Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q689D1 (TLR2_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Toll-like receptor 2
Alternative name(s):
CD_antigen=CD282
Gene names
Name:TLR2
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length785 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins By similarity.

Subunit structure

Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1 or TLR6. Interacts with CNPY3. Interacts with ATG16L1 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Domain

Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12 By similarity.

The ATG16L1-binding motif mediates interaction with ATG16L1 By similarity.

Sequence similarities

Belongs to the Toll-like receptor family.

Contains 19 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 TIR domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 785768Toll-like receptor 2
PRO_0000034708

Regions

Topological domain18 – 589572Extracellular Potential
Transmembrane590 – 61021Helical; Potential
Topological domain611 – 785175Cytoplasmic Potential
Repeat54 – 7724LRR 1
Repeat78 – 10124LRR 2
Repeat102 – 12524LRR 3
Repeat126 – 15025LRR 4
Repeat151 – 17525LRR 5
Repeat176 – 19924LRR 6
Repeat200 – 22324LRR 7
Repeat224 – 25027LRR 8
Repeat251 – 27828LRR 9
Repeat279 – 30830LRR 10
Repeat309 – 33729LRR 11
Repeat338 – 36124LRR 12
Repeat362 – 38827LRR 13
Repeat389 – 41426LRR 14
Repeat415 – 43723LRR 15
Repeat438 – 45720LRR 16
Repeat458 – 47821LRR 17
Repeat479 – 50022LRR 18
Repeat501 – 52424LRR 19
Domain525 – 57955LRRCT
Domain640 – 785146TIR
Motif762 – 77918ATG16L1-binding motif

Sites

Site3501Interaction with bacterial lipopeptide By similarity

Amino acid modifications

Glycosylation1151N-linked (GlcNAc...) Potential
Glycosylation2001N-linked (GlcNAc...) Potential
Glycosylation2461N-linked (GlcNAc...) Potential
Glycosylation4151N-linked (GlcNAc...) Potential
Glycosylation4431N-linked (GlcNAc...) Potential
Disulfide bond31 ↔ 37 By similarity
Disulfide bond354 ↔ 383 By similarity
Disulfide bond433 ↔ 455 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q689D1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 717606848DD91881

FASTA78590,277
        10         20         30         40         50         60 
MSRVLWTLWV LGAVTNLSKE EAPDQSSSLS CDPTGVCDGR SRSLNSMPSG LTAAVRSLDL 

        70         80         90        100        110        120 
SNNEITYIGN SDLRDCVNLK ALRLESNGIN TIEEESFLSL WSLEHLDLSY NLLSNLSSSW 

       130        140        150        160        170        180 
FRPLSSLKFL NLLGNPYKSL GETPLFSQLT NLRILKVGNI YSFTEIQDKD FAGLTFLEEL 

       190        200        210        220        230        240 
EIDASNLQRY EPKSLKSIQN ISYLALRMKQ PVLLVEIFVD LSSSLKHLEL RDTHLDTFHF 

       250        260        270        280        290        300 
SEASINETHT LVKKWTFRNV KVTDRSFTGV VRLLNYVSGV LEVEFEDCTL YGLGDFDIPD 

       310        320        330        340        350        360 
VDKIKNIGQI ETLTVRRLHI PHFYSFYDMS SIYSLTEDVK RITVENSKVF LVPCLLSQHL 

       370        380        390        400        410        420 
KSLEYLDLSE NLMVEEYLKN SACEDAWPSL QTLVLRQNHL ASLERTGETL LTLKNLTNID 

       430        440        450        460        470        480 
ISKNSFHSMP ETCQWPEKMK YLNLSSTRIH SVTGCIPKTL EILDVSNNNL NLFSLNLPQL 

       490        500        510        520        530        540 
KELYISRNKL MTLPDASLLP MLLVLKISRN AITTFSKEQL DSFHTLKTLE AGGNNFICSC 

       550        560        570        580        590        600 
EFLSFTQEQQ ALAKVLIDWP ANYLCDSPSH VRGQQVQDVR LSVSECHRTA LVSGMCCALF 

       610        620        630        640        650        660 
LLILLTEVLC HRFHGLWYMR MMWAWLQAKR KPRKAPSRDV CYDAFVSYSE HDSYWVENLL 

       670        680        690        700        710        720 
VQKLEHFNPP FKLCLHKRDF IPGKWIIDNI IDSIEKSRKT IFVLSENFVK SEWCKYELDF 

       730        740        750        760        770        780 
SHFRLFDENS DAAILILLEP IEKKAIPQRF CKLRKIMNTK TYLEWPTDDA QQEGFWLNLR 


TAIKS 

« Hide

References

[1]"Molecular cloning of canine Toll-like receptor 2 (TLR2) gene."
Ishii M., Kano R., Hasegawa A.
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB189639 mRNA. Translation: BAD42423.1.
UniGeneCfa.15802.

3D structure databases

ProteinModelPortalQ689D1.
SMRQ689D1. Positions 28-554, 640-785.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ689D1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG251801.
HOGENOMHOG000110611.
HOVERGENHBG108574.
InParanoidQ689D1.

Family and domain databases

Gene3D3.40.50.10140. 1 hit.
InterProIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027185. TLR2.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERPTHR24365:SF17. PTHR24365:SF17. 1 hit.
PfamPF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFPIRSF037595. Toll-like_receptor. 1 hit.
SMARTSM00369. LRR_TYP. 1 hit.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMSSF52200. SSF52200. 1 hit.
PROSITEPS51450. LRR. 11 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTLR2_CANFA
AccessionPrimary (citable) accession number: Q689D1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families