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Q68978

- Q68978_HHV1

UniProt

Q68978 - Q68978_HHV1

Protein
Submitted name:

Alkaline exonuclease

Gene

AE

Organism
Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. exonuclease activity Source: UniProtKB-KW

    GO - Biological processi

    1. DNA double-strand break processing involved in repair via single-strand annealing Source: CACAO

    Keywords - Molecular functioni

    ExonucleaseImported, Hydrolase, Nuclease

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Alkaline exonucleaseImported
    Submitted name:
    UL12Imported
    Gene namesi
    Name:AEImported
    Synonyms:UL12Imported
    OrganismiHuman herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)Imported
    Taxonomic identifieri10298 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Structurei

    3D structure databases

    ProteinModelPortaliQ68978.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di3.90.320.10. 1 hit.
    InterProiIPR011604. Exonuc_phg/RecB_C.
    IPR001616. Herpes_alk_exo.
    IPR011335. Restrct_endonuc-II-like.
    [Graphical view]
    PfamiPF01771. Herpes_alk_exo. 1 hit.
    [Graphical view]
    PRINTSiPR00924. ALKEXNUCLASE.
    SUPFAMiSSF52980. SSF52980. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q68978-1 [UniParc]FASTAAdd to Basket

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    MESTGGPACP PGRTVTKRSW ALAEDTPRGP DSPPKRPRPN SLPLTTTFRP    50
    LPPPPQTTSA VDPSSHSPVN PPRDQHATDT ADEKPRAASP ALSDASGPPT 100
    PDIPLSPGGT HARDPDADPD SPDLDSMWSA SVIPNALPSH ILAETFERHL 150
    RGLLRGVRAP LAIGPLWARL DYLCSLAVVL EEAGMVDRGL GRHLWRLTRR 200
    APPAAADAVA PRPLMGFYEA ATQNQADCQL WALLRRGLTT ASTLRWGPQG 250
    PCFSPQWLKH NASLRPDVQS SAVMFGRVNE PTARSLLFRY CVGRADDGGE 300
    AGADTRRFIF HEPSDLAEEN VHTCGVLMDG HTGMVGASLD ILVCPRDIHG 350
    YLAPVPKTPL AFYEVKCRAK YAFDPMDPSD PTASAYEDLM AHRSPEAFRA 400
    FIRSIPKPSV RYFAPGRVPG PEEALVTQDQ AWSEAHASGE KRRCSAADRA 450
    LVELNSGVVS EVLLFGAPDL GRHTISPVSW SSGDLVRREP VFANPRHPNF 500
    KQILVQGYVL DSHFPDCPPH PHLVTFIGRH RTSAEEGVTF RLEDGAGALG 550
    AAGPSKASIL PNQAVPIALI ITPVRIDPEI YKAIQRSSRL AFDDTLAELW 600
    ASRSPGPGPA AAETTSSSPT TGRSSR 626
    Length:626
    Mass (Da):67,470
    Last modified:November 1, 1996 - v1
    Checksum:iA651D03A29C70260
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02022 Genomic DNA. Translation: AAA45771.1.
    DQ889502 Genomic DNA. Translation: ABI63474.1.
    JN420339 Genomic DNA. Translation: AER37806.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02022 Genomic DNA. Translation: AAA45771.1 .
    DQ889502 Genomic DNA. Translation: ABI63474.1 .
    JN420339 Genomic DNA. Translation: AER37806.1 .

    3D structure databases

    ProteinModelPortali Q68978.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.90.320.10. 1 hit.
    InterProi IPR011604. Exonuc_phg/RecB_C.
    IPR001616. Herpes_alk_exo.
    IPR011335. Restrct_endonuc-II-like.
    [Graphical view ]
    Pfami PF01771. Herpes_alk_exo. 1 hit.
    [Graphical view ]
    PRINTSi PR00924. ALKEXNUCLASE.
    SUPFAMi SSF52980. SSF52980. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "High-resolution characterization of herpes simplex virus type 1 transcripts encoding alkaline exonuclease and a 50,000-dalton protein tentatively identified as a capsid protein."
      Costa R.H., Draper K.G., Banks L., Powell K.L., Cohen G., Eisenberg R., Wagner E.K.
      J. Virol. 48:591-603(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Characterization of the genes encoding herpes simplex virus type 1 and type 2 alkaline exonucleases and overlapping proteins."
      Draper K.G., Devi-Rao G., Costa R.H., Blair E.D., Thompson R.L., Wagner E.K.
      J. Virol. 57:1023-1036(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
      Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
      Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: HFImported.
    4. "Multiplex sequencing of seven ocular herpes simplex virus type-1 genomes: phylogeny, sequence variability, and SNP distribution."
      Kolb A.W., Adams M., Cabot E.L., Craven M., Brandt C.R.
      Invest. Ophthalmol. Vis. Sci. 52:9061-9073(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CJ360Imported.

    Entry informationi

    Entry nameiQ68978_HHV1
    AccessioniPrimary (citable) accession number: Q68978
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)