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Protein

Mucin-17

Gene

MUC17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably plays a role in maintaining homeostasis on mucosal surfaces.1 Publication

GO - Molecular functioni

  • extracellular matrix constituent, lubricant activity Source: UniProtKB
  • PDZ domain binding Source: UniProtKB

GO - Biological processi

  • cellular homeostasis Source: UniProtKB
  • O-glycan processing Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1).
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-17
Short name:
MUC-17
Alternative name(s):
Small intestinal mucin-3
Short name:
MUC-3
Gene namesi
Name:MUC17
Synonyms:MUC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:16800. MUC17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 4393ExtracellularSequence analysisAdd BLAST4368
Transmembranei4394 – 4414HelicalSequence analysisAdd BLAST21
Topological domaini4415 – 4493CytoplasmicSequence analysisAdd BLAST79

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • external side of plasma membrane Source: UniProtKB
  • extracellular region Source: UniProtKB-SubCell
  • Golgi lumen Source: Reactome
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi140453.
OpenTargetsiENSG00000169876.
PharmGKBiPA31315.

Polymorphism and mutation databases

BioMutaiMUC17.
DMDMi296439228.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000032625426 – 4493Mucin-17Add BLAST4468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi471N-linked (GlcNAc...)Sequence analysis1
Glycosylationi696N-linked (GlcNAc...)Sequence analysis1
Glycosylationi898N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1345N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2077N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2194N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3344N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4116N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi4135 ↔ 4147PROSITE-ProRule annotation
Disulfide bondi4140 ↔ 4158PROSITE-ProRule annotation
Disulfide bondi4160 ↔ 4169PROSITE-ProRule annotation
Glycosylationi4205N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4236N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4267N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4297N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4305N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Probably cleaved within the SEA domain.
N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei4243 – 4244CleavageSequence analysis2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ685J3.
PeptideAtlasiQ685J3.
PRIDEiQ685J3.

PTM databases

iPTMnetiQ685J3.
PhosphoSitePlusiQ685J3.

Expressioni

Tissue specificityi

Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers.3 Publications

Gene expression databases

BgeeiENSG00000169876.
CleanExiHS_MUC17.
ExpressionAtlasiQ685J3. baseline and differential.
GenevisibleiQ685J3. HS.

Organism-specific databases

HPAiHPA031634.

Interactioni

Subunit structurei

Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization.1 Publication

GO - Molecular functioni

  • PDZ domain binding Source: UniProtKB

Protein-protein interaction databases

STRINGi9606.ENSP00000302716.

Structurei

3D structure databases

ProteinModelPortaliQ685J3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati185 – 2451Add BLAST61
Repeati246 – 3002Add BLAST55
Repeati301 – 3613Add BLAST61
Repeati362 – 4184Add BLAST57
Repeati420 – 4775Add BLAST58
Repeati479 – 5386Add BLAST60
Repeati539 – 5977Add BLAST59
Repeati598 – 6548Add BLAST57
Repeati656 – 7159Add BLAST60
Repeati716 – 77410Add BLAST59
Repeati775 – 83111Add BLAST57
Repeati833 – 89212Add BLAST60
Repeati893 – 95113Add BLAST59
Repeati952 – 101014Add BLAST59
Repeati1011 – 106915Add BLAST59
Repeati1070 – 112116Add BLAST52
Repeati1122 – 118717Add BLAST66
Repeati1188 – 124618Add BLAST59
Repeati1247 – 130519Add BLAST59
Repeati1306 – 136420Add BLAST59
Repeati1365 – 142321Add BLAST59
Repeati1424 – 148222Add BLAST59
Repeati1483 – 154123Add BLAST59
Repeati1542 – 160024Add BLAST59
Repeati1601 – 165625Add BLAST56
Repeati1658 – 171726Add BLAST60
Repeati1718 – 177627Add BLAST59
Repeati1777 – 183528Add BLAST59
Repeati1836 – 189529Add BLAST60
Repeati1896 – 195130Add BLAST56
Repeati1953 – 201231Add BLAST60
Repeati2013 – 207132Add BLAST59
Repeati2072 – 212733Add BLAST56
Repeati2129 – 218834Add BLAST60
Repeati2189 – 224735Add BLAST59
Repeati2248 – 230636Add BLAST59
Repeati2307 – 236537Add BLAST59
Repeati2366 – 242438Add BLAST59
Repeati2425 – 248339Add BLAST59
Repeati2484 – 254040Add BLAST57
Repeati2542 – 260141Add BLAST60
Repeati2602 – 265342Add BLAST52
Repeati2654 – 271943Add BLAST66
Repeati2720 – 277044Add BLAST51
Repeati2772 – 283745Add BLAST66
Repeati2838 – 289646Add BLAST59
Repeati2897 – 295547Add BLAST59
Repeati2956 – 301448Add BLAST59
Repeati3015 – 307349Add BLAST59
Repeati3074 – 313250Add BLAST59
Repeati3133 – 319151Add BLAST59
Repeati3192 – 324752Add BLAST56
Repeati3249 – 330853Add BLAST60
Repeati3309 – 336754Add BLAST59
Repeati3368 – 342655Add BLAST59
Repeati3427 – 348556Add BLAST59
Repeati3486 – 354457Add BLAST59
Repeati3604 – 366258Add BLAST59
Repeati3663 – 372759Add BLAST65
Domaini4131 – 4170EGF-likePROSITE-ProRule annotationAdd BLAST40
Domaini4184 – 4291SEAPROSITE-ProRule annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni185 – 372759 X approximate tandem repeatsAdd BLAST3543

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi84 – 3836Ser-richAdd BLAST3753
Compositional biasi3975 – 3980Poly-Ser6

Sequence similaritiesi

Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK1M. Eukaryota.
ENOG41126RR. LUCA.
GeneTreeiENSGT00730000111040.
HOGENOMiHOG000172388.
InParanoidiQ685J3.
OMAiHEGFPTA.
OrthoDBiEOG091G019T.
PhylomeDBiQ685J3.
TreeFamiTF337883.

Family and domain databases

Gene3Di3.30.70.960. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000082. SEA_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
[Graphical view]
SMARTiSM00200. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q685J3-1) [UniParc]FASTAAdd to basket
Also known as: Major, Mb-MUC17

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRPGTMALC LLTLVLSLLP PQAAAEQDLS VNRAVWDGGG CISQGDVLNR
60 70 80 90 100
QCQQLSQHVR TGSAANTATG TTSTNVVEPR MYLSCSTNPE MTSIESSVTS
110 120 130 140 150
DTPGVSSTRM TPTESRTTSE STSDSTTLFP SSTEDTSSPT TPEGTDVPMS
160 170 180 190 200
TPSEESISST MAFVSTAPLP SFEAYTSLTY KVDMSTPLTT STQASSSPTT
210 220 230 240 250
PESTTIPKST NSEGSTPLTS MPASTMKVAS SEAITLLTTP VEISTPVTIS
260 270 280 290 300
AQASSSPTTA EGPSLSNSAP SGGSTPLTRM PLSVMLVVSS EASTLSTTPA
310 320 330 340 350
ATNIPVITST EASSSPTTAE GTSIPTSTYT EGSTPLTSTP ASTMPVATSE
360 370 380 390 400
MSTLSITPVD TSTLVTTSTE PSSLPTTAEA TSMLTSTLSE GSTPLTNMPV
410 420 430 440 450
STILVASSEA STTSTIPVDS KTFVTTASEA SSSPTTAEDT SIATSTPSEG
460 470 480 490 500
STPLTSMPVS TTPVASSEAS NLSTTPVDSK TQVTTSTEAS SSPPTAEVNS
510 520 530 540 550
MPTSTPSEGS TPLTSMSVST MPVASSEAST LSTTPVDTST PVTTSSEASS
560 570 580 590 600
SSTTPEGTSI PTSTPSEGST PLTNMPVSTR LVVSSEASTT STTPADSNTF
610 620 630 640 650
VTTSSEASSS STTAEGTSMP TSTYSERGTT ITSMSVSTTL VASSEASTLS
660 670 680 690 700
TTPVDSNTPV TTSTEATSSS TTAEGTSMPT STYTEGSTPL TSMPVNTTLV
710 720 730 740 750
ASSEASTLST TPVDTSTPVT TSTEASSSPT TADGASMPTS TPSEGSTPLT
760 770 780 790 800
SMPVSKTLLT SSEASTLSTT PLDTSTHITT STEASCSPTT TEGTSMPIST
810 820 830 840 850
PSEGSPLLTS IPVSITPVTS PEASTLSTTP VDSNSPVTTS TEVSSSPTPA
860 870 880 890 900
EGTSMPTSTY SEGRTPLTSM PVSTTLVATS AISTLSTTPV DTSTPVTNST
910 920 930 940 950
EARSSPTTSE GTSMPTSTPG EGSTPLTSMP DSTTPVVSSE ARTLSATPVD
960 970 980 990 1000
TSTPVTTSTE ATSSPTTAEG TSIPTSTPSE GTTPLTSTPV SHTLVANSEA
1010 1020 1030 1040 1050
STLSTTPVDS NTPLTTSTEA SSPPPTAEGT SMPTSTPSEG STPLTRMPVS
1060 1070 1080 1090 1100
TTMVASSETS TLSTTPADTS TPVTTYSQAS SSSTTADGTS MPTSTYSEGS
1110 1120 1130 1140 1150
TPLTSVPVST RLVVSSEAST LSTTPVDTSI PVTTSTEASS SPTTAEGTSI
1160 1170 1180 1190 1200
PTSPPSEGTT PLASMPVSTT LVVSSEANTL STTPVDSKTQ VATSTEASSP
1210 1220 1230 1240 1250
PPTAEVTSMP TSTPGERSTP LTSMPVRHTP VASSEASTLS TSPVDTSTPV
1260 1270 1280 1290 1300
TTSAETSSSP TTAEGTSLPT STTSEGSTLL TSIPVSTTLV TSPEASTLLT
1310 1320 1330 1340 1350
TPVDTKGPVV TSNEVSSSPT PAEGTSMPTS TYSEGRTPLT SIPVNTTLVA
1360 1370 1380 1390 1400
SSAISILSTT PVDNSTPVTT STEACSSPTT SEGTSMPNSN PSEGTTPLTS
1410 1420 1430 1440 1450
IPVSTTPVVS SEASTLSATP VDTSTPGTTS AEATSSPTTA EGISIPTSTP
1460 1470 1480 1490 1500
SEGKTPLKSI PVSNTPVANS EASTLSTTPV DSNSPVVTST AVSSSPTPAE
1510 1520 1530 1540 1550
GTSIAISTPS EGSTALTSIP VSTTTVASSE INSLSTTPAV TSTPVTTYSQ
1560 1570 1580 1590 1600
ASSSPTTADG TSMQTSTYSE GSTPLTSLPV STMLVVSSEA NTLSTTPIDS
1610 1620 1630 1640 1650
KTQVTASTEA SSSTTAEGSS MTISTPSEGS PLLTSIPVST TPVASPEAST
1660 1670 1680 1690 1700
LSTTPVDSNS PVITSTEVSS SPTPAEGTSM PTSTYTEGRT PLTSITVRTT
1710 1720 1730 1740 1750
PVASSAISTL STTPVDNSTP VTTSTEARSS PTTSEGTSMP NSTPSEGTTP
1760 1770 1780 1790 1800
LTSIPVSTTP VLSSEASTLS ATPIDTSTPV TTSTEATSSP TTAEGTSIPT
1810 1820 1830 1840 1850
STLSEGMTPL TSTPVSHTLV ANSEASTLST TPVDSNSPVV TSTAVSSSPT
1860 1870 1880 1890 1900
PAEGTSIATS TPSEGSTALT SIPVSTTTVA SSETNTLSTT PAVTSTPVTT
1910 1920 1930 1940 1950
YAQVSSSPTT ADGSSMPTST PREGRPPLTS IPVSTTTVAS SEINTLSTTL
1960 1970 1980 1990 2000
ADTRTPVTTY SQASSSPTTA DGTSMPTPAY SEGSTPLTSM PLSTTLVVSS
2010 2020 2030 2040 2050
EASTLSTTPV DTSTPATTST EGSSSPTTAG GTSIQTSTPS ERTTPLAGMP
2060 2070 2080 2090 2100
VSTTLVVSSE GNTLSTTPVD SKTQVTNSTE ASSSATAEGS SMTISAPSEG
2110 2120 2130 2140 2150
SPLLTSIPLS TTPVASPEAS TLSTTPVDSN SPVITSTEVS SSPIPTEGTS
2160 2170 2180 2190 2200
MQTSTYSDRR TPLTSMPVST TVVASSAIST LSTTPVDTST PVTNSTEARS
2210 2220 2230 2240 2250
SPTTSEGTSM PTSTPSEGST PFTSMPVSTM PVVTSEASTL SATPVDTSTP
2260 2270 2280 2290 2300
VTTSTEATSS PTTAEGTSIP TSTLSEGTTP LTSIPVSHTL VANSEVSTLS
2310 2320 2330 2340 2350
TTPVDSNTPF TTSTEASSPP PTAEGTSMPT STSSEGNTPL TRMPVSTTMV
2360 2370 2380 2390 2400
ASFETSTLST TPADTSTPVT TYSQAGSSPT TADDTSMPTS TYSEGSTPLT
2410 2420 2430 2440 2450
SVPVSTMPVV SSEASTHSTT PVDTSTPVTT STEASSSPTT AEGTSIPTSP
2460 2470 2480 2490 2500
PSEGTTPLAS MPVSTTPVVS SEAGTLSTTP VDTSTPMTTS TEASSSPTTA
2510 2520 2530 2540 2550
EDIVVPISTA SEGSTLLTSI PVSTTPVASP EASTLSTTPV DSNSPVVTST
2560 2570 2580 2590 2600
EISSSATSAE GTSMPTSTYS EGSTPLRSMP VSTKPLASSE ASTLSTTPVD
2610 2620 2630 2640 2650
TSIPVTTSTE TSSSPTTAKD TSMPISTPSE VSTSLTSILV STMPVASSEA
2660 2670 2680 2690 2700
STLSTTPVDT RTLVTTSTGT SSSPTTAEGS SMPTSTPGER STPLTNILVS
2710 2720 2730 2740 2750
TTLLANSEAS TLSTTPVDTS TPVTTSAEAS SSPTTAEGTS MRISTPSDGS
2760 2770 2780 2790 2800
TPLTSILVST LPVASSEAST VSTTAVDTSI PVTTSTEASS SPTTAEVTSM
2810 2820 2830 2840 2850
PTSTPSETST PLTSMPVNHT PVASSEAGTL STTPVDTSTP VTTSTKASSS
2860 2870 2880 2890 2900
PTTAEGIVVP ISTASEGSTL LTSIPVSTTP VASSEASTLS TTPVDTSIPV
2910 2920 2930 2940 2950
TTSTEGSSSP TTAEGTSMPI STPSEVSTPL TSILVSTVPV AGSEASTLST
2960 2970 2980 2990 3000
TPVDTRTPVT TSAEASSSPT TAEGTSMPIS TPGERRTPLT SMSVSTMPVA
3010 3020 3030 3040 3050
SSEASTLSRT PADTSTPVTT STEASSSPTT AEGTGIPIST PSEGSTPLTS
3060 3070 3080 3090 3100
IPVSTTPVAI PEASTLSTTP VDSNSPVVTS TEVSSSPTPA EGTSMPISTY
3110 3120 3130 3140 3150
SEGSTPLTGV PVSTTPVTSS AISTLSTTPV DTSTPVTTST EAHSSPTTSE
3160 3170 3180 3190 3200
GTSMPTSTPS EGSTPLTYMP VSTMLVVSSE DSTLSATPVD TSTPVTTSTE
3210 3220 3230 3240 3250
ATSSTTAEGT SIPTSTPSEG MTPLTSVPVS NTPVASSEAS ILSTTPVDSN
3260 3270 3280 3290 3300
TPLTTSTEAS SSPPTAEGTS MPTSTPSEGS TPLTSMPVST TTVASSETST
3310 3320 3330 3340 3350
LSTTPADTST PVTTYSQASS SPPIADGTSM PTSTYSEGST PLTNMSFSTT
3360 3370 3380 3390 3400
PVVSSEASTL STTPVDTSTP VTTSTEASLS PTTAEGTSIP TSSPSEGTTP
3410 3420 3430 3440 3450
LASMPVSTTP VVSSEVNTLS TTPVDSNTLV TTSTEASSSP TIAEGTSLPT
3460 3470 3480 3490 3500
STTSEGSTPL SIMPLSTTPV ASSEASTLST TPVDTSTPVT TSSPTNSSPT
3510 3520 3530 3540 3550
TAEVTSMPTS TAGEGSTPLT NMPVSTTPVA SSEASTLSTT PVDSNTFVTS
3560 3570 3580 3590 3600
SSQASSSPAT LQVTTMRMST PSEGSSSLTT MLLSSTYVTS SEASTPSTPS
3610 3620 3630 3640 3650
VDRSTPVTTS TQSNSTPTPP EVITLPMSTP SEVSTPLTIM PVSTTSVTIS
3660 3670 3680 3690 3700
EAGTASTLPV DTSTPVITST QVSSSPVTPE GTTMPIWTPS EGSTPLTTMP
3710 3720 3730 3740 3750
VSTTRVTSSE GSTLSTPSVV TSTPVTTSTE AISSSATLDS TTMSVSMPME
3760 3770 3780 3790 3800
ISTLGTTILV STTPVTRFPE SSTPSIPSVY TSMSMTTASE GSSSPTTLEG
3810 3820 3830 3840 3850
TTTMPMSTTS ERSTLLTTVL ISPISVMSPS EASTLSTPPG DTSTPLLTST
3860 3870 3880 3890 3900
KAGSFSIPAE VTTIRISITS ERSTPLTTLL VSTTLPTSFP GASIASTPPL
3910 3920 3930 3940 3950
DTSTTFTPST DTASTPTIPV ATTISVSVIT EGSTPGTTIF IPSTPVTSST
3960 3970 3980 3990 4000
ADVFPATTGA VSTPVITSTE LNTPSTSSSS TTTSFSTTKE FTTPAMTTAA
4010 4020 4030 4040 4050
PLTYVTMSTA PSTPRTTSRG CTTSASTLSA TSTPHTSTSV TTRPVTPSSE
4060 4070 4080 4090 4100
SSRPSTITSH TIPPTFPPAH SSTPPTTSAS STTVNPEAVT TMTTRTKPST
4110 4120 4130 4140 4150
RTTSFPTVTT TAVPTNTTIK SNPTSTPTVP RTTTCFGDGC QNTASRCKNG
4160 4170 4180 4190 4200
GTWDGLKCQC PNLYYGELCE EVVSSIDIGP PETISAQMEL TVTVTSVKFT
4210 4220 4230 4240 4250
EELKNHSSQE FQEFKQTFTE QMNIVYSGIP EYVGVNITKL RLGSVVVEHD
4260 4270 4280 4290 4300
VLLRTKYTPE YKTVLDNATE VVKEKITKVT TQQIMINDIC SDMMCFNTTG
4310 4320 4330 4340 4350
TQVQNITVTQ YDPEEDCRKM AKEYGDYFVV EYRDQKPYCI SPCEPGFSVS
4360 4370 4380 4390 4400
KNCNLGKCQM SLSGPQCLCV TTETHWYSGE TCNQGTQKSL VYGLVGAGVV
4410 4420 4430 4440 4450
LMLIILVALL MLVFRSKREV KRQKYRLSQL YKWQEEDSGP APGTFQNIGF
4460 4470 4480 4490
DICQDDDSIH LESIYSNFQP SLRHIDPETK IRIQRPQVMT TSF
Length:4,493
Mass (Da):451,741
Last modified:May 18, 2010 - v2
Checksum:i883D68DDB0D6E3C1
GO
Isoform 2 (identifier: Q685J3-2) [UniParc]FASTAAdd to basket
Also known as: Minor, s-MUC17

The sequence of this isoform differs from the canonical sequence as follows:
     4241-4262: RLGSVVVEHDVLLRTKYTPEYK → HDVFQHHWHPSAKHYGDPVRP
     4363-4493: Missing.

Show »
Length:4,361
Mass (Da):436,777
Checksum:i334BF9C863B8B7F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28D → G in CAE54435 (PubMed:16737958).Curated1
Sequence conflicti28D → G in CAE54436 (PubMed:16737958).Curated1
Sequence conflicti65A → T in CAE54435 (PubMed:16737958).Curated1
Sequence conflicti65A → T in CAE54436 (PubMed:16737958).Curated1
Sequence conflicti132S → P in CAE54435 (PubMed:16737958).Curated1
Sequence conflicti132S → P in CAE54436 (PubMed:16737958).Curated1
Sequence conflicti3481T → S in AAL89737 (PubMed:11855812).Curated1
Sequence conflicti3491T → N in AAL89737 (PubMed:11855812).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040047227K → Q.Corresponds to variant rs10229731dbSNPEnsembl.1
Natural variantiVAR_040048272G → E.Corresponds to variant rs10259584dbSNPEnsembl.1
Natural variantiVAR_061489427A → T.Corresponds to variant rs56103274dbSNPEnsembl.1
Natural variantiVAR_061490571P → L.Corresponds to variant rs34834039dbSNPEnsembl.1
Natural variantiVAR_061491925P → R.Corresponds to variant rs11979706dbSNPEnsembl.1
Natural variantiVAR_040049942R → S.Corresponds to variant rs10238201dbSNPEnsembl.1
Natural variantiVAR_040050982T → M.Corresponds to variant rs4729646dbSNPEnsembl.1
Natural variantiVAR_0400511130I → T.Corresponds to variant rs4729647dbSNPEnsembl.1
Natural variantiVAR_0400521242S → T.Corresponds to variant rs10265276dbSNPEnsembl.1
Natural variantiVAR_0400531246T → N.Corresponds to variant rs4729652dbSNPEnsembl.1
Natural variantiVAR_0400541246T → S.Corresponds to variant rs4729651dbSNPEnsembl.1
Natural variantiVAR_0400551249P → A.Corresponds to variant rs4729653dbSNPEnsembl.1
Natural variantiVAR_0400561348L → P.1 PublicationCorresponds to variant rs4269454dbSNPEnsembl.1
Natural variantiVAR_0400571375C → R.1 PublicationCorresponds to variant rs4367469dbSNPEnsembl.1
Natural variantiVAR_0614921480V → A.1 PublicationCorresponds to variant rs7780935dbSNPEnsembl.1
Natural variantiVAR_0614932096A → T.Corresponds to variant rs28593004dbSNPEnsembl.1
Natural variantiVAR_0614942159R → G.Corresponds to variant rs61382267dbSNPEnsembl.1
Natural variantiVAR_0614953299S → N.Corresponds to variant rs35988443dbSNPEnsembl.1
Natural variantiVAR_0400584334D → N.Corresponds to variant rs6946812dbSNPEnsembl.1
Natural variantiVAR_0400594482R → Q.Corresponds to variant rs9656065dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0326484241 – 4262RLGSV…TPEYK → HDVFQHHWHPSAKHYGDPVR P in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0326494363 – 4493Missing in isoform 2. 1 PublicationAdd BLAST131

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ606307 mRNA. Translation: CAE54435.1.
AJ606308 mRNA. Translation: CAE54436.1.
AC105446 Genomic DNA. No translation available.
AF016693 mRNA. Translation: AAB71686.1.
AF430017 mRNA. Translation: AAL89737.1.
CCDSiCCDS34711.1. [Q685J3-1]
PIRiPC4396.
RefSeqiNP_001035194.1. NM_001040105.1. [Q685J3-1]
UniGeneiHs.271819.

Genome annotation databases

EnsembliENST00000306151; ENSP00000302716; ENSG00000169876. [Q685J3-1]
GeneIDi140453.
KEGGihsa:140453.
UCSCiuc003uxp.2. human. [Q685J3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ606307 mRNA. Translation: CAE54435.1.
AJ606308 mRNA. Translation: CAE54436.1.
AC105446 Genomic DNA. No translation available.
AF016693 mRNA. Translation: AAB71686.1.
AF430017 mRNA. Translation: AAL89737.1.
CCDSiCCDS34711.1. [Q685J3-1]
PIRiPC4396.
RefSeqiNP_001035194.1. NM_001040105.1. [Q685J3-1]
UniGeneiHs.271819.

3D structure databases

ProteinModelPortaliQ685J3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302716.

PTM databases

iPTMnetiQ685J3.
PhosphoSitePlusiQ685J3.

Polymorphism and mutation databases

BioMutaiMUC17.
DMDMi296439228.

Proteomic databases

PaxDbiQ685J3.
PeptideAtlasiQ685J3.
PRIDEiQ685J3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306151; ENSP00000302716; ENSG00000169876. [Q685J3-1]
GeneIDi140453.
KEGGihsa:140453.
UCSCiuc003uxp.2. human. [Q685J3-1]

Organism-specific databases

CTDi140453.
DisGeNETi140453.
GeneCardsiMUC17.
H-InvDBHIX0006940.
HGNCiHGNC:16800. MUC17.
HPAiHPA031634.
MIMi608424. gene.
neXtProtiNX_Q685J3.
OpenTargetsiENSG00000169876.
PharmGKBiPA31315.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK1M. Eukaryota.
ENOG41126RR. LUCA.
GeneTreeiENSGT00730000111040.
HOGENOMiHOG000172388.
InParanoidiQ685J3.
OMAiHEGFPTA.
OrthoDBiEOG091G019T.
PhylomeDBiQ685J3.
TreeFamiTF337883.

Enzyme and pathway databases

ReactomeiR-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1).
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

GeneWikiiMUC17.
GenomeRNAii140453.
PROiQ685J3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169876.
CleanExiHS_MUC17.
ExpressionAtlasiQ685J3. baseline and differential.
GenevisibleiQ685J3. HS.

Family and domain databases

Gene3Di3.30.70.960. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000082. SEA_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
[Graphical view]
SMARTiSM00200. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUC17_HUMAN
AccessioniPrimary (citable) accession number: Q685J3
Secondary accession number(s): O14761, Q685J2, Q8TDH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.