ID TPGS2_HUMAN Reviewed; 300 AA. AC Q68CL5; B4DIX2; K7EIJ9; Q4KN59; Q8WTU3; Q96BT9; Q9Y435; DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot. DT 05-SEP-2006, sequence version 2. DT 24-JAN-2024, entry version 141. DE RecName: Full=Tubulin polyglutamylase complex subunit 2; DE Short=PGs2; GN Name=TPGS2; Synonyms=C18orf10; ORFNames=HMFN0601, L17; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). RC TISSUE=Hippocampus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Liver; RX PubMed=15221005; DOI=10.1038/sj.onc.1207782; RA Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., RA Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., RA Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.; RT "Expression profiling and differential screening between hepatoblastomas RT and the corresponding normal livers: identification of high expression of RT the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."; RL Oncogene 23:5901-5911(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16177791; DOI=10.1038/nature03983; RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J., RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.; RT "DNA sequence and analysis of human chromosome 18."; RL Nature 437:551-555(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). RC TISSUE=Lung, Pancreas, and Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-300 (ISOFORM 2). RC TISSUE=Uterus; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] OF 61-300 (ISOFORM 2), AND SUBCELLULAR LOCATION. RX PubMed=15334068; DOI=10.1038/sj.onc.1207921; RA Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., RA Cerveny C., Law C.-L., Wahl A., Carter P.; RT "Suppression subtractive hybridization and expression profiling identifies RT a unique set of genes overexpressed in non-small-cell lung cancer."; RL Oncogene 23:7734-7745(2004). RN [7] RP FUNCTION, INTERACTION WITH CSTPP1 AND LRRC49, AND SUBCELLULAR LOCATION. RX PubMed=34782749; DOI=10.1038/s41422-021-00584-9; RA Wang L., Paudyal S.C., Kang Y., Owa M., Liang F.X., Spektor A., Knaut H., RA Sanchez I., Dynlacht B.D.; RT "Regulators of tubulin polyglutamylation control nuclear shape and cilium RT disassembly by balancing microtubule and actin assembly."; RL Cell Res. 32:190-209(2022). CC -!- FUNCTION: Subunit of the tubulin polyglutamylase complex (TPGC). The CC complex mediates cilia and flagella polyglutamylation which is CC essential for their biogenesis and motility. CC {ECO:0000305|PubMed:34782749}. CC -!- SUBUNIT: Part of the neuronal tubulin polyglutamylase complex which CC contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1 (Probable). Interacts CC with CSTPP1 and LRRC49 (PubMed:34782749). {ECO:0000269|PubMed:34782749, CC ECO:0000305|PubMed:34782749}. CC -!- INTERACTION: CC Q68CL5; Q5XKR4: OTP; NbExp=3; IntAct=EBI-748091, EBI-12865884; CC Q68CL5-3; P27797: CALR; NbExp=3; IntAct=EBI-9091010, EBI-1049597; CC Q68CL5-3; P36957: DLST; NbExp=3; IntAct=EBI-9091010, EBI-351007; CC Q68CL5-3; Q8TDX7: NEK7; NbExp=3; IntAct=EBI-9091010, EBI-1055945; CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton CC {ECO:0000269|PubMed:34782749}. Cytoplasm, cytoskeleton, microtubule CC organizing center, centrosome, centriolar satellite CC {ECO:0000269|PubMed:34782749}. Note=Associated with microtubules. CC {ECO:0000269|PubMed:34782749}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=2; CC IsoId=Q68CL5-2; Sequence=Displayed; CC Name=1; CC IsoId=Q68CL5-1; Sequence=VSP_020113; CC Name=3; CC IsoId=Q68CL5-3; Sequence=VSP_014884, VSP_014885; CC Name=4; CC IsoId=Q68CL5-4; Sequence=VSP_054525; CC Name=5; CC IsoId=Q68CL5-5; Sequence=VSP_055634; CC -!- SEQUENCE CAUTION: CC Sequence=AAH22199.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=CAB43322.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK295817; BAG58634.1; -; mRNA. DR EMBL; AB073382; BAD38633.1; -; mRNA. DR EMBL; AC009854; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC090333; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC015178; AAH15178.2; -; mRNA. DR EMBL; BC022199; AAH22199.2; ALT_INIT; mRNA. DR EMBL; BC087845; AAH87845.1; -; mRNA. DR EMBL; AL050225; CAB43322.2; ALT_INIT; mRNA. DR EMBL; AY598336; AAT06747.1; -; mRNA. DR CCDS; CCDS32817.1; -. [Q68CL5-2] DR CCDS; CCDS62421.1; -. [Q68CL5-1] DR CCDS; CCDS62422.1; -. [Q68CL5-4] DR CCDS; CCDS62423.1; -. [Q68CL5-3] DR CCDS; CCDS62424.1; -. [Q68CL5-5] DR PIR; T08811; T08811. DR RefSeq; NP_001258878.1; NM_001271949.1. [Q68CL5-4] DR RefSeq; NP_001258879.1; NM_001271950.1. [Q68CL5-1] DR RefSeq; NP_001258880.1; NM_001271951.1. [Q68CL5-5] DR RefSeq; NP_001258881.1; NM_001271952.1. DR RefSeq; NP_001258883.1; NM_001271954.1. [Q68CL5-3] DR RefSeq; NP_056291.2; NM_015476.3. [Q68CL5-2] DR AlphaFoldDB; Q68CL5; -. DR BioGRID; 117438; 23. DR ComplexPortal; CPX-2572; Tubulin polyglutamylase complex. DR IntAct; Q68CL5; 14. DR STRING; 9606.ENSP00000464780; -. DR iPTMnet; Q68CL5; -. DR PhosphoSitePlus; Q68CL5; -. DR BioMuta; TPGS2; -. DR DMDM; 114152891; -. DR EPD; Q68CL5; -. DR jPOST; Q68CL5; -. DR MassIVE; Q68CL5; -. DR MaxQB; Q68CL5; -. DR PaxDb; 9606-ENSP00000464780; -. DR PeptideAtlas; Q68CL5; -. DR ProteomicsDB; 66006; -. [Q68CL5-2] DR ProteomicsDB; 66007; -. [Q68CL5-1] DR ProteomicsDB; 66008; -. [Q68CL5-3] DR Pumba; Q68CL5; -. DR Antibodypedia; 22336; 117 antibodies from 17 providers. DR DNASU; 25941; -. DR Ensembl; ENST00000334295.9; ENSP00000335144.3; ENSG00000134779.15. [Q68CL5-2] DR Ensembl; ENST00000383056.7; ENSP00000372530.2; ENSG00000134779.15. [Q68CL5-1] DR Ensembl; ENST00000589049.5; ENSP00000466973.1; ENSG00000134779.15. [Q68CL5-3] DR Ensembl; ENST00000590842.5; ENSP00000464780.1; ENSG00000134779.15. [Q68CL5-5] DR Ensembl; ENST00000593035.5; ENSP00000467392.1; ENSG00000134779.15. [Q68CL5-4] DR GeneID; 25941; -. DR KEGG; hsa:25941; -. DR MANE-Select; ENST00000334295.9; ENSP00000335144.3; NM_015476.4; NP_056291.2. DR UCSC; uc002kzw.3; human. [Q68CL5-2] DR AGR; HGNC:24561; -. DR CTD; 25941; -. DR DisGeNET; 25941; -. DR GeneCards; TPGS2; -. DR HGNC; HGNC:24561; TPGS2. DR HPA; ENSG00000134779; Tissue enhanced (choroid). DR neXtProt; NX_Q68CL5; -. DR OpenTargets; ENSG00000134779; -. DR PharmGKB; PA128394637; -. DR VEuPathDB; HostDB:ENSG00000134779; -. DR eggNOG; ENOG502R21Z; Eukaryota. DR GeneTree; ENSGT00390000018344; -. DR HOGENOM; CLU_079178_0_0_1; -. DR InParanoid; Q68CL5; -. DR OMA; LRMSIAH; -. DR OrthoDB; 5477158at2759; -. DR PhylomeDB; Q68CL5; -. DR TreeFam; TF325540; -. DR PathwayCommons; Q68CL5; -. DR Reactome; R-HSA-8955332; Carboxyterminal post-translational modifications of tubulin. DR SignaLink; Q68CL5; -. DR BioGRID-ORCS; 25941; 11 hits in 1152 CRISPR screens. DR ChiTaRS; TPGS2; human. DR GenomeRNAi; 25941; -. DR Pharos; Q68CL5; Tdark. DR PRO; PR:Q68CL5; -. DR Proteomes; UP000005640; Chromosome 18. DR RNAct; Q68CL5; Protein. DR Bgee; ENSG00000134779; Expressed in ganglionic eminence and 200 other cell types or tissues. DR ExpressionAtlas; Q68CL5; baseline and differential. DR GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW. DR InterPro; IPR018958; Knr4/Smi1-like_dom. DR InterPro; IPR037883; Knr4/Smi1-like_sf. DR InterPro; IPR039231; TPGS2. DR PANTHER; PTHR31854; TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 2; 1. DR PANTHER; PTHR31854:SF2; TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 2; 1. DR SMART; SM00860; SMI1_KNR4; 1. DR SUPFAM; SSF160631; SMI1/KNR4-like; 1. DR Genevisible; Q68CL5; HS. PE 1: Evidence at protein level; KW Alternative splicing; Cytoplasm; Cytoskeleton; Microtubule; KW Reference proteome. FT CHAIN 1..300 FT /note="Tubulin polyglutamylase complex subunit 2" FT /id="PRO_0000079304" FT REGION 257..300 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 277..300 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 85..127 FT /note="Missing (in isoform 1)" FT /evidence="ECO:0000303|PubMed:15221005, FT ECO:0000303|PubMed:15489334" FT /id="VSP_020113" FT VAR_SEQ 85..119 FT /note="Missing (in isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_054525" FT VAR_SEQ 220..300 FT /note="QWFSMYKPITYNTNLLTEETDSFVNKLDPSKVFKSKNKIVIPKKKGPVQPAG FT GQKGPSGPSGPSTSSTSKSSSGSGNPTRK -> ITYNIKMNRRKCVHWKLAVEPLQWEL FT RSCVSAGMGTGHKQRVSSMKPRSCSVCSRRQSNSMGTTVSQSFLSYGKNVLFFTVRCCF FT (in isoform 5)" FT /evidence="ECO:0000305" FT /id="VSP_055634" FT VAR_SEQ 220..227 FT /note="QWFSMYKP -> VREEHLPL (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_014884" FT VAR_SEQ 228..300 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_014885" FT VARIANT 47 FT /note="R -> C (in dbSNP:rs2303507)" FT /id="VAR_027410" FT CONFLICT 44 FT /note="P -> S (in Ref. 5; CAB43322)" FT /evidence="ECO:0000305" SQ SEQUENCE 300 AA; 33318 MW; F3AADD55882EC1E5 CRC64; MEEEASSPGL GCSKPHLEKL TLGITRILES SPGVTEVTII EKPPAERHMI SSWEQKNNCV MPEDVKNFYL MTNGFHMTWS VKLDEHIIPL GSMAINSISK LTQLTQSSMY SLPNAPTLAD LEDDTHEASD DQPEKPHFDS RSVIFELDSC NGSGKVCLVY KSGKPALAED TEIWFLDRAL YWHFLTDTFT AYYRLLITHL GLPQWQYAFT SYGISPQAKQ WFSMYKPITY NTNLLTEETD SFVNKLDPSK VFKSKNKIVI PKKKGPVQPA GGQKGPSGPS GPSTSSTSKS SSGSGNPTRK //