Q68BL7 (OLM2A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactomedin-like protein 2A

Alternative name(s):
Photomedin-1

Gene names

Name:	OLFML2A
ORF Names:	UNQ9394/PRO34319

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	652 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Homodimer. Binds to heparin and chondroitin sulfate E By similarity.
Subcellular location	Secreted By similarity.
Post-translational modification	May be cleaved at Lys-295 after secretion By similarity. O-glycosylated but not N-glycosylated By similarity.
Sequence similarities	Contains 1 olfactomedin-like domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	extracellular matrix organization Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular matrix Inferred from electronic annotation. Source: Compara extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	extracellular matrix binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q68BL7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q68BL7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Isoform 3 (identifier: Q68BL7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-214: Missing.
     215-223: ATGTGSKAQ → MSKRDKAGK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	By similarity
	Chain	28 – 652	625	Olfactomedin-like protein 2A		PRO_0000311428
Regions
	Domain	394 – 652	259	Olfactomedin-like
	Coiled coil	157 – 183	27	Potential
	Compositional bias	207 – 212	6	Poly-Ala
	Compositional bias	354 – 378	25	Thr-rich
Sites
	Site	294 – 295	2	Cleavage By similarity
Amino acid modifications
	Disulfide bond	395 ↔ 582		By similarity
Natural variations
	Alternative sequence	1 – 214	214	Missing in isoform 3.		VSP_029565
	Alternative sequence	1 – 39	39	Missing in isoform 2.		VSP_029566
	Alternative sequence	215 – 223	9	ATGTGSKAQ → MSKRDKAGK in isoform 3.		VSP_029567
	Natural variant	309	1	T → A. Ref.1 Ref.5 Corresponds to variant rs7874348 [ dbSNP | Ensembl ].		VAR_037250
	Natural variant	425	1	R → Q. Corresponds to variant rs16927649 [ dbSNP | Ensembl ].		VAR_037251

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: E3D3B61C8CC0699C	FASTA	652	73,054
	10 20 30 40 50 60 MAAAALPPRP LLLLPLVLLL SGRPTRADSK VFGDLDQVRM TSEGSDCRCK CIMRPLSKDA 70 80 90 100 110 120 CSRVRSGRAR VEDFYTVETV SSGTDCRCSC TAPPSSLNPC ENEWKMEKLK KQAPELLKLQ 130 140 150 160 170 180 SMVDLLEGTL YSMDLMKVHA YVHKVASQMN TLEESIKANL SRENEVVKDS VRHLSEQLRH 190 200 210 220 230 240 YENHSAIMLG IKKELSRLGL QLLQKDAAAA PATPATGTGS KAQDTARGKG KDISKYGSVQ 250 260 270 280 290 300 KSFADRGLPK PPKEKLLQVE KLRKESGKGS FLQPTAKPRA LAQQQAVIRG FTYYKAGKQE 310 320 330 340 350 360 VTEAVADNTL QGTSWLEQLP PKVEGRSNSA EPNSAEQDEA EPRSSERVDL ASGTPTSIPA 370 380 390 400 410 420 TTTTATTTPT PTTSLLPTEP PSGPEVSSQG REASCEGTLR AVDPPVRHHS YGRHEGAWMK 430 440 450 460 470 480 DPAARDDRIY VTNYYYGNSL VEFRNLENFK QGRWSNMYKL PYNWIGTGHV VYQGAFYYNR 490 500 510 520 530 540 AFTKNIIKYD LRQRFVASWA LLPDVVYEDT TPWKWRGHSD IDFAVDESGL WVIYPAVDDR 550 560 570 580 590 600 DEAQPEVIVL SRLDPGDLSV HRETTWKTRL RRNSYGNCFL VCGILYAVDT YNQQEGQVAY 610 620 630 640 650 AFDTHTGTDA RPQLPFLNEH AYTTQIDYNP KERVLYAWDN GHQLTYTLHF VV
	Isoform 2 [UniParc]. Checksum: 72B0B88735C37394	FASTA	613	68,890
	10 20 30 40 50 60 MTSEGSDCRC KCIMRPLSKD ACSRVRSGRA RVEDFYTVET VSSGTDCRCS CTAPPSSLNP 70 80 90 100 110 120 CENEWKMEKL KKQAPELLKL QSMVDLLEGT LYSMDLMKVH AYVHKVASQM NTLEESIKAN 130 140 150 160 170 180 LSRENEVVKD SVRHLSEQLR HYENHSAIML GIKKELSRLG LQLLQKDAAA APATPATGTG 190 200 210 220 230 240 SKAQDTARGK GKDISKYGSV QKSFADRGLP KPPKEKLLQV EKLRKESGKG SFLQPTAKPR 250 260 270 280 290 300 ALAQQQAVIR GFTYYKAGKQ EVTEAVADNT LQGTSWLEQL PPKVEGRSNS AEPNSAEQDE 310 320 330 340 350 360 AEPRSSERVD LASGTPTSIP ATTTTATTTP TPTTSLLPTE PPSGPEVSSQ GREASCEGTL 370 380 390 400 410 420 RAVDPPVRHH SYGRHEGAWM KDPAARDDRI YVTNYYYGNS LVEFRNLENF KQGRWSNMYK 430 440 450 460 470 480 LPYNWIGTGH VVYQGAFYYN RAFTKNIIKY DLRQRFVASW ALLPDVVYED TTPWKWRGHS 490 500 510 520 530 540 DIDFAVDESG LWVIYPAVDD RDEAQPEVIV LSRLDPGDLS VHRETTWKTR LRRNSYGNCF 550 560 570 580 590 600 LVCGILYAVD TYNQQEGQVA YAFDTHTGTD ARPQLPFLNE HAYTTQIDYN PKERVLYAWD 610 NGHQLTYTLH FVV
	Isoform 3 [UniParc]. Checksum: 4E264070E97F49B5	FASTA	438	49,505
	10 20 30 40 50 60 MSKRDKAGKD TARGKGKDIS KYGSVQKSFA DRGLPKPPKE KLLQVEKLRK ESGKGSFLQP 70 80 90 100 110 120 TAKPRALAQQ QAVIRGFTYY KAGKQEVTEA VADNTLQGTS WLEQLPPKVE GRSNSAEPNS 130 140 150 160 170 180 AEQDEAEPRS SERVDLASGT PTSIPATTTT ATTTPTPTTS LLPTEPPSGP EVSSQGREAS 190 200 210 220 230 240 CEGTLRAVDP PVRHHSYGRH EGAWMKDPAA RDDRIYVTNY YYGNSLVEFR NLENFKQGRW 250 260 270 280 290 300 SNMYKLPYNW IGTGHVVYQG AFYYNRAFTK NIIKYDLRQR FVASWALLPD VVYEDTTPWK 310 320 330 340 350 360 WRGHSDIDFA VDESGLWVIY PAVDDRDEAQ PEVIVLSRLD PGDLSVHRET TWKTRLRRNS 370 380 390 400 410 420 YGNCFLVCGI LYAVDTYNQQ EGQVAYAFDT HTGTDARPQL PFLNEHAYTT QIDYNPKERV 430 LYAWDNGHQL TYTLHFVV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-309.
[2]	"Photomedin-1 and -2, novel extracellular glycoproteins with olfactomedin domain, isolated from RIKEN full-length mouse cDNA clones by computational screening." Furutani Y., Manabe R., Tsutsui K., Yamada T., Sugimoto N., Kawai J., Hayashizaki Y., Sekiguchi K. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Retina.
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ALA-309. Tissue: Lymph.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358185 mRNA. Translation: AAQ88552.1. AB119055 mRNA. Translation: BAD38864.1. AL354928 Genomic DNA. Translation: CAI39635.2. AL354928 Genomic DNA. Translation: CAI39636.2. CH471090 Genomic DNA. Translation: EAW87596.1. BC054001 mRNA. Translation: AAH54001.1.
IPI	IPI00385326. IPI00641492. IPI00871730.
RefSeq	NP_872293.2. NM_182487.2.
UniGene	Hs.357004.
3D structure databases
ProteinModelPortal	Q68BL7.
ModBase	Search...
Polymorphism databases
DMDM	74748246.
Proteomic databases
PaxDb	Q68BL7.
PRIDE	Q68BL7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000288815; ENSP00000288815; ENSG00000185585. ENST00000373580; ENSP00000362682; ENSG00000185585.
GeneID	169611.
KEGG	hsa:169611.
UCSC	uc004bov.3. human. uc004bow.3. human.
Organism-specific databases
CTD	169611.
GeneCards	GC09P127539.
H-InvDB	HIX0008375.
HGNC	HGNC:27270. OLFML2A.
HPA	HPA021180. HPA022254.
neXtProt	NX_Q68BL7.
PharmGKB	PA134967883.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG290478.
HOGENOM	HOG000043072.
HOVERGEN	HBG108214.
InParanoid	Q68BL7.
OMA	ADSKVFG.
OrthoDB	EOG441QBD.
Gene expression databases
ArrayExpress	Q68BL7.
Bgee	Q68BL7.
CleanEx	HS_OLFML2A.
Genevestigator	Q68BL7.
Family and domain databases
InterPro	IPR003112. Olfac-like. [Graphical view]
Pfam	PF02191. OLF. 1 hit. [Graphical view]
SMART	SM00284. OLF. 1 hit. [Graphical view]
PROSITE	PS51132. OLF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	OLFML2A. human.
GenomeRNAi	169611.
NextBio	88819.

Entry information

Entry name

OLM2A_HUMAN

Accession

Primary (citable) accession number: Q68BL7
Secondary accession number(s): Q5JTM5 , Q5JTM6, Q6UXW1, Q7Z5V3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	October 11, 2004
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.