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Protein

Interleukin-17A

Gene

IL17A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiR-BTA-448424. Interleukin-17 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17A
Short name:
IL-17
Short name:
IL-17A
Gene namesi
Name:IL17A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000022750024 – 153Interleukin-17AAdd BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi92 ↔ 142By similarity
Disulfide bondi97 ↔ 144By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ687Y7.
PRIDEiQ687Y7.

Interactioni

Subunit structurei

Homodimer. Heterodimer with IL17F.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002786.

Structurei

3D structure databases

ProteinModelPortaliQ687Y7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J12P. Eukaryota.
ENOG410YS4N. LUCA.
GeneTreeiENSGT00730000110824.
HOGENOMiHOG000064520.
HOVERGENiHBG006143.
InParanoidiQ687Y7.
KOiK05489.
OMAiHMNSVPI.
OrthoDBiEOG091G0RG1.
TreeFamiTF314701.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q687Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASMRTSSMS LLLLLSLVAL VKAGVIIPQS PGCPPTEDKN FPQHVRVNLN
60 70 80 90 100
IVNRSTNSRR PTDYHKRSTS PWTLHRNEDP ERYPSVIWEA KCSHSGCINA
110 120 130 140 150
EGKVDHHMNS VTIQQEILVL RRESQHCPHS FRLEKMLVAV GCTCVTPIVR

HLA
Length:153
Mass (Da):17,242
Last modified:October 11, 2004 - v1
Checksum:i658D88BE75EE381B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF412040 mRNA. Translation: AAQ03220.1.
AF416586 mRNA. Translation: AAL08013.1.
RefSeqiNP_001008412.1. NM_001008412.2.
UniGeneiBt.12772.

Genome annotation databases

EnsembliENSBTAT00000002786; ENSBTAP00000002786; ENSBTAG00000002150.
GeneIDi282863.
KEGGibta:282863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF412040 mRNA. Translation: AAQ03220.1.
AF416586 mRNA. Translation: AAL08013.1.
RefSeqiNP_001008412.1. NM_001008412.2.
UniGeneiBt.12772.

3D structure databases

ProteinModelPortaliQ687Y7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002786.

Proteomic databases

PaxDbiQ687Y7.
PRIDEiQ687Y7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000002786; ENSBTAP00000002786; ENSBTAG00000002150.
GeneIDi282863.
KEGGibta:282863.

Organism-specific databases

CTDi3605.

Phylogenomic databases

eggNOGiENOG410J12P. Eukaryota.
ENOG410YS4N. LUCA.
GeneTreeiENSGT00730000110824.
HOGENOMiHOG000064520.
HOVERGENiHBG006143.
InParanoidiQ687Y7.
KOiK05489.
OMAiHMNSVPI.
OrthoDBiEOG091G0RG1.
TreeFamiTF314701.

Enzyme and pathway databases

ReactomeiR-BTA-448424. Interleukin-17 signaling.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIL17_BOVIN
AccessioniPrimary (citable) accession number: Q687Y7
Secondary accession number(s): Q95L56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.