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Q68A93 (CCL25_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 25
Alternative name(s):
Small-inducible cytokine A25
Gene names
Name:CCL25
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length151 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

leukocyte migration

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionchemokine receptor binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 151129C-C motif chemokine 25
PRO_0000005234

Amino acid modifications

Disulfide bond29 ↔ 57 By similarity
Disulfide bond30 ↔ 73 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68A93 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: DC0CD4106B1F922B

FASTA15117,109
        10         20         30         40         50         60 
MNLWLLVCLV ASLMGAWSTV HTQGVSEDCC LAYHHRARPR LLMRAQGYQR QEVSGSCNLP 

        70         80         90        100        110        120 
AVIFFFPKNK MLCVNPRVNW LPNVFKFLDN RNNTHSKQHL GSRRNLQDSH LGGQRSNTGM 

       130        140        150 
SRLAHSKSKS SRSTRSNKKK TSFLNMANPG P 

« Hide

References

[1]"Expression analysis of gene in canine atopic dermatitis."
Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB164617 mRNA. Translation: BAD42446.1.
RefSeqNP_001005259.1. NM_001005259.1.
XP_005632371.1. XM_005632314.1.
XP_005632372.1. XM_005632315.1.
UniGeneCfa.15806.

3D structure databases

ProteinModelPortalQ68A93.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000027121.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000029163; ENSCAFP00000027121; ENSCAFG00000018358.
GeneID448798.
KEGGcfa:448798.

Organism-specific databases

CTD6370.

Phylogenomic databases

eggNOGNOG39655.
GeneTreeENSGT00510000049257.
HOGENOMHOG000293281.
HOVERGENHBG050832.
InParanoidQ68A93.
KOK13072.
OMAAWAPAVH.
OrthoDBEOG76MKB6.
TreeFamTF353160.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20832527.

Entry information

Entry nameCCL25_CANFA
AccessionPrimary (citable) accession number: Q68A93
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families