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Q68A91

- CCL28_CANFA

UniProt

Q68A91 - CCL28_CANFA

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Protein
C-C motif chemokine 28
Gene
CCL28, SCYA28
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner By similarity.

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. positive regulation of cytosolic calcium ion concentration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 28
Alternative name(s):
Small-inducible cytokine A28
Gene namesi
Name:CCL28
Synonyms:SCYA28
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 4

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 128104C-C motif chemokine 28
PRO_0000005241Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 60 By similarity
Disulfide bondi33 ↔ 75 By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000031374.

Structurei

3D structure databases

ProteinModelPortaliQ68A91.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41057.
GeneTreeiENSGT00530000063923.
HOGENOMiHOG000036970.
HOVERGENiHBG101413.
InParanoidiQ68A91.
KOiK05513.
OMAiHVIKQWM.
OrthoDBiEOG70W3G4.
TreeFamiTF337014.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68A91-1 [UniParc]FASTAAdd to Basket

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MQQTGLTLAL VALAVCVALP SSEAILPIAS SCCTEVSHHI SRRLLERVNI    50
CRIQRADGDC DLAAVILHVR RRRLCVSPHS HVIKQWMKEQ AAKKNTKGNI 100
CHKKQAGKRK SKGAHQEKPE IHSHKSPY 128
Length:128
Mass (Da):14,258
Last modified:October 11, 2004 - v1
Checksum:i617666AA64BDF1F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB164619 mRNA. Translation: BAD42448.1.
RefSeqiNP_001005257.1. NM_001005257.1.
UniGeneiCfa.15807.

Genome annotation databases

EnsembliENSCAFT00000036043; ENSCAFP00000031374; ENSCAFG00000023453.
GeneIDi448795.
KEGGicfa:448795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB164619 mRNA. Translation: BAD42448.1 .
RefSeqi NP_001005257.1. NM_001005257.1.
UniGenei Cfa.15807.

3D structure databases

ProteinModelPortali Q68A91.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000031374.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000036043 ; ENSCAFP00000031374 ; ENSCAFG00000023453 .
GeneIDi 448795.
KEGGi cfa:448795.

Organism-specific databases

CTDi 56477.

Phylogenomic databases

eggNOGi NOG41057.
GeneTreei ENSGT00530000063923.
HOGENOMi HOG000036970.
HOVERGENi HBG101413.
InParanoidi Q68A91.
KOi K05513.
OMAi HVIKQWM.
OrthoDBi EOG70W3G4.
TreeFami TF337014.

Miscellaneous databases

NextBioi 20832525.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression analysis of gene in canine atopic dermatitis."
    Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL28_CANFA
AccessioniPrimary (citable) accession number: Q68A91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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