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Protein
Submitted name:

Alkaline exonuclease

Gene

AE

Organism
Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ExonucleaseImported, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Submitted name:
Alkaline exonucleaseImported
Submitted name:
UL12Imported
Gene namesi
Name:AEImported
Synonyms:UL12Imported
OrganismiHuman herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)Imported
Taxonomic identifieri10298 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Structurei

3D structure databases

ProteinModelPortaliQ68978.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.90.320.10. 1 hit.
InterProiIPR011604. Exonuc_phg/RecB_C.
IPR001616. Herpes_alk_exo.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF01771. Herpes_alk_exo. 1 hit.
[Graphical view]
PRINTSiPR00924. ALKEXNUCLASE.
SUPFAMiSSF52980. SSF52980. 2 hits.

Sequencei

Sequence statusi: Complete.

Q68978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTGGPACP PGRTVTKRSW ALAEDTPRGP DSPPKRPRPN SLPLTTTFRP
60 70 80 90 100
LPPPPQTTSA VDPSSHSPVN PPRDQHATDT ADEKPRAASP ALSDASGPPT
110 120 130 140 150
PDIPLSPGGT HARDPDADPD SPDLDSMWSA SVIPNALPSH ILAETFERHL
160 170 180 190 200
RGLLRGVRAP LAIGPLWARL DYLCSLAVVL EEAGMVDRGL GRHLWRLTRR
210 220 230 240 250
APPAAADAVA PRPLMGFYEA ATQNQADCQL WALLRRGLTT ASTLRWGPQG
260 270 280 290 300
PCFSPQWLKH NASLRPDVQS SAVMFGRVNE PTARSLLFRY CVGRADDGGE
310 320 330 340 350
AGADTRRFIF HEPSDLAEEN VHTCGVLMDG HTGMVGASLD ILVCPRDIHG
360 370 380 390 400
YLAPVPKTPL AFYEVKCRAK YAFDPMDPSD PTASAYEDLM AHRSPEAFRA
410 420 430 440 450
FIRSIPKPSV RYFAPGRVPG PEEALVTQDQ AWSEAHASGE KRRCSAADRA
460 470 480 490 500
LVELNSGVVS EVLLFGAPDL GRHTISPVSW SSGDLVRREP VFANPRHPNF
510 520 530 540 550
KQILVQGYVL DSHFPDCPPH PHLVTFIGRH RTSAEEGVTF RLEDGAGALG
560 570 580 590 600
AAGPSKASIL PNQAVPIALI ITPVRIDPEI YKAIQRSSRL AFDDTLAELW
610 620
ASRSPGPGPA AAETTSSSPT TGRSSR
Length:626
Mass (Da):67,470
Last modified:November 1, 1996 - v1
Checksum:iA651D03A29C70260
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02022 Genomic DNA. Translation: AAA45771.1.
DQ889502 Genomic DNA. Translation: ABI63474.1.
JN420339 Genomic DNA. Translation: AER37806.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02022 Genomic DNA. Translation: AAA45771.1.
DQ889502 Genomic DNA. Translation: ABI63474.1.
JN420339 Genomic DNA. Translation: AER37806.1.

3D structure databases

ProteinModelPortaliQ68978.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.90.320.10. 1 hit.
InterProiIPR011604. Exonuc_phg/RecB_C.
IPR001616. Herpes_alk_exo.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF01771. Herpes_alk_exo. 1 hit.
[Graphical view]
PRINTSiPR00924. ALKEXNUCLASE.
SUPFAMiSSF52980. SSF52980. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "High-resolution characterization of herpes simplex virus type 1 transcripts encoding alkaline exonuclease and a 50,000-dalton protein tentatively identified as a capsid protein."
    Costa R.H., Draper K.G., Banks L., Powell K.L., Cohen G., Eisenberg R., Wagner E.K.
    J. Virol. 48:591-603(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Characterization of the genes encoding herpes simplex virus type 1 and type 2 alkaline exonucleases and overlapping proteins."
    Draper K.G., Devi-Rao G., Costa R.H., Blair E.D., Thompson R.L., Wagner E.K.
    J. Virol. 57:1023-1036(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HFImported.
  4. "Multiplex sequencing of seven ocular herpes simplex virus type-1 genomes: phylogeny, sequence variability, and SNP distribution."
    Kolb A.W., Adams M., Cabot E.L., Craven M., Brandt C.R.
    Invest. Ophthalmol. Vis. Sci. 52:9061-9073(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CJ360Imported.

Entry informationi

Entry nameiQ68978_HHV1
AccessioniPrimary (citable) accession number: Q68978
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.