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Q68AY9

- CCL8_CANFA

UniProt

Q68AY9 - CCL8_CANFA

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Protein

C-C motif chemokine 8

Gene

CCL8

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity).By similarity

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. phospholipase activator activity Source: Ensembl
  3. protein kinase activity Source: Ensembl

GO - Biological processi

  1. calcium ion transport Source: Ensembl
  2. cell-cell signaling Source: Ensembl
  3. cell chemotaxis Source: GOC
  4. cellular calcium ion homeostasis Source: Ensembl
  5. exocytosis Source: Ensembl
  6. immune response Source: InterPro
  7. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 8
Alternative name(s):
Monocyte chemoattractant protein 2
Monocyte chemotactic protein 2
Short name:
MCP-2
Small-inducible cytokine A8
Gene namesi
Name:CCL8
Synonyms:MCP2
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 9

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9976C-C motif chemokine 8PRO_0000005187Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Disulfide bondi34 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000027105.

Structurei

3D structure databases

ProteinModelPortaliQ68AY9.
SMRiQ68AY9. Positions 24-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG75507.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ68AY9.
KOiK16596.
OMAiQKLESYT.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68AY9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFSTALLCL LLTAASFSTF VLAQPDSVSI PITCCFSMVK RKIPMQKLES
60 70 80 90
YMRITNSQCP QEAVIFKTKA SREICADPKQ KWVQDYMNHL DQKSQAQKP
Length:99
Mass (Da):11,263
Last modified:October 11, 2004 - v1
Checksum:iFD56D8405DC010E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB163436 mRNA. Translation: BAD37149.1.
AY675234 mRNA. Translation: AAU14059.1.
RefSeqiNP_001005255.1. NM_001005255.1.
UniGeneiCfa.15810.

Genome annotation databases

EnsembliENSCAFT00000029147; ENSCAFP00000027105; ENSCAFG00000023928.
GeneIDi448792.
KEGGicfa:448792.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB163436 mRNA. Translation: BAD37149.1 .
AY675234 mRNA. Translation: AAU14059.1 .
RefSeqi NP_001005255.1. NM_001005255.1.
UniGenei Cfa.15810.

3D structure databases

ProteinModelPortali Q68AY9.
SMRi Q68AY9. Positions 24-99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000027105.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000029147 ; ENSCAFP00000027105 ; ENSCAFG00000023928 .
GeneIDi 448792.
KEGGi cfa:448792.

Organism-specific databases

CTDi 6355.

Phylogenomic databases

eggNOGi NOG75507.
GeneTreei ENSGT00730000110714.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.
InParanoidi Q68AY9.
KOi K16596.
OMAi QKLESYT.
OrthoDBi EOG7C5MC2.
TreeFami TF334888.

Miscellaneous databases

NextBioi 20832522.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression analysis of chemokine gene in canine atopic dermatitis."
    Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of coding sequences for canine monocyte chemotactic protein-2 (CCL8), eotaxin 2 (CCL24), eotaxin 3 (CCL26) and C-C chemokine receptor 3 (CCR3)."
    Peters I.R., Peeters D., Clercx C., Day M.J.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL8_CANFA
AccessioniPrimary (citable) accession number: Q68AY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3