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Protein

Tubulin polyglutamylase complex subunit 2

Gene

TPGS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin polyglutamylase complex subunit 2
Short name:
PGs2
Gene namesi
Name:TPGS2
Synonyms:C18orf10
ORF Names:HMFN0601, L17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:24561. TPGS2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394637.

Polymorphism and mutation databases

DMDMi114152891.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Tubulin polyglutamylase complex subunit 2PRO_0000079304Add
BLAST

Proteomic databases

MaxQBiQ68CL5.
PRIDEiQ68CL5.

PTM databases

PhosphoSiteiQ68CL5.

Expressioni

Gene expression databases

BgeeiQ68CL5.
CleanExiHS_C18orf10.
ExpressionAtlasiQ68CL5. baseline and differential.
GenevestigatoriQ68CL5.

Organism-specific databases

HPAiHPA040596.
HPA040617.
HPA061753.

Interactioni

Subunit structurei

Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.By similarity

Protein-protein interaction databases

BioGridi117438. 8 interactions.
IntActiQ68CL5. 2 interactions.
STRINGi9606.ENSP00000335144.

Structurei

3D structure databases

ProteinModelPortaliQ68CL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG74715.
GeneTreeiENSGT00390000018344.
HOGENOMiHOG000294114.
HOVERGENiHBG073636.
InParanoidiQ68CL5.
KOiK16605.
PhylomeDBiQ68CL5.
TreeFamiTF325540.

Family and domain databases

InterProiIPR018958. SMI1/KNR4_like_dom.
[Graphical view]
SMARTiSM00860. SMI1_KNR4. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q68CL5-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEEASSPGL GCSKPHLEKL TLGITRILES SPGVTEVTII EKPPAERHMI
60 70 80 90 100
SSWEQKNNCV MPEDVKNFYL MTNGFHMTWS VKLDEHIIPL GSMAINSISK
110 120 130 140 150
LTQLTQSSMY SLPNAPTLAD LEDDTHEASD DQPEKPHFDS RSVIFELDSC
160 170 180 190 200
NGSGKVCLVY KSGKPALAED TEIWFLDRAL YWHFLTDTFT AYYRLLITHL
210 220 230 240 250
GLPQWQYAFT SYGISPQAKQ WFSMYKPITY NTNLLTEETD SFVNKLDPSK
260 270 280 290 300
VFKSKNKIVI PKKKGPVQPA GGQKGPSGPS GPSTSSTSKS SSGSGNPTRK
Length:300
Mass (Da):33,318
Last modified:September 5, 2006 - v2
Checksum:iF3AADD55882EC1E5
GO
Isoform 1 (identifier: Q68CL5-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-127: Missing.

Show »
Length:257
Mass (Da):28,653
Checksum:i4E3780AD249BBD57
GO
Isoform 3 (identifier: Q68CL5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-227: QWFSMYKP → VREEHLPL
     228-300: Missing.

Show »
Length:227
Mass (Da):25,665
Checksum:i7021B602DBC24361
GO
Isoform 4 (identifier: Q68CL5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-119: Missing.

Note: No experimental confirmation available.

Show »
Length:265
Mass (Da):29,607
Checksum:iE10DBB66D27A01B8
GO
Isoform 5 (identifier: Q68CL5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-300: QWFSMYKPIT...SSGSGNPTRK → ITYNIKMNRR...VLFFTVRCCF

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »
Length:304
Mass (Da):34,399
Checksum:i5D2E6312F59D33CF
GO

Sequence cautioni

The sequence AAH22199.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB43322.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441P → S in CAB43322 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471R → C.
Corresponds to variant rs2303507 [ dbSNP | Ensembl ].
VAR_027410

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei85 – 12743Missing in isoform 1. 2 PublicationsVSP_020113Add
BLAST
Alternative sequencei85 – 11935Missing in isoform 4. 1 PublicationVSP_054525Add
BLAST
Alternative sequencei220 – 30081QWFSM…NPTRK → ITYNIKMNRRKCVHWKLAVE PLQWELRSCVSAGMGTGHKQ RVSSMKPRSCSVCSRRQSNS MGTTVSQSFLSYGKNVLFFT VRCCF in isoform 5. CuratedVSP_055634Add
BLAST
Alternative sequencei220 – 2278QWFSMYKP → VREEHLPL in isoform 3. 1 PublicationVSP_014884
Alternative sequencei228 – 30073Missing in isoform 3. 1 PublicationVSP_014885Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295817 mRNA. Translation: BAG58634.1.
AB073382 mRNA. Translation: BAD38633.1.
AC009854 Genomic DNA. No translation available.
AC090333 Genomic DNA. No translation available.
BC015178 mRNA. Translation: AAH15178.2.
BC022199 mRNA. Translation: AAH22199.2. Different initiation.
BC087845 mRNA. Translation: AAH87845.1.
AL050225 mRNA. Translation: CAB43322.2. Different initiation.
AY598336 mRNA. Translation: AAT06747.1.
CCDSiCCDS32817.1. [Q68CL5-2]
CCDS62421.1. [Q68CL5-1]
CCDS62422.1. [Q68CL5-4]
CCDS62423.1. [Q68CL5-3]
CCDS62424.1. [Q68CL5-5]
PIRiT08811.
RefSeqiNP_001258878.1. NM_001271949.1. [Q68CL5-4]
NP_001258879.1. NM_001271950.1. [Q68CL5-1]
NP_001258880.1. NM_001271951.1. [Q68CL5-5]
NP_001258881.1. NM_001271952.1.
NP_001258883.1. NM_001271954.1. [Q68CL5-3]
NP_056291.2. NM_015476.3. [Q68CL5-2]
UniGeneiHs.436636.

Genome annotation databases

EnsembliENST00000334295; ENSP00000335144; ENSG00000134779. [Q68CL5-2]
ENST00000383056; ENSP00000372530; ENSG00000134779. [Q68CL5-1]
ENST00000589049; ENSP00000466973; ENSG00000134779. [Q68CL5-3]
ENST00000590842; ENSP00000464780; ENSG00000134779. [Q68CL5-5]
ENST00000593035; ENSP00000467392; ENSG00000134779. [Q68CL5-4]
GeneIDi25941.
KEGGihsa:25941.
UCSCiuc002kzw.2. human. [Q68CL5-2]
uc002kzx.2. human. [Q68CL5-1]
uc002kzy.4. human. [Q68CL5-3]
uc010xci.2. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295817 mRNA. Translation: BAG58634.1.
AB073382 mRNA. Translation: BAD38633.1.
AC009854 Genomic DNA. No translation available.
AC090333 Genomic DNA. No translation available.
BC015178 mRNA. Translation: AAH15178.2.
BC022199 mRNA. Translation: AAH22199.2. Different initiation.
BC087845 mRNA. Translation: AAH87845.1.
AL050225 mRNA. Translation: CAB43322.2. Different initiation.
AY598336 mRNA. Translation: AAT06747.1.
CCDSiCCDS32817.1. [Q68CL5-2]
CCDS62421.1. [Q68CL5-1]
CCDS62422.1. [Q68CL5-4]
CCDS62423.1. [Q68CL5-3]
CCDS62424.1. [Q68CL5-5]
PIRiT08811.
RefSeqiNP_001258878.1. NM_001271949.1. [Q68CL5-4]
NP_001258879.1. NM_001271950.1. [Q68CL5-1]
NP_001258880.1. NM_001271951.1. [Q68CL5-5]
NP_001258881.1. NM_001271952.1.
NP_001258883.1. NM_001271954.1. [Q68CL5-3]
NP_056291.2. NM_015476.3. [Q68CL5-2]
UniGeneiHs.436636.

3D structure databases

ProteinModelPortaliQ68CL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117438. 8 interactions.
IntActiQ68CL5. 2 interactions.
STRINGi9606.ENSP00000335144.

PTM databases

PhosphoSiteiQ68CL5.

Polymorphism and mutation databases

DMDMi114152891.

Proteomic databases

MaxQBiQ68CL5.
PRIDEiQ68CL5.

Protocols and materials databases

DNASUi25941.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334295; ENSP00000335144; ENSG00000134779. [Q68CL5-2]
ENST00000383056; ENSP00000372530; ENSG00000134779. [Q68CL5-1]
ENST00000589049; ENSP00000466973; ENSG00000134779. [Q68CL5-3]
ENST00000590842; ENSP00000464780; ENSG00000134779. [Q68CL5-5]
ENST00000593035; ENSP00000467392; ENSG00000134779. [Q68CL5-4]
GeneIDi25941.
KEGGihsa:25941.
UCSCiuc002kzw.2. human. [Q68CL5-2]
uc002kzx.2. human. [Q68CL5-1]
uc002kzy.4. human. [Q68CL5-3]
uc010xci.2. human.

Organism-specific databases

CTDi25941.
GeneCardsiGC18M034359.
HGNCiHGNC:24561. TPGS2.
HPAiHPA040596.
HPA040617.
HPA061753.
neXtProtiNX_Q68CL5.
PharmGKBiPA128394637.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG74715.
GeneTreeiENSGT00390000018344.
HOGENOMiHOG000294114.
HOVERGENiHBG073636.
InParanoidiQ68CL5.
KOiK16605.
PhylomeDBiQ68CL5.
TreeFamiTF325540.

Miscellaneous databases

ChiTaRSiTPGS2. human.
GenomeRNAii25941.
NextBioi35472377.
PROiQ68CL5.

Gene expression databases

BgeeiQ68CL5.
CleanExiHS_C18orf10.
ExpressionAtlasiQ68CL5. baseline and differential.
GenevestigatoriQ68CL5.

Family and domain databases

InterProiIPR018958. SMI1/KNR4_like_dom.
[Graphical view]
SMARTiSM00860. SMI1_KNR4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Hippocampus.
  2. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
    Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
    Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Lung, Pancreas and Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-300 (ISOFORM 2).
    Tissue: Uterus.
  6. "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer."
    Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P.
    Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 61-300 (ISOFORM 2), SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTPGS2_HUMAN
AccessioniPrimary (citable) accession number: Q68CL5
Secondary accession number(s): B4DIX2
, K7EIJ9, Q4KN59, Q8WTU3, Q96BT9, Q9Y435
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: September 5, 2006
Last modified: April 29, 2015
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.