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Q68978

- Q68978_HHV1

UniProt

Q68978 - Q68978_HHV1

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Protein
Submitted name:

Alkaline exonuclease

Gene

AE

Organism
Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. exonuclease activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA double-strand break processing involved in repair via single-strand annealing Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

ExonucleaseImported, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Submitted name:
Alkaline exonucleaseImported
Submitted name:
UL12Imported
Gene namesi
Name:AEImported
Synonyms:UL12Imported
OrganismiHuman herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)Imported
Taxonomic identifieri10298 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Structurei

3D structure databases

ProteinModelPortaliQ68978.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.90.320.10. 1 hit.
InterProiIPR011604. Exonuc_phg/RecB_C.
IPR001616. Herpes_alk_exo.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF01771. Herpes_alk_exo. 1 hit.
[Graphical view]
PRINTSiPR00924. ALKEXNUCLASE.
SUPFAMiSSF52980. SSF52980. 2 hits.

Sequencei

Sequence statusi: Complete.

Q68978 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MESTGGPACP PGRTVTKRSW ALAEDTPRGP DSPPKRPRPN SLPLTTTFRP
60 70 80 90 100
LPPPPQTTSA VDPSSHSPVN PPRDQHATDT ADEKPRAASP ALSDASGPPT
110 120 130 140 150
PDIPLSPGGT HARDPDADPD SPDLDSMWSA SVIPNALPSH ILAETFERHL
160 170 180 190 200
RGLLRGVRAP LAIGPLWARL DYLCSLAVVL EEAGMVDRGL GRHLWRLTRR
210 220 230 240 250
APPAAADAVA PRPLMGFYEA ATQNQADCQL WALLRRGLTT ASTLRWGPQG
260 270 280 290 300
PCFSPQWLKH NASLRPDVQS SAVMFGRVNE PTARSLLFRY CVGRADDGGE
310 320 330 340 350
AGADTRRFIF HEPSDLAEEN VHTCGVLMDG HTGMVGASLD ILVCPRDIHG
360 370 380 390 400
YLAPVPKTPL AFYEVKCRAK YAFDPMDPSD PTASAYEDLM AHRSPEAFRA
410 420 430 440 450
FIRSIPKPSV RYFAPGRVPG PEEALVTQDQ AWSEAHASGE KRRCSAADRA
460 470 480 490 500
LVELNSGVVS EVLLFGAPDL GRHTISPVSW SSGDLVRREP VFANPRHPNF
510 520 530 540 550
KQILVQGYVL DSHFPDCPPH PHLVTFIGRH RTSAEEGVTF RLEDGAGALG
560 570 580 590 600
AAGPSKASIL PNQAVPIALI ITPVRIDPEI YKAIQRSSRL AFDDTLAELW
610 620
ASRSPGPGPA AAETTSSSPT TGRSSR
Length:626
Mass (Da):67,470
Last modified:November 1, 1996 - v1
Checksum:iA651D03A29C70260
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K02022 Genomic DNA. Translation: AAA45771.1.
DQ889502 Genomic DNA. Translation: ABI63474.1.
JN420339 Genomic DNA. Translation: AER37806.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K02022 Genomic DNA. Translation: AAA45771.1 .
DQ889502 Genomic DNA. Translation: ABI63474.1 .
JN420339 Genomic DNA. Translation: AER37806.1 .

3D structure databases

ProteinModelPortali Q68978.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.90.320.10. 1 hit.
InterProi IPR011604. Exonuc_phg/RecB_C.
IPR001616. Herpes_alk_exo.
IPR011335. Restrct_endonuc-II-like.
[Graphical view ]
Pfami PF01771. Herpes_alk_exo. 1 hit.
[Graphical view ]
PRINTSi PR00924. ALKEXNUCLASE.
SUPFAMi SSF52980. SSF52980. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "High-resolution characterization of herpes simplex virus type 1 transcripts encoding alkaline exonuclease and a 50,000-dalton protein tentatively identified as a capsid protein."
    Costa R.H., Draper K.G., Banks L., Powell K.L., Cohen G., Eisenberg R., Wagner E.K.
    J. Virol. 48:591-603(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Characterization of the genes encoding herpes simplex virus type 1 and type 2 alkaline exonucleases and overlapping proteins."
    Draper K.G., Devi-Rao G., Costa R.H., Blair E.D., Thompson R.L., Wagner E.K.
    J. Virol. 57:1023-1036(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HFImported.
  4. "Multiplex sequencing of seven ocular herpes simplex virus type-1 genomes: phylogeny, sequence variability, and SNP distribution."
    Kolb A.W., Adams M., Cabot E.L., Craven M., Brandt C.R.
    Invest. Ophthalmol. Vis. Sci. 52:9061-9073(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CJ360Imported.

Entry informationi

Entry nameiQ68978_HHV1
AccessioniPrimary (citable) accession number: Q68978
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)