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Q685J3

- MUC17_HUMAN

UniProt

Q685J3 - MUC17_HUMAN

Protein

Mucin-17

Gene

MUC17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Probably plays a role in maintaining homeostasis on mucosal surfaces.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei4243 – 42442CleavageSequence Analysis

    GO - Molecular functioni

    1. extracellular matrix constituent, lubricant activity Source: UniProtKB
    2. PDZ domain binding Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. cellular homeostasis Source: UniProtKB
    2. cellular protein metabolic process Source: Reactome
    3. O-glycan processing Source: Reactome
    4. post-translational protein modification Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_115606. O-linked glycosylation of mucins.
    REACT_115835. Termination of O-glycan biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mucin-17
    Short name:
    MUC-17
    Alternative name(s):
    Small intestinal mucin-3
    Short name:
    MUC-3
    Gene namesi
    Name:MUC17
    Synonyms:MUC3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:16800. MUC17.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. external side of plasma membrane Source: UniProtKB
    3. extracellular region Source: UniProtKB-SubCell
    4. Golgi lumen Source: Reactome
    5. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31315.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 44934468Mucin-17PRO_0000326254Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi696 – 6961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi898 – 8981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1345 – 13451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2077 – 20771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2194 – 21941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3344 – 33441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4116 – 41161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4135 ↔ 4147PROSITE-ProRule annotation
    Disulfide bondi4140 ↔ 4158PROSITE-ProRule annotation
    Disulfide bondi4160 ↔ 4169PROSITE-ProRule annotation
    Glycosylationi4205 – 42051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4236 – 42361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4267 – 42671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4297 – 42971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4305 – 43051N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Probably cleaved within the SEA domain.
    N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ685J3.
    PRIDEiQ685J3.

    PTM databases

    PhosphoSiteiQ685J3.

    Expressioni

    Tissue specificityi

    Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers.3 Publications

    Gene expression databases

    BgeeiQ685J3.
    CleanExiHS_MUC17.
    GenevestigatoriQ685J3.

    Organism-specific databases

    HPAiHPA031634.

    Interactioni

    Subunit structurei

    Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization.1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000302716.

    Structurei

    3D structure databases

    ProteinModelPortaliQ685J3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 43934368ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini4415 – 449379CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4394 – 441421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati185 – 245611Add
    BLAST
    Repeati246 – 300552Add
    BLAST
    Repeati301 – 361613Add
    BLAST
    Repeati362 – 418574Add
    BLAST
    Repeati420 – 477585Add
    BLAST
    Repeati479 – 538606Add
    BLAST
    Repeati539 – 597597Add
    BLAST
    Repeati598 – 654578Add
    BLAST
    Repeati656 – 715609Add
    BLAST
    Repeati716 – 7745910Add
    BLAST
    Repeati775 – 8315711Add
    BLAST
    Repeati833 – 8926012Add
    BLAST
    Repeati893 – 9515913Add
    BLAST
    Repeati952 – 10105914Add
    BLAST
    Repeati1011 – 10695915Add
    BLAST
    Repeati1070 – 11215216Add
    BLAST
    Repeati1122 – 11876617Add
    BLAST
    Repeati1188 – 12465918Add
    BLAST
    Repeati1247 – 13055919Add
    BLAST
    Repeati1306 – 13645920Add
    BLAST
    Repeati1365 – 14235921Add
    BLAST
    Repeati1424 – 14825922Add
    BLAST
    Repeati1483 – 15415923Add
    BLAST
    Repeati1542 – 16005924Add
    BLAST
    Repeati1601 – 16565625Add
    BLAST
    Repeati1658 – 17176026Add
    BLAST
    Repeati1718 – 17765927Add
    BLAST
    Repeati1777 – 18355928Add
    BLAST
    Repeati1836 – 18956029Add
    BLAST
    Repeati1896 – 19515630Add
    BLAST
    Repeati1953 – 20126031Add
    BLAST
    Repeati2013 – 20715932Add
    BLAST
    Repeati2072 – 21275633Add
    BLAST
    Repeati2129 – 21886034Add
    BLAST
    Repeati2189 – 22475935Add
    BLAST
    Repeati2248 – 23065936Add
    BLAST
    Repeati2307 – 23655937Add
    BLAST
    Repeati2366 – 24245938Add
    BLAST
    Repeati2425 – 24835939Add
    BLAST
    Repeati2484 – 25405740Add
    BLAST
    Repeati2542 – 26016041Add
    BLAST
    Repeati2602 – 26535242Add
    BLAST
    Repeati2654 – 27196643Add
    BLAST
    Repeati2720 – 27705144Add
    BLAST
    Repeati2772 – 28376645Add
    BLAST
    Repeati2838 – 28965946Add
    BLAST
    Repeati2897 – 29555947Add
    BLAST
    Repeati2956 – 30145948Add
    BLAST
    Repeati3015 – 30735949Add
    BLAST
    Repeati3074 – 31325950Add
    BLAST
    Repeati3133 – 31915951Add
    BLAST
    Repeati3192 – 32475652Add
    BLAST
    Repeati3249 – 33086053Add
    BLAST
    Repeati3309 – 33675954Add
    BLAST
    Repeati3368 – 34265955Add
    BLAST
    Repeati3427 – 34855956Add
    BLAST
    Repeati3486 – 35445957Add
    BLAST
    Repeati3604 – 36625958Add
    BLAST
    Repeati3663 – 37276559Add
    BLAST
    Domaini4131 – 417040EGF-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini4184 – 4291108SEAPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni185 – 3727354359 X approximate tandem repeatsAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi84 – 38363753Ser-richAdd
    BLAST
    Compositional biasi3975 – 39806Poly-Ser

    Sequence similaritiesi

    Contains 1 EGF-like domain.PROSITE-ProRule annotation
    Contains 1 SEA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000172388.
    InParanoidiQ685J3.
    OMAiPTSTYSE.
    OrthoDBiEOG764723.
    PhylomeDBiQ685J3.
    TreeFamiTF337883.

    Family and domain databases

    Gene3Di3.30.70.960. 1 hit.
    InterProiIPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR000082. SEA_dom.
    [Graphical view]
    PfamiPF01390. SEA. 1 hit.
    [Graphical view]
    SMARTiSM00181. EGF. 1 hit.
    SM00200. SEA. 1 hit.
    [Graphical view]
    SUPFAMiSSF82671. SSF82671. 1 hit.
    PROSITEiPS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50024. SEA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q685J3-1) [UniParc]FASTAAdd to Basket

    Also known as: Major, Mb-MUC17

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MPRPGTMALC LLTLVLSLLP PQAAAEQDLS VNRAVWDGGG CISQGDVLNR     50
    QCQQLSQHVR TGSAANTATG TTSTNVVEPR MYLSCSTNPE MTSIESSVTS 100
    DTPGVSSTRM TPTESRTTSE STSDSTTLFP SSTEDTSSPT TPEGTDVPMS 150
    TPSEESISST MAFVSTAPLP SFEAYTSLTY KVDMSTPLTT STQASSSPTT 200
    PESTTIPKST NSEGSTPLTS MPASTMKVAS SEAITLLTTP VEISTPVTIS 250
    AQASSSPTTA EGPSLSNSAP SGGSTPLTRM PLSVMLVVSS EASTLSTTPA 300
    ATNIPVITST EASSSPTTAE GTSIPTSTYT EGSTPLTSTP ASTMPVATSE 350
    MSTLSITPVD TSTLVTTSTE PSSLPTTAEA TSMLTSTLSE GSTPLTNMPV 400
    STILVASSEA STTSTIPVDS KTFVTTASEA SSSPTTAEDT SIATSTPSEG 450
    STPLTSMPVS TTPVASSEAS NLSTTPVDSK TQVTTSTEAS SSPPTAEVNS 500
    MPTSTPSEGS TPLTSMSVST MPVASSEAST LSTTPVDTST PVTTSSEASS 550
    SSTTPEGTSI PTSTPSEGST PLTNMPVSTR LVVSSEASTT STTPADSNTF 600
    VTTSSEASSS STTAEGTSMP TSTYSERGTT ITSMSVSTTL VASSEASTLS 650
    TTPVDSNTPV TTSTEATSSS TTAEGTSMPT STYTEGSTPL TSMPVNTTLV 700
    ASSEASTLST TPVDTSTPVT TSTEASSSPT TADGASMPTS TPSEGSTPLT 750
    SMPVSKTLLT SSEASTLSTT PLDTSTHITT STEASCSPTT TEGTSMPIST 800
    PSEGSPLLTS IPVSITPVTS PEASTLSTTP VDSNSPVTTS TEVSSSPTPA 850
    EGTSMPTSTY SEGRTPLTSM PVSTTLVATS AISTLSTTPV DTSTPVTNST 900
    EARSSPTTSE GTSMPTSTPG EGSTPLTSMP DSTTPVVSSE ARTLSATPVD 950
    TSTPVTTSTE ATSSPTTAEG TSIPTSTPSE GTTPLTSTPV SHTLVANSEA 1000
    STLSTTPVDS NTPLTTSTEA SSPPPTAEGT SMPTSTPSEG STPLTRMPVS 1050
    TTMVASSETS TLSTTPADTS TPVTTYSQAS SSSTTADGTS MPTSTYSEGS 1100
    TPLTSVPVST RLVVSSEAST LSTTPVDTSI PVTTSTEASS SPTTAEGTSI 1150
    PTSPPSEGTT PLASMPVSTT LVVSSEANTL STTPVDSKTQ VATSTEASSP 1200
    PPTAEVTSMP TSTPGERSTP LTSMPVRHTP VASSEASTLS TSPVDTSTPV 1250
    TTSAETSSSP TTAEGTSLPT STTSEGSTLL TSIPVSTTLV TSPEASTLLT 1300
    TPVDTKGPVV TSNEVSSSPT PAEGTSMPTS TYSEGRTPLT SIPVNTTLVA 1350
    SSAISILSTT PVDNSTPVTT STEACSSPTT SEGTSMPNSN PSEGTTPLTS 1400
    IPVSTTPVVS SEASTLSATP VDTSTPGTTS AEATSSPTTA EGISIPTSTP 1450
    SEGKTPLKSI PVSNTPVANS EASTLSTTPV DSNSPVVTST AVSSSPTPAE 1500
    GTSIAISTPS EGSTALTSIP VSTTTVASSE INSLSTTPAV TSTPVTTYSQ 1550
    ASSSPTTADG TSMQTSTYSE GSTPLTSLPV STMLVVSSEA NTLSTTPIDS 1600
    KTQVTASTEA SSSTTAEGSS MTISTPSEGS PLLTSIPVST TPVASPEAST 1650
    LSTTPVDSNS PVITSTEVSS SPTPAEGTSM PTSTYTEGRT PLTSITVRTT 1700
    PVASSAISTL STTPVDNSTP VTTSTEARSS PTTSEGTSMP NSTPSEGTTP 1750
    LTSIPVSTTP VLSSEASTLS ATPIDTSTPV TTSTEATSSP TTAEGTSIPT 1800
    STLSEGMTPL TSTPVSHTLV ANSEASTLST TPVDSNSPVV TSTAVSSSPT 1850
    PAEGTSIATS TPSEGSTALT SIPVSTTTVA SSETNTLSTT PAVTSTPVTT 1900
    YAQVSSSPTT ADGSSMPTST PREGRPPLTS IPVSTTTVAS SEINTLSTTL 1950
    ADTRTPVTTY SQASSSPTTA DGTSMPTPAY SEGSTPLTSM PLSTTLVVSS 2000
    EASTLSTTPV DTSTPATTST EGSSSPTTAG GTSIQTSTPS ERTTPLAGMP 2050
    VSTTLVVSSE GNTLSTTPVD SKTQVTNSTE ASSSATAEGS SMTISAPSEG 2100
    SPLLTSIPLS TTPVASPEAS TLSTTPVDSN SPVITSTEVS SSPIPTEGTS 2150
    MQTSTYSDRR TPLTSMPVST TVVASSAIST LSTTPVDTST PVTNSTEARS 2200
    SPTTSEGTSM PTSTPSEGST PFTSMPVSTM PVVTSEASTL SATPVDTSTP 2250
    VTTSTEATSS PTTAEGTSIP TSTLSEGTTP LTSIPVSHTL VANSEVSTLS 2300
    TTPVDSNTPF TTSTEASSPP PTAEGTSMPT STSSEGNTPL TRMPVSTTMV 2350
    ASFETSTLST TPADTSTPVT TYSQAGSSPT TADDTSMPTS TYSEGSTPLT 2400
    SVPVSTMPVV SSEASTHSTT PVDTSTPVTT STEASSSPTT AEGTSIPTSP 2450
    PSEGTTPLAS MPVSTTPVVS SEAGTLSTTP VDTSTPMTTS TEASSSPTTA 2500
    EDIVVPISTA SEGSTLLTSI PVSTTPVASP EASTLSTTPV DSNSPVVTST 2550
    EISSSATSAE GTSMPTSTYS EGSTPLRSMP VSTKPLASSE ASTLSTTPVD 2600
    TSIPVTTSTE TSSSPTTAKD TSMPISTPSE VSTSLTSILV STMPVASSEA 2650
    STLSTTPVDT RTLVTTSTGT SSSPTTAEGS SMPTSTPGER STPLTNILVS 2700
    TTLLANSEAS TLSTTPVDTS TPVTTSAEAS SSPTTAEGTS MRISTPSDGS 2750
    TPLTSILVST LPVASSEAST VSTTAVDTSI PVTTSTEASS SPTTAEVTSM 2800
    PTSTPSETST PLTSMPVNHT PVASSEAGTL STTPVDTSTP VTTSTKASSS 2850
    PTTAEGIVVP ISTASEGSTL LTSIPVSTTP VASSEASTLS TTPVDTSIPV 2900
    TTSTEGSSSP TTAEGTSMPI STPSEVSTPL TSILVSTVPV AGSEASTLST 2950
    TPVDTRTPVT TSAEASSSPT TAEGTSMPIS TPGERRTPLT SMSVSTMPVA 3000
    SSEASTLSRT PADTSTPVTT STEASSSPTT AEGTGIPIST PSEGSTPLTS 3050
    IPVSTTPVAI PEASTLSTTP VDSNSPVVTS TEVSSSPTPA EGTSMPISTY 3100
    SEGSTPLTGV PVSTTPVTSS AISTLSTTPV DTSTPVTTST EAHSSPTTSE 3150
    GTSMPTSTPS EGSTPLTYMP VSTMLVVSSE DSTLSATPVD TSTPVTTSTE 3200
    ATSSTTAEGT SIPTSTPSEG MTPLTSVPVS NTPVASSEAS ILSTTPVDSN 3250
    TPLTTSTEAS SSPPTAEGTS MPTSTPSEGS TPLTSMPVST TTVASSETST 3300
    LSTTPADTST PVTTYSQASS SPPIADGTSM PTSTYSEGST PLTNMSFSTT 3350
    PVVSSEASTL STTPVDTSTP VTTSTEASLS PTTAEGTSIP TSSPSEGTTP 3400
    LASMPVSTTP VVSSEVNTLS TTPVDSNTLV TTSTEASSSP TIAEGTSLPT 3450
    STTSEGSTPL SIMPLSTTPV ASSEASTLST TPVDTSTPVT TSSPTNSSPT 3500
    TAEVTSMPTS TAGEGSTPLT NMPVSTTPVA SSEASTLSTT PVDSNTFVTS 3550
    SSQASSSPAT LQVTTMRMST PSEGSSSLTT MLLSSTYVTS SEASTPSTPS 3600
    VDRSTPVTTS TQSNSTPTPP EVITLPMSTP SEVSTPLTIM PVSTTSVTIS 3650
    EAGTASTLPV DTSTPVITST QVSSSPVTPE GTTMPIWTPS EGSTPLTTMP 3700
    VSTTRVTSSE GSTLSTPSVV TSTPVTTSTE AISSSATLDS TTMSVSMPME 3750
    ISTLGTTILV STTPVTRFPE SSTPSIPSVY TSMSMTTASE GSSSPTTLEG 3800
    TTTMPMSTTS ERSTLLTTVL ISPISVMSPS EASTLSTPPG DTSTPLLTST 3850
    KAGSFSIPAE VTTIRISITS ERSTPLTTLL VSTTLPTSFP GASIASTPPL 3900
    DTSTTFTPST DTASTPTIPV ATTISVSVIT EGSTPGTTIF IPSTPVTSST 3950
    ADVFPATTGA VSTPVITSTE LNTPSTSSSS TTTSFSTTKE FTTPAMTTAA 4000
    PLTYVTMSTA PSTPRTTSRG CTTSASTLSA TSTPHTSTSV TTRPVTPSSE 4050
    SSRPSTITSH TIPPTFPPAH SSTPPTTSAS STTVNPEAVT TMTTRTKPST 4100
    RTTSFPTVTT TAVPTNTTIK SNPTSTPTVP RTTTCFGDGC QNTASRCKNG 4150
    GTWDGLKCQC PNLYYGELCE EVVSSIDIGP PETISAQMEL TVTVTSVKFT 4200
    EELKNHSSQE FQEFKQTFTE QMNIVYSGIP EYVGVNITKL RLGSVVVEHD 4250
    VLLRTKYTPE YKTVLDNATE VVKEKITKVT TQQIMINDIC SDMMCFNTTG 4300
    TQVQNITVTQ YDPEEDCRKM AKEYGDYFVV EYRDQKPYCI SPCEPGFSVS 4350
    KNCNLGKCQM SLSGPQCLCV TTETHWYSGE TCNQGTQKSL VYGLVGAGVV 4400
    LMLIILVALL MLVFRSKREV KRQKYRLSQL YKWQEEDSGP APGTFQNIGF 4450
    DICQDDDSIH LESIYSNFQP SLRHIDPETK IRIQRPQVMT TSF 4493
    Length:4,493
    Mass (Da):451,741
    Last modified:May 18, 2010 - v2
    Checksum:i883D68DDB0D6E3C1
    GO
    Isoform 2 (identifier: Q685J3-2) [UniParc]FASTAAdd to Basket

    Also known as: Minor, s-MUC17

    The sequence of this isoform differs from the canonical sequence as follows:
         4241-4262: RLGSVVVEHDVLLRTKYTPEYK → HDVFQHHWHPSAKHYGDPVRP
         4363-4493: Missing.

    Show »
    Length:4,361
    Mass (Da):436,777
    Checksum:i334BF9C863B8B7F7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 281D → G in CAE54435. (PubMed:16737958)Curated
    Sequence conflicti28 – 281D → G in CAE54436. (PubMed:16737958)Curated
    Sequence conflicti65 – 651A → T in CAE54435. (PubMed:16737958)Curated
    Sequence conflicti65 – 651A → T in CAE54436. (PubMed:16737958)Curated
    Sequence conflicti132 – 1321S → P in CAE54435. (PubMed:16737958)Curated
    Sequence conflicti132 – 1321S → P in CAE54436. (PubMed:16737958)Curated
    Sequence conflicti3481 – 34811T → S in AAL89737. (PubMed:11855812)Curated
    Sequence conflicti3491 – 34911T → N in AAL89737. (PubMed:11855812)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti227 – 2271K → Q.
    Corresponds to variant rs10229731 [ dbSNP | Ensembl ].
    VAR_040047
    Natural varianti272 – 2721G → E.
    Corresponds to variant rs10259584 [ dbSNP | Ensembl ].
    VAR_040048
    Natural varianti427 – 4271A → T.
    Corresponds to variant rs56103274 [ dbSNP | Ensembl ].
    VAR_061489
    Natural varianti571 – 5711P → L.
    Corresponds to variant rs34834039 [ dbSNP | Ensembl ].
    VAR_061490
    Natural varianti925 – 9251P → R.
    Corresponds to variant rs11979706 [ dbSNP | Ensembl ].
    VAR_061491
    Natural varianti942 – 9421R → S.
    Corresponds to variant rs10238201 [ dbSNP | Ensembl ].
    VAR_040049
    Natural varianti982 – 9821T → M.
    Corresponds to variant rs4729646 [ dbSNP | Ensembl ].
    VAR_040050
    Natural varianti1130 – 11301I → T.
    Corresponds to variant rs4729647 [ dbSNP | Ensembl ].
    VAR_040051
    Natural varianti1242 – 12421S → T.
    Corresponds to variant rs10265276 [ dbSNP | Ensembl ].
    VAR_040052
    Natural varianti1246 – 12461T → N.
    Corresponds to variant rs4729652 [ dbSNP | Ensembl ].
    VAR_040053
    Natural varianti1246 – 12461T → S.
    Corresponds to variant rs4729651 [ dbSNP | Ensembl ].
    VAR_040054
    Natural varianti1249 – 12491P → A.
    Corresponds to variant rs4729653 [ dbSNP | Ensembl ].
    VAR_040055
    Natural varianti1348 – 13481L → P.1 Publication
    Corresponds to variant rs4269454 [ dbSNP | Ensembl ].
    VAR_040056
    Natural varianti1375 – 13751C → R.1 Publication
    Corresponds to variant rs4367469 [ dbSNP | Ensembl ].
    VAR_040057
    Natural varianti1480 – 14801V → A.1 Publication
    Corresponds to variant rs7780935 [ dbSNP | Ensembl ].
    VAR_061492
    Natural varianti2096 – 20961A → T.
    Corresponds to variant rs28593004 [ dbSNP | Ensembl ].
    VAR_061493
    Natural varianti2159 – 21591R → G.
    Corresponds to variant rs61382267 [ dbSNP | Ensembl ].
    VAR_061494
    Natural varianti3299 – 32991S → N.
    Corresponds to variant rs35988443 [ dbSNP | Ensembl ].
    VAR_061495
    Natural varianti4334 – 43341D → N.
    Corresponds to variant rs6946812 [ dbSNP | Ensembl ].
    VAR_040058
    Natural varianti4482 – 44821R → Q.
    Corresponds to variant rs9656065 [ dbSNP | Ensembl ].
    VAR_040059

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei4241 – 426222RLGSV…TPEYK → HDVFQHHWHPSAKHYGDPVR P in isoform 2. 1 PublicationVSP_032648Add
    BLAST
    Alternative sequencei4363 – 4493131Missing in isoform 2. 1 PublicationVSP_032649Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ606307 mRNA. Translation: CAE54435.1.
    AJ606308 mRNA. Translation: CAE54436.1.
    AC105446 Genomic DNA. No translation available.
    AF016693 mRNA. Translation: AAB71686.1.
    AF430017 mRNA. Translation: AAL89737.1.
    CCDSiCCDS34711.1. [Q685J3-1]
    PIRiPC4396.
    RefSeqiNP_001035194.1. NM_001040105.1. [Q685J3-1]
    UniGeneiHs.271819.

    Genome annotation databases

    EnsembliENST00000306151; ENSP00000302716; ENSG00000169876. [Q685J3-1]
    GeneIDi140453.
    KEGGihsa:140453.
    UCSCiuc003uxp.1. human. [Q685J3-1]

    Polymorphism databases

    DMDMi296439228.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology
    Mucin database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ606307 mRNA. Translation: CAE54435.1 .
    AJ606308 mRNA. Translation: CAE54436.1 .
    AC105446 Genomic DNA. No translation available.
    AF016693 mRNA. Translation: AAB71686.1 .
    AF430017 mRNA. Translation: AAL89737.1 .
    CCDSi CCDS34711.1. [Q685J3-1 ]
    PIRi PC4396.
    RefSeqi NP_001035194.1. NM_001040105.1. [Q685J3-1 ]
    UniGenei Hs.271819.

    3D structure databases

    ProteinModelPortali Q685J3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000302716.

    PTM databases

    PhosphoSitei Q685J3.

    Polymorphism databases

    DMDMi 296439228.

    Proteomic databases

    PaxDbi Q685J3.
    PRIDEi Q685J3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306151 ; ENSP00000302716 ; ENSG00000169876 . [Q685J3-1 ]
    GeneIDi 140453.
    KEGGi hsa:140453.
    UCSCi uc003uxp.1. human. [Q685J3-1 ]

    Organism-specific databases

    CTDi 140453.
    GeneCardsi GC07P100663.
    H-InvDB HIX0006940.
    HGNCi HGNC:16800. MUC17.
    HPAi HPA031634.
    MIMi 608424. gene.
    neXtProti NX_Q685J3.
    PharmGKBi PA31315.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000172388.
    InParanoidi Q685J3.
    OMAi PTSTYSE.
    OrthoDBi EOG764723.
    PhylomeDBi Q685J3.
    TreeFami TF337883.

    Enzyme and pathway databases

    Reactomei REACT_115606. O-linked glycosylation of mucins.
    REACT_115835. Termination of O-glycan biosynthesis.

    Miscellaneous databases

    GeneWikii MUC17.
    GenomeRNAii 140453.
    NextBioi 84093.
    PROi Q685J3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q685J3.
    CleanExi HS_MUC17.
    Genevestigatori Q685J3.

    Family and domain databases

    Gene3Di 3.30.70.960. 1 hit.
    InterProi IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR000082. SEA_dom.
    [Graphical view ]
    Pfami PF01390. SEA. 1 hit.
    [Graphical view ]
    SMARTi SM00181. EGF. 1 hit.
    SM00200. SEA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82671. SSF82671. 1 hit.
    PROSITEi PS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50024. SEA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of human mucin MUC17. Complete coding sequence and organization."
      Moniaux N., Junker W.M., Singh A.P., Jones A.M., Batra S.K.
      J. Biol. Chem. 281:23676-23685(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
      Tissue: Pancreatic adenocarcinoma.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Molecular cloning of human MUC3 cDNA reveals a novel 59 amino acid tandem repeat region."
      Van Klinken B.J.-W., Van Dijken T.C., Oussoren E., Buller H.A., Dekker J., Einerhand A.W.
      Biochem. Biophys. Res. Commun. 238:143-148(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1347-1582, TISSUE SPECIFICITY, VARIANTS PRO-1348; ARG-1375 AND ALA-1480.
      Tissue: Small intestine.
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3465-4493 (ISOFORM 1), TISSUE SPECIFICITY.
    5. "N-glycosylation is required for the surface localization of MUC17 mucin."
      Ho J.J.L., Jaituni R.S., Crawley S.C., Yang S.C., Gum J.R., Kim Y.S.
      Int. J. Oncol. 23:585-592(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION, SUBCELLULAR LOCATION.
    6. "The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine."
      Malmberg E.K., Pelaseyed T., Petersson A.C., Seidler U.E., De Jonge H., Riordan J.R., Hansson G.C.
      Biochem. J. 410:283-289(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PDZK1.

    Entry informationi

    Entry nameiMUC17_HUMAN
    AccessioniPrimary (citable) accession number: Q685J3
    Secondary accession number(s): O14761, Q685J2, Q8TDH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3