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Q68A92

- CCL3_CANFA

UniProt

Q68A92 - CCL3_CANFA

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Protein
C-C motif chemokine 3
Gene
CCL3
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 By similarity.

GO - Molecular functioni

  1. calcium-dependent protein kinase C activity Source: UniProtKB
  2. chemoattractant activity Source: UniProtKB
  3. chemokine activity Source: UniProtKB
  4. kinase activity Source: UniProtKB
  5. phospholipase activator activity Source: UniProtKB
  6. protein kinase activity Source: UniProtKB

GO - Biological processi

  1. MAPK cascade Source: UniProtKB
  2. T cell chemotaxis Source: UniProtKB
  3. astrocyte cell migration Source: Ensembl
  4. behavior Source: UniProtKB
  5. calcium ion transport Source: UniProtKB
  6. calcium-mediated signaling Source: UniProtKB
  7. cell activation Source: UniProtKB
  8. cell-cell signaling Source: UniProtKB
  9. cellular calcium ion homeostasis Source: UniProtKB
  10. cellular response to organic cyclic compound Source: UniProtKB
  11. chemotaxis Source: UniProtKB
  12. cytoskeleton organization Source: UniProtKB
  13. eosinophil chemotaxis Source: UniProtKB
  14. eosinophil degranulation Source: UniProtKB
  15. exocytosis Source: UniProtKB
  16. granulocyte chemotaxis Source: UniProtKB
  17. inflammatory response Source: UniProtKB
  18. lipopolysaccharide-mediated signaling pathway Source: UniProtKB
  19. lymphocyte chemotaxis Source: UniProtKB
  20. macrophage chemotaxis Source: Ensembl
  21. monocyte chemotaxis Source: UniProtKB
  22. negative regulation by host of viral transcription Source: UniProtKB
  23. negative regulation of gene expression Source: UniProtKB
  24. negative regulation of osteoclast differentiation Source: UniProtKB
  25. neutrophil chemotaxis Source: UniProtKB
  26. osteoblast differentiation Source: UniProtKB
  27. phosphorylation Source: UniProtKB
  28. positive chemotaxis Source: UniProtKB
  29. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  30. positive regulation of calcium ion transport Source: UniProtKB
  31. positive regulation of calcium-mediated signaling Source: UniProtKB
  32. positive regulation of catalytic activity Source: GOC
  33. positive regulation of cell migration Source: UniProtKB
  34. positive regulation of gene expression Source: UniProtKB
  35. positive regulation of inflammatory response Source: Ensembl
  36. positive regulation of interleukin-1 beta secretion Source: Ensembl
  37. positive regulation of natural killer cell chemotaxis Source: UniProtKB
  38. positive regulation of neuron apoptotic process Source: Ensembl
  39. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  40. positive regulation of tumor necrosis factor production Source: Ensembl
  41. protein kinase B signaling Source: UniProtKB
  42. protein phosphorylation Source: UniProtKB
  43. regulation of cell shape Source: UniProtKB
  44. regulation of sensory perception of pain Source: UniProtKB
  45. release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: UniProtKB
  46. response to cholesterol Source: UniProtKB
  47. response to toxic substance Source: UniProtKB
  48. signaling Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 3
Alternative name(s):
Small-inducible cytokine A3
Gene namesi
Name:CCL3
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. intracellular Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 9273C-C motif chemokine 3
PRO_0000005155Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57 By similarity
Disulfide bondi34 ↔ 73 By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000026832.

Structurei

3D structure databases

ProteinModelPortaliQ68A92.
SMRiQ68A92. Positions 25-92.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42742.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ68A92.
KOiK05408.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68A92-1 [UniParc]FASTAAdd to Basket

« Hide

MKVPGAALAV LLCTMSLCSQ VFSPFGADTP IACCFSYVSK QIPRKFIVDC   50
FETSSQCSKP GIIFETRKGR QACANPSEAW VQEYVADLKL KA 92
Length:92
Mass (Da):10,029
Last modified:October 11, 2004 - v1
Checksum:i9D44596B37FD6910
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB164618 mRNA. Translation: BAD42447.1.
RefSeqiNP_001005251.1. NM_001005251.1.
UniGeneiCfa.36214.

Genome annotation databases

GeneIDi448787.
KEGGicfa:448787.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB164618 mRNA. Translation: BAD42447.1 .
RefSeqi NP_001005251.1. NM_001005251.1.
UniGenei Cfa.36214.

3D structure databases

ProteinModelPortali Q68A92.
SMRi Q68A92. Positions 25-92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000026832.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 448787.
KEGGi cfa:448787.

Organism-specific databases

CTDi 6348.

Phylogenomic databases

eggNOGi NOG42742.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q68A92.
KOi K05408.

Miscellaneous databases

NextBioi 20832517.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression analysis of gene in canine atopic dermatitis."
    Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL3_CANFA
AccessioniPrimary (citable) accession number: Q68A92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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