYMLTEMGD VACTKIAKVE KSIDMLVCLV
460 470 480 490 500
SMDIQMFGPD ALAAVKLIEH PSSSHQMLSE IRPQAIEQVQ TQTHVASAPA
510 520 530 540 550
SRAVVAQHVA PPPGIVEIDS EKFACQWLNA HFEVNPDCSV SRAEMYSEYL
560 570 580 590 600
STCSKLARGG ILTSTGFYKC LRTVFPNHTV KRVEDSSSNG QAHIHVVGVK
610 620 630 640 650
RRAIPLPIQM YYQQQPVSTS VVRVDSVPDV SPAPSPAGIP HGSQTIGNHF
660 670 680 690 700
QRTPVANQSS NLTATQMSFP VQGVHTVAQT VSRIPQNPSP HTHQQQNAPV
710 720 730 740 750
TVIQSKAPIP CEVVKATVIQ NSIPQTGVPV SIAVGGGPPQ SSVVQNHSTG
760 770 780 790 800
PQPVTVVNSQ TLLHHPSVIP QQSPLHTVVP GQIPSGTPVT VIQQAVPQSH
810 820 830 840 850
MFGRVQNIPA CTSTVSQGQQ LITTSPQPVQ TSSQQTSAGS QSQDTVIIAP
860 870 880 890 900
PQYVTTSASN IVSATSVQNF QVATGQMVTI AGVPSPQASR VGFQNIAPKP
910 920 930 940 950
LPSQQVSSTV VQQPIQQPQQ PTQQSVVIVS QPAQQGQTYA PAIHQIVLAN
960 970 980 990 1000
PAALPAGQTV QLTGQPNITP SSSPSPVPAT NNQVPTAMSS SSTPQSQGPP
1010 1020 1030 1040 1050
PTVSQMLSVK RQQQQQHSPA PPPQQVQVQV QQPQQVQMQV QPQQSNAGVG
1060 1070 1080 1090 1100
QPASGESSLI KQLLLPKRGP STPGGKLILP APQIPPPNNA RAPSPQVVYQ
1110 1120 1130 1140 1150
VASNQAAGFG VQGQTPAQQL LVGQQNVQLV PSAMPPSGGV QTVPISNLQI
1160 1170 1180 1190 1200
LPGPLISNSP ATIFQGTSGN QVTITVVPNT SFAPATVSQG NATQLIAPAG
1210 1220 1230 1240 1250
ITMSGTQTGV GLPVQTLPAT QASPAGQSSC TTATPPFKGD KIICQKEEEA
1260 1270 1280 1290 1300
KEATGLHVHE RKIEVMENPS CRRGATNTSN GDTKENEMHV GSLLNGRKYS
1310 1320 1330 1340 1350
DSSLPPSNSG KIQSETNQCS LISNGPSLEL GENGASGKQN SEQIDMQDIK
1360 1370 1380 1390 1400
SDLRKPLVNG ICDFDKGDGS HLSKNIPNHK TSNHVGNGEI SPMEPQGTLD
1410 1420 1430 1440 1450
ITQQDTAKGD QLERISNGPV LTLGGSSVSS IQEASNAATQ QFSGTDLLNG
1460 1470 1480 1490 1500
PLASSLNSDV PQQRPSVVVS PHSTTSVIQG HQIIAVPDSG SKVSHSPALS
1510 1520 1530 1540 1550
SDVRSTNGTA ECKTVKRPAE DTDRETVAGI PNKVGVRIVT ISDPNNAGCS
1560 1570 1580 1590 1600
ATMVAVPAGA DPSTVAKVAI ESAVQQKQQH PPTYVQNVVP QNTPMPPSPA
1610 1620 1630 1640 1650
VQVQGQPNSS QPSPFSGSSQ PGDPMRKPGQ NFMCLWQSCK KWFQTPSQVF
1660 1670 1680 1690 1700
YHAATEHGGK DVYPGQCLWE GCEPFQRQRF SFITHLQDKH CSKDALLAGL
1710 1720 1730 1740 1750
KQDEPGQAGS QKSSTKQPTV GGTSSTPRAQ KAIVNHPSAA LMALRRGSRN
1760 1770 1780 1790 1800
LVFRDFTDEK EGPITKHIRL TAALILKNIG KYSECGRRLL KRHENNLSVL
1810 1820 1830
AISNMEASST LAKCLYELNF TVQSKEQEKD SEMLQ
Length:1,835
Mass (Da):197,391
Last modified:August 30, 2005 - v2
Checksum:iF540A029FA2264D4
GO
Isoform 2 (identifier: Q68CP9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1784-1835: Missing.

Note: No experimental confirmation available.
Show »
Length:1,783
Mass (Da):191,422
Checksum:iDD2BB28AF96DC860
GO

Sequence cautioni

The sequence AAU20329 differs from that shown. Differs from position 1094 onward for unknown reason.Curated
The sequence BAB55320 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC87171 differs from that shown. Unlikely isoform. Cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169L → P in CAH18689 (PubMed:17974005).Curated1
Sequence conflicti217F → L in CAD91164 (PubMed:17974005).Curated1
Sequence conflicti665T → I in CAD91164 (PubMed:17974005).Curated1
Sequence conflicti801M → T in AAZ74794 (PubMed:16782067).Curated1
Sequence conflicti825S → P in CAH18689 (PubMed:17974005).Curated1
Sequence conflicti906V → F in CAD91164 (PubMed:17974005).Curated1
Sequence conflicti956A → V in CAD91164 (PubMed:17974005).Curated1
Sequence conflicti988M → T in CAH18689 (PubMed:17974005).Curated1
Sequence conflicti989S → P in CAD97878 (PubMed:17974005).Curated1
Sequence conflicti1035Q → R in BAB55320 (PubMed:14702039).Curated1
Sequence conflicti1062Q → R in CAH18689 (PubMed:17974005).Curated1
Sequence conflicti1204S → G in CAD97878 (PubMed:17974005).Curated1
Sequence conflicti1292S → N in CAD97878 (PubMed:17974005).Curated1
Sequence conflicti1460V → A in CAD97878 (PubMed:17974005).Curated1
Sequence conflicti1543D → G in CAD91164 (PubMed:17974005).Curated1
Sequence conflicti1543D → N in BAC87171 (PubMed:14702039).Curated1
Sequence conflicti1647S → P in CAD97878 (PubMed:17974005).Curated1
Sequence conflicti1700L → S in CAD91164 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0152301784 – 1835Missing in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ096628 mRNA. Translation: AAZ74794.1.
AY727870 mRNA. Translation: AAU20329.2. Different termination.
AL832200 mRNA. Translation: CAD91164.1.
BX537879 mRNA. Translation: CAD97878.1.
CR749833 mRNA. Translation: CAH18689.1.
AK027718 mRNA. Translation: BAB55320.1. Different initiation.
AK127872 mRNA. Translation: BAC87171.1. Sequence problems.
BC090062 mRNA. Translation: AAH90062.1.
AB046777 mRNA. Translation: BAB13383.1.
CCDSiCCDS31783.1. [Q68CP9-1]
RefSeqiNP_689854.2. NM_152641.2. [Q68CP9-1]
UniGeneiHs.317304.

Genome annotation databases

EnsembliENST00000334344; ENSP00000335044; ENSG00000189079. [Q68CP9-1]
GeneIDi196528.
KEGGihsa:196528.
UCSCiuc001ros.2. human. [Q68CP9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ096628 mRNA. Translation: AAZ74794.1.
AY727870 mRNA. Translation: AAU20329.2. Different termination.
AL832200 mRNA. Translation: CAD91164.1.
BX537879 mRNA. Translation: CAD97878.1.
CR749833 mRNA. Translation: CAH18689.1.
AK027718 mRNA. Translation: BAB55320.1. Different initiation.
AK127872 mRNA. Translation: BAC87171.1. Sequence problems.
BC090062 mRNA. Translation: AAH90062.1.
AB046777 mRNA. Translation: BAB13383.1.
CCDSiCCDS31783.1. [Q68CP9-1]
RefSeqiNP_689854.2. NM_152641.2. [Q68CP9-1]
UniGeneiHs.317304.

3D structure databases

ProteinModelPortaliQ68CP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128219. 31 interactors.
DIPiDIP-33391N.
IntActiQ68CP9. 22 interactors.
STRINGi9606.ENSP00000335044.

PTM databases

iPTMnetiQ68CP9.
PhosphoSitePlusiQ68CP9.

Polymorphism and mutation databases

BioMutaiARID2.
DMDMi73921721.

Proteomic databases

EPDiQ68CP9.
MaxQBiQ68CP9.
PaxDbiQ68CP9.
PeptideAtlasiQ68CP9.
PRIDEiQ68CP9.

Protocols and materials databases

DNASUi196528.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334344; ENSP00000335044; ENSG00000189079. [Q68CP9-1]
GeneIDi196528.
KEGGihsa:196528.
UCSCiuc001ros.2. human. [Q68CP9-1]

Organism-specific databases

CTDi196528.
DisGeNETi196528.
GeneCardsiARID2.
HGNCiHGNC:18037. ARID2.
HPAiHPA063044.
MIMi609539. gene.
neXtProtiNX_Q68CP9.
OpenTargetsiENSG00000189079.
PharmGKBiPA134916396.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2312. Eukaryota.
KOG2744. Eukaryota.
ENOG410XT3H. LUCA.
GeneTreeiENSGT00390000016138.
HOVERGENiHBG068777.
InParanoidiQ68CP9.
KOiK11765.
OMAiLKQYYLR.
OrthoDBiEOG091G169Y.
PhylomeDBiQ68CP9.
TreeFamiTF106406.

Enzyme and pathway databases

BioCyciZFISH:G66-31096-MONOMER.
ReactomeiR-HSA-3214858. RMTs methylate histone arginines.
SIGNORiQ68CP9.

Miscellaneous databases

ChiTaRSiARID2. human.
GeneWikiiARID2.
GenomeRNAii196528.
PMAP-CutDBQ68CP9.
PROiQ68CP9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000189079.
ExpressionAtlasiQ68CP9. baseline and differential.
GenevisibleiQ68CP9. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.60. 1 hit.
InterProiIPR001606. ARID_dom.
IPR016024. ARM-type_fold.
IPR003150. DNA-bd_RFX.
IPR011991. WHTH_DNA-bd_dom.
IPR007087. Znf_C2H2.
[Graphical view]
PfamiPF01388. ARID. 1 hit.
PF02257. RFX_DNA_binding. 1 hit.
[Graphical view]
SMARTiSM00501. BRIGHT. 1 hit.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
SSF46785. SSF46785. 1 hit.
SSF48371. SSF48371. 2 hits.
PROSITEiPS51011. ARID. 1 hit.
PS51526. RFX_DBD. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARID2_HUMAN
AccessioniPrimary (citable) accession number: Q68CP9
Secondary accession number(s): Q15KG9
, Q5EB51, Q645I3, Q6ZRY5, Q7Z3I5, Q86T28, Q96SJ6, Q9HCL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: November 2, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.