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Q68A92 (CCL3_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 3
Alternative name(s):
Small-inducible cytokine A3
Gene names
Name:CCL3
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from sequence or structural similarity. Source: UniProtKB

T cell chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

astrocyte cell migration

Inferred from electronic annotation. Source: Ensembl

behavior

Inferred from sequence or structural similarity. Source: UniProtKB

calcium ion transport

Inferred from sequence or structural similarity. Source: UniProtKB

calcium-mediated signaling

Inferred from sequence or structural similarity. Source: UniProtKB

cell activation

Inferred from sequence or structural similarity. Source: UniProtKB

cell-cell signaling

Inferred from sequence or structural similarity. Source: UniProtKB

cellular calcium ion homeostasis

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to organic cyclic compound

Inferred from sequence or structural similarity. Source: UniProtKB

chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

cytoskeleton organization

Inferred from sequence or structural similarity. Source: UniProtKB

eosinophil chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

eosinophil degranulation

Inferred from sequence or structural similarity. Source: UniProtKB

exocytosis

Inferred from sequence or structural similarity. Source: UniProtKB

granulocyte chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

inflammatory response

Inferred from sequence or structural similarity. Source: UniProtKB

lipopolysaccharide-mediated signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

lymphocyte chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

macrophage chemotaxis

Inferred from electronic annotation. Source: Ensembl

monocyte chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation by host of viral transcription

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of gene expression

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of osteoclast differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

neutrophil chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

osteoblast differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

positive chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of ERK1 and ERK2 cascade

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of calcium ion transport

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of calcium-mediated signaling

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of catalytic activity

Inferred from sequence or structural similarity. Source: GOC

positive regulation of cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of gene expression

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of inflammatory response

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-1 beta secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of natural killer cell chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor production

Inferred from electronic annotation. Source: Ensembl

protein kinase B signaling

Inferred from sequence or structural similarity. Source: UniProtKB

protein phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of cell shape

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of sensory perception of pain

Inferred from sequence or structural similarity. Source: UniProtKB

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

Inferred from sequence or structural similarity. Source: UniProtKB

response to cholesterol

Inferred from sequence or structural similarity. Source: UniProtKB

response to toxic substance

Inferred from sequence or structural similarity. Source: UniProtKB

signaling

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

cytosol

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular space

Inferred from sequence or structural similarity. Source: UniProtKB

intracellular

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functioncalcium-dependent protein kinase C activity

Inferred from sequence or structural similarity. Source: UniProtKB

chemoattractant activity

Inferred from sequence or structural similarity. Source: UniProtKB

chemokine activity

Inferred from sequence or structural similarity. Source: UniProtKB

kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

phospholipase activator activity

Inferred from sequence or structural similarity. Source: UniProtKB

protein kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 9273C-C motif chemokine 3
PRO_0000005155

Amino acid modifications

Disulfide bond33 ↔ 57 By similarity
Disulfide bond34 ↔ 73 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68A92 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 9D44596B37FD6910

FASTA9210,029
        10         20         30         40         50         60 
MKVPGAALAV LLCTMSLCSQ VFSPFGADTP IACCFSYVSK QIPRKFIVDC FETSSQCSKP 

        70         80         90 
GIIFETRKGR QACANPSEAW VQEYVADLKL KA 

« Hide

References

[1]"Expression analysis of gene in canine atopic dermatitis."
Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB164618 mRNA. Translation: BAD42447.1.
RefSeqNP_001005251.1. NM_001005251.1.
UniGeneCfa.36214.

3D structure databases

ProteinModelPortalQ68A92.
SMRQ68A92. Positions 25-92.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000026832.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID448787.
KEGGcfa:448787.

Organism-specific databases

CTD6348.

Phylogenomic databases

eggNOGNOG42742.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidQ68A92.
KOK05408.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20832517.

Entry information

Entry nameCCL3_CANFA
AccessionPrimary (citable) accession number: Q68A92
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families