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Q68CL5

- TPGS2_HUMAN

UniProt

Q68CL5 - TPGS2_HUMAN

Protein

Tubulin polyglutamylase complex subunit 2

Gene

TPGS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (05 Sep 2006)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tubulin polyglutamylase complex subunit 2
    Short name:
    PGs2
    Gene namesi
    Name:TPGS2
    Synonyms:C18orf10
    ORF Names:HMFN0601, L17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:24561. TPGS2.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394637.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 300300Tubulin polyglutamylase complex subunit 2PRO_0000079304Add
    BLAST

    Proteomic databases

    MaxQBiQ68CL5.
    PRIDEiQ68CL5.

    PTM databases

    PhosphoSiteiQ68CL5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ68CL5.
    BgeeiQ68CL5.
    CleanExiHS_C18orf10.
    GenevestigatoriQ68CL5.

    Organism-specific databases

    HPAiHPA040596.
    HPA040617.

    Interactioni

    Subunit structurei

    Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.By similarity

    Protein-protein interaction databases

    BioGridi117438. 2 interactions.
    IntActiQ68CL5. 2 interactions.
    STRINGi9606.ENSP00000335144.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68CL5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG74715.
    HOGENOMiHOG000294114.
    HOVERGENiHBG073636.
    InParanoidiQ68CL5.
    KOiK16605.
    OMAiLPYWELC.
    PhylomeDBiQ68CL5.
    TreeFamiTF325540.

    Family and domain databases

    InterProiIPR018958. SMI1/KNR4_like_dom.
    [Graphical view]
    SMARTiSM00860. SMI1_KNR4. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 2 (identifier: Q68CL5-2) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEEEASSPGL GCSKPHLEKL TLGITRILES SPGVTEVTII EKPPAERHMI    50
    SSWEQKNNCV MPEDVKNFYL MTNGFHMTWS VKLDEHIIPL GSMAINSISK 100
    LTQLTQSSMY SLPNAPTLAD LEDDTHEASD DQPEKPHFDS RSVIFELDSC 150
    NGSGKVCLVY KSGKPALAED TEIWFLDRAL YWHFLTDTFT AYYRLLITHL 200
    GLPQWQYAFT SYGISPQAKQ WFSMYKPITY NTNLLTEETD SFVNKLDPSK 250
    VFKSKNKIVI PKKKGPVQPA GGQKGPSGPS GPSTSSTSKS SSGSGNPTRK 300
    Length:300
    Mass (Da):33,318
    Last modified:September 5, 2006 - v2
    Checksum:iF3AADD55882EC1E5
    GO
    Isoform 1 (identifier: Q68CL5-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         85-127: Missing.

    Show »
    Length:257
    Mass (Da):28,653
    Checksum:i4E3780AD249BBD57
    GO
    Isoform 3 (identifier: Q68CL5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         220-227: QWFSMYKP → VREEHLPL
         228-300: Missing.

    Show »
    Length:227
    Mass (Da):25,665
    Checksum:i7021B602DBC24361
    GO
    Isoform 4 (identifier: Q68CL5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         85-119: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:265
    Mass (Da):29,607
    Checksum:iE10DBB66D27A01B8
    GO
    Isoform 5 (identifier: Q68CL5-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         220-300: QWFSMYKPIT...SSGSGNPTRK → ITYNIKMNRR...VLFFTVRCCF

    Note: No experimental confirmation available. Gene prediction based on EST data.

    Show »
    Length:304
    Mass (Da):34,399
    Checksum:i5D2E6312F59D33CF
    GO

    Sequence cautioni

    The sequence AAH22199.2 differs from that shown. Reason: Erroneous initiation.
    The sequence CAB43322.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 441P → S in CAB43322. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti47 – 471R → C.
    Corresponds to variant rs2303507 [ dbSNP | Ensembl ].
    VAR_027410

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei85 – 12743Missing in isoform 1. 2 PublicationsVSP_020113Add
    BLAST
    Alternative sequencei85 – 11935Missing in isoform 4. 1 PublicationVSP_054525Add
    BLAST
    Alternative sequencei220 – 30081QWFSM…NPTRK → ITYNIKMNRRKCVHWKLAVE PLQWELRSCVSAGMGTGHKQ RVSSMKPRSCSVCSRRQSNS MGTTVSQSFLSYGKNVLFFT VRCCF in isoform 5. CuratedVSP_055634Add
    BLAST
    Alternative sequencei220 – 2278QWFSMYKP → VREEHLPL in isoform 3. 1 PublicationVSP_014884
    Alternative sequencei228 – 30073Missing in isoform 3. 1 PublicationVSP_014885Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK295817 mRNA. Translation: BAG58634.1.
    AB073382 mRNA. Translation: BAD38633.1.
    AC009854 Genomic DNA. No translation available.
    AC090333 Genomic DNA. No translation available.
    BC015178 mRNA. Translation: AAH15178.2.
    BC022199 mRNA. Translation: AAH22199.2. Different initiation.
    BC087845 mRNA. Translation: AAH87845.1.
    AL050225 mRNA. Translation: CAB43322.2. Different initiation.
    AY598336 mRNA. Translation: AAT06747.1.
    CCDSiCCDS32817.1. [Q68CL5-2]
    CCDS62421.1. [Q68CL5-1]
    CCDS62422.1. [Q68CL5-4]
    CCDS62423.1. [Q68CL5-3]
    PIRiT08811.
    RefSeqiNP_001258878.1. NM_001271949.1. [Q68CL5-4]
    NP_001258879.1. NM_001271950.1. [Q68CL5-1]
    NP_001258881.1. NM_001271952.1.
    NP_001258883.1. NM_001271954.1. [Q68CL5-3]
    NP_056291.2. NM_015476.3. [Q68CL5-2]
    UniGeneiHs.436636.

    Genome annotation databases

    EnsembliENST00000334295; ENSP00000335144; ENSG00000134779. [Q68CL5-2]
    ENST00000383056; ENSP00000372530; ENSG00000134779. [Q68CL5-1]
    ENST00000589049; ENSP00000466973; ENSG00000134779. [Q68CL5-3]
    ENST00000590842; ENSP00000464780; ENSG00000134779. [Q68CL5-5]
    ENST00000593035; ENSP00000467392; ENSG00000134779. [Q68CL5-4]
    GeneIDi25941.
    KEGGihsa:25941.
    UCSCiuc002kzw.2. human. [Q68CL5-2]
    uc002kzx.2. human. [Q68CL5-1]
    uc002kzy.4. human. [Q68CL5-3]

    Polymorphism databases

    DMDMi114152891.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK295817 mRNA. Translation: BAG58634.1 .
    AB073382 mRNA. Translation: BAD38633.1 .
    AC009854 Genomic DNA. No translation available.
    AC090333 Genomic DNA. No translation available.
    BC015178 mRNA. Translation: AAH15178.2 .
    BC022199 mRNA. Translation: AAH22199.2 . Different initiation.
    BC087845 mRNA. Translation: AAH87845.1 .
    AL050225 mRNA. Translation: CAB43322.2 . Different initiation.
    AY598336 mRNA. Translation: AAT06747.1 .
    CCDSi CCDS32817.1. [Q68CL5-2 ]
    CCDS62421.1. [Q68CL5-1 ]
    CCDS62422.1. [Q68CL5-4 ]
    CCDS62423.1. [Q68CL5-3 ]
    PIRi T08811.
    RefSeqi NP_001258878.1. NM_001271949.1. [Q68CL5-4 ]
    NP_001258879.1. NM_001271950.1. [Q68CL5-1 ]
    NP_001258881.1. NM_001271952.1.
    NP_001258883.1. NM_001271954.1. [Q68CL5-3 ]
    NP_056291.2. NM_015476.3. [Q68CL5-2 ]
    UniGenei Hs.436636.

    3D structure databases

    ProteinModelPortali Q68CL5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117438. 2 interactions.
    IntActi Q68CL5. 2 interactions.
    STRINGi 9606.ENSP00000335144.

    PTM databases

    PhosphoSitei Q68CL5.

    Polymorphism databases

    DMDMi 114152891.

    Proteomic databases

    MaxQBi Q68CL5.
    PRIDEi Q68CL5.

    Protocols and materials databases

    DNASUi 25941.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334295 ; ENSP00000335144 ; ENSG00000134779 . [Q68CL5-2 ]
    ENST00000383056 ; ENSP00000372530 ; ENSG00000134779 . [Q68CL5-1 ]
    ENST00000589049 ; ENSP00000466973 ; ENSG00000134779 . [Q68CL5-3 ]
    ENST00000590842 ; ENSP00000464780 ; ENSG00000134779 . [Q68CL5-5 ]
    ENST00000593035 ; ENSP00000467392 ; ENSG00000134779 . [Q68CL5-4 ]
    GeneIDi 25941.
    KEGGi hsa:25941.
    UCSCi uc002kzw.2. human. [Q68CL5-2 ]
    uc002kzx.2. human. [Q68CL5-1 ]
    uc002kzy.4. human. [Q68CL5-3 ]

    Organism-specific databases

    CTDi 25941.
    GeneCardsi GC18M034359.
    HGNCi HGNC:24561. TPGS2.
    HPAi HPA040596.
    HPA040617.
    neXtProti NX_Q68CL5.
    PharmGKBi PA128394637.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74715.
    HOGENOMi HOG000294114.
    HOVERGENi HBG073636.
    InParanoidi Q68CL5.
    KOi K16605.
    OMAi LPYWELC.
    PhylomeDBi Q68CL5.
    TreeFami TF325540.

    Miscellaneous databases

    ChiTaRSi TPGS2. human.
    GenomeRNAii 25941.
    NextBioi 35472377.
    PROi Q68CL5.

    Gene expression databases

    ArrayExpressi Q68CL5.
    Bgeei Q68CL5.
    CleanExi HS_C18orf10.
    Genevestigatori Q68CL5.

    Family and domain databases

    InterProi IPR018958. SMI1/KNR4_like_dom.
    [Graphical view ]
    SMARTi SM00860. SMI1_KNR4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Hippocampus.
    2. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
      Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
      Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Liver.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Lung, Pancreas and Testis.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-300 (ISOFORM 2).
      Tissue: Uterus.
    6. "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer."
      Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P.
      Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 61-300 (ISOFORM 2), SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiTPGS2_HUMAN
    AccessioniPrimary (citable) accession number: Q68CL5
    Secondary accession number(s): B4DIX2
    , K7EIJ9, Q4KN59, Q8WTU3, Q96BT9, Q9Y435
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3