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Q68AZ0

- CCL4_CANFA

UniProt

Q68AZ0 - CCL4_CANFA

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Protein

C-C motif chemokine 4

Gene

CCL4

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties.By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 4
Alternative name(s):
Small-inducible cytokine A4
Gene namesi
Name:CCL4
Synonyms:SCYA4
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 9

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9269C-C motif chemokine 4PRO_0000326236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi35 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer. Interacts with CCR5 By similarity.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000026827.

Structurei

3D structure databases

ProteinModelPortaliQ68AZ0.
SMRiQ68AZ0. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG124416.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ68AZ0.
KOiK12964.
OMAiLRKIPRN.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68AZ0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLCVTVLSL LVLVAAFCSP ALSAPMGSDP PTACCFSYTL RKIPRNFVAD
60 70 80 90
YFETSSLCSQ PAVVFQTRRG RQVCANPSEP WVQEYMDDLE LN
Length:92
Mass (Da):10,197
Last modified:October 11, 2004 - v1
Checksum:i7628FBC425BCED9C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB163435 mRNA. Translation: BAD37148.1.
AB183194 mRNA. Translation: BAD83842.1.
RefSeqiNP_001005250.1. NM_001005250.1.
UniGeneiCfa.15795.

Genome annotation databases

EnsembliENSCAFT00000028847; ENSCAFP00000026825; ENSCAFG00000018164.
GeneIDi448786.
KEGGicfa:448786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB163435 mRNA. Translation: BAD37148.1 .
AB183194 mRNA. Translation: BAD83842.1 .
RefSeqi NP_001005250.1. NM_001005250.1.
UniGenei Cfa.15795.

3D structure databases

ProteinModelPortali Q68AZ0.
SMRi Q68AZ0. Positions 24-92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000026827.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000028847 ; ENSCAFP00000026825 ; ENSCAFG00000018164 .
GeneIDi 448786.
KEGGi cfa:448786.

Organism-specific databases

CTDi 6351.

Phylogenomic databases

eggNOGi NOG124416.
GeneTreei ENSGT00730000110278.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q68AZ0.
KOi K12964.
OMAi LRKIPRN.
OrthoDBi EOG7CVQ1F.
TreeFami TF334888.

Miscellaneous databases

NextBioi 20832516.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression analysis of chemokine gene in canine atopic dermatitis."
    Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL4_CANFA
AccessioniPrimary (citable) accession number: Q68AZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3