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Q68BL8

- OLM2B_HUMAN

UniProt

Q68BL8 - OLM2B_HUMAN

Protein

Olfactomedin-like protein 2B

Gene

OLFML2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. extracellular matrix binding Source: Ensembl

    GO - Biological processi

    1. extracellular matrix organization Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactomedin-like protein 2B
    Alternative name(s):
    Photomedin-2
    Gene namesi
    Name:OLFML2B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:24558. OLFML2B.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular matrix Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134990758.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 750728Olfactomedin-like protein 2BPRO_0000311426Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi494 ↔ 680PROSITE-ProRule annotation
    Glycosylationi695 – 6951N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    O-glycosylated and N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ68BL8.
    PaxDbiQ68BL8.
    PRIDEiQ68BL8.

    PTM databases

    PhosphoSiteiQ68BL8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ68BL8.
    BgeeiQ68BL8.
    CleanExiHS_OLFML2B.
    GenevestigatoriQ68BL8.

    Organism-specific databases

    HPAiHPA054136.

    Interactioni

    Subunit structurei

    Homodimer. Binds to heparin and chondroitin sulfate E By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ68BL8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini493 – 750258Olfactomedin-likePROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili40 – 6829Sequence AnalysisAdd
    BLAST
    Coiled coili179 – 21335Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi233 – 2386Poly-Ala

    Sequence similaritiesi

    Contains 1 olfactomedin-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiNOG290478.
    HOGENOMiHOG000043072.
    HOVERGENiHBG108214.
    InParanoidiQ68BL8.
    OrthoDBiEOG75F4CZ.
    PhylomeDBiQ68BL8.
    TreeFamiTF351220.

    Family and domain databases

    InterProiIPR003112. Olfac-like.
    [Graphical view]
    PfamiPF02191. OLF. 1 hit.
    [Graphical view]
    SMARTiSM00284. OLF. 1 hit.
    [Graphical view]
    PROSITEiPS51132. OLF. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q68BL8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKPRLLVLY FALIVVPAWV SSIVLTGTSE PPDAQTVAPA EDETLQNEAD    50
    NQENVLSQLL GDYDKVKAMS EGSDCQCKCV VRPLGRDACQ RINAGASRKE 100
    DFYTVETITS GSSCKCACVA PPSALNPCEG DFRLQKLREA DSQDLKLSTI 150
    IDMLEGAFYG LDLLKLHSVT TKLVGRVDKL EEEVSKNLTK ENEQIKEDME 200
    EIRTEMNKRG KENCSENILD SMPDIRSALQ RDAAAAYAHP EYEERFLQEE 250
    TVSQQINSIE LLQTRPLALP EVVKSQRPLQ RQVHLRGRPA SQPTVIRGIT 300
    YYKAKVSEEE NDIEEQQDEF FSGDNGVDLL IEDQLLRHNG LMTSVTRRPA 350
    ATRQGHSTAV TSDLNARTAP WSSALPQPST SDPSIANHAS VGPTLQTTSV 400
    SPDPTRESVL QPSPQVPATT VAHTATQQPA APAPPAVSPR EALMEAMHTV 450
    PVPPTTVRTD SLGKDAPAGW GTTPASPTLS PEEEDDIRNV IGRCKDTLST 500
    ITGPTTQNTY GRNEGAWMKD PLAKDERIYV TNYYYGNTLV EFRNLENFKQ 550
    GRWSNSYKLP YSWIGTGHVV YNGAFYYNRA FTRNIIKYDL KQRYVAAWAM 600
    LHDVAYEEAT PWRWQGHSDV DFAVDENGLW LIYPALDDEG FSQEVIVLSK 650
    LNAADLSTQK ETTWRTGLRR NFYGNCFVIC GVLYAVDSYN QRNANISYAF 700
    DTHTNTQIVP RLLFENEYSY TTQIDYNPKD RLLYAWDNGH QVTYHVIFAY 750
    Length:750
    Mass (Da):83,999
    Last modified:November 13, 2007 - v2
    Checksum:i85014757EDC8C3D0
    GO
    Isoform 2 (identifier: Q68BL8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-517: Missing.

    Show »
    Length:233
    Mass (Da):27,554
    Checksum:i5044803E2AA2FECC
    GO

    Sequence cautioni

    The sequence CAH71496.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101Y → C.
    Corresponds to variant rs12130792 [ dbSNP | Ensembl ].
    VAR_037248
    Natural varianti470 – 4701W → R.2 Publications
    Corresponds to variant rs2499836 [ dbSNP | Ensembl ].
    VAR_037249

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 517517Missing in isoform 2. 1 PublicationVSP_029564Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB119054 mRNA. Translation: BAD38863.1.
    AK316154 mRNA. Translation: BAH14525.1.
    BX648975 mRNA. Translation: CAI45982.1.
    AL050137 mRNA. Translation: CAB43286.1.
    AL590408, AL391825 Genomic DNA. Translation: CAH71496.1. Sequence problems.
    AL391825, AL590408 Genomic DNA. Translation: CAH73984.1.
    AL391825 Genomic DNA. Translation: CAH73987.1.
    BC047472 mRNA. Translation: AAH47472.1.
    BC067274 mRNA. Translation: AAH67274.1.
    CCDSiCCDS1236.1. [Q68BL8-1]
    PIRiT08771.
    RefSeqiNP_056256.1. NM_015441.1. [Q68BL8-1]
    UniGeneiHs.507515.

    Genome annotation databases

    EnsembliENST00000294794; ENSP00000294794; ENSG00000162745. [Q68BL8-1]
    ENST00000367938; ENSP00000356915; ENSG00000162745. [Q68BL8-2]
    GeneIDi25903.
    KEGGihsa:25903.
    UCSCiuc001gbt.3. human. [Q68BL8-2]
    uc001gbu.3. human. [Q68BL8-1]

    Polymorphism databases

    DMDMi160418997.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB119054 mRNA. Translation: BAD38863.1 .
    AK316154 mRNA. Translation: BAH14525.1 .
    BX648975 mRNA. Translation: CAI45982.1 .
    AL050137 mRNA. Translation: CAB43286.1 .
    AL590408 , AL391825 Genomic DNA. Translation: CAH71496.1 . Sequence problems.
    AL391825 , AL590408 Genomic DNA. Translation: CAH73984.1 .
    AL391825 Genomic DNA. Translation: CAH73987.1 .
    BC047472 mRNA. Translation: AAH47472.1 .
    BC067274 mRNA. Translation: AAH67274.1 .
    CCDSi CCDS1236.1. [Q68BL8-1 ]
    PIRi T08771.
    RefSeqi NP_056256.1. NM_015441.1. [Q68BL8-1 ]
    UniGenei Hs.507515.

    3D structure databases

    ProteinModelPortali Q68BL8.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q68BL8.

    Polymorphism databases

    DMDMi 160418997.

    Proteomic databases

    MaxQBi Q68BL8.
    PaxDbi Q68BL8.
    PRIDEi Q68BL8.

    Protocols and materials databases

    DNASUi 25903.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294794 ; ENSP00000294794 ; ENSG00000162745 . [Q68BL8-1 ]
    ENST00000367938 ; ENSP00000356915 ; ENSG00000162745 . [Q68BL8-2 ]
    GeneIDi 25903.
    KEGGi hsa:25903.
    UCSCi uc001gbt.3. human. [Q68BL8-2 ]
    uc001gbu.3. human. [Q68BL8-1 ]

    Organism-specific databases

    CTDi 25903.
    GeneCardsi GC01M161952.
    HGNCi HGNC:24558. OLFML2B.
    HPAi HPA054136.
    neXtProti NX_Q68BL8.
    PharmGKBi PA134990758.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG290478.
    HOGENOMi HOG000043072.
    HOVERGENi HBG108214.
    InParanoidi Q68BL8.
    OrthoDBi EOG75F4CZ.
    PhylomeDBi Q68BL8.
    TreeFami TF351220.

    Miscellaneous databases

    ChiTaRSi OLFML2B. human.
    GenomeRNAii 25903.
    NextBioi 47374.
    PROi Q68BL8.

    Gene expression databases

    ArrayExpressi Q68BL8.
    Bgeei Q68BL8.
    CleanExi HS_OLFML2B.
    Genevestigatori Q68BL8.

    Family and domain databases

    InterProi IPR003112. Olfac-like.
    [Graphical view ]
    Pfami PF02191. OLF. 1 hit.
    [Graphical view ]
    SMARTi SM00284. OLF. 1 hit.
    [Graphical view ]
    PROSITEi PS51132. OLF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Photomedin-1 and -2, novel extracellular glycoproteins with olfactomedin domain, isolated from RIKEN full-length mouse cDNA clones by computational screening."
      Furutani Y., Manabe R., Tsutsui K., Yamada T., Sugimoto N., Kawai J., Hayashizaki Y., Sekiguchi K.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-470.
      Tissue: Retina.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-470.
      Tissue: Endometrium and Uterus.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: PNS and Testis.

    Entry informationi

    Entry nameiOLM2B_HUMAN
    AccessioniPrimary (citable) accession number: Q68BL8
    Secondary accession number(s): B7ZA39
    , Q5VU96, Q6NX46, Q86X11, Q9Y3X6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3