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Protein

Regenerating islet-derived protein 4

Gene

Reg4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Regenerating islet-derived protein 4
Short name:
REG-4
Gene namesi
Name:Reg4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1303341. Reg4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 157135Regenerating islet-derived protein 4PRO_0000017439Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 40PROSITE-ProRule annotation
Glycosylationi49 – 491N-linked (GlcNAc...)Sequence analysis
Disulfide bondi57 ↔ 153PROSITE-ProRule annotation
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence analysis
Disulfide bondi128 ↔ 145PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ68AX7.
PRIDEiQ68AX7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019046.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025821.

Structurei

3D structure databases

ProteinModelPortaliQ68AX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 154119C-type lectinPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 1015Carbohydrate-bindingBy similarity
Regioni134 – 1363Carbohydrate-bindingBy similarity

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104249.
HOGENOMiHOG000010281.
HOVERGENiHBG004151.
InParanoidiQ68AX7.
OMAiEARHCTE.
OrthoDBiEOG091G0PSR.
PhylomeDBiQ68AX7.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68AX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKCVRLLL LLSWVAGPEV LSDILRPSCA SGWFNYRSHC YGYFRKLRNW
60 70 80 90 100
SHAELECQSY GNGSHLASVL NPKEASVISK YITGYQRSLP VWIGLHDPQK
110 120 130 140 150
NASWQWIDGS TNQYRPWSPR TKSEARHCTE MNPKDKFLTW NKNGCTKRQH

FLCKYRP
Length:157
Mass (Da):18,269
Last modified:October 11, 2004 - v1
Checksum:i55B129FB10BA4D1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164049 mRNA. Translation: BAD38673.1.
RefSeqiNP_001004096.1. NM_001004096.1.
XP_006233071.1. XM_006233009.2.
XP_008759543.1. XM_008761321.1.
UniGeneiRn.83573.

Genome annotation databases

EnsembliENSRNOT00000025821; ENSRNOP00000025821; ENSRNOG00000019046.
GeneIDi445583.
KEGGirno:445583.
UCSCiRGD:1303341. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164049 mRNA. Translation: BAD38673.1.
RefSeqiNP_001004096.1. NM_001004096.1.
XP_006233071.1. XM_006233009.2.
XP_008759543.1. XM_008761321.1.
UniGeneiRn.83573.

3D structure databases

ProteinModelPortaliQ68AX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025821.

Proteomic databases

PaxDbiQ68AX7.
PRIDEiQ68AX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025821; ENSRNOP00000025821; ENSRNOG00000019046.
GeneIDi445583.
KEGGirno:445583.
UCSCiRGD:1303341. rat.

Organism-specific databases

CTDi83998.
RGDi1303341. Reg4.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104249.
HOGENOMiHOG000010281.
HOVERGENiHBG004151.
InParanoidiQ68AX7.
OMAiEARHCTE.
OrthoDBiEOG091G0PSR.
PhylomeDBiQ68AX7.

Miscellaneous databases

PROiQ68AX7.

Gene expression databases

BgeeiENSRNOG00000019046.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREG4_RAT
AccessioniPrimary (citable) accession number: Q68AX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.