Q68AZ0 (CCL4_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C motif chemokine 4

Alternative name(s):
Small-inducible cytokine A4

Gene names

Name:	CCL4
Synonyms:	SCYA4

Organism

Canis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	92 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Monokine with inflammatory and chemokinetic properties By similarity.
Subunit structure	Homodimer. Interacts with CCR5 By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
Biological process	Chemotaxis Inflammatory response
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	By similarity
	Chain	24 – 92	69	C-C motif chemokine 4		PRO_0000326236
Amino acid modifications
	Disulfide bond	34 ↔ 58		By similarity
	Disulfide bond	35 ↔ 74		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q68AZ0 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 7628FBC425BCED9C	FASTA	92	10,197
	10 20 30 40 50 60 MKLCVTVLSL LVLVAAFCSP ALSAPMGSDP PTACCFSYTL RKIPRNFVAD YFETSSLCSQ 70 80 90 PAVVFQTRRG RQVCANPSEP WVQEYMDDLE LN

References

[1]	"Expression analysis of chemokine gene in canine atopic dermatitis." Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB163435 mRNA. Translation: BAD37148.1. AB183194 mRNA. Translation: BAD83842.1.
RefSeq	NP_001005250.1. NM_001005250.1.
UniGene	Cfa.15795.
3D structure databases
HSSP	HSSP built from PDB template 1HUM based on UniProtKB P13236.
ProteinModelPortal	Q68AZ0.
SMR	Q68AZ0. Positions 24-92.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSCAFT00000028847; ENSCAFP00000026825; ENSCAFG00000018164.
GeneID	448786.
KEGG	cfa:448786.
Organism-specific databases
CTD	6351.
Phylogenomic databases
eggNOG	NOG124416.
GeneTree	ENSGT00560000077010.
HOGENOM	HOG000036685.
HOVERGEN	HBG017871.
KO	K12964.
OMA	LMAAFCS.
OrthoDB	EOG42Z4RR.
Family and domain databases
InterPro	IPR000827. Chemokine_CC_CS. IPR001811. Chemokine_IL8-like_dom. [Graphical view]
Pfam	PF00048. IL8. 1 hit. [Graphical view]
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
PROSITE	PS00472. SMALL_CYTOKINES_CC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20832516.

Entry information

Entry name

CCL4_CANFA

Accession

Primary (citable) accession number: Q68AZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	October 11, 2004
Last modified:	April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program