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Protein

C-C motif chemokine 8

Gene

CCL8

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity).By similarity

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. phospholipase activator activity Source: Ensembl
  3. protein kinase activity Source: Ensembl

GO - Biological processi

  1. calcium ion transport Source: Ensembl
  2. cell-cell signaling Source: Ensembl
  3. cell chemotaxis Source: GOC
  4. cellular calcium ion homeostasis Source: Ensembl
  5. exocytosis Source: Ensembl
  6. immune response Source: InterPro
  7. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 8
Alternative name(s):
Monocyte chemoattractant protein 2
Monocyte chemotactic protein 2
Short name:
MCP-2
Small-inducible cytokine A8
Gene namesi
Name:CCL8
Synonyms:MCP2
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254 Componenti: Chromosome 9

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9976C-C motif chemokine 8PRO_0000005187Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Disulfide bondi34 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000027105.

Structurei

3D structure databases

ProteinModelPortaliQ68AY9.
SMRiQ68AY9. Positions 24-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG75507.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ68AY9.
KOiK16596.
OMAiSMKHLDQ.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68AY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFSTALLCL LLTAASFSTF VLAQPDSVSI PITCCFSMVK RKIPMQKLES
60 70 80 90
YMRITNSQCP QEAVIFKTKA SREICADPKQ KWVQDYMNHL DQKSQAQKP
Length:99
Mass (Da):11,263
Last modified:October 10, 2004 - v1
Checksum:iFD56D8405DC010E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB163436 mRNA. Translation: BAD37149.1.
AY675234 mRNA. Translation: AAU14059.1.
RefSeqiNP_001005255.1. NM_001005255.1.
UniGeneiCfa.15810.

Genome annotation databases

EnsembliENSCAFT00000029147; ENSCAFP00000027105; ENSCAFG00000023928.
GeneIDi448792.
KEGGicfa:448792.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB163436 mRNA. Translation: BAD37149.1.
AY675234 mRNA. Translation: AAU14059.1.
RefSeqiNP_001005255.1. NM_001005255.1.
UniGeneiCfa.15810.

3D structure databases

ProteinModelPortaliQ68AY9.
SMRiQ68AY9. Positions 24-99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000027105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000029147; ENSCAFP00000027105; ENSCAFG00000023928.
GeneIDi448792.
KEGGicfa:448792.

Organism-specific databases

CTDi6355.

Phylogenomic databases

eggNOGiNOG75507.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ68AY9.
KOiK16596.
OMAiSMKHLDQ.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Miscellaneous databases

NextBioi20832522.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression analysis of chemokine gene in canine atopic dermatitis."
    Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of coding sequences for canine monocyte chemotactic protein-2 (CCL8), eotaxin 2 (CCL24), eotaxin 3 (CCL26) and C-C chemokine receptor 3 (CCR3)."
    Peters I.R., Peeters D., Clercx C., Day M.J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL8_CANFA
AccessioniPrimary (citable) accession number: Q68AY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 25, 2005
Last sequence update: October 10, 2004
Last modified: March 3, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.