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Q68AY9

- CCL8_CANFA

UniProt

Q68AY9 - CCL8_CANFA

Protein

C-C motif chemokine 8

Gene

CCL8

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemotactic factor that attracts monocytes. This protein can bind heparin By similarity.By similarity

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. phospholipase activator activity Source: Ensembl
    3. protein kinase activity Source: Ensembl

    GO - Biological processi

    1. calcium ion transport Source: Ensembl
    2. cell-cell signaling Source: Ensembl
    3. cell chemotaxis Source: GOC
    4. cellular calcium ion homeostasis Source: Ensembl
    5. exocytosis Source: Ensembl
    6. immune response Source: InterPro
    7. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Keywords - Ligandi

    Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 8
    Alternative name(s):
    Monocyte chemoattractant protein 2
    Monocyte chemotactic protein 2
    Short name:
    MCP-2
    Small-inducible cytokine A8
    Gene namesi
    Name:CCL8
    Synonyms:MCP2
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 9

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 9976C-C motif chemokine 8PRO_0000005187Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi34 ↔ 59By similarity
    Disulfide bondi35 ↔ 75By similarity

    Keywords - PTMi

    Disulfide bond, Pyrrolidone carboxylic acid

    Interactioni

    Subunit structurei

    Monomer or homodimer; in equilibrium.By similarity

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000027105.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68AY9.
    SMRiQ68AY9. Positions 24-99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG75507.
    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiQ68AY9.
    KOiK16596.
    OMAiQKLESYT.
    OrthoDBiEOG7C5MC2.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q68AY9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFSTALLCL LLTAASFSTF VLAQPDSVSI PITCCFSMVK RKIPMQKLES   50
    YMRITNSQCP QEAVIFKTKA SREICADPKQ KWVQDYMNHL DQKSQAQKP 99
    Length:99
    Mass (Da):11,263
    Last modified:October 11, 2004 - v1
    Checksum:iFD56D8405DC010E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB163436 mRNA. Translation: BAD37149.1.
    AY675234 mRNA. Translation: AAU14059.1.
    RefSeqiNP_001005255.1. NM_001005255.1.
    UniGeneiCfa.15810.

    Genome annotation databases

    EnsembliENSCAFT00000029147; ENSCAFP00000027105; ENSCAFG00000023928.
    GeneIDi448792.
    KEGGicfa:448792.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB163436 mRNA. Translation: BAD37149.1 .
    AY675234 mRNA. Translation: AAU14059.1 .
    RefSeqi NP_001005255.1. NM_001005255.1.
    UniGenei Cfa.15810.

    3D structure databases

    ProteinModelPortali Q68AY9.
    SMRi Q68AY9. Positions 24-99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000027105.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000029147 ; ENSCAFP00000027105 ; ENSCAFG00000023928 .
    GeneIDi 448792.
    KEGGi cfa:448792.

    Organism-specific databases

    CTDi 6355.

    Phylogenomic databases

    eggNOGi NOG75507.
    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi Q68AY9.
    KOi K16596.
    OMAi QKLESYT.
    OrthoDBi EOG7C5MC2.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 20832522.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression analysis of chemokine gene in canine atopic dermatitis."
      Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification of coding sequences for canine monocyte chemotactic protein-2 (CCL8), eotaxin 2 (CCL24), eotaxin 3 (CCL26) and C-C chemokine receptor 3 (CCR3)."
      Peters I.R., Peeters D., Clercx C., Day M.J.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL8_CANFA
    AccessioniPrimary (citable) accession number: Q68AY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3