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Q68BL8 (OLM2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactomedin-like protein 2B
Alternative name(s):
Photomedin-2
Gene names
Name:OLFML2B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length750 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Homodimer. Binds to heparin and chondroitin sulfate E By similarity.

Subcellular location

Secreted By similarity.

Post-translational modification

O-glycosylated and N-glycosylated By similarity.

Sequence similarities

Contains 1 olfactomedin-like domain.

Sequence caution

The sequence CAH71496.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processextracellular matrix organization

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular matrix

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionextracellular matrix binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q68BL8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q68BL8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-517: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Chain23 – 750728Olfactomedin-like protein 2B
PRO_0000311426

Regions

Domain493 – 750258Olfactomedin-like
Coiled coil40 – 6829 Potential
Coiled coil179 – 21335 Potential
Compositional bias233 – 2386Poly-Ala

Amino acid modifications

Glycosylation1871N-linked (GlcNAc...) Potential
Glycosylation2131N-linked (GlcNAc...) Potential
Glycosylation6951N-linked (GlcNAc...) Potential
Disulfide bond494 ↔ 680 By similarity

Natural variations

Alternative sequence1 – 517517Missing in isoform 2.
VSP_029564
Natural variant101Y → C.
Corresponds to variant rs12130792 [ dbSNP | Ensembl ].
VAR_037248
Natural variant4701W → R. Ref.1 Ref.3
Corresponds to variant rs2499836 [ dbSNP | Ensembl ].
VAR_037249

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: 85014757EDC8C3D0

FASTA75083,999
        10         20         30         40         50         60 
MAKPRLLVLY FALIVVPAWV SSIVLTGTSE PPDAQTVAPA EDETLQNEAD NQENVLSQLL 

        70         80         90        100        110        120 
GDYDKVKAMS EGSDCQCKCV VRPLGRDACQ RINAGASRKE DFYTVETITS GSSCKCACVA 

       130        140        150        160        170        180 
PPSALNPCEG DFRLQKLREA DSQDLKLSTI IDMLEGAFYG LDLLKLHSVT TKLVGRVDKL 

       190        200        210        220        230        240 
EEEVSKNLTK ENEQIKEDME EIRTEMNKRG KENCSENILD SMPDIRSALQ RDAAAAYAHP 

       250        260        270        280        290        300 
EYEERFLQEE TVSQQINSIE LLQTRPLALP EVVKSQRPLQ RQVHLRGRPA SQPTVIRGIT 

       310        320        330        340        350        360 
YYKAKVSEEE NDIEEQQDEF FSGDNGVDLL IEDQLLRHNG LMTSVTRRPA ATRQGHSTAV 

       370        380        390        400        410        420 
TSDLNARTAP WSSALPQPST SDPSIANHAS VGPTLQTTSV SPDPTRESVL QPSPQVPATT 

       430        440        450        460        470        480 
VAHTATQQPA APAPPAVSPR EALMEAMHTV PVPPTTVRTD SLGKDAPAGW GTTPASPTLS 

       490        500        510        520        530        540 
PEEEDDIRNV IGRCKDTLST ITGPTTQNTY GRNEGAWMKD PLAKDERIYV TNYYYGNTLV 

       550        560        570        580        590        600 
EFRNLENFKQ GRWSNSYKLP YSWIGTGHVV YNGAFYYNRA FTRNIIKYDL KQRYVAAWAM 

       610        620        630        640        650        660 
LHDVAYEEAT PWRWQGHSDV DFAVDENGLW LIYPALDDEG FSQEVIVLSK LNAADLSTQK 

       670        680        690        700        710        720 
ETTWRTGLRR NFYGNCFVIC GVLYAVDSYN QRNANISYAF DTHTNTQIVP RLLFENEYSY 

       730        740        750 
TTQIDYNPKD RLLYAWDNGH QVTYHVIFAY 

« Hide

Isoform 2 [UniParc].

Checksum: 5044803E2AA2FECC
Show »

FASTA23327,554

References

« Hide 'large scale' references
[1]"Photomedin-1 and -2, novel extracellular glycoproteins with olfactomedin domain, isolated from RIKEN full-length mouse cDNA clones by computational screening."
Furutani Y., Manabe R., Tsutsui K., Yamada T., Sugimoto N., Kawai J., Hayashizaki Y., Sekiguchi K.
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-470.
Tissue: Retina.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-470.
Tissue: Endometrium and Uterus.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: PNS and Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB119054 mRNA. Translation: BAD38863.1.
AK316154 mRNA. Translation: BAH14525.1.
BX648975 mRNA. Translation: CAI45982.1.
AL050137 mRNA. Translation: CAB43286.1.
AL590408, AL391825 Genomic DNA. Translation: CAH71496.1. Sequence problems.
AL391825, AL590408 Genomic DNA. Translation: CAH73984.1.
AL391825 Genomic DNA. Translation: CAH73987.1.
BC047472 mRNA. Translation: AAH47472.1.
BC067274 mRNA. Translation: AAH67274.1.
CCDSCCDS1236.1. [Q68BL8-1]
PIRT08771.
RefSeqNP_056256.1. NM_015441.1. [Q68BL8-1]
UniGeneHs.507515.

3D structure databases

ProteinModelPortalQ68BL8.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ68BL8.

Polymorphism databases

DMDM160418997.

Proteomic databases

MaxQBQ68BL8.
PaxDbQ68BL8.
PRIDEQ68BL8.

Protocols and materials databases

DNASU25903.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000294794; ENSP00000294794; ENSG00000162745. [Q68BL8-1]
ENST00000367938; ENSP00000356915; ENSG00000162745. [Q68BL8-2]
GeneID25903.
KEGGhsa:25903.
UCSCuc001gbt.3. human. [Q68BL8-2]
uc001gbu.3. human. [Q68BL8-1]

Organism-specific databases

CTD25903.
GeneCardsGC01M161952.
HGNCHGNC:24558. OLFML2B.
HPAHPA054136.
neXtProtNX_Q68BL8.
PharmGKBPA134990758.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG290478.
HOGENOMHOG000043072.
HOVERGENHBG108214.
InParanoidQ68BL8.
OrthoDBEOG75F4CZ.
PhylomeDBQ68BL8.
TreeFamTF351220.

Gene expression databases

ArrayExpressQ68BL8.
BgeeQ68BL8.
CleanExHS_OLFML2B.
GenevestigatorQ68BL8.

Family and domain databases

InterProIPR003112. Olfac-like.
[Graphical view]
PfamPF02191. OLF. 1 hit.
[Graphical view]
SMARTSM00284. OLF. 1 hit.
[Graphical view]
PROSITEPS51132. OLF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSOLFML2B. human.
GenomeRNAi25903.
NextBio47374.
PROQ68BL8.

Entry information

Entry nameOLM2B_HUMAN
AccessionPrimary (citable) accession number: Q68BL8
Secondary accession number(s): B7ZA39 expand/collapse secondary AC list , Q5VU96, Q6NX46, Q86X11, Q9Y3X6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: July 9, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM