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Q68BL8

- OLM2B_HUMAN

UniProt

Q68BL8 - OLM2B_HUMAN

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Protein
Olfactomedin-like protein 2B
Gene
OLFML2B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. extracellular matrix binding Source: Ensembl

GO - Biological processi

  1. extracellular matrix organization Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactomedin-like protein 2B
Alternative name(s):
Photomedin-2
Gene namesi
Name:OLFML2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:24558. OLFML2B.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular matrix Source: Ensembl
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134990758.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 By similarity
Add
BLAST
Chaini23 – 750728Olfactomedin-like protein 2B
PRO_0000311426Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi187 – 1871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi213 – 2131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi494 ↔ 680 By similarity
Glycosylationi695 – 6951N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

O-glycosylated and N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ68BL8.
PaxDbiQ68BL8.
PRIDEiQ68BL8.

PTM databases

PhosphoSiteiQ68BL8.

Expressioni

Gene expression databases

ArrayExpressiQ68BL8.
BgeeiQ68BL8.
CleanExiHS_OLFML2B.
GenevestigatoriQ68BL8.

Organism-specific databases

HPAiHPA054136.

Interactioni

Subunit structurei

Homodimer. Binds to heparin and chondroitin sulfate E By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ68BL8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini493 – 750258Olfactomedin-like
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili40 – 6829 Reviewed prediction
Add
BLAST
Coiled coili179 – 21335 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi233 – 2386Poly-Ala

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG290478.
HOGENOMiHOG000043072.
HOVERGENiHBG108214.
InParanoidiQ68BL8.
OrthoDBiEOG75F4CZ.
PhylomeDBiQ68BL8.
TreeFamiTF351220.

Family and domain databases

InterProiIPR003112. Olfac-like.
[Graphical view]
PfamiPF02191. OLF. 1 hit.
[Graphical view]
SMARTiSM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS51132. OLF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q68BL8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAKPRLLVLY FALIVVPAWV SSIVLTGTSE PPDAQTVAPA EDETLQNEAD    50
NQENVLSQLL GDYDKVKAMS EGSDCQCKCV VRPLGRDACQ RINAGASRKE 100
DFYTVETITS GSSCKCACVA PPSALNPCEG DFRLQKLREA DSQDLKLSTI 150
IDMLEGAFYG LDLLKLHSVT TKLVGRVDKL EEEVSKNLTK ENEQIKEDME 200
EIRTEMNKRG KENCSENILD SMPDIRSALQ RDAAAAYAHP EYEERFLQEE 250
TVSQQINSIE LLQTRPLALP EVVKSQRPLQ RQVHLRGRPA SQPTVIRGIT 300
YYKAKVSEEE NDIEEQQDEF FSGDNGVDLL IEDQLLRHNG LMTSVTRRPA 350
ATRQGHSTAV TSDLNARTAP WSSALPQPST SDPSIANHAS VGPTLQTTSV 400
SPDPTRESVL QPSPQVPATT VAHTATQQPA APAPPAVSPR EALMEAMHTV 450
PVPPTTVRTD SLGKDAPAGW GTTPASPTLS PEEEDDIRNV IGRCKDTLST 500
ITGPTTQNTY GRNEGAWMKD PLAKDERIYV TNYYYGNTLV EFRNLENFKQ 550
GRWSNSYKLP YSWIGTGHVV YNGAFYYNRA FTRNIIKYDL KQRYVAAWAM 600
LHDVAYEEAT PWRWQGHSDV DFAVDENGLW LIYPALDDEG FSQEVIVLSK 650
LNAADLSTQK ETTWRTGLRR NFYGNCFVIC GVLYAVDSYN QRNANISYAF 700
DTHTNTQIVP RLLFENEYSY TTQIDYNPKD RLLYAWDNGH QVTYHVIFAY 750
Length:750
Mass (Da):83,999
Last modified:November 13, 2007 - v2
Checksum:i85014757EDC8C3D0
GO
Isoform 2 (identifier: Q68BL8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-517: Missing.

Show »
Length:233
Mass (Da):27,554
Checksum:i5044803E2AA2FECC
GO

Sequence cautioni

The sequence CAH71496.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101Y → C.
Corresponds to variant rs12130792 [ dbSNP | Ensembl ].
VAR_037248
Natural varianti470 – 4701W → R.2 Publications
Corresponds to variant rs2499836 [ dbSNP | Ensembl ].
VAR_037249

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 517517Missing in isoform 2.
VSP_029564Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB119054 mRNA. Translation: BAD38863.1.
AK316154 mRNA. Translation: BAH14525.1.
BX648975 mRNA. Translation: CAI45982.1.
AL050137 mRNA. Translation: CAB43286.1.
AL590408, AL391825 Genomic DNA. Translation: CAH71496.1. Sequence problems.
AL391825, AL590408 Genomic DNA. Translation: CAH73984.1.
AL391825 Genomic DNA. Translation: CAH73987.1.
BC047472 mRNA. Translation: AAH47472.1.
BC067274 mRNA. Translation: AAH67274.1.
CCDSiCCDS1236.1. [Q68BL8-1]
PIRiT08771.
RefSeqiNP_056256.1. NM_015441.1. [Q68BL8-1]
UniGeneiHs.507515.

Genome annotation databases

EnsembliENST00000294794; ENSP00000294794; ENSG00000162745. [Q68BL8-1]
ENST00000367938; ENSP00000356915; ENSG00000162745. [Q68BL8-2]
GeneIDi25903.
KEGGihsa:25903.
UCSCiuc001gbt.3. human. [Q68BL8-2]
uc001gbu.3. human. [Q68BL8-1]

Polymorphism databases

DMDMi160418997.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB119054 mRNA. Translation: BAD38863.1 .
AK316154 mRNA. Translation: BAH14525.1 .
BX648975 mRNA. Translation: CAI45982.1 .
AL050137 mRNA. Translation: CAB43286.1 .
AL590408 , AL391825 Genomic DNA. Translation: CAH71496.1 . Sequence problems.
AL391825 , AL590408 Genomic DNA. Translation: CAH73984.1 .
AL391825 Genomic DNA. Translation: CAH73987.1 .
BC047472 mRNA. Translation: AAH47472.1 .
BC067274 mRNA. Translation: AAH67274.1 .
CCDSi CCDS1236.1. [Q68BL8-1 ]
PIRi T08771.
RefSeqi NP_056256.1. NM_015441.1. [Q68BL8-1 ]
UniGenei Hs.507515.

3D structure databases

ProteinModelPortali Q68BL8.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q68BL8.

Polymorphism databases

DMDMi 160418997.

Proteomic databases

MaxQBi Q68BL8.
PaxDbi Q68BL8.
PRIDEi Q68BL8.

Protocols and materials databases

DNASUi 25903.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000294794 ; ENSP00000294794 ; ENSG00000162745 . [Q68BL8-1 ]
ENST00000367938 ; ENSP00000356915 ; ENSG00000162745 . [Q68BL8-2 ]
GeneIDi 25903.
KEGGi hsa:25903.
UCSCi uc001gbt.3. human. [Q68BL8-2 ]
uc001gbu.3. human. [Q68BL8-1 ]

Organism-specific databases

CTDi 25903.
GeneCardsi GC01M161952.
HGNCi HGNC:24558. OLFML2B.
HPAi HPA054136.
neXtProti NX_Q68BL8.
PharmGKBi PA134990758.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG290478.
HOGENOMi HOG000043072.
HOVERGENi HBG108214.
InParanoidi Q68BL8.
OrthoDBi EOG75F4CZ.
PhylomeDBi Q68BL8.
TreeFami TF351220.

Miscellaneous databases

ChiTaRSi OLFML2B. human.
GenomeRNAii 25903.
NextBioi 47374.
PROi Q68BL8.

Gene expression databases

ArrayExpressi Q68BL8.
Bgeei Q68BL8.
CleanExi HS_OLFML2B.
Genevestigatori Q68BL8.

Family and domain databases

InterProi IPR003112. Olfac-like.
[Graphical view ]
Pfami PF02191. OLF. 1 hit.
[Graphical view ]
SMARTi SM00284. OLF. 1 hit.
[Graphical view ]
PROSITEi PS51132. OLF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Photomedin-1 and -2, novel extracellular glycoproteins with olfactomedin domain, isolated from RIKEN full-length mouse cDNA clones by computational screening."
    Furutani Y., Manabe R., Tsutsui K., Yamada T., Sugimoto N., Kawai J., Hayashizaki Y., Sekiguchi K.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-470.
    Tissue: Retina.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-470.
    Tissue: Endometrium and Uterus.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: PNS and Testis.

Entry informationi

Entry nameiOLM2B_HUMAN
AccessioniPrimary (citable) accession number: Q68BL8
Secondary accession number(s): B7ZA39
, Q5VU96, Q6NX46, Q86X11, Q9Y3X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: July 9, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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