ID   OLM2B_HUMAN             Reviewed;         750 AA.
AC   Q68BL8; B7ZA39; Q5VU96; Q6NX46; Q86X11; Q9Y3X6;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   24-JAN-2024, entry version 130.
DE   RecName: Full=Olfactomedin-like protein 2B;
DE   AltName: Full=Photomedin-2;
DE   Flags: Precursor;
GN   Name=OLFML2B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ARG-470.
RC   TISSUE=Retina;
RA   Furutani Y., Manabe R., Tsutsui K., Yamada T., Sugimoto N., Kawai J.,
RA   Hayashizaki Y., Sekiguchi K.;
RT   "Photomedin-1 and -2, novel extracellular glycoproteins with olfactomedin
RT   domain, isolated from RIKEN full-length mouse cDNA clones by computational
RT   screening.";
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-470.
RC   TISSUE=Endometrium, and Uterus;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=PNS, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Homodimer. Binds to heparin and chondroitin sulfate E (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q68BL8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q68BL8-2; Sequence=VSP_029564;
CC   -!- PTM: O-glycosylated and N-glycosylated. {ECO:0000250}.
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DR   EMBL; AB119054; BAD38863.1; -; mRNA.
DR   EMBL; AK316154; BAH14525.1; -; mRNA.
DR   EMBL; BX648975; CAI45982.1; -; mRNA.
DR   EMBL; AL050137; CAB43286.1; -; mRNA.
DR   EMBL; AL391825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL590408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC047472; AAH47472.1; -; mRNA.
DR   EMBL; BC067274; AAH67274.1; -; mRNA.
DR   CCDS; CCDS1236.1; -. [Q68BL8-1]
DR   PIR; T08771; T08771.
DR   RefSeq; NP_001284642.1; NM_001297713.1.
DR   RefSeq; NP_001334629.1; NM_001347700.1.
DR   RefSeq; NP_056256.1; NM_015441.2. [Q68BL8-1]
DR   AlphaFoldDB; Q68BL8; -.
DR   SMR; Q68BL8; -.
DR   BioGRID; 117410; 16.
DR   IntAct; Q68BL8; 1.
DR   STRING; 9606.ENSP00000356917; -.
DR   GlyCosmos; Q68BL8; 5 sites, 1 glycan.
DR   GlyGen; Q68BL8; 11 sites, 3 O-linked glycans (8 sites).
DR   iPTMnet; Q68BL8; -.
DR   PhosphoSitePlus; Q68BL8; -.
DR   BioMuta; OLFML2B; -.
DR   DMDM; 160418997; -.
DR   EPD; Q68BL8; -.
DR   MassIVE; Q68BL8; -.
DR   MaxQB; Q68BL8; -.
DR   PaxDb; 9606-ENSP00000356917; -.
DR   PeptideAtlas; Q68BL8; -.
DR   ProteomicsDB; 65999; -. [Q68BL8-1]
DR   ProteomicsDB; 66000; -. [Q68BL8-2]
DR   TopDownProteomics; Q68BL8-1; -. [Q68BL8-1]
DR   Antibodypedia; 34317; 171 antibodies from 20 providers.
DR   DNASU; 25903; -.
DR   Ensembl; ENST00000294794.8; ENSP00000294794.3; ENSG00000162745.11. [Q68BL8-1]
DR   Ensembl; ENST00000367938.1; ENSP00000356915.1; ENSG00000162745.11. [Q68BL8-2]
DR   GeneID; 25903; -.
DR   KEGG; hsa:25903; -.
DR   MANE-Select; ENST00000294794.8; ENSP00000294794.3; NM_015441.3; NP_056256.1.
DR   UCSC; uc001gbt.4; human. [Q68BL8-1]
DR   AGR; HGNC:24558; -.
DR   CTD; 25903; -.
DR   DisGeNET; 25903; -.
DR   GeneCards; OLFML2B; -.
DR   HGNC; HGNC:24558; OLFML2B.
DR   HPA; ENSG00000162745; Tissue enhanced (gallbladder).
DR   neXtProt; NX_Q68BL8; -.
DR   OpenTargets; ENSG00000162745; -.
DR   PharmGKB; PA134990758; -.
DR   VEuPathDB; HostDB:ENSG00000162745; -.
DR   eggNOG; KOG3545; Eukaryota.
DR   GeneTree; ENSGT00940000157757; -.
DR   HOGENOM; CLU_024107_0_0_1; -.
DR   InParanoid; Q68BL8; -.
DR   OMA; YEEKFIG; -.
DR   OrthoDB; 2876896at2759; -.
DR   PhylomeDB; Q68BL8; -.
DR   TreeFam; TF351220; -.
DR   PathwayCommons; Q68BL8; -.
DR   SignaLink; Q68BL8; -.
DR   BioGRID-ORCS; 25903; 9 hits in 1142 CRISPR screens.
DR   ChiTaRS; OLFML2B; human.
DR   GenomeRNAi; 25903; -.
DR   Pharos; Q68BL8; Tbio.
DR   PRO; PR:Q68BL8; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q68BL8; Protein.
DR   Bgee; ENSG00000162745; Expressed in decidua and 164 other cell types or tissues.
DR   ExpressionAtlas; Q68BL8; baseline and differential.
DR   GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0050840; F:extracellular matrix binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR003112; Olfac-like_dom.
DR   PANTHER; PTHR23192:SF37; OLFACTOMEDIN-LIKE PROTEIN 2B; 1.
DR   PANTHER; PTHR23192; OLFACTOMEDIN-RELATED; 1.
DR   Pfam; PF02191; OLF; 1.
DR   SMART; SM00284; OLF; 1.
DR   PROSITE; PS51132; OLF; 1.
DR   Genevisible; Q68BL8; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..750
FT                   /note="Olfactomedin-like protein 2B"
FT                   /id="PRO_0000311426"
FT   DOMAIN          493..750
FT                   /note="Olfactomedin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT   REGION          346..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          452..484
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          40..68
FT                   /evidence="ECO:0000255"
FT   COILED          179..213
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        346..427
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        187
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        213
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        695
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        494..680
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT   VAR_SEQ         1..517
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_029564"
FT   VARIANT         10
FT                   /note="Y -> C (in dbSNP:rs12130792)"
FT                   /id="VAR_037248"
FT   VARIANT         470
FT                   /note="W -> R (in dbSNP:rs2499836)"
FT                   /evidence="ECO:0000269|PubMed:17974005, ECO:0000269|Ref.1"
FT                   /id="VAR_037249"
SQ   SEQUENCE   750 AA;  83999 MW;  85014757EDC8C3D0 CRC64;
     MAKPRLLVLY FALIVVPAWV SSIVLTGTSE PPDAQTVAPA EDETLQNEAD NQENVLSQLL
     GDYDKVKAMS EGSDCQCKCV VRPLGRDACQ RINAGASRKE DFYTVETITS GSSCKCACVA
     PPSALNPCEG DFRLQKLREA DSQDLKLSTI IDMLEGAFYG LDLLKLHSVT TKLVGRVDKL
     EEEVSKNLTK ENEQIKEDME EIRTEMNKRG KENCSENILD SMPDIRSALQ RDAAAAYAHP
     EYEERFLQEE TVSQQINSIE LLQTRPLALP EVVKSQRPLQ RQVHLRGRPA SQPTVIRGIT
     YYKAKVSEEE NDIEEQQDEF FSGDNGVDLL IEDQLLRHNG LMTSVTRRPA ATRQGHSTAV
     TSDLNARTAP WSSALPQPST SDPSIANHAS VGPTLQTTSV SPDPTRESVL QPSPQVPATT
     VAHTATQQPA APAPPAVSPR EALMEAMHTV PVPPTTVRTD SLGKDAPAGW GTTPASPTLS
     PEEEDDIRNV IGRCKDTLST ITGPTTQNTY GRNEGAWMKD PLAKDERIYV TNYYYGNTLV
     EFRNLENFKQ GRWSNSYKLP YSWIGTGHVV YNGAFYYNRA FTRNIIKYDL KQRYVAAWAM
     LHDVAYEEAT PWRWQGHSDV DFAVDENGLW LIYPALDDEG FSQEVIVLSK LNAADLSTQK
     ETTWRTGLRR NFYGNCFVIC GVLYAVDSYN QRNANISYAF DTHTNTQIVP RLLFENEYSY
     TTQIDYNPKD RLLYAWDNGH QVTYHVIFAY
//