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Q68CL5

- TPGS2_HUMAN

UniProt

Q68CL5 - TPGS2_HUMAN

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Protein
Tubulin polyglutamylase complex subunit 2
Gene
TPGS2, C18orf10, HMFN0601, L17
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin polyglutamylase complex subunit 2
Short name:
PGs2
Gene namesi
Name:TPGS2
Synonyms:C18orf10
ORF Names:HMFN0601, L17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:24561. TPGS2.

Subcellular locationi

Cytoplasmcytoskeleton By similarity 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394637.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Tubulin polyglutamylase complex subunit 2
PRO_0000079304Add
BLAST

Proteomic databases

MaxQBiQ68CL5.
PRIDEiQ68CL5.

PTM databases

PhosphoSiteiQ68CL5.

Expressioni

Gene expression databases

ArrayExpressiQ68CL5.
BgeeiQ68CL5.
CleanExiHS_C18orf10.
GenevestigatoriQ68CL5.

Organism-specific databases

HPAiHPA040596.
HPA040617.

Interactioni

Subunit structurei

Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1 By similarity.

Protein-protein interaction databases

BioGridi117438. 2 interactions.
IntActiQ68CL5. 2 interactions.
STRINGi9606.ENSP00000335144.

Structurei

3D structure databases

ProteinModelPortaliQ68CL5.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG74715.
HOGENOMiHOG000294114.
HOVERGENiHBG073636.
InParanoidiQ68CL5.
KOiK16605.
OMAiLPYWELC.
PhylomeDBiQ68CL5.
TreeFamiTF325540.

Family and domain databases

InterProiIPR018958. SMI1/KNR4_like_dom.
[Graphical view]
SMARTiSM00860. SMI1_KNR4. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 2 (identifier: Q68CL5-2) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEEEASSPGL GCSKPHLEKL TLGITRILES SPGVTEVTII EKPPAERHMI    50
SSWEQKNNCV MPEDVKNFYL MTNGFHMTWS VKLDEHIIPL GSMAINSISK 100
LTQLTQSSMY SLPNAPTLAD LEDDTHEASD DQPEKPHFDS RSVIFELDSC 150
NGSGKVCLVY KSGKPALAED TEIWFLDRAL YWHFLTDTFT AYYRLLITHL 200
GLPQWQYAFT SYGISPQAKQ WFSMYKPITY NTNLLTEETD SFVNKLDPSK 250
VFKSKNKIVI PKKKGPVQPA GGQKGPSGPS GPSTSSTSKS SSGSGNPTRK 300
Length:300
Mass (Da):33,318
Last modified:September 5, 2006 - v2
Checksum:iF3AADD55882EC1E5
GO
Isoform 1 (identifier: Q68CL5-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-127: Missing.

Show »
Length:257
Mass (Da):28,653
Checksum:i4E3780AD249BBD57
GO
Isoform 3 (identifier: Q68CL5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-227: QWFSMYKP → VREEHLPL
     228-300: Missing.

Show »
Length:227
Mass (Da):25,665
Checksum:i7021B602DBC24361
GO
Isoform 4 (identifier: Q68CL5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-119: Missing.

Note: No experimental confirmation available.

Show »
Length:265
Mass (Da):29,607
Checksum:iE10DBB66D27A01B8
GO
Isoform 5 (identifier: Q68CL5-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-300: QWFSMYKPIT...SSGSGNPTRK → ITYNIKMNRR...VLFFTVRCCF

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »
Length:304
Mass (Da):34,399
Checksum:i5D2E6312F59D33CF
GO

Sequence cautioni

The sequence AAH22199.2 differs from that shown. Reason: Erroneous initiation.
The sequence CAB43322.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471R → C.
Corresponds to variant rs2303507 [ dbSNP | Ensembl ].
VAR_027410

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei85 – 12743Missing in isoform 1.
VSP_020113Add
BLAST
Alternative sequencei85 – 11935Missing in isoform 4.
VSP_054525Add
BLAST
Alternative sequencei220 – 30081QWFSM…NPTRK → ITYNIKMNRRKCVHWKLAVE PLQWELRSCVSAGMGTGHKQ RVSSMKPRSCSVCSRRQSNS MGTTVSQSFLSYGKNVLFFT VRCCF in isoform 5.
VSP_055634Add
BLAST
Alternative sequencei220 – 2278QWFSMYKP → VREEHLPL in isoform 3.
VSP_014884
Alternative sequencei228 – 30073Missing in isoform 3.
VSP_014885Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441P → S in CAB43322. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK295817 mRNA. Translation: BAG58634.1.
AB073382 mRNA. Translation: BAD38633.1.
AC009854 Genomic DNA. No translation available.
AC090333 Genomic DNA. No translation available.
BC015178 mRNA. Translation: AAH15178.2.
BC022199 mRNA. Translation: AAH22199.2. Different initiation.
BC087845 mRNA. Translation: AAH87845.1.
AL050225 mRNA. Translation: CAB43322.2. Different initiation.
AY598336 mRNA. Translation: AAT06747.1.
CCDSiCCDS32817.1. [Q68CL5-2]
CCDS62421.1. [Q68CL5-1]
CCDS62422.1. [Q68CL5-4]
CCDS62423.1. [Q68CL5-3]
PIRiT08811.
RefSeqiNP_001258878.1. NM_001271949.1. [Q68CL5-4]
NP_001258879.1. NM_001271950.1. [Q68CL5-1]
NP_001258881.1. NM_001271952.1.
NP_001258883.1. NM_001271954.1. [Q68CL5-3]
NP_056291.2. NM_015476.3. [Q68CL5-2]
UniGeneiHs.436636.

Genome annotation databases

EnsembliENST00000334295; ENSP00000335144; ENSG00000134779. [Q68CL5-2]
ENST00000383056; ENSP00000372530; ENSG00000134779. [Q68CL5-1]
ENST00000589049; ENSP00000466973; ENSG00000134779. [Q68CL5-3]
ENST00000590842; ENSP00000464780; ENSG00000134779.
ENST00000593035; ENSP00000467392; ENSG00000134779.
GeneIDi25941.
KEGGihsa:25941.
UCSCiuc002kzw.2. human. [Q68CL5-2]
uc002kzx.2. human. [Q68CL5-1]
uc002kzy.4. human. [Q68CL5-3]

Polymorphism databases

DMDMi114152891.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK295817 mRNA. Translation: BAG58634.1 .
AB073382 mRNA. Translation: BAD38633.1 .
AC009854 Genomic DNA. No translation available.
AC090333 Genomic DNA. No translation available.
BC015178 mRNA. Translation: AAH15178.2 .
BC022199 mRNA. Translation: AAH22199.2 . Different initiation.
BC087845 mRNA. Translation: AAH87845.1 .
AL050225 mRNA. Translation: CAB43322.2 . Different initiation.
AY598336 mRNA. Translation: AAT06747.1 .
CCDSi CCDS32817.1. [Q68CL5-2 ]
CCDS62421.1. [Q68CL5-1 ]
CCDS62422.1. [Q68CL5-4 ]
CCDS62423.1. [Q68CL5-3 ]
PIRi T08811.
RefSeqi NP_001258878.1. NM_001271949.1. [Q68CL5-4 ]
NP_001258879.1. NM_001271950.1. [Q68CL5-1 ]
NP_001258881.1. NM_001271952.1.
NP_001258883.1. NM_001271954.1. [Q68CL5-3 ]
NP_056291.2. NM_015476.3. [Q68CL5-2 ]
UniGenei Hs.436636.

3D structure databases

ProteinModelPortali Q68CL5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117438. 2 interactions.
IntActi Q68CL5. 2 interactions.
STRINGi 9606.ENSP00000335144.

PTM databases

PhosphoSitei Q68CL5.

Polymorphism databases

DMDMi 114152891.

Proteomic databases

MaxQBi Q68CL5.
PRIDEi Q68CL5.

Protocols and materials databases

DNASUi 25941.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334295 ; ENSP00000335144 ; ENSG00000134779 . [Q68CL5-2 ]
ENST00000383056 ; ENSP00000372530 ; ENSG00000134779 . [Q68CL5-1 ]
ENST00000589049 ; ENSP00000466973 ; ENSG00000134779 . [Q68CL5-3 ]
ENST00000590842 ; ENSP00000464780 ; ENSG00000134779 .
ENST00000593035 ; ENSP00000467392 ; ENSG00000134779 .
GeneIDi 25941.
KEGGi hsa:25941.
UCSCi uc002kzw.2. human. [Q68CL5-2 ]
uc002kzx.2. human. [Q68CL5-1 ]
uc002kzy.4. human. [Q68CL5-3 ]

Organism-specific databases

CTDi 25941.
GeneCardsi GC18M034359.
HGNCi HGNC:24561. TPGS2.
HPAi HPA040596.
HPA040617.
neXtProti NX_Q68CL5.
PharmGKBi PA128394637.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG74715.
HOGENOMi HOG000294114.
HOVERGENi HBG073636.
InParanoidi Q68CL5.
KOi K16605.
OMAi LPYWELC.
PhylomeDBi Q68CL5.
TreeFami TF325540.

Miscellaneous databases

ChiTaRSi TPGS2. human.
GenomeRNAii 25941.
NextBioi 35472377.
PROi Q68CL5.

Gene expression databases

ArrayExpressi Q68CL5.
Bgeei Q68CL5.
CleanExi HS_C18orf10.
Genevestigatori Q68CL5.

Family and domain databases

InterProi IPR018958. SMI1/KNR4_like_dom.
[Graphical view ]
SMARTi SM00860. SMI1_KNR4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Hippocampus.
  2. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
    Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
    Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Lung, Pancreas and Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-300 (ISOFORM 2).
    Tissue: Uterus.
  6. "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer."
    Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P.
    Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 61-300 (ISOFORM 2), SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTPGS2_HUMAN
AccessioniPrimary (citable) accession number: Q68CL5
Secondary accession number(s): B4DIX2
, K7EIJ9, Q4KN59, Q8WTU3, Q96BT9, Q9Y435
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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