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Q685J3

- MUC17_HUMAN

UniProt

Q685J3 - MUC17_HUMAN

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Protein

Mucin-17

Gene

MUC17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probably plays a role in maintaining homeostasis on mucosal surfaces.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei4243 – 42442CleavageSequence Analysis

GO - Molecular functioni

  1. extracellular matrix constituent, lubricant activity Source: UniProtKB
  2. PDZ domain binding Source: UniProtKB

GO - Biological processi

  1. cellular homeostasis Source: UniProtKB
  2. cellular protein metabolic process Source: Reactome
  3. O-glycan processing Source: Reactome
  4. post-translational protein modification Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-17
Short name:
MUC-17
Alternative name(s):
Small intestinal mucin-3
Short name:
MUC-3
Gene namesi
Name:MUC17
Synonyms:MUC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:16800. MUC17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 43934368ExtracellularSequence AnalysisAdd
BLAST
Transmembranei4394 – 441421HelicalSequence AnalysisAdd
BLAST
Topological domaini4415 – 449379CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. external side of plasma membrane Source: UniProtKB
  3. extracellular region Source: UniProtKB-KW
  4. Golgi lumen Source: Reactome
  5. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31315.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 44934468Mucin-17PRO_0000326254Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi696 – 6961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi898 – 8981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1345 – 13451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2077 – 20771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2194 – 21941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3344 – 33441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4116 – 41161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi4135 ↔ 4147PROSITE-ProRule annotation
Disulfide bondi4140 ↔ 4158PROSITE-ProRule annotation
Disulfide bondi4160 ↔ 4169PROSITE-ProRule annotation
Glycosylationi4205 – 42051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4236 – 42361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4267 – 42671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4297 – 42971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4305 – 43051N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Probably cleaved within the SEA domain.
N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ685J3.
PRIDEiQ685J3.

PTM databases

PhosphoSiteiQ685J3.

Expressioni

Tissue specificityi

Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers.3 Publications

Gene expression databases

BgeeiQ685J3.
CleanExiHS_MUC17.
ExpressionAtlasiQ685J3. baseline.
GenevestigatoriQ685J3.

Organism-specific databases

HPAiHPA031634.

Interactioni

Subunit structurei

Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000302716.

Structurei

3D structure databases

ProteinModelPortaliQ685J3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati185 – 245611Add
BLAST
Repeati246 – 300552Add
BLAST
Repeati301 – 361613Add
BLAST
Repeati362 – 418574Add
BLAST
Repeati420 – 477585Add
BLAST
Repeati479 – 538606Add
BLAST
Repeati539 – 597597Add
BLAST
Repeati598 – 654578Add
BLAST
Repeati656 – 715609Add
BLAST
Repeati716 – 7745910Add
BLAST
Repeati775 – 8315711Add
BLAST
Repeati833 – 8926012Add
BLAST
Repeati893 – 9515913Add
BLAST
Repeati952 – 10105914Add
BLAST
Repeati1011 – 10695915Add
BLAST
Repeati1070 – 11215216Add
BLAST
Repeati1122 – 11876617Add
BLAST
Repeati1188 – 12465918Add
BLAST
Repeati1247 – 13055919Add
BLAST
Repeati1306 – 13645920Add
BLAST
Repeati1365 – 14235921Add
BLAST
Repeati1424 – 14825922Add
BLAST
Repeati1483 – 15415923Add
BLAST
Repeati1542 – 16005924Add
BLAST
Repeati1601 – 16565625Add
BLAST
Repeati1658 – 17176026Add
BLAST
Repeati1718 – 17765927Add
BLAST
Repeati1777 – 18355928Add
BLAST
Repeati1836 – 18956029Add
BLAST
Repeati1896 – 19515630Add
BLAST
Repeati1953 – 20126031Add
BLAST
Repeati2013 – 20715932Add
BLAST
Repeati2072 – 21275633Add
BLAST
Repeati2129 – 21886034Add
BLAST
Repeati2189 – 22475935Add
BLAST
Repeati2248 – 23065936Add
BLAST
Repeati2307 – 23655937Add
BLAST
Repeati2366 – 24245938Add
BLAST
Repeati2425 – 24835939Add
BLAST
Repeati2484 – 25405740Add
BLAST
Repeati2542 – 26016041Add
BLAST
Repeati2602 – 26535242Add
BLAST
Repeati2654 – 27196643Add
BLAST
Repeati2720 – 27705144Add
BLAST
Repeati2772 – 28376645Add
BLAST
Repeati2838 – 28965946Add
BLAST
Repeati2897 – 29555947Add
BLAST
Repeati2956 – 30145948Add
BLAST
Repeati3015 – 30735949Add
BLAST
Repeati3074 – 31325950Add
BLAST
Repeati3133 – 31915951Add
BLAST
Repeati3192 – 32475652Add
BLAST
Repeati3249 – 33086053Add
BLAST
Repeati3309 – 33675954Add
BLAST
Repeati3368 – 34265955Add
BLAST
Repeati3427 – 34855956Add
BLAST
Repeati3486 – 35445957Add
BLAST
Repeati3604 – 36625958Add
BLAST
Repeati3663 – 37276559Add
BLAST
Domaini4131 – 417040EGF-likePROSITE-ProRule annotationAdd
BLAST
Domaini4184 – 4291108SEAPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni185 – 3727354359 X approximate tandem repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi84 – 38363753Ser-richAdd
BLAST
Compositional biasi3975 – 39806Poly-Ser

Sequence similaritiesi

Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00730000111040.
HOGENOMiHOG000172388.
InParanoidiQ685J3.
OMAiPTSTYSE.
OrthoDBiEOG764723.
PhylomeDBiQ685J3.
TreeFamiTF337883.

Family and domain databases

Gene3Di3.30.70.960. 1 hit.
InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000082. SEA_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00200. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q685J3-1) [UniParc]FASTAAdd to Basket

Also known as: Major, Mb-MUC17

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MPRPGTMALC LLTLVLSLLP PQAAAEQDLS VNRAVWDGGG CISQGDVLNR
60 70 80 90 100
QCQQLSQHVR TGSAANTATG TTSTNVVEPR MYLSCSTNPE MTSIESSVTS
110 120 130 140 150
DTPGVSSTRM TPTESRTTSE STSDSTTLFP SSTEDTSSPT TPEGTDVPMS
160 170 180 190 200
TPSEESISST MAFVSTAPLP SFEAYTSLTY KVDMSTPLTT STQASSSPTT
210 220 230 240 250
PESTTIPKST NSEGSTPLTS MPASTMKVAS SEAITLLTTP VEISTPVTIS
260 270 280 290 300
AQASSSPTTA EGPSLSNSAP SGGSTPLTRM PLSVMLVVSS EASTLSTTPA
310 320 330 340 350
ATNIPVITST EASSSPTTAE GTSIPTSTYT EGSTPLTSTP ASTMPVATSE
360 370 380 390 400
MSTLSITPVD TSTLVTTSTE PSSLPTTAEA TSMLTSTLSE GSTPLTNMPV
410 420 430 440 450
STILVASSEA STTSTIPVDS KTFVTTASEA SSSPTTAEDT SIATSTPSEG
460 470 480 490 500
STPLTSMPVS TTPVASSEAS NLSTTPVDSK TQVTTSTEAS SSPPTAEVNS
510 520 530 540 550
MPTSTPSEGS TPLTSMSVST MPVASSEAST LSTTPVDTST PVTTSSEASS
560 570 580 590 600
SSTTPEGTSI PTSTPSEGST PLTNMPVSTR LVVSSEASTT STTPADSNTF
610 620 630 640 650
VTTSSEASSS STTAEGTSMP TSTYSERGTT ITSMSVSTTL VASSEASTLS
660 670 680 690 700
TTPVDSNTPV TTSTEATSSS TTAEGTSMPT STYTEGSTPL TSMPVNTTLV
710 720 730 740 750
ASSEASTLST TPVDTSTPVT TSTEASSSPT TADGASMPTS TPSEGSTPLT
760 770 780 790 800
SMPVSKTLLT SSEASTLSTT PLDTSTHITT STEASCSPTT TEGTSMPIST
810 820 830 840 850
PSEGSPLLTS IPVSITPVTS PEASTLSTTP VDSNSPVTTS TEVSSSPTPA
860 870 880 890 900
EGTSMPTSTY SEGRTPLTSM PVSTTLVATS AISTLSTTPV DTSTPVTNST
910 920 930 940 950
EARSSPTTSE GTSMPTSTPG EGSTPLTSMP DSTTPVVSSE ARTLSATPVD
960 970 980 990 1000
TSTPVTTSTE ATSSPTTAEG TSIPTSTPSE GTTPLTSTPV SHTLVANSEA
1010 1020 1030 1040 1050
STLSTTPVDS NTPLTTSTEA SSPPPTAEGT SMPTSTPSEG STPLTRMPVS
1060 1070 1080 1090 1100
TTMVASSETS TLSTTPADTS TPVTTYSQAS SSSTTADGTS MPTSTYSEGS
1110 1120 1130 1140 1150
TPLTSVPVST RLVVSSEAST LSTTPVDTSI PVTTSTEASS SPTTAEGTSI
1160 1170 1180 1190 1200
PTSPPSEGTT PLASMPVSTT LVVSSEANTL STTPVDSKTQ VATSTEASSP
1210 1220 1230 1240 1250
PPTAEVTSMP TSTPGERSTP LTSMPVRHTP VASSEASTLS TSPVDTSTPV
1260 1270 1280 1290 1300
TTSAETSSSP TTAEGTSLPT STTSEGSTLL TSIPVSTTLV TSPEASTLLT
1310 1320 1330 1340 1350
TPVDTKGPVV TSNEVSSSPT PAEGTSMPTS TYSEGRTPLT SIPVNTTLVA
1360 1370 1380 1390 1400
SSAISILSTT PVDNSTPVTT STEACSSPTT SEGTSMPNSN PSEGTTPLTS
1410 1420 1430 1440 1450
IPVSTTPVVS SEASTLSATP VDTSTPGTTS AEATSSPTTA EGISIPTSTP
1460 1470 1480 1490 1500
SEGKTPLKSI PVSNTPVANS EASTLSTTPV DSNSPVVTST AVSSSPTPAE
1510 1520 1530 1540 1550
GTSIAISTPS EGSTALTSIP VSTTTVASSE INSLSTTPAV TSTPVTTYSQ
1560 1570 1580 1590 1600
ASSSPTTADG TSMQTSTYSE GSTPLTSLPV STMLVVSSEA NTLSTTPIDS
1610 1620 1630 1640 1650
KTQVTASTEA SSSTTAEGSS MTISTPSEGS PLLTSIPVST TPVASPEAST
1660 1670 1680 1690 1700
LSTTPVDSNS PVITSTEVSS SPTPAEGTSM PTSTYTEGRT PLTSITVRTT
1710 1720 1730 1740 1750
PVASSAISTL STTPVDNSTP VTTSTEARSS PTTSEGTSMP NSTPSEGTTP
1760 1770 1780 1790 1800
LTSIPVSTTP VLSSEASTLS ATPIDTSTPV TTSTEATSSP TTAEGTSIPT
1810 1820 1830 1840 1850
STLSEGMTPL TSTPVSHTLV ANSEASTLST TPVDSNSPVV TSTAVSSSPT
1860 1870 1880 1890 1900
PAEGTSIATS TPSEGSTALT SIPVSTTTVA SSETNTLSTT PAVTSTPVTT
1910 1920 1930 1940 1950
YAQVSSSPTT ADGSSMPTST PREGRPPLTS IPVSTTTVAS SEINTLSTTL
1960 1970 1980 1990 2000
ADTRTPVTTY SQASSSPTTA DGTSMPTPAY SEGSTPLTSM PLSTTLVVSS
2010 2020 2030 2040 2050
EASTLSTTPV DTSTPATTST EGSSSPTTAG GTSIQTSTPS ERTTPLAGMP
2060 2070 2080 2090 2100
VSTTLVVSSE GNTLSTTPVD SKTQVTNSTE ASSSATAEGS SMTISAPSEG
2110 2120 2130 2140 2150
SPLLTSIPLS TTPVASPEAS TLSTTPVDSN SPVITSTEVS SSPIPTEGTS
2160 2170 2180 2190 2200
MQTSTYSDRR TPLTSMPVST TVVASSAIST LSTTPVDTST PVTNSTEARS
2210 2220 2230 2240 2250
SPTTSEGTSM PTSTPSEGST PFTSMPVSTM PVVTSEASTL SATPVDTSTP
2260 2270 2280 2290 2300
VTTSTEATSS PTTAEGTSIP TSTLSEGTTP LTSIPVSHTL VANSEVSTLS
2310 2320 2330 2340 2350
TTPVDSNTPF TTSTEASSPP PTAEGTSMPT STSSEGNTPL TRMPVSTTMV
2360 2370 2380 2390 2400
ASFETSTLST TPADTSTPVT TYSQAGSSPT TADDTSMPTS TYSEGSTPLT
2410 2420 2430 2440 2450
SVPVSTMPVV SSEASTHSTT PVDTSTPVTT STEASSSPTT AEGTSIPTSP
2460 2470 2480 2490 2500
PSEGTTPLAS MPVSTTPVVS SEAGTLSTTP VDTSTPMTTS TEASSSPTTA
2510 2520 2530 2540 2550
EDIVVPISTA SEGSTLLTSI PVSTTPVASP EASTLSTTPV DSNSPVVTST
2560 2570 2580 2590 2600
EISSSATSAE GTSMPTSTYS EGSTPLRSMP VSTKPLASSE ASTLSTTPVD
2610 2620 2630 2640 2650
TSIPVTTSTE TSSSPTTAKD TSMPISTPSE VSTSLTSILV STMPVASSEA
2660 2670 2680 2690 2700
STLSTTPVDT RTLVTTSTGT SSSPTTAEGS SMPTSTPGER STPLTNILVS
2710 2720 2730 2740 2750
TTLLANSEAS TLSTTPVDTS TPVTTSAEAS SSPTTAEGTS MRISTPSDGS
2760 2770 2780 2790 2800
TPLTSILVST LPVASSEAST VSTTAVDTSI PVTTSTEASS SPTTAEVTSM
2810 2820 2830 2840 2850
PTSTPSETST PLTSMPVNHT PVASSEAGTL STTPVDTSTP VTTSTKASSS
2860 2870 2880 2890 2900
PTTAEGIVVP ISTASEGSTL LTSIPVSTTP VASSEASTLS TTPVDTSIPV
2910 2920 2930 2940 2950
TTSTEGSSSP TTAEGTSMPI STPSEVSTPL TSILVSTVPV AGSEASTLST
2960 2970 2980 2990 3000
TPVDTRTPVT TSAEASSSPT TAEGTSMPIS TPGERRTPLT SMSVSTMPVA
3010 3020 3030 3040 3050
SSEASTLSRT PADTSTPVTT STEASSSPTT AEGTGIPIST PSEGSTPLTS
3060 3070 3080 3090 3100
IPVSTTPVAI PEASTLSTTP VDSNSPVVTS TEVSSSPTPA EGTSMPISTY
3110 3120 3130 3140 3150
SEGSTPLTGV PVSTTPVTSS AISTLSTTPV DTSTPVTTST EAHSSPTTSE
3160 3170 3180 3190 3200
GTSMPTSTPS EGSTPLTYMP VSTMLVVSSE DSTLSATPVD TSTPVTTSTE
3210 3220 3230 3240 3250
ATSSTTAEGT SIPTSTPSEG MTPLTSVPVS NTPVASSEAS ILSTTPVDSN
3260 3270 3280 3290 3300
TPLTTSTEAS SSPPTAEGTS MPTSTPSEGS TPLTSMPVST TTVASSETST
3310 3320 3330 3340 3350
LSTTPADTST PVTTYSQASS SPPIADGTSM PTSTYSEGST PLTNMSFSTT
3360 3370 3380 3390 3400
PVVSSEASTL STTPVDTSTP VTTSTEASLS PTTAEGTSIP TSSPSEGTTP
3410 3420 3430 3440 3450
LASMPVSTTP VVSSEVNTLS TTPVDSNTLV TTSTEASSSP TIAEGTSLPT
3460 3470 3480 3490 3500
STTSEGSTPL SIMPLSTTPV ASSEASTLST TPVDTSTPVT TSSPTNSSPT
3510 3520 3530 3540 3550
TAEVTSMPTS TAGEGSTPLT NMPVSTTPVA SSEASTLSTT PVDSNTFVTS
3560 3570 3580 3590 3600
SSQASSSPAT LQVTTMRMST PSEGSSSLTT MLLSSTYVTS SEASTPSTPS
3610 3620 3630 3640 3650
VDRSTPVTTS TQSNSTPTPP EVITLPMSTP SEVSTPLTIM PVSTTSVTIS
3660 3670 3680 3690 3700
EAGTASTLPV DTSTPVITST QVSSSPVTPE GTTMPIWTPS EGSTPLTTMP
3710 3720 3730 3740 3750
VSTTRVTSSE GSTLSTPSVV TSTPVTTSTE AISSSATLDS TTMSVSMPME
3760 3770 3780 3790 3800
ISTLGTTILV STTPVTRFPE SSTPSIPSVY TSMSMTTASE GSSSPTTLEG
3810 3820 3830 3840 3850
TTTMPMSTTS ERSTLLTTVL ISPISVMSPS EASTLSTPPG DTSTPLLTST
3860 3870 3880 3890 3900
KAGSFSIPAE VTTIRISITS ERSTPLTTLL VSTTLPTSFP GASIASTPPL
3910 3920 3930 3940 3950
DTSTTFTPST DTASTPTIPV ATTISVSVIT EGSTPGTTIF IPSTPVTSST
3960 3970 3980 3990 4000
ADVFPATTGA VSTPVITSTE LNTPSTSSSS TTTSFSTTKE FTTPAMTTAA
4010 4020 4030 4040 4050
PLTYVTMSTA PSTPRTTSRG CTTSASTLSA TSTPHTSTSV TTRPVTPSSE
4060 4070 4080 4090 4100
SSRPSTITSH TIPPTFPPAH SSTPPTTSAS STTVNPEAVT TMTTRTKPST
4110 4120 4130 4140 4150
RTTSFPTVTT TAVPTNTTIK SNPTSTPTVP RTTTCFGDGC QNTASRCKNG
4160 4170 4180 4190 4200
GTWDGLKCQC PNLYYGELCE EVVSSIDIGP PETISAQMEL TVTVTSVKFT
4210 4220 4230 4240 4250
EELKNHSSQE FQEFKQTFTE QMNIVYSGIP EYVGVNITKL RLGSVVVEHD
4260 4270 4280 4290 4300
VLLRTKYTPE YKTVLDNATE VVKEKITKVT TQQIMINDIC SDMMCFNTTG
4310 4320 4330 4340 4350
TQVQNITVTQ YDPEEDCRKM AKEYGDYFVV EYRDQKPYCI SPCEPGFSVS
4360 4370 4380 4390 4400
KNCNLGKCQM SLSGPQCLCV TTETHWYSGE TCNQGTQKSL VYGLVGAGVV
4410 4420 4430 4440 4450
LMLIILVALL MLVFRSKREV KRQKYRLSQL YKWQEEDSGP APGTFQNIGF
4460 4470 4480 4490
DICQDDDSIH LESIYSNFQP SLRHIDPETK IRIQRPQVMT TSF
Length:4,493
Mass (Da):451,741
Last modified:May 18, 2010 - v2
Checksum:i883D68DDB0D6E3C1
GO
Isoform 2 (identifier: Q685J3-2) [UniParc]FASTAAdd to Basket

Also known as: Minor, s-MUC17

The sequence of this isoform differs from the canonical sequence as follows:
     4241-4262: RLGSVVVEHDVLLRTKYTPEYK → HDVFQHHWHPSAKHYGDPVRP
     4363-4493: Missing.

Show »
Length:4,361
Mass (Da):436,777
Checksum:i334BF9C863B8B7F7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281D → G in CAE54435. (PubMed:16737958)Curated
Sequence conflicti28 – 281D → G in CAE54436. (PubMed:16737958)Curated
Sequence conflicti65 – 651A → T in CAE54435. (PubMed:16737958)Curated
Sequence conflicti65 – 651A → T in CAE54436. (PubMed:16737958)Curated
Sequence conflicti132 – 1321S → P in CAE54435. (PubMed:16737958)Curated
Sequence conflicti132 – 1321S → P in CAE54436. (PubMed:16737958)Curated
Sequence conflicti3481 – 34811T → S in AAL89737. (PubMed:11855812)Curated
Sequence conflicti3491 – 34911T → N in AAL89737. (PubMed:11855812)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti227 – 2271K → Q.
Corresponds to variant rs10229731 [ dbSNP | Ensembl ].
VAR_040047
Natural varianti272 – 2721G → E.
Corresponds to variant rs10259584 [ dbSNP | Ensembl ].
VAR_040048
Natural varianti427 – 4271A → T.
Corresponds to variant rs56103274 [ dbSNP | Ensembl ].
VAR_061489
Natural varianti571 – 5711P → L.
Corresponds to variant rs34834039 [ dbSNP | Ensembl ].
VAR_061490
Natural varianti925 – 9251P → R.
Corresponds to variant rs11979706 [ dbSNP | Ensembl ].
VAR_061491
Natural varianti942 – 9421R → S.
Corresponds to variant rs10238201 [ dbSNP | Ensembl ].
VAR_040049
Natural varianti982 – 9821T → M.
Corresponds to variant rs4729646 [ dbSNP | Ensembl ].
VAR_040050
Natural varianti1130 – 11301I → T.
Corresponds to variant rs4729647 [ dbSNP | Ensembl ].
VAR_040051
Natural varianti1242 – 12421S → T.
Corresponds to variant rs10265276 [ dbSNP | Ensembl ].
VAR_040052
Natural varianti1246 – 12461T → N.
Corresponds to variant rs4729652 [ dbSNP | Ensembl ].
VAR_040053
Natural varianti1246 – 12461T → S.
Corresponds to variant rs4729651 [ dbSNP | Ensembl ].
VAR_040054
Natural varianti1249 – 12491P → A.
Corresponds to variant rs4729653 [ dbSNP | Ensembl ].
VAR_040055
Natural varianti1348 – 13481L → P.1 Publication
Corresponds to variant rs4269454 [ dbSNP | Ensembl ].
VAR_040056
Natural varianti1375 – 13751C → R.1 Publication
Corresponds to variant rs4367469 [ dbSNP | Ensembl ].
VAR_040057
Natural varianti1480 – 14801V → A.1 Publication
Corresponds to variant rs7780935 [ dbSNP | Ensembl ].
VAR_061492
Natural varianti2096 – 20961A → T.
Corresponds to variant rs28593004 [ dbSNP | Ensembl ].
VAR_061493
Natural varianti2159 – 21591R → G.
Corresponds to variant rs61382267 [ dbSNP | Ensembl ].
VAR_061494
Natural varianti3299 – 32991S → N.
Corresponds to variant rs35988443 [ dbSNP | Ensembl ].
VAR_061495
Natural varianti4334 – 43341D → N.
Corresponds to variant rs6946812 [ dbSNP | Ensembl ].
VAR_040058
Natural varianti4482 – 44821R → Q.
Corresponds to variant rs9656065 [ dbSNP | Ensembl ].
VAR_040059

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei4241 – 426222RLGSV…TPEYK → HDVFQHHWHPSAKHYGDPVR P in isoform 2. 1 PublicationVSP_032648Add
BLAST
Alternative sequencei4363 – 4493131Missing in isoform 2. 1 PublicationVSP_032649Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ606307 mRNA. Translation: CAE54435.1.
AJ606308 mRNA. Translation: CAE54436.1.
AC105446 Genomic DNA. No translation available.
AF016693 mRNA. Translation: AAB71686.1.
AF430017 mRNA. Translation: AAL89737.1.
CCDSiCCDS34711.1. [Q685J3-1]
PIRiPC4396.
RefSeqiNP_001035194.1. NM_001040105.1. [Q685J3-1]
UniGeneiHs.271819.

Genome annotation databases

EnsembliENST00000306151; ENSP00000302716; ENSG00000169876. [Q685J3-1]
GeneIDi140453.
KEGGihsa:140453.
UCSCiuc003uxp.1. human. [Q685J3-1]

Polymorphism databases

DMDMi296439228.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ606307 mRNA. Translation: CAE54435.1 .
AJ606308 mRNA. Translation: CAE54436.1 .
AC105446 Genomic DNA. No translation available.
AF016693 mRNA. Translation: AAB71686.1 .
AF430017 mRNA. Translation: AAL89737.1 .
CCDSi CCDS34711.1. [Q685J3-1 ]
PIRi PC4396.
RefSeqi NP_001035194.1. NM_001040105.1. [Q685J3-1 ]
UniGenei Hs.271819.

3D structure databases

ProteinModelPortali Q685J3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000302716.

PTM databases

PhosphoSitei Q685J3.

Polymorphism databases

DMDMi 296439228.

Proteomic databases

PaxDbi Q685J3.
PRIDEi Q685J3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306151 ; ENSP00000302716 ; ENSG00000169876 . [Q685J3-1 ]
GeneIDi 140453.
KEGGi hsa:140453.
UCSCi uc003uxp.1. human. [Q685J3-1 ]

Organism-specific databases

CTDi 140453.
GeneCardsi GC07P100663.
H-InvDB HIX0006940.
HGNCi HGNC:16800. MUC17.
HPAi HPA031634.
MIMi 608424. gene.
neXtProti NX_Q685J3.
PharmGKBi PA31315.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00730000111040.
HOGENOMi HOG000172388.
InParanoidi Q685J3.
OMAi PTSTYSE.
OrthoDBi EOG764723.
PhylomeDBi Q685J3.
TreeFami TF337883.

Enzyme and pathway databases

Reactomei REACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Miscellaneous databases

GeneWikii MUC17.
GenomeRNAii 140453.
NextBioi 84093.
PROi Q685J3.
SOURCEi Search...

Gene expression databases

Bgeei Q685J3.
CleanExi HS_MUC17.
ExpressionAtlasi Q685J3. baseline.
Genevestigatori Q685J3.

Family and domain databases

Gene3Di 3.30.70.960. 1 hit.
InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000082. SEA_dom.
[Graphical view ]
Pfami PF01390. SEA. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 1 hit.
SM00200. SEA. 1 hit.
[Graphical view ]
SUPFAMi SSF82671. SSF82671. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of human mucin MUC17. Complete coding sequence and organization."
    Moniaux N., Junker W.M., Singh A.P., Jones A.M., Batra S.K.
    J. Biol. Chem. 281:23676-23685(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Tissue: Pancreatic adenocarcinoma.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Molecular cloning of human MUC3 cDNA reveals a novel 59 amino acid tandem repeat region."
    Van Klinken B.J.-W., Van Dijken T.C., Oussoren E., Buller H.A., Dekker J., Einerhand A.W.
    Biochem. Biophys. Res. Commun. 238:143-148(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1347-1582, TISSUE SPECIFICITY, VARIANTS PRO-1348; ARG-1375 AND ALA-1480.
    Tissue: Small intestine.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3465-4493 (ISOFORM 1), TISSUE SPECIFICITY.
  5. "N-glycosylation is required for the surface localization of MUC17 mucin."
    Ho J.J.L., Jaituni R.S., Crawley S.C., Yang S.C., Gum J.R., Kim Y.S.
    Int. J. Oncol. 23:585-592(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION, SUBCELLULAR LOCATION.
  6. "The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine."
    Malmberg E.K., Pelaseyed T., Petersson A.C., Seidler U.E., De Jonge H., Riordan J.R., Hansson G.C.
    Biochem. J. 410:283-289(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PDZK1.

Entry informationi

Entry nameiMUC17_HUMAN
AccessioniPrimary (citable) accession number: Q685J3
Secondary accession number(s): O14761, Q685J2, Q8TDH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3