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Protein

C-C motif chemokine 28

Gene

CCL28

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner (By similarity).By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. negative regulation of leukocyte tethering or rolling Source: Ensembl
  4. positive regulation of cell-matrix adhesion Source: Ensembl
  5. positive regulation of cytosolic calcium ion concentration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_299681. Chemokine receptors bind chemokines.
REACT_311133. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 28
Alternative name(s):
Small-inducible cytokine A28
Gene namesi
Name:CCL28
Synonyms:SCYA28
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254 Componenti: Chromosome 4

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 128104C-C motif chemokine 28PRO_0000005241Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 60By similarity
Disulfide bondi33 ↔ 75By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000031374.

Structurei

3D structure databases

ProteinModelPortaliQ68A91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41057.
GeneTreeiENSGT00530000063923.
HOGENOMiHOG000036970.
HOVERGENiHBG101413.
InParanoidiQ68A91.
KOiK05513.
OMAiGNICHKK.
OrthoDBiEOG70W3G4.
TreeFamiTF337014.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68A91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQTGLTLAL VALAVCVALP SSEAILPIAS SCCTEVSHHI SRRLLERVNI
60 70 80 90 100
CRIQRADGDC DLAAVILHVR RRRLCVSPHS HVIKQWMKEQ AAKKNTKGNI
110 120
CHKKQAGKRK SKGAHQEKPE IHSHKSPY
Length:128
Mass (Da):14,258
Last modified:October 10, 2004 - v1
Checksum:i617666AA64BDF1F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164619 mRNA. Translation: BAD42448.1.
RefSeqiNP_001005257.1. NM_001005257.1.
UniGeneiCfa.15807.

Genome annotation databases

EnsembliENSCAFT00000036043; ENSCAFP00000031374; ENSCAFG00000023453.
GeneIDi448795.
KEGGicfa:448795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB164619 mRNA. Translation: BAD42448.1.
RefSeqiNP_001005257.1. NM_001005257.1.
UniGeneiCfa.15807.

3D structure databases

ProteinModelPortaliQ68A91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000031374.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000036043; ENSCAFP00000031374; ENSCAFG00000023453.
GeneIDi448795.
KEGGicfa:448795.

Organism-specific databases

CTDi56477.

Phylogenomic databases

eggNOGiNOG41057.
GeneTreeiENSGT00530000063923.
HOGENOMiHOG000036970.
HOVERGENiHBG101413.
InParanoidiQ68A91.
KOiK05513.
OMAiGNICHKK.
OrthoDBiEOG70W3G4.
TreeFamiTF337014.

Enzyme and pathway databases

ReactomeiREACT_299681. Chemokine receptors bind chemokines.
REACT_311133. G alpha (i) signalling events.

Miscellaneous databases

NextBioi20832525.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression analysis of gene in canine atopic dermatitis."
    Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL28_CANFA
AccessioniPrimary (citable) accession number: Q68A91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2005
Last sequence update: October 10, 2004
Last modified: March 31, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.