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Q68AZ0

- CCL4_CANFA

UniProt

Q68AZ0 - CCL4_CANFA

Protein

C-C motif chemokine 4

Gene

CCL4

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Monokine with inflammatory and chemokinetic properties.By similarity

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 4
    Alternative name(s):
    Small-inducible cytokine A4
    Gene namesi
    Name:CCL4
    Synonyms:SCYA4
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 9

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 9269C-C motif chemokine 4PRO_0000326236Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 58By similarity
    Disulfide bondi35 ↔ 74By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Homodimer. Interacts with CCR5 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000026827.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68AZ0.
    SMRiQ68AZ0. Positions 24-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG124416.
    GeneTreeiENSGT00730000110278.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    KOiK12964.
    OMAiLRKIPRN.
    OrthoDBiEOG7CVQ1F.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q68AZ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLCVTVLSL LVLVAAFCSP ALSAPMGSDP PTACCFSYTL RKIPRNFVAD   50
    YFETSSLCSQ PAVVFQTRRG RQVCANPSEP WVQEYMDDLE LN 92
    Length:92
    Mass (Da):10,197
    Last modified:October 11, 2004 - v1
    Checksum:i7628FBC425BCED9C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB163435 mRNA. Translation: BAD37148.1.
    AB183194 mRNA. Translation: BAD83842.1.
    RefSeqiNP_001005250.1. NM_001005250.1.
    UniGeneiCfa.15795.

    Genome annotation databases

    EnsembliENSCAFT00000028847; ENSCAFP00000026825; ENSCAFG00000018164.
    GeneIDi448786.
    KEGGicfa:448786.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB163435 mRNA. Translation: BAD37148.1 .
    AB183194 mRNA. Translation: BAD83842.1 .
    RefSeqi NP_001005250.1. NM_001005250.1.
    UniGenei Cfa.15795.

    3D structure databases

    ProteinModelPortali Q68AZ0.
    SMRi Q68AZ0. Positions 24-92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000026827.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000028847 ; ENSCAFP00000026825 ; ENSCAFG00000018164 .
    GeneIDi 448786.
    KEGGi cfa:448786.

    Organism-specific databases

    CTDi 6351.

    Phylogenomic databases

    eggNOGi NOG124416.
    GeneTreei ENSGT00730000110278.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    KOi K12964.
    OMAi LRKIPRN.
    OrthoDBi EOG7CVQ1F.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 20832516.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression analysis of chemokine gene in canine atopic dermatitis."
      Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL4_CANFA
    AccessioniPrimary (citable) accession number: Q68AZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3