ID CCL8_CANLF Reviewed; 99 AA. AC Q68AY9; DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot. DT 11-OCT-2004, sequence version 1. DT 27-MAR-2024, entry version 118. DE RecName: Full=C-C motif chemokine 8; DE AltName: Full=Monocyte chemoattractant protein 2; DE AltName: Full=Monocyte chemotactic protein 2; DE Short=MCP-2; DE AltName: Full=Small-inducible cytokine A8; DE Flags: Precursor; GN Name=CCL8; Synonyms=MCP2; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., RA Tsujimoto H., Iwabuchi S.; RT "Expression analysis of chemokine gene in canine atopic dermatitis."; RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Peters I.R., Peeters D., Clercx C., Day M.J.; RT "Identification of coding sequences for canine monocyte chemotactic RT protein-2 (CCL8), eotaxin 2 (CCL24), eotaxin 3 (CCL26) and C-C chemokine RT receptor 3 (CCR3)."; RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Chemotactic factor that attracts monocytes. This protein can CC bind heparin (By similarity). {ECO:0000250}. CC -!- SUBUNIT: Monomer or homodimer; in equilibrium. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB163436; BAD37149.1; -; mRNA. DR EMBL; AY675234; AAU14059.1; -; mRNA. DR RefSeq; NP_001005255.1; NM_001005255.1. DR AlphaFoldDB; Q68AY9; -. DR SMR; Q68AY9; -. DR STRING; 9615.ENSCAFP00000027105; -. DR PaxDb; 9612-ENSCAFP00000027105; -. DR Ensembl; ENSCAFT00000029147.5; ENSCAFP00000027105.3; ENSCAFG00000023928.4. DR Ensembl; ENSCAFT00030031804.1; ENSCAFP00030027731.1; ENSCAFG00030017255.1. DR Ensembl; ENSCAFT00040021001.1; ENSCAFP00040018234.1; ENSCAFG00040011377.1. DR Ensembl; ENSCAFT00805008969; ENSCAFP00805007023; ENSCAFG00805004798. DR Ensembl; ENSCAFT00845020092.1; ENSCAFP00845015744.1; ENSCAFG00845011338.1. DR GeneID; 448792; -. DR KEGG; cfa:448792; -. DR CTD; 6355; -. DR VEuPathDB; HostDB:ENSCAFG00845011338; -. DR VGNC; VGNC:55561; CCL8. DR eggNOG; ENOG502S8M4; Eukaryota. DR GeneTree; ENSGT01100000263482; -. DR HOGENOM; CLU_141716_1_0_1; -. DR InParanoid; Q68AY9; -. DR OMA; SIPVTCC; -. DR OrthoDB; 4265193at2759; -. DR TreeFam; TF334888; -. DR Proteomes; UP000002254; Chromosome 9. DR Proteomes; UP000694429; Chromosome 9. DR Proteomes; UP000694542; Chromosome 9. DR Proteomes; UP000805418; Chromosome 9. DR Bgee; ENSCAFG00000023928; Expressed in cardiac muscle of left ventricle and 34 other cell types or tissues. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central. DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central. DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW. DR GO; GO:0016004; F:phospholipase activator activity; IEA:Ensembl. DR GO; GO:0004672; F:protein kinase activity; IEA:Ensembl. DR GO; GO:0006816; P:calcium ion transport; IEA:Ensembl. DR GO; GO:0007267; P:cell-cell signaling; IEA:Ensembl. DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central. DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central. DR GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central. DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central. DR GO; GO:0006887; P:exocytosis; IEA:Ensembl. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central. DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central. DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl. DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central. DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central. DR GO; GO:0044828; P:negative regulation by host of viral genome replication; IEA:Ensembl. DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central. DR CDD; cd00272; Chemokine_CC; 1. DR Gene3D; 2.40.50.40; -; 1. DR InterPro; IPR039809; Chemokine_b/g/d. DR InterPro; IPR000827; Chemokine_CC_CS. DR InterPro; IPR001811; Chemokine_IL8-like_dom. DR InterPro; IPR036048; Interleukin_8-like_sf. DR PANTHER; PTHR12015:SF168; C-C MOTIF CHEMOKINE 8; 1. DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1. DR Pfam; PF00048; IL8; 1. DR SMART; SM00199; SCY; 1. DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1. DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1. PE 3: Inferred from homology; KW Chemotaxis; Cytokine; Disulfide bond; Heparin-binding; KW Inflammatory response; Pyrrolidone carboxylic acid; Reference proteome; KW Secreted; Signal. FT SIGNAL 1..23 FT /evidence="ECO:0000250|UniProtKB:P80075" FT CHAIN 24..99 FT /note="C-C motif chemokine 8" FT /id="PRO_0000005187" FT MOD_RES 24 FT /note="Pyrrolidone carboxylic acid" FT /evidence="ECO:0000250|UniProtKB:P80075" FT DISULFID 34..59 FT /evidence="ECO:0000250" FT DISULFID 35..75 FT /evidence="ECO:0000250" SQ SEQUENCE 99 AA; 11263 MW; FD56D8405DC010E8 CRC64; MKFSTALLCL LLTAASFSTF VLAQPDSVSI PITCCFSMVK RKIPMQKLES YMRITNSQCP QEAVIFKTKA SREICADPKQ KWVQDYMNHL DQKSQAQKP //