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Q68CL5 (TPGS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tubulin polyglutamylase complex subunit 2

Short name=PGs2
Gene names
Name:TPGS2
Synonyms:C18orf10
ORF Names:HMFN0601, L17
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1 By similarity.

Subcellular location

Cytoplasmcytoskeleton By similarity Ref.6.

Sequence caution

The sequence AAH22199.2 differs from that shown. Reason: Erroneous initiation.

The sequence CAB43322.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
Microtubule
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 2 (identifier: Q68CL5-2)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: Q68CL5-1)

The sequence of this isoform differs from the canonical sequence as follows:
     85-127: Missing.
Isoform 3 (identifier: Q68CL5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     220-227: QWFSMYKP → VREEHLPL
     228-300: Missing.
Isoform 4 (identifier: Q68CL5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     85-119: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 300300Tubulin polyglutamylase complex subunit 2
PRO_0000079304

Natural variations

Alternative sequence85 – 12743Missing in isoform 1.
VSP_020113
Alternative sequence85 – 11935Missing in isoform 4.
VSP_054525
Alternative sequence220 – 2278QWFSMYKP → VREEHLPL in isoform 3.
VSP_014884
Alternative sequence228 – 30073Missing in isoform 3.
VSP_014885
Natural variant471R → C.
Corresponds to variant rs2303507 [ dbSNP | Ensembl ].
VAR_027410

Experimental info

Sequence conflict441P → S in CAB43322. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 2 [UniParc].

Last modified September 5, 2006. Version 2.
Checksum: F3AADD55882EC1E5

FASTA30033,318
        10         20         30         40         50         60 
MEEEASSPGL GCSKPHLEKL TLGITRILES SPGVTEVTII EKPPAERHMI SSWEQKNNCV 

        70         80         90        100        110        120 
MPEDVKNFYL MTNGFHMTWS VKLDEHIIPL GSMAINSISK LTQLTQSSMY SLPNAPTLAD 

       130        140        150        160        170        180 
LEDDTHEASD DQPEKPHFDS RSVIFELDSC NGSGKVCLVY KSGKPALAED TEIWFLDRAL 

       190        200        210        220        230        240 
YWHFLTDTFT AYYRLLITHL GLPQWQYAFT SYGISPQAKQ WFSMYKPITY NTNLLTEETD 

       250        260        270        280        290        300 
SFVNKLDPSK VFKSKNKIVI PKKKGPVQPA GGQKGPSGPS GPSTSSTSKS SSGSGNPTRK 

« Hide

Isoform 1 [UniParc].

Checksum: 4E3780AD249BBD57
Show »

FASTA25728,653
Isoform 3 [UniParc].

Checksum: 7021B602DBC24361
Show »

FASTA22725,665
Isoform 4 [UniParc].

Checksum: E10DBB66D27A01B8
Show »

FASTA26529,607

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Hippocampus.
[2]"Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Liver.
[3]"DNA sequence and analysis of human chromosome 18."
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. expand/collapse author list , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Lung, Pancreas and Testis.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-300 (ISOFORM 2).
Tissue: Uterus.
[6]"Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer."
Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P.
Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 61-300 (ISOFORM 2), SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK295817 mRNA. Translation: BAG58634.1.
AB073382 mRNA. Translation: BAD38633.1.
AC009854 Genomic DNA. No translation available.
AC090333 Genomic DNA. No translation available.
BC015178 mRNA. Translation: AAH15178.2.
BC022199 mRNA. Translation: AAH22199.2. Different initiation.
BC087845 mRNA. Translation: AAH87845.1.
AL050225 mRNA. Translation: CAB43322.2. Different initiation.
AY598336 mRNA. Translation: AAT06747.1.
CCDSCCDS32817.1. [Q68CL5-2]
CCDS62421.1. [Q68CL5-1]
CCDS62423.1. [Q68CL5-3]
PIRT08811.
RefSeqNP_001258878.1. NM_001271949.1. [Q68CL5-4]
NP_001258879.1. NM_001271950.1. [Q68CL5-1]
NP_001258881.1. NM_001271952.1.
NP_001258883.1. NM_001271954.1. [Q68CL5-3]
NP_056291.2. NM_015476.3. [Q68CL5-2]
UniGeneHs.436636.

3D structure databases

ProteinModelPortalQ68CL5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117438. 2 interactions.
IntActQ68CL5. 2 interactions.
STRING9606.ENSP00000335144.

PTM databases

PhosphoSiteQ68CL5.

Polymorphism databases

DMDM114152891.

Proteomic databases

MaxQBQ68CL5.
PRIDEQ68CL5.

Protocols and materials databases

DNASU25941.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334295; ENSP00000335144; ENSG00000134779. [Q68CL5-2]
ENST00000383056; ENSP00000372530; ENSG00000134779. [Q68CL5-1]
ENST00000589049; ENSP00000466973; ENSG00000134779. [Q68CL5-3]
ENST00000593035; ENSP00000467392; ENSG00000134779.
GeneID25941.
KEGGhsa:25941.
UCSCuc002kzw.2. human. [Q68CL5-2]
uc002kzx.2. human. [Q68CL5-1]
uc002kzy.4. human. [Q68CL5-3]

Organism-specific databases

CTD25941.
GeneCardsGC18M034359.
HGNCHGNC:24561. TPGS2.
HPAHPA040596.
HPA040617.
neXtProtNX_Q68CL5.
PharmGKBPA128394637.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG74715.
HOGENOMHOG000294114.
HOVERGENHBG073636.
InParanoidQ68CL5.
KOK16605.
OMALPYWELC.
PhylomeDBQ68CL5.
TreeFamTF325540.

Gene expression databases

ArrayExpressQ68CL5.
BgeeQ68CL5.
CleanExHS_C18orf10.
GenevestigatorQ68CL5.

Family and domain databases

InterProIPR018958. SMI1/KNR4_like_dom.
[Graphical view]
SMARTSM00860. SMI1_KNR4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTPGS2. human.
GenomeRNAi25941.
NextBio35472377.
PROQ68CL5.

Entry information

Entry nameTPGS2_HUMAN
AccessionPrimary (citable) accession number: Q68CL5
Secondary accession number(s): B4DIX2 expand/collapse secondary AC list , Q4KN59, Q8WTU3, Q96BT9, Q9Y435
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM