Reviewed, UniProtKB/Swiss-Prot Q68CL5 (TPGS2_HUMAN)

Names and origin

Protein names

Recommended name:
    Tubulin polyglutamylase complex subunit 2
      Short name=PGs2

Gene names

Name:	C18orf10
ORF Names:	HMFN0601, L17

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subunit structure	Part of the neuronal tubulin polyglutamylase complex which contains C19orf20/PGs1, C18orf10/PGs2, TTLL1, LRRC49 and NICN1 By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2 (identifier: Q68CL5-2)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q68CL5-1)

The sequence of this isoform differs from the canonical sequence as follows:
     85-127: Missing.

Isoform 3 (identifier: Q68CL5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     220-227: QWFSMYKP → VREEHLPL
     228-300: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 300	300	Tubulin polyglutamylase complex subunit 2		PRO_0000079304
Natural variations
	Alternative sequence	85 – 127	43	Missing in isoform 1.		VSP_020113
	Alternative sequence	220 – 227	8	QWFSMYKP → VREEHLPL in isoform 3.		VSP_014884
	Alternative sequence	228 – 300	73	Missing in isoform 3.		VSP_014885
	Natural variant	47	1	R → C: dbSNP rs2303507.		VAR_027410
Experimental info
	Sequence conflict	44	1	P → S in CAB43322. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: F3AADD55882EC1E5	FASTA	300	33,318
	10 20 30 40 50 60 MEEEASSPGL GCSKPHLEKL TLGITRILES SPGVTEVTII EKPPAERHMI SSWEQKNNCV 70 80 90 100 110 120 MPEDVKNFYL MTNGFHMTWS VKLDEHIIPL GSMAINSISK LTQLTQSSMY SLPNAPTLAD 130 140 150 160 170 180 LEDDTHEASD DQPEKPHFDS RSVIFELDSC NGSGKVCLVY KSGKPALAED TEIWFLDRAL 190 200 210 220 230 240 YWHFLTDTFT AYYRLLITHL GLPQWQYAFT SYGISPQAKQ WFSMYKPITY NTNLLTEETD 250 260 270 280 290 300 SFVNKLDPSK VFKSKNKIVI PKKKGPVQPA GGQKGPSGPS GPSTSSTSKS SSGSGNPTRK
	Isoform 1. Checksum: 4E3780AD249BBD57	FASTA	257	28,653
	10 20 30 40 50 60 MEEEASSPGL GCSKPHLEKL TLGITRILES SPGVTEVTII EKPPAERHMI SSWEQKNNCV 70 80 90 100 110 120 MPEDVKNFYL MTNGFHMTWS VKLDASDDQP EKPHFDSRSV IFELDSCNGS GKVCLVYKSG 130 140 150 160 170 180 KPALAEDTEI WFLDRALYWH FLTDTFTAYY RLLITHLGLP QWQYAFTSYG ISPQAKQWFS 190 200 210 220 230 240 MYKPITYNTN LLTEETDSFV NKLDPSKVFK SKNKIVIPKK KGPVQPAGGQ KGPSGPSGPS 250 TSSTSKSSSG SGNPTRK
	Isoform 3. Checksum: 7021B602DBC24361	FASTA	227	25,665
	10 20 30 40 50 60 MEEEASSPGL GCSKPHLEKL TLGITRILES SPGVTEVTII EKPPAERHMI SSWEQKNNCV 70 80 90 100 110 120 MPEDVKNFYL MTNGFHMTWS VKLDEHIIPL GSMAINSISK LTQLTQSSMY SLPNAPTLAD 130 140 150 160 170 180 LEDDTHEASD DQPEKPHFDS RSVIFELDSC NGSGKVCLVY KSGKPALAED TEIWFLDRAL 190 200 210 220 YWHFLTDTFT AYYRLLITHL GLPQWQYAFT SYGISPQAKV REEHLPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas." Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A. Oncogene 23:5901-5911(2004) [PubMed: 15221005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Lung, Pancreas and Testis.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-300 (ISOFORM 2). Tissue: Uterus.
[4]	"Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer." Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P. Oncogene 23:7734-7745(2004) [PubMed: 15334068] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 61-300 (ISOFORM 2), SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB073382 mRNA. Translation: BAD38633.1. BC015178 mRNA. Translation: AAH15178.2. BC022199 mRNA. Translation: AAH22199.2. Different initiation. BC087845 mRNA. Translation: AAH87845.1. AL050225 mRNA. Translation: CAB43322.2. Different initiation. AY598336 mRNA. Translation: AAT06747.1.
IPI	IPI00414449. IPI00470794. IPI00607682.
PIR	T08811.
RefSeq	NP_056291.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q68CL5. 1 interaction.
PTM databases
PhosphoSite	Q68CL5.
Proteomic databases
PRIDE	Q68CL5.
Genome annotation databases
Ensembl	ENST00000334295; ENSP00000335144; ENSG00000134779; Homo sapiens. [Genome view]
GeneID	25941.
KEGG	hsa:25941.
UCSC	uc002kzv.1. human. uc002kzw.1. human. uc002kzx.1. human.
Organism-specific databases
CTD	25941.
GeneCards	GC18M032630.
HGNC	HGNC:24561. C18orf10.
PharmGKB	PA128394637.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG282621.
HOVERGEN	Q68CL5.
InParanoid	Q68CL5.
OMA	LNQSSMY.
OrthoDB	EOG9PZMT7.
Gene expression databases
ArrayExpress	Q68CL5.
Bgee	Q68CL5.
CleanEx	HS_C18orf10.
Genevestigator	Q68CL5.
GermOnline	ENSG00000134779. Homo sapiens.
Family and domain databases
InterPro	IPR018958. Cell_wall_assmbl_KNR4-like. [Graphical view]
SMART	SM00860. SMI1_KNR4. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	47512.

Entry information

Entry name

TPGS2_HUMAN

Accession

Primary (citable) accession number: Q68CL5
Secondary accession number(s): Q4KN59 , Q8WTU3, Q96BT9, Q9Y435

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	September 5, 2006
Last modified:	December 15, 2009
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.