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Q68A93

- CCL25_CANFA

UniProt

Q68A93 - CCL25_CANFA

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Protein

C-C motif chemokine 25

Gene

CCL25

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity).By similarity

GO - Molecular functioni

  1. chemokine receptor binding Source: UniProtKB

GO - Biological processi

  1. cell chemotaxis Source: Ensembl
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
  4. leukocyte migration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_254648. G alpha (i) signalling events.
REACT_258590. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 25
Alternative name(s):
Small-inducible cytokine A25
Gene namesi
Name:CCL25
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 20

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 151129C-C motif chemokine 25PRO_0000005234Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 57By similarity
Disulfide bondi30 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000027121.

Structurei

3D structure databases

ProteinModelPortaliQ68A93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39655.
GeneTreeiENSGT00510000049257.
HOGENOMiHOG000293281.
HOVERGENiHBG050832.
InParanoidiQ68A93.
KOiK13072.
OMAiAWAPAVH.
OrthoDBiEOG76MKB6.
TreeFamiTF353160.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68A93-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLWLLVCLV ASLMGAWSTV HTQGVSEDCC LAYHHRARPR LLMRAQGYQR
60 70 80 90 100
QEVSGSCNLP AVIFFFPKNK MLCVNPRVNW LPNVFKFLDN RNNTHSKQHL
110 120 130 140 150
GSRRNLQDSH LGGQRSNTGM SRLAHSKSKS SRSTRSNKKK TSFLNMANPG

P
Length:151
Mass (Da):17,109
Last modified:October 11, 2004 - v1
Checksum:iDC0CD4106B1F922B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164617 mRNA. Translation: BAD42446.1.
RefSeqiNP_001005259.1. NM_001005259.1.
XP_005632371.1. XM_005632314.1.
XP_005632372.1. XM_005632315.1.
UniGeneiCfa.15806.

Genome annotation databases

EnsembliENSCAFT00000029163; ENSCAFP00000027121; ENSCAFG00000018358.
GeneIDi448798.
KEGGicfa:448798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164617 mRNA. Translation: BAD42446.1 .
RefSeqi NP_001005259.1. NM_001005259.1.
XP_005632371.1. XM_005632314.1.
XP_005632372.1. XM_005632315.1.
UniGenei Cfa.15806.

3D structure databases

ProteinModelPortali Q68A93.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000027121.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000029163 ; ENSCAFP00000027121 ; ENSCAFG00000018358 .
GeneIDi 448798.
KEGGi cfa:448798.

Organism-specific databases

CTDi 6370.

Phylogenomic databases

eggNOGi NOG39655.
GeneTreei ENSGT00510000049257.
HOGENOMi HOG000293281.
HOVERGENi HBG050832.
InParanoidi Q68A93.
KOi K13072.
OMAi AWAPAVH.
OrthoDBi EOG76MKB6.
TreeFami TF353160.

Enzyme and pathway databases

Reactomei REACT_254648. G alpha (i) signalling events.
REACT_258590. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi 20832527.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression analysis of gene in canine atopic dermatitis."
    Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL25_CANFA
AccessioniPrimary (citable) accession number: Q68A93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 11, 2004
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3