Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q685J3 (MUC17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mucin-17

Short name=MUC-17
Alternative name(s):
Small intestinal mucin-3
Short name=MUC-3
Gene names
Name:MUC17
Synonyms:MUC3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length4493 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably plays a role in maintaining homeostasis on mucosal surfaces. Ref.6

Subunit structure

Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Ref.6

Subcellular location

Isoform 1: Cell membrane; Single-pass membrane protein Ref.5.

Isoform 2: Secreted Probable. Cell membrane Ref.5.

Tissue specificity

Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers. Ref.1 Ref.3 Ref.4

Post-translational modification

Probably cleaved within the SEA domain.

N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated. Ref.5

Sequence similarities

Contains 1 EGF-like domain.

Contains 1 SEA domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q685J3-1)

Also known as: Major; Mb-MUC17;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q685J3-2)

Also known as: Minor; s-MUC17;

The sequence of this isoform differs from the canonical sequence as follows:
     4241-4262: RLGSVVVEHDVLLRTKYTPEYK → HDVFQHHWHPSAKHYGDPVRP
     4363-4493: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 44934468Mucin-17
PRO_0000326254

Regions

Topological domain26 – 43934368Extracellular Potential
Transmembrane4394 – 441421Helical; Potential
Topological domain4415 – 449379Cytoplasmic Potential
Repeat185 – 245611
Repeat246 – 300552
Repeat301 – 361613
Repeat362 – 418574
Repeat420 – 477585
Repeat479 – 538606
Repeat539 – 597597
Repeat598 – 654578
Repeat656 – 715609
Repeat716 – 7745910
Repeat775 – 8315711
Repeat833 – 8926012
Repeat893 – 9515913
Repeat952 – 10105914
Repeat1011 – 10695915
Repeat1070 – 11215216
Repeat1122 – 11876617
Repeat1188 – 12465918
Repeat1247 – 13055919
Repeat1306 – 13645920
Repeat1365 – 14235921
Repeat1424 – 14825922
Repeat1483 – 15415923
Repeat1542 – 16005924
Repeat1601 – 16565625
Repeat1658 – 17176026
Repeat1718 – 17765927
Repeat1777 – 18355928
Repeat1836 – 18956029
Repeat1896 – 19515630
Repeat1953 – 20126031
Repeat2013 – 20715932
Repeat2072 – 21275633
Repeat2129 – 21886034
Repeat2189 – 22475935
Repeat2248 – 23065936
Repeat2307 – 23655937
Repeat2366 – 24245938
Repeat2425 – 24835939
Repeat2484 – 25405740
Repeat2542 – 26016041
Repeat2602 – 26535242
Repeat2654 – 27196643
Repeat2720 – 27705144
Repeat2772 – 28376645
Repeat2838 – 28965946
Repeat2897 – 29555947
Repeat2956 – 30145948
Repeat3015 – 30735949
Repeat3074 – 31325950
Repeat3133 – 31915951
Repeat3192 – 32475652
Repeat3249 – 33086053
Repeat3309 – 33675954
Repeat3368 – 34265955
Repeat3427 – 34855956
Repeat3486 – 35445957
Repeat3604 – 36625958
Repeat3663 – 37276559
Domain4131 – 417040EGF-like
Domain4184 – 4291108SEA
Region185 – 3727354359 X approximate tandem repeats
Compositional bias84 – 38363753Ser-rich
Compositional bias3975 – 39806Poly-Ser

Sites

Site4243 – 42442Cleavage Potential

Amino acid modifications

Glycosylation4711N-linked (GlcNAc...) Potential
Glycosylation6961N-linked (GlcNAc...) Potential
Glycosylation8981N-linked (GlcNAc...) Potential
Glycosylation13451N-linked (GlcNAc...) Potential
Glycosylation20771N-linked (GlcNAc...) Potential
Glycosylation21941N-linked (GlcNAc...) Potential
Glycosylation33441N-linked (GlcNAc...) Potential
Glycosylation41161N-linked (GlcNAc...) Potential
Glycosylation42051N-linked (GlcNAc...) Potential
Glycosylation42361N-linked (GlcNAc...) Potential
Glycosylation42671N-linked (GlcNAc...) Potential
Glycosylation42971N-linked (GlcNAc...) Potential
Glycosylation43051N-linked (GlcNAc...) Potential
Disulfide bond4135 ↔ 4147 By similarity
Disulfide bond4140 ↔ 4158 By similarity
Disulfide bond4160 ↔ 4169 By similarity

Natural variations

Alternative sequence4241 – 426222RLGSV…TPEYK → HDVFQHHWHPSAKHYGDPVR P in isoform 2.
VSP_032648
Alternative sequence4363 – 4493131Missing in isoform 2.
VSP_032649
Natural variant2271K → Q.
Corresponds to variant rs10229731 [ dbSNP | Ensembl ].
VAR_040047
Natural variant2721G → E.
Corresponds to variant rs10259584 [ dbSNP | Ensembl ].
VAR_040048
Natural variant4271A → T.
Corresponds to variant rs56103274 [ dbSNP | Ensembl ].
VAR_061489
Natural variant5711P → L.
Corresponds to variant rs34834039 [ dbSNP | Ensembl ].
VAR_061490
Natural variant9251P → R.
Corresponds to variant rs11979706 [ dbSNP | Ensembl ].
VAR_061491
Natural variant9421R → S.
Corresponds to variant rs10238201 [ dbSNP | Ensembl ].
VAR_040049
Natural variant9821T → M.
Corresponds to variant rs4729646 [ dbSNP | Ensembl ].
VAR_040050
Natural variant11301I → T.
Corresponds to variant rs4729647 [ dbSNP | Ensembl ].
VAR_040051
Natural variant12421S → T.
Corresponds to variant rs10265276 [ dbSNP | Ensembl ].
VAR_040052
Natural variant12461T → N.
Corresponds to variant rs4729652 [ dbSNP | Ensembl ].
VAR_040053
Natural variant12461T → S.
Corresponds to variant rs4729651 [ dbSNP | Ensembl ].
VAR_040054
Natural variant12491P → A.
Corresponds to variant rs4729653 [ dbSNP | Ensembl ].
VAR_040055
Natural variant13481L → P. Ref.3
Corresponds to variant rs4269454 [ dbSNP | Ensembl ].
VAR_040056
Natural variant13751C → R. Ref.3
Corresponds to variant rs4367469 [ dbSNP | Ensembl ].
VAR_040057
Natural variant14801V → A. Ref.3
Corresponds to variant rs7780935 [ dbSNP | Ensembl ].
VAR_061492
Natural variant20961A → T.
Corresponds to variant rs28593004 [ dbSNP | Ensembl ].
VAR_061493
Natural variant21591R → G.
Corresponds to variant rs61382267 [ dbSNP | Ensembl ].
VAR_061494
Natural variant32991S → N.
Corresponds to variant rs35988443 [ dbSNP | Ensembl ].
VAR_061495
Natural variant43341D → N.
Corresponds to variant rs6946812 [ dbSNP | Ensembl ].
VAR_040058
Natural variant44821R → Q.
Corresponds to variant rs9656065 [ dbSNP | Ensembl ].
VAR_040059

Experimental info

Sequence conflict281D → G in CAE54435. Ref.1
Sequence conflict281D → G in CAE54436. Ref.1
Sequence conflict651A → T in CAE54435. Ref.1
Sequence conflict651A → T in CAE54436. Ref.1
Sequence conflict1321S → P in CAE54435. Ref.1
Sequence conflict1321S → P in CAE54436. Ref.1
Sequence conflict34811T → S in AAL89737. Ref.4
Sequence conflict34911T → N in AAL89737. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Major) (Mb-MUC17) [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 883D68DDB0D6E3C1

FASTA4,493451,741
        10         20         30         40         50         60 
MPRPGTMALC LLTLVLSLLP PQAAAEQDLS VNRAVWDGGG CISQGDVLNR QCQQLSQHVR 

        70         80         90        100        110        120 
TGSAANTATG TTSTNVVEPR MYLSCSTNPE MTSIESSVTS DTPGVSSTRM TPTESRTTSE 

       130        140        150        160        170        180 
STSDSTTLFP SSTEDTSSPT TPEGTDVPMS TPSEESISST MAFVSTAPLP SFEAYTSLTY 

       190        200        210        220        230        240 
KVDMSTPLTT STQASSSPTT PESTTIPKST NSEGSTPLTS MPASTMKVAS SEAITLLTTP 

       250        260        270        280        290        300 
VEISTPVTIS AQASSSPTTA EGPSLSNSAP SGGSTPLTRM PLSVMLVVSS EASTLSTTPA 

       310        320        330        340        350        360 
ATNIPVITST EASSSPTTAE GTSIPTSTYT EGSTPLTSTP ASTMPVATSE MSTLSITPVD 

       370        380        390        400        410        420 
TSTLVTTSTE PSSLPTTAEA TSMLTSTLSE GSTPLTNMPV STILVASSEA STTSTIPVDS 

       430        440        450        460        470        480 
KTFVTTASEA SSSPTTAEDT SIATSTPSEG STPLTSMPVS TTPVASSEAS NLSTTPVDSK 

       490        500        510        520        530        540 
TQVTTSTEAS SSPPTAEVNS MPTSTPSEGS TPLTSMSVST MPVASSEAST LSTTPVDTST 

       550        560        570        580        590        600 
PVTTSSEASS SSTTPEGTSI PTSTPSEGST PLTNMPVSTR LVVSSEASTT STTPADSNTF 

       610        620        630        640        650        660 
VTTSSEASSS STTAEGTSMP TSTYSERGTT ITSMSVSTTL VASSEASTLS TTPVDSNTPV 

       670        680        690        700        710        720 
TTSTEATSSS TTAEGTSMPT STYTEGSTPL TSMPVNTTLV ASSEASTLST TPVDTSTPVT 

       730        740        750        760        770        780 
TSTEASSSPT TADGASMPTS TPSEGSTPLT SMPVSKTLLT SSEASTLSTT PLDTSTHITT 

       790        800        810        820        830        840 
STEASCSPTT TEGTSMPIST PSEGSPLLTS IPVSITPVTS PEASTLSTTP VDSNSPVTTS 

       850        860        870        880        890        900 
TEVSSSPTPA EGTSMPTSTY SEGRTPLTSM PVSTTLVATS AISTLSTTPV DTSTPVTNST 

       910        920        930        940        950        960 
EARSSPTTSE GTSMPTSTPG EGSTPLTSMP DSTTPVVSSE ARTLSATPVD TSTPVTTSTE 

       970        980        990       1000       1010       1020 
ATSSPTTAEG TSIPTSTPSE GTTPLTSTPV SHTLVANSEA STLSTTPVDS NTPLTTSTEA 

      1030       1040       1050       1060       1070       1080 
SSPPPTAEGT SMPTSTPSEG STPLTRMPVS TTMVASSETS TLSTTPADTS TPVTTYSQAS 

      1090       1100       1110       1120       1130       1140 
SSSTTADGTS MPTSTYSEGS TPLTSVPVST RLVVSSEAST LSTTPVDTSI PVTTSTEASS 

      1150       1160       1170       1180       1190       1200 
SPTTAEGTSI PTSPPSEGTT PLASMPVSTT LVVSSEANTL STTPVDSKTQ VATSTEASSP 

      1210       1220       1230       1240       1250       1260 
PPTAEVTSMP TSTPGERSTP LTSMPVRHTP VASSEASTLS TSPVDTSTPV TTSAETSSSP 

      1270       1280       1290       1300       1310       1320 
TTAEGTSLPT STTSEGSTLL TSIPVSTTLV TSPEASTLLT TPVDTKGPVV TSNEVSSSPT 

      1330       1340       1350       1360       1370       1380 
PAEGTSMPTS TYSEGRTPLT SIPVNTTLVA SSAISILSTT PVDNSTPVTT STEACSSPTT 

      1390       1400       1410       1420       1430       1440 
SEGTSMPNSN PSEGTTPLTS IPVSTTPVVS SEASTLSATP VDTSTPGTTS AEATSSPTTA 

      1450       1460       1470       1480       1490       1500 
EGISIPTSTP SEGKTPLKSI PVSNTPVANS EASTLSTTPV DSNSPVVTST AVSSSPTPAE 

      1510       1520       1530       1540       1550       1560 
GTSIAISTPS EGSTALTSIP VSTTTVASSE INSLSTTPAV TSTPVTTYSQ ASSSPTTADG 

      1570       1580       1590       1600       1610       1620 
TSMQTSTYSE GSTPLTSLPV STMLVVSSEA NTLSTTPIDS KTQVTASTEA SSSTTAEGSS 

      1630       1640       1650       1660       1670       1680 
MTISTPSEGS PLLTSIPVST TPVASPEAST LSTTPVDSNS PVITSTEVSS SPTPAEGTSM 

      1690       1700       1710       1720       1730       1740 
PTSTYTEGRT PLTSITVRTT PVASSAISTL STTPVDNSTP VTTSTEARSS PTTSEGTSMP 

      1750       1760       1770       1780       1790       1800 
NSTPSEGTTP LTSIPVSTTP VLSSEASTLS ATPIDTSTPV TTSTEATSSP TTAEGTSIPT 

      1810       1820       1830       1840       1850       1860 
STLSEGMTPL TSTPVSHTLV ANSEASTLST TPVDSNSPVV TSTAVSSSPT PAEGTSIATS 

      1870       1880       1890       1900       1910       1920 
TPSEGSTALT SIPVSTTTVA SSETNTLSTT PAVTSTPVTT YAQVSSSPTT ADGSSMPTST 

      1930       1940       1950       1960       1970       1980 
PREGRPPLTS IPVSTTTVAS SEINTLSTTL ADTRTPVTTY SQASSSPTTA DGTSMPTPAY 

      1990       2000       2010       2020       2030       2040 
SEGSTPLTSM PLSTTLVVSS EASTLSTTPV DTSTPATTST EGSSSPTTAG GTSIQTSTPS 

      2050       2060       2070       2080       2090       2100 
ERTTPLAGMP VSTTLVVSSE GNTLSTTPVD SKTQVTNSTE ASSSATAEGS SMTISAPSEG 

      2110       2120       2130       2140       2150       2160 
SPLLTSIPLS TTPVASPEAS TLSTTPVDSN SPVITSTEVS SSPIPTEGTS MQTSTYSDRR 

      2170       2180       2190       2200       2210       2220 
TPLTSMPVST TVVASSAIST LSTTPVDTST PVTNSTEARS SPTTSEGTSM PTSTPSEGST 

      2230       2240       2250       2260       2270       2280 
PFTSMPVSTM PVVTSEASTL SATPVDTSTP VTTSTEATSS PTTAEGTSIP TSTLSEGTTP 

      2290       2300       2310       2320       2330       2340 
LTSIPVSHTL VANSEVSTLS TTPVDSNTPF TTSTEASSPP PTAEGTSMPT STSSEGNTPL 

      2350       2360       2370       2380       2390       2400 
TRMPVSTTMV ASFETSTLST TPADTSTPVT TYSQAGSSPT TADDTSMPTS TYSEGSTPLT 

      2410       2420       2430       2440       2450       2460 
SVPVSTMPVV SSEASTHSTT PVDTSTPVTT STEASSSPTT AEGTSIPTSP PSEGTTPLAS 

      2470       2480       2490       2500       2510       2520 
MPVSTTPVVS SEAGTLSTTP VDTSTPMTTS TEASSSPTTA EDIVVPISTA SEGSTLLTSI 

      2530       2540       2550       2560       2570       2580 
PVSTTPVASP EASTLSTTPV DSNSPVVTST EISSSATSAE GTSMPTSTYS EGSTPLRSMP 

      2590       2600       2610       2620       2630       2640 
VSTKPLASSE ASTLSTTPVD TSIPVTTSTE TSSSPTTAKD TSMPISTPSE VSTSLTSILV 

      2650       2660       2670       2680       2690       2700 
STMPVASSEA STLSTTPVDT RTLVTTSTGT SSSPTTAEGS SMPTSTPGER STPLTNILVS 

      2710       2720       2730       2740       2750       2760 
TTLLANSEAS TLSTTPVDTS TPVTTSAEAS SSPTTAEGTS MRISTPSDGS TPLTSILVST 

      2770       2780       2790       2800       2810       2820 
LPVASSEAST VSTTAVDTSI PVTTSTEASS SPTTAEVTSM PTSTPSETST PLTSMPVNHT 

      2830       2840       2850       2860       2870       2880 
PVASSEAGTL STTPVDTSTP VTTSTKASSS PTTAEGIVVP ISTASEGSTL LTSIPVSTTP 

      2890       2900       2910       2920       2930       2940 
VASSEASTLS TTPVDTSIPV TTSTEGSSSP TTAEGTSMPI STPSEVSTPL TSILVSTVPV 

      2950       2960       2970       2980       2990       3000 
AGSEASTLST TPVDTRTPVT TSAEASSSPT TAEGTSMPIS TPGERRTPLT SMSVSTMPVA 

      3010       3020       3030       3040       3050       3060 
SSEASTLSRT PADTSTPVTT STEASSSPTT AEGTGIPIST PSEGSTPLTS IPVSTTPVAI 

      3070       3080       3090       3100       3110       3120 
PEASTLSTTP VDSNSPVVTS TEVSSSPTPA EGTSMPISTY SEGSTPLTGV PVSTTPVTSS 

      3130       3140       3150       3160       3170       3180 
AISTLSTTPV DTSTPVTTST EAHSSPTTSE GTSMPTSTPS EGSTPLTYMP VSTMLVVSSE 

      3190       3200       3210       3220       3230       3240 
DSTLSATPVD TSTPVTTSTE ATSSTTAEGT SIPTSTPSEG MTPLTSVPVS NTPVASSEAS 

      3250       3260       3270       3280       3290       3300 
ILSTTPVDSN TPLTTSTEAS SSPPTAEGTS MPTSTPSEGS TPLTSMPVST TTVASSETST 

      3310       3320       3330       3340       3350       3360 
LSTTPADTST PVTTYSQASS SPPIADGTSM PTSTYSEGST PLTNMSFSTT PVVSSEASTL 

      3370       3380       3390       3400       3410       3420 
STTPVDTSTP VTTSTEASLS PTTAEGTSIP TSSPSEGTTP LASMPVSTTP VVSSEVNTLS 

      3430       3440       3450       3460       3470       3480 
TTPVDSNTLV TTSTEASSSP TIAEGTSLPT STTSEGSTPL SIMPLSTTPV ASSEASTLST 

      3490       3500       3510       3520       3530       3540 
TPVDTSTPVT TSSPTNSSPT TAEVTSMPTS TAGEGSTPLT NMPVSTTPVA SSEASTLSTT 

      3550       3560       3570       3580       3590       3600 
PVDSNTFVTS SSQASSSPAT LQVTTMRMST PSEGSSSLTT MLLSSTYVTS SEASTPSTPS 

      3610       3620       3630       3640       3650       3660 
VDRSTPVTTS TQSNSTPTPP EVITLPMSTP SEVSTPLTIM PVSTTSVTIS EAGTASTLPV 

      3670       3680       3690       3700       3710       3720 
DTSTPVITST QVSSSPVTPE GTTMPIWTPS EGSTPLTTMP VSTTRVTSSE GSTLSTPSVV 

      3730       3740       3750       3760       3770       3780 
TSTPVTTSTE AISSSATLDS TTMSVSMPME ISTLGTTILV STTPVTRFPE SSTPSIPSVY 

      3790       3800       3810       3820       3830       3840 
TSMSMTTASE GSSSPTTLEG TTTMPMSTTS ERSTLLTTVL ISPISVMSPS EASTLSTPPG 

      3850       3860       3870       3880       3890       3900 
DTSTPLLTST KAGSFSIPAE VTTIRISITS ERSTPLTTLL VSTTLPTSFP GASIASTPPL 

      3910       3920       3930       3940       3950       3960 
DTSTTFTPST DTASTPTIPV ATTISVSVIT EGSTPGTTIF IPSTPVTSST ADVFPATTGA 

      3970       3980       3990       4000       4010       4020 
VSTPVITSTE LNTPSTSSSS TTTSFSTTKE FTTPAMTTAA PLTYVTMSTA PSTPRTTSRG 

      4030       4040       4050       4060       4070       4080 
CTTSASTLSA TSTPHTSTSV TTRPVTPSSE SSRPSTITSH TIPPTFPPAH SSTPPTTSAS 

      4090       4100       4110       4120       4130       4140 
STTVNPEAVT TMTTRTKPST RTTSFPTVTT TAVPTNTTIK SNPTSTPTVP RTTTCFGDGC 

      4150       4160       4170       4180       4190       4200 
QNTASRCKNG GTWDGLKCQC PNLYYGELCE EVVSSIDIGP PETISAQMEL TVTVTSVKFT 

      4210       4220       4230       4240       4250       4260 
EELKNHSSQE FQEFKQTFTE QMNIVYSGIP EYVGVNITKL RLGSVVVEHD VLLRTKYTPE 

      4270       4280       4290       4300       4310       4320 
YKTVLDNATE VVKEKITKVT TQQIMINDIC SDMMCFNTTG TQVQNITVTQ YDPEEDCRKM 

      4330       4340       4350       4360       4370       4380 
AKEYGDYFVV EYRDQKPYCI SPCEPGFSVS KNCNLGKCQM SLSGPQCLCV TTETHWYSGE 

      4390       4400       4410       4420       4430       4440 
TCNQGTQKSL VYGLVGAGVV LMLIILVALL MLVFRSKREV KRQKYRLSQL YKWQEEDSGP 

      4450       4460       4470       4480       4490 
APGTFQNIGF DICQDDDSIH LESIYSNFQP SLRHIDPETK IRIQRPQVMT TSF 

« Hide

Isoform 2 (Minor) (s-MUC17) [UniParc].

Checksum: 334BF9C863B8B7F7
Show »

FASTA4,361436,777

References

« Hide 'large scale' references
[1]"Characterization of human mucin MUC17. Complete coding sequence and organization."
Moniaux N., Junker W.M., Singh A.P., Jones A.M., Batra S.K.
J. Biol. Chem. 281:23676-23685(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
Tissue: Pancreatic adenocarcinoma.
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Molecular cloning of human MUC3 cDNA reveals a novel 59 amino acid tandem repeat region."
Van Klinken B.J.-W., Van Dijken T.C., Oussoren E., Buller H.A., Dekker J., Einerhand A.W.
Biochem. Biophys. Res. Commun. 238:143-148(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1347-1582, TISSUE SPECIFICITY, VARIANTS PRO-1348; ARG-1375 AND ALA-1480.
Tissue: Small intestine.
[4]"MUC17, a novel membrane-tethered mucin."
Gum J.R. Jr., Crawley S.C., Hicks J.W., Szymkowski D.E., Kim Y.S.
Biochem. Biophys. Res. Commun. 291:466-475(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3465-4493 (ISOFORM 1), TISSUE SPECIFICITY.
[5]"N-glycosylation is required for the surface localization of MUC17 mucin."
Ho J.J.L., Jaituni R.S., Crawley S.C., Yang S.C., Gum J.R., Kim Y.S.
Int. J. Oncol. 23:585-592(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION, SUBCELLULAR LOCATION.
[6]"The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine."
Malmberg E.K., Pelaseyed T., Petersson A.C., Seidler U.E., De Jonge H., Riordan J.R., Hansson G.C.
Biochem. J. 410:283-289(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH PDZK1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ606307 mRNA. Translation: CAE54435.1.
AJ606308 mRNA. Translation: CAE54436.1.
AC105446 Genomic DNA. No translation available.
AF016693 mRNA. Translation: AAB71686.1.
AF430017 mRNA. Translation: AAL89737.1.
CCDSCCDS34711.1. [Q685J3-1]
PIRPC4396.
RefSeqNP_001035194.1. NM_001040105.1. [Q685J3-1]
UniGeneHs.271819.

3D structure databases

ProteinModelPortalQ685J3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000302716.

PTM databases

PhosphoSiteQ685J3.

Polymorphism databases

DMDM296439228.

Proteomic databases

PaxDbQ685J3.
PRIDEQ685J3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306151; ENSP00000302716; ENSG00000169876. [Q685J3-1]
GeneID140453.
KEGGhsa:140453.
UCSCuc003uxp.1. human. [Q685J3-1]

Organism-specific databases

CTD140453.
GeneCardsGC07P100663.
H-InvDBHIX0006940.
HGNCHGNC:16800. MUC17.
HPAHPA031634.
MIM608424. gene.
neXtProtNX_Q685J3.
PharmGKBPA31315.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000172388.
InParanoidQ685J3.
OMAPTSTYSE.
OrthoDBEOG764723.
PhylomeDBQ685J3.
TreeFamTF337883.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

BgeeQ685J3.
CleanExHS_MUC17.
GenevestigatorQ685J3.

Family and domain databases

Gene3D3.30.70.960. 1 hit.
InterProIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000082. SEA_dom.
[Graphical view]
PfamPF01390. SEA. 1 hit.
[Graphical view]
SMARTSM00181. EGF. 1 hit.
SM00200. SEA. 1 hit.
[Graphical view]
SUPFAMSSF82671. SSF82671. 1 hit.
PROSITEPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50024. SEA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMUC17.
GenomeRNAi140453.
NextBio84093.
PROQ685J3.
SOURCESearch...

Entry information

Entry nameMUC17_HUMAN
AccessionPrimary (citable) accession number: Q685J3
Secondary accession number(s): O14761, Q685J2, Q8TDH7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM