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Protein

Nuclear GTPase SLIP-GC

Gene

NUGGC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi107 – 114GTPSequence analysis8

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • cellular response to lipopolysaccharide Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • regulation of DNA stability Source: UniProtKB

Keywordsi

Molecular functionHydrolase
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear GTPase SLIP-GC (EC:3.6.1.-)
Alternative name(s):
Speckled-like pattern in the germinal center
Gene namesi
Name:NUGGC
Synonyms:C8orf80
ORF Names:HMFN0672
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000189233.11.
HGNCiHGNC:33550. NUGGC.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189233.
PharmGKBiPA162380784.

Polymorphism and mutation databases

BioMutaiNUGGC.
DMDMi292495064.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002994791 – 796Nuclear GTPase SLIP-GCAdd BLAST796

Proteomic databases

PaxDbiQ68CJ6.
PeptideAtlasiQ68CJ6.
PRIDEiQ68CJ6.

PTM databases

iPTMnetiQ68CJ6.
PhosphoSitePlusiQ68CJ6.

Expressioni

Tissue specificityi

Expressed in germinal center B-cell and in lymphomas derived from germinal center B-cell.1 Publication

Gene expression databases

BgeeiENSG00000189233.
CleanExiHS_C8orf80.
ExpressionAtlasiQ68CJ6. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ68CJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili158 – 185Sequence analysisAdd BLAST28
Coiled coili745 – 775Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGY7. Eukaryota.
ENOG411207A. LUCA.
GeneTreeiENSGT00390000007091.
HOGENOMiHOG000168527.
InParanoidiQ68CJ6.
OMAiKACERMK.
OrthoDBiEOG091G0031.
PhylomeDBiQ68CJ6.
TreeFamiTF352086.

Family and domain databases

InterProiView protein in InterPro
IPR022812. Dynamin_SF.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00350. Dynamin_N. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q68CJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETKDVFGQ EPHPVEDDLY KERTRKRRKS DRDQRFRAFP SMEQSALKEY
60 70 80 90 100
EKLESRTRRV LSNTYQKLIQ SVFLDDSIPN GVKYLINRLL ALIEKPTVDP
110 120 130 140 150
IYIALFGSTG AGKSSLINAI IQQAMFLPVS GESICTSCIV QVSSGCCVQY
160 170 180 190 200
EAKIHLLSDQ EWREELKNLT KLLHRTEELS REEADAWNRD EAVEEATWKL
210 220 230 240 250
QMIYGNGAES KNYEELLRAK PKRKIPTSRV ITLKAEEAEE LSIKLDPYIR
260 270 280 290 300
TQRRDWDGEA AEMRIWPLIK HVEVTLPKSD LIPEGVVLVD IPGTGDFNSK
310 320 330 340 350
RDEMWKKTID KCSVIWVISD IERVSGGQAH EDLLNESIKA CQRGFCRDVA
360 370 380 390 400
LVVTKMDKLH LPEYLRERKA GNQAIQSQRE AVLERNEMIK LQRTRILKEK
410 420 430 440 450
LKRKLPADFK VLEASDLVYT VSAQEYWQQA LLTEEETEIP KLREYIRKSL
460 470 480 490 500
LDKKKRTVTK YVTEAFGLLL LTDSFNSTQN LPNEHLHMSV LRRFAEEKVE
510 520 530 540 550
LLEKAIAQCF ACMEQPLQEG VRTARTSYRC ILRACLVRSK GNQGFHQTLK
560 570 580 590 600
AVCLKNGIYA SRTLARIDLN EALTQPVYDQ IDPVFGSIFR TGKPTGSALM
610 620 630 640 650
PHIDAFKQSL QEKMTEIGIR SGWKYDSCKK NFLIQEISAI LGGLEDHILR
660 670 680 690 700
RKRRIYESLT ASVQSDLKLC YEEAAQITGK KACERMKDAI RRGVDRQVAE
710 720 730 740 750
GMFERAQERM QHQFQQLKTG IVEKVKGSIT TMLALASSQG DGLYKELADV
760 770 780 790
GSEYKEMEKL HRSLREVAEN ARLRKGMQEF LLRASPSKAG PPGTSL
Length:796
Mass (Da):91,132
Last modified:March 23, 2010 - v3
Checksum:iFB8EAA38B9329003
GO

Sequence cautioni

Q68CJ6: The sequence BAC85251 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Q68CJ6: The sequence BAD38652 differs from that shown. Probable cloning artifact.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03482323R → P1 PublicationCorresponds to variant dbSNP:rs6998705Ensembl.1
Natural variantiVAR_034824180S → G. Corresponds to variant dbSNP:rs4732620Ensembl.1
Natural variantiVAR_034825328Q → R1 PublicationCorresponds to variant dbSNP:rs7817227Ensembl.1
Natural variantiVAR_034826474S → N1 PublicationCorresponds to variant dbSNP:rs13279787Ensembl.1
Natural variantiVAR_056814492R → W. Corresponds to variant dbSNP:rs2305453Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091573 Genomic DNA. No translation available.
AB075870 mRNA. Translation: BAD38652.1. Sequence problems.
AK129923 mRNA. Translation: BAC85251.1. Different initiation.
CCDSiCCDS47833.1.
RefSeqiNP_001010906.1. NM_001010906.1.
UniGeneiHs.370129.

Genome annotation databases

EnsembliENST00000413272; ENSP00000408697; ENSG00000189233.
GeneIDi389643.
KEGGihsa:389643.
UCSCiuc003xgm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSLIP_HUMAN
AccessioniPrimary (citable) accession number: Q68CJ6
Secondary accession number(s): Q6ZP73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 23, 2010
Last modified: September 27, 2017
This is version 99 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations