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Q68BL7

- OLM2A_HUMAN

UniProt

Q68BL7 - OLM2A_HUMAN

Protein

Olfactomedin-like protein 2A

Gene

OLFML2A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei294 – 2952CleavageBy similarity

    GO - Molecular functioni

    1. extracellular matrix binding Source: Ensembl

    GO - Biological processi

    1. extracellular matrix organization Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactomedin-like protein 2A
    Alternative name(s):
    Photomedin-1
    Gene namesi
    Name:OLFML2A
    ORF Names:UNQ9394/PRO34319
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:27270. OLFML2A.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular matrix Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134967883.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727By similarityAdd
    BLAST
    Chaini28 – 652625Olfactomedin-like protein 2APRO_0000311428Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi395 ↔ 582PROSITE-ProRule annotation

    Post-translational modificationi

    May be cleaved at Lys-295 after secretion.By similarity
    O-glycosylated but not N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ68BL7.
    PRIDEiQ68BL7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ68BL7.
    BgeeiQ68BL7.
    CleanExiHS_OLFML2A.
    GenevestigatoriQ68BL7.

    Organism-specific databases

    HPAiHPA021180.
    HPA022254.

    Interactioni

    Subunit structurei

    Homodimer. Binds to heparin and chondroitin sulfate E By similarity.By similarity

    Protein-protein interaction databases

    BioGridi127983. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68BL7.
    SMRiQ68BL7. Positions 468-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini394 – 652259Olfactomedin-likePROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili157 – 18327Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi207 – 2126Poly-Ala
    Compositional biasi354 – 37825Thr-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 olfactomedin-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiNOG290478.
    HOGENOMiHOG000043072.
    HOVERGENiHBG108214.
    InParanoidiQ68BL7.
    OMAiADSKVFG.
    OrthoDBiEOG75F4CZ.
    PhylomeDBiQ68BL7.
    TreeFamiTF351220.

    Family and domain databases

    InterProiIPR003112. Olfac-like.
    [Graphical view]
    PfamiPF02191. OLF. 1 hit.
    [Graphical view]
    SMARTiSM00284. OLF. 1 hit.
    [Graphical view]
    PROSITEiPS51132. OLF. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q68BL7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAALPPRP LLLLPLVLLL SGRPTRADSK VFGDLDQVRM TSEGSDCRCK    50
    CIMRPLSKDA CSRVRSGRAR VEDFYTVETV SSGTDCRCSC TAPPSSLNPC 100
    ENEWKMEKLK KQAPELLKLQ SMVDLLEGTL YSMDLMKVHA YVHKVASQMN 150
    TLEESIKANL SRENEVVKDS VRHLSEQLRH YENHSAIMLG IKKELSRLGL 200
    QLLQKDAAAA PATPATGTGS KAQDTARGKG KDISKYGSVQ KSFADRGLPK 250
    PPKEKLLQVE KLRKESGKGS FLQPTAKPRA LAQQQAVIRG FTYYKAGKQE 300
    VTEAVADNTL QGTSWLEQLP PKVEGRSNSA EPNSAEQDEA EPRSSERVDL 350
    ASGTPTSIPA TTTTATTTPT PTTSLLPTEP PSGPEVSSQG REASCEGTLR 400
    AVDPPVRHHS YGRHEGAWMK DPAARDDRIY VTNYYYGNSL VEFRNLENFK 450
    QGRWSNMYKL PYNWIGTGHV VYQGAFYYNR AFTKNIIKYD LRQRFVASWA 500
    LLPDVVYEDT TPWKWRGHSD IDFAVDESGL WVIYPAVDDR DEAQPEVIVL 550
    SRLDPGDLSV HRETTWKTRL RRNSYGNCFL VCGILYAVDT YNQQEGQVAY 600
    AFDTHTGTDA RPQLPFLNEH AYTTQIDYNP KERVLYAWDN GHQLTYTLHF 650
    VV 652
    Length:652
    Mass (Da):73,054
    Last modified:October 11, 2004 - v1
    Checksum:iE3D3B61C8CC0699C
    GO
    Isoform 2 (identifier: Q68BL7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-39: Missing.

    Show »
    Length:613
    Mass (Da):68,890
    Checksum:i72B0B88735C37394
    GO
    Isoform 3 (identifier: Q68BL7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-214: Missing.
         215-223: ATGTGSKAQ → MSKRDKAGK

    Show »
    Length:438
    Mass (Da):49,505
    Checksum:i4E264070E97F49B5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti309 – 3091T → A.2 Publications
    Corresponds to variant rs7874348 [ dbSNP | Ensembl ].
    VAR_037250
    Natural varianti425 – 4251R → Q.
    Corresponds to variant rs16927649 [ dbSNP | Ensembl ].
    VAR_037251

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 214214Missing in isoform 3. 1 PublicationVSP_029565Add
    BLAST
    Alternative sequencei1 – 3939Missing in isoform 2. 1 PublicationVSP_029566Add
    BLAST
    Alternative sequencei215 – 2239ATGTGSKAQ → MSKRDKAGK in isoform 3. 1 PublicationVSP_029567

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358185 mRNA. Translation: AAQ88552.1.
    AB119055 mRNA. Translation: BAD38864.1.
    AL354928 Genomic DNA. Translation: CAI39635.2.
    AL354928 Genomic DNA. Translation: CAI39636.2.
    CH471090 Genomic DNA. Translation: EAW87596.1.
    BC054001 mRNA. Translation: AAH54001.1.
    CCDSiCCDS65129.1. [Q68BL7-3]
    CCDS6857.2. [Q68BL7-1]
    RefSeqiNP_001269644.1. NM_001282715.1. [Q68BL7-3]
    NP_872293.2. NM_182487.3. [Q68BL7-1]
    XP_005251816.1. XM_005251759.2. [Q68BL7-2]
    UniGeneiHs.357004.

    Genome annotation databases

    EnsembliENST00000288815; ENSP00000288815; ENSG00000185585. [Q68BL7-3]
    ENST00000373580; ENSP00000362682; ENSG00000185585. [Q68BL7-1]
    GeneIDi169611.
    KEGGihsa:169611.
    UCSCiuc004bov.3. human. [Q68BL7-1]
    uc004bow.3. human. [Q68BL7-3]

    Polymorphism databases

    DMDMi74748246.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358185 mRNA. Translation: AAQ88552.1 .
    AB119055 mRNA. Translation: BAD38864.1 .
    AL354928 Genomic DNA. Translation: CAI39635.2 .
    AL354928 Genomic DNA. Translation: CAI39636.2 .
    CH471090 Genomic DNA. Translation: EAW87596.1 .
    BC054001 mRNA. Translation: AAH54001.1 .
    CCDSi CCDS65129.1. [Q68BL7-3 ]
    CCDS6857.2. [Q68BL7-1 ]
    RefSeqi NP_001269644.1. NM_001282715.1. [Q68BL7-3 ]
    NP_872293.2. NM_182487.3. [Q68BL7-1 ]
    XP_005251816.1. XM_005251759.2. [Q68BL7-2 ]
    UniGenei Hs.357004.

    3D structure databases

    ProteinModelPortali Q68BL7.
    SMRi Q68BL7. Positions 468-503.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127983. 2 interactions.

    Polymorphism databases

    DMDMi 74748246.

    Proteomic databases

    PaxDbi Q68BL7.
    PRIDEi Q68BL7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000288815 ; ENSP00000288815 ; ENSG00000185585 . [Q68BL7-3 ]
    ENST00000373580 ; ENSP00000362682 ; ENSG00000185585 . [Q68BL7-1 ]
    GeneIDi 169611.
    KEGGi hsa:169611.
    UCSCi uc004bov.3. human. [Q68BL7-1 ]
    uc004bow.3. human. [Q68BL7-3 ]

    Organism-specific databases

    CTDi 169611.
    GeneCardsi GC09P127539.
    H-InvDB HIX0008375.
    HGNCi HGNC:27270. OLFML2A.
    HPAi HPA021180.
    HPA022254.
    neXtProti NX_Q68BL7.
    PharmGKBi PA134967883.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG290478.
    HOGENOMi HOG000043072.
    HOVERGENi HBG108214.
    InParanoidi Q68BL7.
    OMAi ADSKVFG.
    OrthoDBi EOG75F4CZ.
    PhylomeDBi Q68BL7.
    TreeFami TF351220.

    Miscellaneous databases

    ChiTaRSi OLFML2A. human.
    GenomeRNAii 169611.
    NextBioi 88819.
    PROi Q68BL7.

    Gene expression databases

    ArrayExpressi Q68BL7.
    Bgeei Q68BL7.
    CleanExi HS_OLFML2A.
    Genevestigatori Q68BL7.

    Family and domain databases

    InterProi IPR003112. Olfac-like.
    [Graphical view ]
    Pfami PF02191. OLF. 1 hit.
    [Graphical view ]
    SMARTi SM00284. OLF. 1 hit.
    [Graphical view ]
    PROSITEi PS51132. OLF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-309.
    2. "Photomedin-1 and -2, novel extracellular glycoproteins with olfactomedin domain, isolated from RIKEN full-length mouse cDNA clones by computational screening."
      Furutani Y., Manabe R., Tsutsui K., Yamada T., Sugimoto N., Kawai J., Hayashizaki Y., Sekiguchi K.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Retina.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ALA-309.
      Tissue: Lymph.

    Entry informationi

    Entry nameiOLM2A_HUMAN
    AccessioniPrimary (citable) accession number: Q68BL7
    Secondary accession number(s): Q5JTM5
    , Q5JTM6, Q6UXW1, Q7Z5V3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3