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Q68BL7 (OLM2A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactomedin-like protein 2A
Alternative name(s):
Photomedin-1
Gene names
Name:OLFML2A
ORF Names:UNQ9394/PRO34319
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length652 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Homodimer. Binds to heparin and chondroitin sulfate E By similarity.

Subcellular location

Secreted By similarity.

Post-translational modification

May be cleaved at Lys-295 after secretion By similarity.

O-glycosylated but not N-glycosylated By similarity.

Sequence similarities

Contains 1 olfactomedin-like domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processextracellular matrix organization

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular matrix

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionextracellular matrix binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q68BL7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q68BL7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
Isoform 3 (identifier: Q68BL7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-214: Missing.
     215-223: ATGTGSKAQ → MSKRDKAGK

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 By similarity
Chain28 – 652625Olfactomedin-like protein 2A
PRO_0000311428

Regions

Domain394 – 652259Olfactomedin-like
Coiled coil157 – 18327 Potential
Compositional bias207 – 2126Poly-Ala
Compositional bias354 – 37825Thr-rich

Sites

Site294 – 2952Cleavage By similarity

Amino acid modifications

Disulfide bond395 ↔ 582 By similarity

Natural variations

Alternative sequence1 – 214214Missing in isoform 3.
VSP_029565
Alternative sequence1 – 3939Missing in isoform 2.
VSP_029566
Alternative sequence215 – 2239ATGTGSKAQ → MSKRDKAGK in isoform 3.
VSP_029567
Natural variant3091T → A. Ref.1 Ref.5
Corresponds to variant rs7874348 [ dbSNP | Ensembl ].
VAR_037250
Natural variant4251R → Q.
Corresponds to variant rs16927649 [ dbSNP | Ensembl ].
VAR_037251

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: E3D3B61C8CC0699C

FASTA65273,054
        10         20         30         40         50         60 
MAAAALPPRP LLLLPLVLLL SGRPTRADSK VFGDLDQVRM TSEGSDCRCK CIMRPLSKDA 

        70         80         90        100        110        120 
CSRVRSGRAR VEDFYTVETV SSGTDCRCSC TAPPSSLNPC ENEWKMEKLK KQAPELLKLQ 

       130        140        150        160        170        180 
SMVDLLEGTL YSMDLMKVHA YVHKVASQMN TLEESIKANL SRENEVVKDS VRHLSEQLRH 

       190        200        210        220        230        240 
YENHSAIMLG IKKELSRLGL QLLQKDAAAA PATPATGTGS KAQDTARGKG KDISKYGSVQ 

       250        260        270        280        290        300 
KSFADRGLPK PPKEKLLQVE KLRKESGKGS FLQPTAKPRA LAQQQAVIRG FTYYKAGKQE 

       310        320        330        340        350        360 
VTEAVADNTL QGTSWLEQLP PKVEGRSNSA EPNSAEQDEA EPRSSERVDL ASGTPTSIPA 

       370        380        390        400        410        420 
TTTTATTTPT PTTSLLPTEP PSGPEVSSQG REASCEGTLR AVDPPVRHHS YGRHEGAWMK 

       430        440        450        460        470        480 
DPAARDDRIY VTNYYYGNSL VEFRNLENFK QGRWSNMYKL PYNWIGTGHV VYQGAFYYNR 

       490        500        510        520        530        540 
AFTKNIIKYD LRQRFVASWA LLPDVVYEDT TPWKWRGHSD IDFAVDESGL WVIYPAVDDR 

       550        560        570        580        590        600 
DEAQPEVIVL SRLDPGDLSV HRETTWKTRL RRNSYGNCFL VCGILYAVDT YNQQEGQVAY 

       610        620        630        640        650 
AFDTHTGTDA RPQLPFLNEH AYTTQIDYNP KERVLYAWDN GHQLTYTLHF VV 

« Hide

Isoform 2 [UniParc].

Checksum: 72B0B88735C37394
Show »

FASTA61368,890
Isoform 3 [UniParc].

Checksum: 4E264070E97F49B5
Show »

FASTA43849,505

References

« Hide 'large scale' references
[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-309.
[2]"Photomedin-1 and -2, novel extracellular glycoproteins with olfactomedin domain, isolated from RIKEN full-length mouse cDNA clones by computational screening."
Furutani Y., Manabe R., Tsutsui K., Yamada T., Sugimoto N., Kawai J., Hayashizaki Y., Sekiguchi K.
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Retina.
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ALA-309.
Tissue: Lymph.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358185 mRNA. Translation: AAQ88552.1.
AB119055 mRNA. Translation: BAD38864.1.
AL354928 Genomic DNA. Translation: CAI39635.2.
AL354928 Genomic DNA. Translation: CAI39636.2.
CH471090 Genomic DNA. Translation: EAW87596.1.
BC054001 mRNA. Translation: AAH54001.1.
RefSeqNP_001269644.1. NM_001282715.1.
NP_872293.2. NM_182487.3.
XP_005251816.1. XM_005251759.2.
UniGeneHs.357004.

3D structure databases

ProteinModelPortalQ68BL7.
SMRQ68BL7. Positions 468-503.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127983. 2 interactions.

Polymorphism databases

DMDM74748246.

Proteomic databases

PaxDbQ68BL7.
PRIDEQ68BL7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000288815; ENSP00000288815; ENSG00000185585. [Q68BL7-3]
ENST00000373580; ENSP00000362682; ENSG00000185585. [Q68BL7-1]
GeneID169611.
KEGGhsa:169611.
UCSCuc004bov.3. human. [Q68BL7-1]
uc004bow.3. human. [Q68BL7-3]

Organism-specific databases

CTD169611.
GeneCardsGC09P127539.
H-InvDBHIX0008375.
HGNCHGNC:27270. OLFML2A.
HPAHPA021180.
HPA022254.
neXtProtNX_Q68BL7.
PharmGKBPA134967883.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG290478.
HOGENOMHOG000043072.
HOVERGENHBG108214.
InParanoidQ68BL7.
OMAADSKVFG.
OrthoDBEOG75F4CZ.
PhylomeDBQ68BL7.
TreeFamTF351220.

Gene expression databases

ArrayExpressQ68BL7.
BgeeQ68BL7.
CleanExHS_OLFML2A.
GenevestigatorQ68BL7.

Family and domain databases

InterProIPR003112. Olfac-like.
[Graphical view]
PfamPF02191. OLF. 1 hit.
[Graphical view]
SMARTSM00284. OLF. 1 hit.
[Graphical view]
PROSITEPS51132. OLF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSOLFML2A. human.
GenomeRNAi169611.
NextBio88819.
PROQ68BL7.

Entry information

Entry nameOLM2A_HUMAN
AccessionPrimary (citable) accession number: Q68BL7
Secondary accession number(s): Q5JTM5 expand/collapse secondary AC list , Q5JTM6, Q6UXW1, Q7Z5V3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM