Q68978 (Q68978_HHV1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Alkaline exonuclease EMBL AAA45771.1

Submitted name:
UL12 EMBL ABI63474.1

Gene names

Name:	AE EMBL AAA45771.1
Synonyms:	UL12 EMBL AER37806.1

Organism

Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1) EMBL AAA45771.1

Taxonomic identifier

10298 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	626 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Molecular function	Exonuclease EMBL AAA45771.1 Hydrolase Nuclease
Gene Ontology (GO)
Biological_process	nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro exonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q68978 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: A651D03A29C70260	FASTA	626	67,470
	10 20 30 40 50 60 MESTGGPACP PGRTVTKRSW ALAEDTPRGP DSPPKRPRPN SLPLTTTFRP LPPPPQTTSA 70 80 90 100 110 120 VDPSSHSPVN PPRDQHATDT ADEKPRAASP ALSDASGPPT PDIPLSPGGT HARDPDADPD 130 140 150 160 170 180 SPDLDSMWSA SVIPNALPSH ILAETFERHL RGLLRGVRAP LAIGPLWARL DYLCSLAVVL 190 200 210 220 230 240 EEAGMVDRGL GRHLWRLTRR APPAAADAVA PRPLMGFYEA ATQNQADCQL WALLRRGLTT 250 260 270 280 290 300 ASTLRWGPQG PCFSPQWLKH NASLRPDVQS SAVMFGRVNE PTARSLLFRY CVGRADDGGE 310 320 330 340 350 360 AGADTRRFIF HEPSDLAEEN VHTCGVLMDG HTGMVGASLD ILVCPRDIHG YLAPVPKTPL 370 380 390 400 410 420 AFYEVKCRAK YAFDPMDPSD PTASAYEDLM AHRSPEAFRA FIRSIPKPSV RYFAPGRVPG 430 440 450 460 470 480 PEEALVTQDQ AWSEAHASGE KRRCSAADRA LVELNSGVVS EVLLFGAPDL GRHTISPVSW 490 500 510 520 530 540 SSGDLVRREP VFANPRHPNF KQILVQGYVL DSHFPDCPPH PHLVTFIGRH RTSAEEGVTF 550 560 570 580 590 600 RLEDGAGALG AAGPSKASIL PNQAVPIALI ITPVRIDPEI YKAIQRSSRL AFDDTLAELW 610 620 ASRSPGPGPA AAETTSSSPT TGRSSR

References

[1]	"High-resolution characterization of herpes simplex virus type 1 transcripts encoding alkaline exonuclease and a 50,000-dalton protein tentatively identified as a capsid protein." Costa R.H., Draper K.G., Banks L., Powell K.L., Cohen G., Eisenberg R., Wagner E.K. J. Virol. 48:591-603(1983) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Characterization of the genes encoding herpes simplex virus type 1 and type 2 alkaline exonucleases and overlapping proteins." Draper K.G., Devi-Rao G., Costa R.H., Blair E.D., Thompson R.L., Wagner E.K. J. Virol. 57:1023-1036(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus." Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y. Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: HF EMBL ABI63474.1.
[4]	"Multiplex Sequencing of Seven Ocular Herpes Simplex Virus Type-1 Genomes: Phylogeny, Sequence Variability and SNP Distribution." Kolb A.W., Adams M., Cabot E.L., Craven M., Brandt C.R. Invest. Ophthalmol. Vis. Sci. 0:0-0(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: CJ360 EMBL AER37806.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	K02022 Genomic DNA. Translation: AAA45771.1. DQ889502 Genomic DNA. Translation: ABI63474.1. JN420339 Genomic DNA. Translation: AER37806.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.90.320.10. 1 hit.
InterPro	IPR011604. Exonuc_phg/RecB_C. IPR001616. Herpes_alk_exo. IPR011335. Restrct_endonuc-II-like. [Graphical view]
Pfam	PF01771. Herpes_alk_exo. 1 hit. [Graphical view]
PRINTS	PR00924. ALKEXNUCLASE.
SUPFAM	SSF52980. Restrict_endonuc_II-like_core. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q68978_HHV1

Accession

Primary (citable) accession number: Q68978

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)