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Q68A93

- CCL25_CANFA

UniProt

Q68A93 - CCL25_CANFA

Protein

C-C motif chemokine 25

Gene

CCL25

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 By similarity.By similarity

    GO - Molecular functioni

    1. chemokine receptor binding Source: UniProtKB

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW
    4. leukocyte migration Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 25
    Alternative name(s):
    Small-inducible cytokine A25
    Gene namesi
    Name:CCL25
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 20

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 151129C-C motif chemokine 25PRO_0000005234Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi29 ↔ 57By similarity
    Disulfide bondi30 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000027121.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68A93.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39655.
    GeneTreeiENSGT00510000049257.
    HOGENOMiHOG000293281.
    HOVERGENiHBG050832.
    InParanoidiQ68A93.
    KOiK13072.
    OMAiAWAPAVH.
    OrthoDBiEOG76MKB6.
    TreeFamiTF353160.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q68A93-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLWLLVCLV ASLMGAWSTV HTQGVSEDCC LAYHHRARPR LLMRAQGYQR    50
    QEVSGSCNLP AVIFFFPKNK MLCVNPRVNW LPNVFKFLDN RNNTHSKQHL 100
    GSRRNLQDSH LGGQRSNTGM SRLAHSKSKS SRSTRSNKKK TSFLNMANPG 150
    P 151
    Length:151
    Mass (Da):17,109
    Last modified:October 11, 2004 - v1
    Checksum:iDC0CD4106B1F922B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB164617 mRNA. Translation: BAD42446.1.
    RefSeqiNP_001005259.1. NM_001005259.1.
    XP_005632371.1. XM_005632314.1.
    XP_005632372.1. XM_005632315.1.
    UniGeneiCfa.15806.

    Genome annotation databases

    EnsembliENSCAFT00000029163; ENSCAFP00000027121; ENSCAFG00000018358.
    GeneIDi448798.
    KEGGicfa:448798.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB164617 mRNA. Translation: BAD42446.1 .
    RefSeqi NP_001005259.1. NM_001005259.1.
    XP_005632371.1. XM_005632314.1.
    XP_005632372.1. XM_005632315.1.
    UniGenei Cfa.15806.

    3D structure databases

    ProteinModelPortali Q68A93.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000027121.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000029163 ; ENSCAFP00000027121 ; ENSCAFG00000018358 .
    GeneIDi 448798.
    KEGGi cfa:448798.

    Organism-specific databases

    CTDi 6370.

    Phylogenomic databases

    eggNOGi NOG39655.
    GeneTreei ENSGT00510000049257.
    HOGENOMi HOG000293281.
    HOVERGENi HBG050832.
    InParanoidi Q68A93.
    KOi K13072.
    OMAi AWAPAVH.
    OrthoDBi EOG76MKB6.
    TreeFami TF353160.

    Miscellaneous databases

    NextBioi 20832527.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression analysis of gene in canine atopic dermatitis."
      Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL25_CANFA
    AccessioniPrimary (citable) accession number: Q68A93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3