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Q685J3

- MUC17_HUMAN

UniProt

Q685J3 - MUC17_HUMAN

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Protein
Mucin-17
Gene
MUC17, MUC3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probably plays a role in maintaining homeostasis on mucosal surfaces.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei4243 – 42442Cleavage Reviewed prediction

GO - Molecular functioni

  1. PDZ domain binding Source: UniProtKB
  2. extracellular matrix constituent, lubricant activity Source: UniProtKB
  3. protein binding Source: UniProtKB

GO - Biological processi

  1. O-glycan processing Source: Reactome
  2. cellular homeostasis Source: UniProtKB
  3. cellular protein metabolic process Source: Reactome
  4. post-translational protein modification Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-17
Short name:
MUC-17
Alternative name(s):
Small intestinal mucin-3
Short name:
MUC-3
Gene namesi
Name:MUC17
Synonyms:MUC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:16800. MUC17.

Subcellular locationi

Isoform 1 : Cell membrane; Single-pass membrane protein 1 Publication
Isoform 2 : Secreted Inferred. Cell membrane 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 43934368Extracellular Reviewed prediction
Add
BLAST
Transmembranei4394 – 441421Helical; Reviewed prediction
Add
BLAST
Topological domaini4415 – 449379Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi lumen Source: Reactome
  2. apical plasma membrane Source: UniProtKB
  3. external side of plasma membrane Source: UniProtKB
  4. extracellular region Source: UniProtKB-SubCell
  5. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31315.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 44934468Mucin-17
PRO_0000326254Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi471 – 4711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi696 – 6961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi898 – 8981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1345 – 13451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2077 – 20771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2194 – 21941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3344 – 33441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4116 – 41161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4135 ↔ 4147 By similarity
Disulfide bondi4140 ↔ 4158 By similarity
Disulfide bondi4160 ↔ 4169 By similarity
Glycosylationi4205 – 42051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4236 – 42361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4267 – 42671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4297 – 42971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4305 – 43051N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Probably cleaved within the SEA domain.
N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ685J3.
PRIDEiQ685J3.

PTM databases

PhosphoSiteiQ685J3.

Expressioni

Tissue specificityi

Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers.3 Publications

Gene expression databases

BgeeiQ685J3.
CleanExiHS_MUC17.
GenevestigatoriQ685J3.

Organism-specific databases

HPAiHPA031634.

Interactioni

Subunit structurei

Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000302716.

Structurei

3D structure databases

ProteinModelPortaliQ685J3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati185 – 245611
Add
BLAST
Repeati246 – 300552
Add
BLAST
Repeati301 – 361613
Add
BLAST
Repeati362 – 418574
Add
BLAST
Repeati420 – 477585
Add
BLAST
Repeati479 – 538606
Add
BLAST
Repeati539 – 597597
Add
BLAST
Repeati598 – 654578
Add
BLAST
Repeati656 – 715609
Add
BLAST
Repeati716 – 7745910
Add
BLAST
Repeati775 – 8315711
Add
BLAST
Repeati833 – 8926012
Add
BLAST
Repeati893 – 9515913
Add
BLAST
Repeati952 – 10105914
Add
BLAST
Repeati1011 – 10695915
Add
BLAST
Repeati1070 – 11215216
Add
BLAST
Repeati1122 – 11876617
Add
BLAST
Repeati1188 – 12465918
Add
BLAST
Repeati1247 – 13055919
Add
BLAST
Repeati1306 – 13645920
Add
BLAST
Repeati1365 – 14235921
Add
BLAST
Repeati1424 – 14825922
Add
BLAST
Repeati1483 – 15415923
Add
BLAST
Repeati1542 – 16005924
Add
BLAST
Repeati1601 – 16565625
Add
BLAST
Repeati1658 – 17176026
Add
BLAST
Repeati1718 – 17765927
Add
BLAST
Repeati1777 – 18355928
Add
BLAST
Repeati1836 – 18956029
Add
BLAST
Repeati1896 – 19515630
Add
BLAST
Repeati1953 – 20126031
Add
BLAST
Repeati2013 – 20715932
Add
BLAST
Repeati2072 – 21275633
Add
BLAST
Repeati2129 – 21886034
Add
BLAST
Repeati2189 – 22475935
Add
BLAST
Repeati2248 – 23065936
Add
BLAST
Repeati2307 – 23655937
Add
BLAST
Repeati2366 – 24245938
Add
BLAST
Repeati2425 – 24835939
Add
BLAST
Repeati2484 – 25405740
Add
BLAST
Repeati2542 – 26016041
Add
BLAST
Repeati2602 – 26535242
Add
BLAST
Repeati2654 – 27196643
Add
BLAST
Repeati2720 – 27705144
Add
BLAST
Repeati2772 – 28376645
Add
BLAST
Repeati2838 – 28965946
Add
BLAST
Repeati2897 – 29555947
Add
BLAST
Repeati2956 – 30145948
Add
BLAST
Repeati3015 – 30735949
Add
BLAST
Repeati3074 – 31325950
Add
BLAST
Repeati3133 – 31915951
Add
BLAST
Repeati3192 – 32475652
Add
BLAST
Repeati3249 – 33086053
Add
BLAST
Repeati3309 – 33675954
Add
BLAST
Repeati3368 – 34265955
Add
BLAST
Repeati3427 – 34855956
Add
BLAST
Repeati3486 – 35445957
Add
BLAST
Repeati3604 – 36625958
Add
BLAST
Repeati3663 – 37276559
Add
BLAST
Domaini4131 – 417040EGF-like
Add
BLAST
Domaini4184 – 4291108SEA
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni185 – 3727354359 X approximate tandem repeats
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi84 – 38363753Ser-rich
Add
BLAST
Compositional biasi3975 – 39806Poly-Ser

Sequence similaritiesi

Contains 1 EGF-like domain.
Contains 1 SEA domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000172388.
InParanoidiQ685J3.
OMAiPTSTYSE.
OrthoDBiEOG764723.
PhylomeDBiQ685J3.
TreeFamiTF337883.

Family and domain databases

Gene3Di3.30.70.960. 1 hit.
InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000082. SEA_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00200. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q685J3-1) [UniParc]FASTAAdd to Basket

Also known as: Major, Mb-MUC17

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPRPGTMALC LLTLVLSLLP PQAAAEQDLS VNRAVWDGGG CISQGDVLNR     50
QCQQLSQHVR TGSAANTATG TTSTNVVEPR MYLSCSTNPE MTSIESSVTS 100
DTPGVSSTRM TPTESRTTSE STSDSTTLFP SSTEDTSSPT TPEGTDVPMS 150
TPSEESISST MAFVSTAPLP SFEAYTSLTY KVDMSTPLTT STQASSSPTT 200
PESTTIPKST NSEGSTPLTS MPASTMKVAS SEAITLLTTP VEISTPVTIS 250
AQASSSPTTA EGPSLSNSAP SGGSTPLTRM PLSVMLVVSS EASTLSTTPA 300
ATNIPVITST EASSSPTTAE GTSIPTSTYT EGSTPLTSTP ASTMPVATSE 350
MSTLSITPVD TSTLVTTSTE PSSLPTTAEA TSMLTSTLSE GSTPLTNMPV 400
STILVASSEA STTSTIPVDS KTFVTTASEA SSSPTTAEDT SIATSTPSEG 450
STPLTSMPVS TTPVASSEAS NLSTTPVDSK TQVTTSTEAS SSPPTAEVNS 500
MPTSTPSEGS TPLTSMSVST MPVASSEAST LSTTPVDTST PVTTSSEASS 550
SSTTPEGTSI PTSTPSEGST PLTNMPVSTR LVVSSEASTT STTPADSNTF 600
VTTSSEASSS STTAEGTSMP TSTYSERGTT ITSMSVSTTL VASSEASTLS 650
TTPVDSNTPV TTSTEATSSS TTAEGTSMPT STYTEGSTPL TSMPVNTTLV 700
ASSEASTLST TPVDTSTPVT TSTEASSSPT TADGASMPTS TPSEGSTPLT 750
SMPVSKTLLT SSEASTLSTT PLDTSTHITT STEASCSPTT TEGTSMPIST 800
PSEGSPLLTS IPVSITPVTS PEASTLSTTP VDSNSPVTTS TEVSSSPTPA 850
EGTSMPTSTY SEGRTPLTSM PVSTTLVATS AISTLSTTPV DTSTPVTNST 900
EARSSPTTSE GTSMPTSTPG EGSTPLTSMP DSTTPVVSSE ARTLSATPVD 950
TSTPVTTSTE ATSSPTTAEG TSIPTSTPSE GTTPLTSTPV SHTLVANSEA 1000
STLSTTPVDS NTPLTTSTEA SSPPPTAEGT SMPTSTPSEG STPLTRMPVS 1050
TTMVASSETS TLSTTPADTS TPVTTYSQAS SSSTTADGTS MPTSTYSEGS 1100
TPLTSVPVST RLVVSSEAST LSTTPVDTSI PVTTSTEASS SPTTAEGTSI 1150
PTSPPSEGTT PLASMPVSTT LVVSSEANTL STTPVDSKTQ VATSTEASSP 1200
PPTAEVTSMP TSTPGERSTP LTSMPVRHTP VASSEASTLS TSPVDTSTPV 1250
TTSAETSSSP TTAEGTSLPT STTSEGSTLL TSIPVSTTLV TSPEASTLLT 1300
TPVDTKGPVV TSNEVSSSPT PAEGTSMPTS TYSEGRTPLT SIPVNTTLVA 1350
SSAISILSTT PVDNSTPVTT STEACSSPTT SEGTSMPNSN PSEGTTPLTS 1400
IPVSTTPVVS SEASTLSATP VDTSTPGTTS AEATSSPTTA EGISIPTSTP 1450
SEGKTPLKSI PVSNTPVANS EASTLSTTPV DSNSPVVTST AVSSSPTPAE 1500
GTSIAISTPS EGSTALTSIP VSTTTVASSE INSLSTTPAV TSTPVTTYSQ 1550
ASSSPTTADG TSMQTSTYSE GSTPLTSLPV STMLVVSSEA NTLSTTPIDS 1600
KTQVTASTEA SSSTTAEGSS MTISTPSEGS PLLTSIPVST TPVASPEAST 1650
LSTTPVDSNS PVITSTEVSS SPTPAEGTSM PTSTYTEGRT PLTSITVRTT 1700
PVASSAISTL STTPVDNSTP VTTSTEARSS PTTSEGTSMP NSTPSEGTTP 1750
LTSIPVSTTP VLSSEASTLS ATPIDTSTPV TTSTEATSSP TTAEGTSIPT 1800
STLSEGMTPL TSTPVSHTLV ANSEASTLST TPVDSNSPVV TSTAVSSSPT 1850
PAEGTSIATS TPSEGSTALT SIPVSTTTVA SSETNTLSTT PAVTSTPVTT 1900
YAQVSSSPTT ADGSSMPTST PREGRPPLTS IPVSTTTVAS SEINTLSTTL 1950
ADTRTPVTTY SQASSSPTTA DGTSMPTPAY SEGSTPLTSM PLSTTLVVSS 2000
EASTLSTTPV DTSTPATTST EGSSSPTTAG GTSIQTSTPS ERTTPLAGMP 2050
VSTTLVVSSE GNTLSTTPVD SKTQVTNSTE ASSSATAEGS SMTISAPSEG 2100
SPLLTSIPLS TTPVASPEAS TLSTTPVDSN SPVITSTEVS SSPIPTEGTS 2150
MQTSTYSDRR TPLTSMPVST TVVASSAIST LSTTPVDTST PVTNSTEARS 2200
SPTTSEGTSM PTSTPSEGST PFTSMPVSTM PVVTSEASTL SATPVDTSTP 2250
VTTSTEATSS PTTAEGTSIP TSTLSEGTTP LTSIPVSHTL VANSEVSTLS 2300
TTPVDSNTPF TTSTEASSPP PTAEGTSMPT STSSEGNTPL TRMPVSTTMV 2350
ASFETSTLST TPADTSTPVT TYSQAGSSPT TADDTSMPTS TYSEGSTPLT 2400
SVPVSTMPVV SSEASTHSTT PVDTSTPVTT STEASSSPTT AEGTSIPTSP 2450
PSEGTTPLAS MPVSTTPVVS SEAGTLSTTP VDTSTPMTTS TEASSSPTTA 2500
EDIVVPISTA SEGSTLLTSI PVSTTPVASP EASTLSTTPV DSNSPVVTST 2550
EISSSATSAE GTSMPTSTYS EGSTPLRSMP VSTKPLASSE ASTLSTTPVD 2600
TSIPVTTSTE TSSSPTTAKD TSMPISTPSE VSTSLTSILV STMPVASSEA 2650
STLSTTPVDT RTLVTTSTGT SSSPTTAEGS SMPTSTPGER STPLTNILVS 2700
TTLLANSEAS TLSTTPVDTS TPVTTSAEAS SSPTTAEGTS MRISTPSDGS 2750
TPLTSILVST LPVASSEAST VSTTAVDTSI PVTTSTEASS SPTTAEVTSM 2800
PTSTPSETST PLTSMPVNHT PVASSEAGTL STTPVDTSTP VTTSTKASSS 2850
PTTAEGIVVP ISTASEGSTL LTSIPVSTTP VASSEASTLS TTPVDTSIPV 2900
TTSTEGSSSP TTAEGTSMPI STPSEVSTPL TSILVSTVPV AGSEASTLST 2950
TPVDTRTPVT TSAEASSSPT TAEGTSMPIS TPGERRTPLT SMSVSTMPVA 3000
SSEASTLSRT PADTSTPVTT STEASSSPTT AEGTGIPIST PSEGSTPLTS 3050
IPVSTTPVAI PEASTLSTTP VDSNSPVVTS TEVSSSPTPA EGTSMPISTY 3100
SEGSTPLTGV PVSTTPVTSS AISTLSTTPV DTSTPVTTST EAHSSPTTSE 3150
GTSMPTSTPS EGSTPLTYMP VSTMLVVSSE DSTLSATPVD TSTPVTTSTE 3200
ATSSTTAEGT SIPTSTPSEG MTPLTSVPVS NTPVASSEAS ILSTTPVDSN 3250
TPLTTSTEAS SSPPTAEGTS MPTSTPSEGS TPLTSMPVST TTVASSETST 3300
LSTTPADTST PVTTYSQASS SPPIADGTSM PTSTYSEGST PLTNMSFSTT 3350
PVVSSEASTL STTPVDTSTP VTTSTEASLS PTTAEGTSIP TSSPSEGTTP 3400
LASMPVSTTP VVSSEVNTLS TTPVDSNTLV TTSTEASSSP TIAEGTSLPT 3450
STTSEGSTPL SIMPLSTTPV ASSEASTLST TPVDTSTPVT TSSPTNSSPT 3500
TAEVTSMPTS TAGEGSTPLT NMPVSTTPVA SSEASTLSTT PVDSNTFVTS 3550
SSQASSSPAT LQVTTMRMST PSEGSSSLTT MLLSSTYVTS SEASTPSTPS 3600
VDRSTPVTTS TQSNSTPTPP EVITLPMSTP SEVSTPLTIM PVSTTSVTIS 3650
EAGTASTLPV DTSTPVITST QVSSSPVTPE GTTMPIWTPS EGSTPLTTMP 3700
VSTTRVTSSE GSTLSTPSVV TSTPVTTSTE AISSSATLDS TTMSVSMPME 3750
ISTLGTTILV STTPVTRFPE SSTPSIPSVY TSMSMTTASE GSSSPTTLEG 3800
TTTMPMSTTS ERSTLLTTVL ISPISVMSPS EASTLSTPPG DTSTPLLTST 3850
KAGSFSIPAE VTTIRISITS ERSTPLTTLL VSTTLPTSFP GASIASTPPL 3900
DTSTTFTPST DTASTPTIPV ATTISVSVIT EGSTPGTTIF IPSTPVTSST 3950
ADVFPATTGA VSTPVITSTE LNTPSTSSSS TTTSFSTTKE FTTPAMTTAA 4000
PLTYVTMSTA PSTPRTTSRG CTTSASTLSA TSTPHTSTSV TTRPVTPSSE 4050
SSRPSTITSH TIPPTFPPAH SSTPPTTSAS STTVNPEAVT TMTTRTKPST 4100
RTTSFPTVTT TAVPTNTTIK SNPTSTPTVP RTTTCFGDGC QNTASRCKNG 4150
GTWDGLKCQC PNLYYGELCE EVVSSIDIGP PETISAQMEL TVTVTSVKFT 4200
EELKNHSSQE FQEFKQTFTE QMNIVYSGIP EYVGVNITKL RLGSVVVEHD 4250
VLLRTKYTPE YKTVLDNATE VVKEKITKVT TQQIMINDIC SDMMCFNTTG 4300
TQVQNITVTQ YDPEEDCRKM AKEYGDYFVV EYRDQKPYCI SPCEPGFSVS 4350
KNCNLGKCQM SLSGPQCLCV TTETHWYSGE TCNQGTQKSL VYGLVGAGVV 4400
LMLIILVALL MLVFRSKREV KRQKYRLSQL YKWQEEDSGP APGTFQNIGF 4450
DICQDDDSIH LESIYSNFQP SLRHIDPETK IRIQRPQVMT TSF 4493
Length:4,493
Mass (Da):451,741
Last modified:May 18, 2010 - v2
Checksum:i883D68DDB0D6E3C1
GO
Isoform 2 (identifier: Q685J3-2) [UniParc]FASTAAdd to Basket

Also known as: Minor, s-MUC17

The sequence of this isoform differs from the canonical sequence as follows:
     4241-4262: RLGSVVVEHDVLLRTKYTPEYK → HDVFQHHWHPSAKHYGDPVRP
     4363-4493: Missing.

Show »
Length:4,361
Mass (Da):436,777
Checksum:i334BF9C863B8B7F7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti227 – 2271K → Q.
Corresponds to variant rs10229731 [ dbSNP | Ensembl ].
VAR_040047
Natural varianti272 – 2721G → E.
Corresponds to variant rs10259584 [ dbSNP | Ensembl ].
VAR_040048
Natural varianti427 – 4271A → T.
Corresponds to variant rs56103274 [ dbSNP | Ensembl ].
VAR_061489
Natural varianti571 – 5711P → L.
Corresponds to variant rs34834039 [ dbSNP | Ensembl ].
VAR_061490
Natural varianti925 – 9251P → R.
Corresponds to variant rs11979706 [ dbSNP | Ensembl ].
VAR_061491
Natural varianti942 – 9421R → S.
Corresponds to variant rs10238201 [ dbSNP | Ensembl ].
VAR_040049
Natural varianti982 – 9821T → M.
Corresponds to variant rs4729646 [ dbSNP | Ensembl ].
VAR_040050
Natural varianti1130 – 11301I → T.
Corresponds to variant rs4729647 [ dbSNP | Ensembl ].
VAR_040051
Natural varianti1242 – 12421S → T.
Corresponds to variant rs10265276 [ dbSNP | Ensembl ].
VAR_040052
Natural varianti1246 – 12461T → N.
Corresponds to variant rs4729652 [ dbSNP | Ensembl ].
VAR_040053
Natural varianti1246 – 12461T → S.
Corresponds to variant rs4729651 [ dbSNP | Ensembl ].
VAR_040054
Natural varianti1249 – 12491P → A.
Corresponds to variant rs4729653 [ dbSNP | Ensembl ].
VAR_040055
Natural varianti1348 – 13481L → P.1 Publication
Corresponds to variant rs4269454 [ dbSNP | Ensembl ].
VAR_040056
Natural varianti1375 – 13751C → R.1 Publication
Corresponds to variant rs4367469 [ dbSNP | Ensembl ].
VAR_040057
Natural varianti1480 – 14801V → A.1 Publication
Corresponds to variant rs7780935 [ dbSNP | Ensembl ].
VAR_061492
Natural varianti2096 – 20961A → T.
Corresponds to variant rs28593004 [ dbSNP | Ensembl ].
VAR_061493
Natural varianti2159 – 21591R → G.
Corresponds to variant rs61382267 [ dbSNP | Ensembl ].
VAR_061494
Natural varianti3299 – 32991S → N.
Corresponds to variant rs35988443 [ dbSNP | Ensembl ].
VAR_061495
Natural varianti4334 – 43341D → N.
Corresponds to variant rs6946812 [ dbSNP | Ensembl ].
VAR_040058
Natural varianti4482 – 44821R → Q.
Corresponds to variant rs9656065 [ dbSNP | Ensembl ].
VAR_040059

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei4241 – 426222RLGSV…TPEYK → HDVFQHHWHPSAKHYGDPVR P in isoform 2.
VSP_032648Add
BLAST
Alternative sequencei4363 – 4493131Missing in isoform 2.
VSP_032649Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281D → G in CAE54435. 1 Publication
Sequence conflicti28 – 281D → G in CAE54436. 1 Publication
Sequence conflicti65 – 651A → T in CAE54435. 1 Publication
Sequence conflicti65 – 651A → T in CAE54436. 1 Publication
Sequence conflicti132 – 1321S → P in CAE54435. 1 Publication
Sequence conflicti132 – 1321S → P in CAE54436. 1 Publication
Sequence conflicti3481 – 34811T → S in AAL89737. 1 Publication
Sequence conflicti3491 – 34911T → N in AAL89737. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ606307 mRNA. Translation: CAE54435.1.
AJ606308 mRNA. Translation: CAE54436.1.
AC105446 Genomic DNA. No translation available.
AF016693 mRNA. Translation: AAB71686.1.
AF430017 mRNA. Translation: AAL89737.1.
CCDSiCCDS34711.1. [Q685J3-1]
PIRiPC4396.
RefSeqiNP_001035194.1. NM_001040105.1. [Q685J3-1]
UniGeneiHs.271819.

Genome annotation databases

EnsembliENST00000306151; ENSP00000302716; ENSG00000169876. [Q685J3-1]
GeneIDi140453.
KEGGihsa:140453.
UCSCiuc003uxp.1. human. [Q685J3-1]

Polymorphism databases

DMDMi296439228.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Mucin database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ606307 mRNA. Translation: CAE54435.1 .
AJ606308 mRNA. Translation: CAE54436.1 .
AC105446 Genomic DNA. No translation available.
AF016693 mRNA. Translation: AAB71686.1 .
AF430017 mRNA. Translation: AAL89737.1 .
CCDSi CCDS34711.1. [Q685J3-1 ]
PIRi PC4396.
RefSeqi NP_001035194.1. NM_001040105.1. [Q685J3-1 ]
UniGenei Hs.271819.

3D structure databases

ProteinModelPortali Q685J3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000302716.

PTM databases

PhosphoSitei Q685J3.

Polymorphism databases

DMDMi 296439228.

Proteomic databases

PaxDbi Q685J3.
PRIDEi Q685J3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306151 ; ENSP00000302716 ; ENSG00000169876 . [Q685J3-1 ]
GeneIDi 140453.
KEGGi hsa:140453.
UCSCi uc003uxp.1. human. [Q685J3-1 ]

Organism-specific databases

CTDi 140453.
GeneCardsi GC07P100663.
H-InvDB HIX0006940.
HGNCi HGNC:16800. MUC17.
HPAi HPA031634.
MIMi 608424. gene.
neXtProti NX_Q685J3.
PharmGKBi PA31315.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000172388.
InParanoidi Q685J3.
OMAi PTSTYSE.
OrthoDBi EOG764723.
PhylomeDBi Q685J3.
TreeFami TF337883.

Enzyme and pathway databases

Reactomei REACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Miscellaneous databases

GeneWikii MUC17.
GenomeRNAii 140453.
NextBioi 84093.
PROi Q685J3.
SOURCEi Search...

Gene expression databases

Bgeei Q685J3.
CleanExi HS_MUC17.
Genevestigatori Q685J3.

Family and domain databases

Gene3Di 3.30.70.960. 1 hit.
InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000082. SEA_dom.
[Graphical view ]
Pfami PF01390. SEA. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 1 hit.
SM00200. SEA. 1 hit.
[Graphical view ]
SUPFAMi SSF82671. SSF82671. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of human mucin MUC17. Complete coding sequence and organization."
    Moniaux N., Junker W.M., Singh A.P., Jones A.M., Batra S.K.
    J. Biol. Chem. 281:23676-23685(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Tissue: Pancreatic adenocarcinoma.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Molecular cloning of human MUC3 cDNA reveals a novel 59 amino acid tandem repeat region."
    Van Klinken B.J.-W., Van Dijken T.C., Oussoren E., Buller H.A., Dekker J., Einerhand A.W.
    Biochem. Biophys. Res. Commun. 238:143-148(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1347-1582, TISSUE SPECIFICITY, VARIANTS PRO-1348; ARG-1375 AND ALA-1480.
    Tissue: Small intestine.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3465-4493 (ISOFORM 1), TISSUE SPECIFICITY.
  5. "N-glycosylation is required for the surface localization of MUC17 mucin."
    Ho J.J.L., Jaituni R.S., Crawley S.C., Yang S.C., Gum J.R., Kim Y.S.
    Int. J. Oncol. 23:585-592(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION, SUBCELLULAR LOCATION.
  6. "The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine."
    Malmberg E.K., Pelaseyed T., Petersson A.C., Seidler U.E., De Jonge H., Riordan J.R., Hansson G.C.
    Biochem. J. 410:283-289(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PDZK1.

Entry informationi

Entry nameiMUC17_HUMAN
AccessioniPrimary (citable) accession number: Q685J3
Secondary accession number(s): O14761, Q685J2, Q8TDH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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