ID   Q68978_HHV1             Unreviewed;       626 AA.
AC   Q68978;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   25-JAN-2012, entry version 38.
DE   SubName: Full=Alkaline exonuclease;
DE   SubName: Full=UL12;
GN   Name=UL12;
OS   Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
OC   Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10298;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=86144016; PubMed=3005609;
RA   Draper K.G., Devi-Rao G., Costa R.H., Blair E.D., Thompson R.L.,
RA   Wagner E.K.;
RT   "Characterization of the genes encoding herpes simplex virus type 1
RT   and type 2 alkaline exonucleases and overlapping proteins.";
RL   J. Virol. 57:1023-1036(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=84036396; PubMed=6313961;
RA   Costa R.H., Draper K.G., Banks L., Powell K.L., Cohen G.,
RA   Eisenberg R., Wagner E.K.;
RT   "High-resolution characterization of herpes simplex virus type 1
RT   transcripts encoding alkaline exonuclease and a 50,000-dalton protein
RT   tentatively identified as a capsid protein.";
RL   J. Virol. 48:591-603(1983).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CJ360;
RX   PubMed=22016062;
RA   Kolb A.W., Adams M., Cabot E.L., Craven M., Brandt C.R.;
RT   "Multiplex Sequencing of Seven Ocular Herpes Simplex Virus Type-1
RT   Genomes: Phylogeny, Sequence Variability and SNP Distribution.";
RL   Invest. Ophthalmol. Vis. Sci. 0:0-0(2011).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HF;
RX   PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA   Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT   "Determination and analysis of the DNA sequence of highly attenuated
RT   herpes simplex virus type 1 mutant HF10, a potential oncolytic
RT   virus.";
RL   Microbes Infect. 9:142-149(2007).
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DR   EMBL; K02022; AAA45771.1; -; Genomic_DNA.
DR   EMBL; DQ889502; ABI63474.1; -; Genomic_DNA.
DR   EMBL; JN420339; AER37806.1; -; Genomic_DNA.
DR   ProteinModelPortal; Q68978; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011604; Exonuc_phg/RecB_C.
DR   InterPro; IPR001616; Herpes_alk_exo.
DR   InterPro; IPR011335; Restrct_endonuc_II-like.
DR   Gene3D; G3DSA:3.90.320.10; Exonuc_phg/RecB_C; 1.
DR   Pfam; PF01771; Herpes_alk_exo; 1.
DR   PRINTS; PR00924; ALKEXNUCLASE.
DR   SUPFAM; SSF52980; Restrict_endonuc_II-like_core; 1.
PE   4: Predicted;
KW   Exonuclease; Hydrolase; Nuclease.
SQ   SEQUENCE   626 AA;  67470 MW;  A651D03A29C70260 CRC64;
     MESTGGPACP PGRTVTKRSW ALAEDTPRGP DSPPKRPRPN SLPLTTTFRP LPPPPQTTSA
     VDPSSHSPVN PPRDQHATDT ADEKPRAASP ALSDASGPPT PDIPLSPGGT HARDPDADPD
     SPDLDSMWSA SVIPNALPSH ILAETFERHL RGLLRGVRAP LAIGPLWARL DYLCSLAVVL
     EEAGMVDRGL GRHLWRLTRR APPAAADAVA PRPLMGFYEA ATQNQADCQL WALLRRGLTT
     ASTLRWGPQG PCFSPQWLKH NASLRPDVQS SAVMFGRVNE PTARSLLFRY CVGRADDGGE
     AGADTRRFIF HEPSDLAEEN VHTCGVLMDG HTGMVGASLD ILVCPRDIHG YLAPVPKTPL
     AFYEVKCRAK YAFDPMDPSD PTASAYEDLM AHRSPEAFRA FIRSIPKPSV RYFAPGRVPG
     PEEALVTQDQ AWSEAHASGE KRRCSAADRA LVELNSGVVS EVLLFGAPDL GRHTISPVSW
     SSGDLVRREP VFANPRHPNF KQILVQGYVL DSHFPDCPPH PHLVTFIGRH RTSAEEGVTF
     RLEDGAGALG AAGPSKASIL PNQAVPIALI ITPVRIDPEI YKAIQRSSRL AFDDTLAELW
     ASRSPGPGPA AAETTSSSPT TGRSSR
//