Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q68A92

- CCL3_CANFA

UniProt

Q68A92 - CCL3_CANFA

Protein

C-C motif chemokine 3

Gene

CCL3

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
  1. Functioni

    Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 By similarity.By similarity

    GO - Molecular functioni

    1. calcium-dependent protein kinase C activity Source: UniProtKB
    2. chemoattractant activity Source: UniProtKB
    3. chemokine activity Source: UniProtKB
    4. kinase activity Source: UniProtKB
    5. phospholipase activator activity Source: UniProtKB
    6. protein kinase activity Source: UniProtKB

    GO - Biological processi

    1. astrocyte cell migration Source: Ensembl
    2. behavior Source: UniProtKB
    3. calcium ion transport Source: UniProtKB
    4. calcium-mediated signaling Source: UniProtKB
    5. cell activation Source: UniProtKB
    6. cell-cell signaling Source: UniProtKB
    7. cellular calcium ion homeostasis Source: UniProtKB
    8. cellular response to organic cyclic compound Source: UniProtKB
    9. chemotaxis Source: UniProtKB
    10. cytoskeleton organization Source: UniProtKB
    11. eosinophil chemotaxis Source: UniProtKB
    12. eosinophil degranulation Source: UniProtKB
    13. exocytosis Source: UniProtKB
    14. granulocyte chemotaxis Source: UniProtKB
    15. inflammatory response Source: UniProtKB
    16. lipopolysaccharide-mediated signaling pathway Source: UniProtKB
    17. lymphocyte chemotaxis Source: UniProtKB
    18. macrophage chemotaxis Source: Ensembl
    19. MAPK cascade Source: UniProtKB
    20. monocyte chemotaxis Source: UniProtKB
    21. negative regulation by host of viral transcription Source: UniProtKB
    22. negative regulation of gene expression Source: UniProtKB
    23. negative regulation of osteoclast differentiation Source: UniProtKB
    24. neutrophil chemotaxis Source: UniProtKB
    25. osteoblast differentiation Source: UniProtKB
    26. phosphorylation Source: UniProtKB
    27. positive chemotaxis Source: UniProtKB
    28. positive regulation of calcium ion transport Source: UniProtKB
    29. positive regulation of calcium-mediated signaling Source: UniProtKB
    30. positive regulation of catalytic activity Source: GOC
    31. positive regulation of cell migration Source: UniProtKB
    32. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    33. positive regulation of gene expression Source: UniProtKB
    34. positive regulation of inflammatory response Source: Ensembl
    35. positive regulation of interleukin-1 beta secretion Source: Ensembl
    36. positive regulation of natural killer cell chemotaxis Source: UniProtKB
    37. positive regulation of neuron apoptotic process Source: Ensembl
    38. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    39. positive regulation of tumor necrosis factor production Source: Ensembl
    40. protein kinase B signaling Source: UniProtKB
    41. protein phosphorylation Source: UniProtKB
    42. regulation of cell shape Source: UniProtKB
    43. regulation of sensory perception of pain Source: UniProtKB
    44. release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: UniProtKB
    45. response to cholesterol Source: UniProtKB
    46. response to toxic substance Source: UniProtKB
    47. signaling Source: UniProtKB
    48. T cell chemotaxis Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 3
    Alternative name(s):
    Small-inducible cytokine A3
    Gene namesi
    Name:CCL3
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. extracellular space Source: UniProtKB
    4. intracellular Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 9273C-C motif chemokine 3PRO_0000005155Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 57By similarity
    Disulfide bondi34 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000026832.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68A92.
    SMRiQ68A92. Positions 25-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42742.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiQ68A92.
    KOiK05408.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q68A92-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVPGAALAV LLCTMSLCSQ VFSPFGADTP IACCFSYVSK QIPRKFIVDC   50
    FETSSQCSKP GIIFETRKGR QACANPSEAW VQEYVADLKL KA 92
    Length:92
    Mass (Da):10,029
    Last modified:October 11, 2004 - v1
    Checksum:i9D44596B37FD6910
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB164618 mRNA. Translation: BAD42447.1.
    RefSeqiNP_001005251.1. NM_001005251.1.
    UniGeneiCfa.36214.

    Genome annotation databases

    GeneIDi448787.
    KEGGicfa:448787.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB164618 mRNA. Translation: BAD42447.1 .
    RefSeqi NP_001005251.1. NM_001005251.1.
    UniGenei Cfa.36214.

    3D structure databases

    ProteinModelPortali Q68A92.
    SMRi Q68A92. Positions 25-92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000026832.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 448787.
    KEGGi cfa:448787.

    Organism-specific databases

    CTDi 6348.

    Phylogenomic databases

    eggNOGi NOG42742.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi Q68A92.
    KOi K05408.

    Miscellaneous databases

    NextBioi 20832517.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression analysis of gene in canine atopic dermatitis."
      Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL3_CANFA
    AccessioniPrimary (citable) accession number: Q68A92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3