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Protein

Olfactomedin-like protein 2A

Gene

OLFML2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei294 – 2952CleavageBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactomedin-like protein 2A
Alternative name(s):
Photomedin-1
Gene namesi
Name:OLFML2A
ORF Names:UNQ9394/PRO34319
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:27270. OLFML2A.

Subcellular locationi

  • Secreted By similarity

  • Note: Localizes to the podocyte major processes. Colocalized with the major process protein VIM throughout podocyte development.1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134967883.

Polymorphism and mutation databases

BioMutaiOLFML2A.
DMDMi74748246.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727By similarityAdd
BLAST
Chaini28 – 652625Olfactomedin-like protein 2APRO_0000311428Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi395 ↔ 582PROSITE-ProRule annotation

Post-translational modificationi

May be cleaved at Lys-295 after secretion.By similarity
O-glycosylated but not N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ68BL7.
PRIDEiQ68BL7.

Expressioni

Tissue specificityi

In the kidney expressed only by podocytes, wherein they localize to major processes.1 Publication

Developmental stagei

Detected at the vesicle stage of developing glomeruli, expressed in invading endothelial cells in the glomerular cleft at the S-shaped stage and is later expressed only at the basal aspect of maturing podocytes.1 Publication

Gene expression databases

BgeeiQ68BL7.
CleanExiHS_OLFML2A.
ExpressionAtlasiQ68BL7. baseline and differential.
GenevisibleiQ68BL7. HS.

Organism-specific databases

HPAiHPA021180.
HPA022254.

Interactioni

Subunit structurei

Homodimer. Binds to heparin and chondroitin sulfate E.By similarity

Protein-protein interaction databases

BioGridi127983. 1 interaction.
STRINGi9606.ENSP00000362682.

Structurei

3D structure databases

ProteinModelPortaliQ68BL7.
SMRiQ68BL7. Positions 416-650.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini394 – 652259Olfactomedin-likePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili157 – 18327Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi207 – 2126Poly-Ala
Compositional biasi354 – 37825Thr-richAdd
BLAST

Sequence similaritiesi

Contains 1 olfactomedin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG290478.
GeneTreeiENSGT00760000119005.
HOGENOMiHOG000043072.
HOVERGENiHBG108214.
InParanoidiQ68BL7.
OMAiADSKVFG.
OrthoDBiEOG75F4CZ.
PhylomeDBiQ68BL7.
TreeFamiTF351220.

Family and domain databases

InterProiIPR003112. Olfac-like.
IPR031231. OLFML2A.
[Graphical view]
PANTHERiPTHR23192:SF29. PTHR23192:SF29. 1 hit.
PfamiPF02191. OLF. 1 hit.
[Graphical view]
SMARTiSM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS51132. OLF. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q68BL7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAALPPRP LLLLPLVLLL SGRPTRADSK VFGDLDQVRM TSEGSDCRCK
60 70 80 90 100
CIMRPLSKDA CSRVRSGRAR VEDFYTVETV SSGTDCRCSC TAPPSSLNPC
110 120 130 140 150
ENEWKMEKLK KQAPELLKLQ SMVDLLEGTL YSMDLMKVHA YVHKVASQMN
160 170 180 190 200
TLEESIKANL SRENEVVKDS VRHLSEQLRH YENHSAIMLG IKKELSRLGL
210 220 230 240 250
QLLQKDAAAA PATPATGTGS KAQDTARGKG KDISKYGSVQ KSFADRGLPK
260 270 280 290 300
PPKEKLLQVE KLRKESGKGS FLQPTAKPRA LAQQQAVIRG FTYYKAGKQE
310 320 330 340 350
VTEAVADNTL QGTSWLEQLP PKVEGRSNSA EPNSAEQDEA EPRSSERVDL
360 370 380 390 400
ASGTPTSIPA TTTTATTTPT PTTSLLPTEP PSGPEVSSQG REASCEGTLR
410 420 430 440 450
AVDPPVRHHS YGRHEGAWMK DPAARDDRIY VTNYYYGNSL VEFRNLENFK
460 470 480 490 500
QGRWSNMYKL PYNWIGTGHV VYQGAFYYNR AFTKNIIKYD LRQRFVASWA
510 520 530 540 550
LLPDVVYEDT TPWKWRGHSD IDFAVDESGL WVIYPAVDDR DEAQPEVIVL
560 570 580 590 600
SRLDPGDLSV HRETTWKTRL RRNSYGNCFL VCGILYAVDT YNQQEGQVAY
610 620 630 640 650
AFDTHTGTDA RPQLPFLNEH AYTTQIDYNP KERVLYAWDN GHQLTYTLHF

VV
Length:652
Mass (Da):73,054
Last modified:October 11, 2004 - v1
Checksum:iE3D3B61C8CC0699C
GO
Isoform 2 (identifier: Q68BL7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Show »
Length:613
Mass (Da):68,890
Checksum:i72B0B88735C37394
GO
Isoform 3 (identifier: Q68BL7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-214: Missing.
     215-223: ATGTGSKAQ → MSKRDKAGK

Show »
Length:438
Mass (Da):49,505
Checksum:i4E264070E97F49B5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti309 – 3091T → A.2 Publications
Corresponds to variant rs7874348 [ dbSNP | Ensembl ].
VAR_037250
Natural varianti425 – 4251R → Q.
Corresponds to variant rs16927649 [ dbSNP | Ensembl ].
VAR_037251

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 214214Missing in isoform 3. 1 PublicationVSP_029565Add
BLAST
Alternative sequencei1 – 3939Missing in isoform 2. 1 PublicationVSP_029566Add
BLAST
Alternative sequencei215 – 2239ATGTGSKAQ → MSKRDKAGK in isoform 3. 1 PublicationVSP_029567

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358185 mRNA. Translation: AAQ88552.1.
AB119055 mRNA. Translation: BAD38864.1.
AL354928 Genomic DNA. Translation: CAI39635.2.
AL354928 Genomic DNA. Translation: CAI39636.2.
CH471090 Genomic DNA. Translation: EAW87596.1.
BC054001 mRNA. Translation: AAH54001.1.
CCDSiCCDS65129.1. [Q68BL7-3]
CCDS6857.2. [Q68BL7-1]
RefSeqiNP_001269644.1. NM_001282715.1. [Q68BL7-3]
NP_872293.2. NM_182487.3. [Q68BL7-1]
XP_005251816.1. XM_005251759.3. [Q68BL7-2]
UniGeneiHs.357004.

Genome annotation databases

EnsembliENST00000288815; ENSP00000288815; ENSG00000185585. [Q68BL7-3]
ENST00000373580; ENSP00000362682; ENSG00000185585.
GeneIDi169611.
KEGGihsa:169611.
UCSCiuc004bov.3. human. [Q68BL7-1]
uc004bow.3. human. [Q68BL7-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358185 mRNA. Translation: AAQ88552.1.
AB119055 mRNA. Translation: BAD38864.1.
AL354928 Genomic DNA. Translation: CAI39635.2.
AL354928 Genomic DNA. Translation: CAI39636.2.
CH471090 Genomic DNA. Translation: EAW87596.1.
BC054001 mRNA. Translation: AAH54001.1.
CCDSiCCDS65129.1. [Q68BL7-3]
CCDS6857.2. [Q68BL7-1]
RefSeqiNP_001269644.1. NM_001282715.1. [Q68BL7-3]
NP_872293.2. NM_182487.3. [Q68BL7-1]
XP_005251816.1. XM_005251759.3. [Q68BL7-2]
UniGeneiHs.357004.

3D structure databases

ProteinModelPortaliQ68BL7.
SMRiQ68BL7. Positions 416-650.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127983. 1 interaction.
STRINGi9606.ENSP00000362682.

Polymorphism and mutation databases

BioMutaiOLFML2A.
DMDMi74748246.

Proteomic databases

PaxDbiQ68BL7.
PRIDEiQ68BL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288815; ENSP00000288815; ENSG00000185585. [Q68BL7-3]
ENST00000373580; ENSP00000362682; ENSG00000185585.
GeneIDi169611.
KEGGihsa:169611.
UCSCiuc004bov.3. human. [Q68BL7-1]
uc004bow.3. human. [Q68BL7-3]

Organism-specific databases

CTDi169611.
GeneCardsiGC09P127539.
H-InvDBHIX0008375.
HGNCiHGNC:27270. OLFML2A.
HPAiHPA021180.
HPA022254.
MIMi615899. gene.
neXtProtiNX_Q68BL7.
PharmGKBiPA134967883.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG290478.
GeneTreeiENSGT00760000119005.
HOGENOMiHOG000043072.
HOVERGENiHBG108214.
InParanoidiQ68BL7.
OMAiADSKVFG.
OrthoDBiEOG75F4CZ.
PhylomeDBiQ68BL7.
TreeFamiTF351220.

Miscellaneous databases

ChiTaRSiOLFML2A. human.
GenomeRNAii169611.
NextBioi88819.
PROiQ68BL7.
SOURCEiSearch...

Gene expression databases

BgeeiQ68BL7.
CleanExiHS_OLFML2A.
ExpressionAtlasiQ68BL7. baseline and differential.
GenevisibleiQ68BL7. HS.

Family and domain databases

InterProiIPR003112. Olfac-like.
IPR031231. OLFML2A.
[Graphical view]
PANTHERiPTHR23192:SF29. PTHR23192:SF29. 1 hit.
PfamiPF02191. OLF. 1 hit.
[Graphical view]
SMARTiSM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS51132. OLF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-309.
  2. "Photomedin-1 and -2, novel extracellular glycoproteins with olfactomedin domain, isolated from RIKEN full-length mouse cDNA clones by computational screening."
    Furutani Y., Manabe R., Tsutsui K., Yamada T., Sugimoto N., Kawai J., Hayashizaki Y., Sekiguchi K.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Retina.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ALA-309.
    Tissue: Lymph.
  6. "Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation."
    Sistani L., Rodriguez P.Q., Hultenby K., Uhlen M., Betsholtz C., Jalanko H., Tryggvason K., Wernerson A., Patrakka J.
    Kidney Int. 83:63-71(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiOLM2A_HUMAN
AccessioniPrimary (citable) accession number: Q68BL7
Secondary accession number(s): Q5JTM5
, Q5JTM6, Q6UXW1, Q7Z5V3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 11, 2004
Last modified: July 22, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.