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Q68A91 (CCL28_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 28
Alternative name(s):
Small-inducible cytokine A28
Gene names
Name:CCL28
Synonyms:SCYA28
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length128 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 128104C-C motif chemokine 28
PRO_0000005241

Amino acid modifications

Disulfide bond32 ↔ 60 By similarity
Disulfide bond33 ↔ 75 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68A91 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 617666AA64BDF1F5

FASTA12814,258
        10         20         30         40         50         60 
MQQTGLTLAL VALAVCVALP SSEAILPIAS SCCTEVSHHI SRRLLERVNI CRIQRADGDC 

        70         80         90        100        110        120 
DLAAVILHVR RRRLCVSPHS HVIKQWMKEQ AAKKNTKGNI CHKKQAGKRK SKGAHQEKPE 


IHSHKSPY 

« Hide

References

[1]"Expression analysis of gene in canine atopic dermatitis."
Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB164619 mRNA. Translation: BAD42448.1.
RefSeqNP_001005257.1. NM_001005257.1.
UniGeneCfa.15807.

3D structure databases

ProteinModelPortalQ68A91.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000031374.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000036043; ENSCAFP00000031374; ENSCAFG00000023453.
GeneID448795.
KEGGcfa:448795.

Organism-specific databases

CTD56477.

Phylogenomic databases

eggNOGNOG41057.
GeneTreeENSGT00530000063923.
HOGENOMHOG000036970.
HOVERGENHBG101413.
InParanoidQ68A91.
KOK05513.
OMAHVIKQWM.
OrthoDBEOG70W3G4.
TreeFamTF337014.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20832525.

Entry information

Entry nameCCL28_CANFA
AccessionPrimary (citable) accession number: Q68A91
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families