Q685J3 (MUC17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mucin-17
Short name=MUC-17

Alternative name(s):
Small intestinal mucin-3
Short name=MUC-3

Gene names

Name:	MUC17
Synonyms:	MUC3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	4493 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably plays a role in maintaining homeostasis on mucosal surfaces. Ref.6
Subunit structure	Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Ref.6
Subcellular location	Isoform 1: Cell membrane; Single-pass membrane protein Ref.5. Isoform 2: Secreted Probable. Cell membrane Ref.5.
Tissue specificity	Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers. Ref.1 Ref.3 Ref.4
Post-translational modification	Probably cleaved within the SEA domain. N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated. Ref.5
Sequence similarities	Contains 1 EGF-like domain. Contains 1 SEA domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	O-glycan processing Traceable author statement. Source: Reactome cellular homeostasis Traceable author statement Ref.6. Source: UniProtKB negative regulation of cell-cell adhesion Inferred from electronic annotation. Source: Compara negative regulation of cell-substrate adhesion Inferred from electronic annotation. Source: Compara post-translational protein modification Traceable author statement. Source: Reactome
Cellular_component	Golgi lumen Traceable author statement. Source: Reactome apical plasma membrane Inferred from direct assay Ref.6. Source: UniProtKB external side of plasma membrane Inferred from direct assay Ref.5. Source: UniProtKB extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	extracellular matrix constituent, lubricant activity Non-traceable author statement Ref.3. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q685J3-1)

Also known as: Major; Mb-MUC17;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q685J3-2)

Also known as: Minor; s-MUC17;

The sequence of this isoform differs from the canonical sequence as follows:
     4241-4262: RLGSVVVEHDVLLRTKYTPEYK → HDVFQHHWHPSAKHYGDPVRP
     4363-4493: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 4493	4468	Mucin-17		PRO_0000326254
Regions
	Topological domain	26 – 4393	4368	Extracellular Potential
	Transmembrane	4394 – 4414	21	Helical; Potential
	Topological domain	4415 – 4493	79	Cytoplasmic Potential
	Repeat	185 – 245	61	1
	Repeat	246 – 300	55	2
	Repeat	301 – 361	61	3
	Repeat	362 – 418	57	4
	Repeat	420 – 477	58	5
	Repeat	479 – 538	60	6
	Repeat	539 – 597	59	7
	Repeat	598 – 654	57	8
	Repeat	656 – 715	60	9
	Repeat	716 – 774	59	10
	Repeat	775 – 831	57	11
	Repeat	833 – 892	60	12
	Repeat	893 – 951	59	13
	Repeat	952 – 1010	59	14
	Repeat	1011 – 1069	59	15
	Repeat	1070 – 1121	52	16
	Repeat	1122 – 1187	66	17
	Repeat	1188 – 1246	59	18
	Repeat	1247 – 1305	59	19
	Repeat	1306 – 1364	59	20
	Repeat	1365 – 1423	59	21
	Repeat	1424 – 1482	59	22
	Repeat	1483 – 1541	59	23
	Repeat	1542 – 1600	59	24
	Repeat	1601 – 1656	56	25
	Repeat	1658 – 1717	60	26
	Repeat	1718 – 1776	59	27
	Repeat	1777 – 1835	59	28
	Repeat	1836 – 1895	60	29
	Repeat	1896 – 1951	56	30
	Repeat	1953 – 2012	60	31
	Repeat	2013 – 2071	59	32
	Repeat	2072 – 2127	56	33
	Repeat	2129 – 2188	60	34
	Repeat	2189 – 2247	59	35
	Repeat	2248 – 2306	59	36
	Repeat	2307 – 2365	59	37
	Repeat	2366 – 2424	59	38
	Repeat	2425 – 2483	59	39
	Repeat	2484 – 2540	57	40
	Repeat	2542 – 2601	60	41
	Repeat	2602 – 2653	52	42
	Repeat	2654 – 2719	66	43
	Repeat	2720 – 2770	51	44
	Repeat	2772 – 2837	66	45
	Repeat	2838 – 2896	59	46
	Repeat	2897 – 2955	59	47
	Repeat	2956 – 3014	59	48
	Repeat	3015 – 3073	59	49
	Repeat	3074 – 3132	59	50
	Repeat	3133 – 3191	59	51
	Repeat	3192 – 3247	56	52
	Repeat	3249 – 3308	60	53
	Repeat	3309 – 3367	59	54
	Repeat	3368 – 3426	59	55
	Repeat	3427 – 3485	59	56
	Repeat	3486 – 3544	59	57
	Repeat	3604 – 3662	59	58
	Repeat	3663 – 3727	65	59
	Domain	4131 – 4170	40	EGF-like
	Domain	4182 – 4296	115	SEA
	Region	185 – 3727	3543	59 X approximate tandem repeats
	Compositional bias	84 – 3836	3753	Ser-rich
	Compositional bias	3975 – 3980	6	Poly-Ser
Sites
	Site	4243 – 4244	2	Cleavage Potential
Amino acid modifications
	Glycosylation	471	1	N-linked (GlcNAc...) Potential
	Glycosylation	696	1	N-linked (GlcNAc...) Potential
	Glycosylation	898	1	N-linked (GlcNAc...) Potential
	Glycosylation	1345	1	N-linked (GlcNAc...) Potential
	Glycosylation	2077	1	N-linked (GlcNAc...) Potential
	Glycosylation	2194	1	N-linked (GlcNAc...) Potential
	Glycosylation	3344	1	N-linked (GlcNAc...) Potential
	Glycosylation	4116	1	N-linked (GlcNAc...) Potential
	Glycosylation	4205	1	N-linked (GlcNAc...) Potential
	Glycosylation	4236	1	N-linked (GlcNAc...) Potential
	Glycosylation	4267	1	N-linked (GlcNAc...) Potential
	Glycosylation	4297	1	N-linked (GlcNAc...) Potential
	Glycosylation	4305	1	N-linked (GlcNAc...) Potential
	Disulfide bond	4135 ↔ 4147		By similarity
	Disulfide bond	4140 ↔ 4158		By similarity
	Disulfide bond	4160 ↔ 4169		By similarity
Natural variations
	Alternative sequence	4241 – 4262	22	RLGSV…TPEYK → HDVFQHHWHPSAKHYGDPVR P in isoform 2.		VSP_032648
	Alternative sequence	4363 – 4493	131	Missing in isoform 2.		VSP_032649
	Natural variant	227	1	K → Q. Corresponds to variant rs10229731 [ dbSNP | Ensembl ].		VAR_040047
	Natural variant	272	1	G → E. Corresponds to variant rs10259584 [ dbSNP | Ensembl ].		VAR_040048
	Natural variant	427	1	A → T. Corresponds to variant rs56103274 [ dbSNP | Ensembl ].		VAR_061489
	Natural variant	571	1	P → L. Corresponds to variant rs34834039 [ dbSNP | Ensembl ].		VAR_061490
	Natural variant	925	1	P → R. Corresponds to variant rs11979706 [ dbSNP | Ensembl ].		VAR_061491
	Natural variant	942	1	R → S. Corresponds to variant rs10238201 [ dbSNP | Ensembl ].		VAR_040049
	Natural variant	982	1	T → M. Corresponds to variant rs4729646 [ dbSNP | Ensembl ].		VAR_040050
	Natural variant	1130	1	I → T. Corresponds to variant rs4729647 [ dbSNP | Ensembl ].		VAR_040051
	Natural variant	1242	1	S → T. Corresponds to variant rs10265276 [ dbSNP | Ensembl ].		VAR_040052
	Natural variant	1246	1	T → N. Corresponds to variant rs4729652 [ dbSNP | Ensembl ].		VAR_040053
	Natural variant	1246	1	T → S. Corresponds to variant rs4729651 [ dbSNP | Ensembl ].		VAR_040054
	Natural variant	1249	1	P → A. Corresponds to variant rs4729653 [ dbSNP | Ensembl ].		VAR_040055
	Natural variant	1348	1	L → P. Ref.3 Corresponds to variant rs4269454 [ dbSNP | Ensembl ].		VAR_040056
	Natural variant	1375	1	C → R. Ref.3 Corresponds to variant rs4367469 [ dbSNP | Ensembl ].		VAR_040057
	Natural variant	1480	1	V → A. Ref.3 Corresponds to variant rs7780935 [ dbSNP | Ensembl ].		VAR_061492
	Natural variant	2096	1	A → T. Corresponds to variant rs28593004 [ dbSNP | Ensembl ].		VAR_061493
	Natural variant	2159	1	R → G. Corresponds to variant rs61382267 [ dbSNP | Ensembl ].		VAR_061494
	Natural variant	3299	1	S → N. Corresponds to variant rs35988443 [ dbSNP | Ensembl ].		VAR_061495
	Natural variant	4334	1	D → N. Corresponds to variant rs6946812 [ dbSNP | Ensembl ].		VAR_040058
	Natural variant	4482	1	R → Q. Corresponds to variant rs9656065 [ dbSNP | Ensembl ].		VAR_040059
Experimental info
	Sequence conflict	28	1	D → G in CAE54435. Ref.1
	Sequence conflict	28	1	D → G in CAE54436. Ref.1
	Sequence conflict	65	1	A → T in CAE54435. Ref.1
	Sequence conflict	65	1	A → T in CAE54436. Ref.1
	Sequence conflict	132	1	S → P in CAE54435. Ref.1
	Sequence conflict	132	1	S → P in CAE54436. Ref.1
	Sequence conflict	3481	1	T → S in AAL89737. Ref.4
	Sequence conflict	3491	1	T → N in AAL89737. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Major) (Mb-MUC17) [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 883D68DDB0D6E3C1	FASTA	4,493	451,741
	10 20 30 40 50 60 MPRPGTMALC LLTLVLSLLP PQAAAEQDLS VNRAVWDGGG CISQGDVLNR QCQQLSQHVR 70 80 90 100 110 120 TGSAANTATG TTSTNVVEPR MYLSCSTNPE MTSIESSVTS DTPGVSSTRM TPTESRTTSE 130 140 150 160 170 180 STSDSTTLFP SSTEDTSSPT TPEGTDVPMS TPSEESISST MAFVSTAPLP SFEAYTSLTY 190 200 210 220 230 240 KVDMSTPLTT STQASSSPTT PESTTIPKST NSEGSTPLTS MPASTMKVAS SEAITLLTTP 250 260 270 280 290 300 VEISTPVTIS AQASSSPTTA EGPSLSNSAP SGGSTPLTRM PLSVMLVVSS EASTLSTTPA 310 320 330 340 350 360 ATNIPVITST EASSSPTTAE GTSIPTSTYT EGSTPLTSTP ASTMPVATSE MSTLSITPVD 370 380 390 400 410 420 TSTLVTTSTE PSSLPTTAEA TSMLTSTLSE GSTPLTNMPV STILVASSEA STTSTIPVDS 430 440 450 460 470 480 KTFVTTASEA SSSPTTAEDT SIATSTPSEG STPLTSMPVS TTPVASSEAS NLSTTPVDSK 490 500 510 520 530 540 TQVTTSTEAS SSPPTAEVNS MPTSTPSEGS TPLTSMSVST MPVASSEAST LSTTPVDTST 550 560 570 580 590 600 PVTTSSEASS SSTTPEGTSI PTSTPSEGST PLTNMPVSTR LVVSSEASTT STTPADSNTF 610 620 630 640 650 660 VTTSSEASSS STTAEGTSMP TSTYSERGTT ITSMSVSTTL VASSEASTLS TTPVDSNTPV 670 680 690 700 710 720 TTSTEATSSS TTAEGTSMPT STYTEGSTPL TSMPVNTTLV ASSEASTLST TPVDTSTPVT 730 740 750 760 770 780 TSTEASSSPT TADGASMPTS TPSEGSTPLT SMPVSKTLLT SSEASTLSTT PLDTSTHITT 790 800 810 820 830 840 STEASCSPTT TEGTSMPIST PSEGSPLLTS IPVSITPVTS PEASTLSTTP VDSNSPVTTS 850 860 870 880 890 900 TEVSSSPTPA EGTSMPTSTY SEGRTPLTSM PVSTTLVATS AISTLSTTPV DTSTPVTNST 910 920 930 940 950 960 EARSSPTTSE GTSMPTSTPG EGSTPLTSMP DSTTPVVSSE ARTLSATPVD TSTPVTTSTE 970 980 990 1000 1010 1020 ATSSPTTAEG TSIPTSTPSE GTTPLTSTPV SHTLVANSEA STLSTTPVDS NTPLTTSTEA 1030 1040 1050 1060 1070 1080 SSPPPTAEGT SMPTSTPSEG STPLTRMPVS TTMVASSETS TLSTTPADTS TPVTTYSQAS 1090 1100 1110 1120 1130 1140 SSSTTADGTS MPTSTYSEGS TPLTSVPVST RLVVSSEAST LSTTPVDTSI PVTTSTEASS 1150 1160 1170 1180 1190 1200 SPTTAEGTSI PTSPPSEGTT PLASMPVSTT LVVSSEANTL STTPVDSKTQ VATSTEASSP 1210 1220 1230 1240 1250 1260 PPTAEVTSMP TSTPGERSTP LTSMPVRHTP VASSEASTLS TSPVDTSTPV TTSAETSSSP 1270 1280 1290 1300 1310 1320 TTAEGTSLPT STTSEGSTLL TSIPVSTTLV TSPEASTLLT TPVDTKGPVV TSNEVSSSPT 1330 1340 1350 1360 1370 1380 PAEGTSMPTS TYSEGRTPLT SIPVNTTLVA SSAISILSTT PVDNSTPVTT STEACSSPTT 1390 1400 1410 1420 1430 1440 SEGTSMPNSN PSEGTTPLTS IPVSTTPVVS SEASTLSATP VDTSTPGTTS AEATSSPTTA 1450 1460 1470 1480 1490 1500 EGISIPTSTP SEGKTPLKSI PVSNTPVANS EASTLSTTPV DSNSPVVTST AVSSSPTPAE 1510 1520 1530 1540 1550 1560 GTSIAISTPS EGSTALTSIP VSTTTVASSE INSLSTTPAV TSTPVTTYSQ ASSSPTTADG 1570 1580 1590 1600 1610 1620 TSMQTSTYSE GSTPLTSLPV STMLVVSSEA NTLSTTPIDS KTQVTASTEA SSSTTAEGSS 1630 1640 1650 1660 1670 1680 MTISTPSEGS PLLTSIPVST TPVASPEAST LSTTPVDSNS PVITSTEVSS SPTPAEGTSM 1690 1700 1710 1720 1730 1740 PTSTYTEGRT PLTSITVRTT PVASSAISTL STTPVDNSTP VTTSTEARSS PTTSEGTSMP 1750 1760 1770 1780 1790 1800 NSTPSEGTTP LTSIPVSTTP VLSSEASTLS ATPIDTSTPV TTSTEATSSP TTAEGTSIPT 1810 1820 1830 1840 1850 1860 STLSEGMTPL TSTPVSHTLV ANSEASTLST TPVDSNSPVV TSTAVSSSPT PAEGTSIATS 1870 1880 1890 1900 1910 1920 TPSEGSTALT SIPVSTTTVA SSETNTLSTT PAVTSTPVTT YAQVSSSPTT ADGSSMPTST 1930 1940 1950 1960 1970 1980 PREGRPPLTS IPVSTTTVAS SEINTLSTTL ADTRTPVTTY SQASSSPTTA DGTSMPTPAY 1990 2000 2010 2020 2030 2040 SEGSTPLTSM PLSTTLVVSS EASTLSTTPV DTSTPATTST EGSSSPTTAG GTSIQTSTPS 2050 2060 2070 2080 2090 2100 ERTTPLAGMP VSTTLVVSSE GNTLSTTPVD SKTQVTNSTE ASSSATAEGS SMTISAPSEG 2110 2120 2130 2140 2150 2160 SPLLTSIPLS TTPVASPEAS TLSTTPVDSN SPVITSTEVS SSPIPTEGTS MQTSTYSDRR 2170 2180 2190 2200 2210 2220 TPLTSMPVST TVVASSAIST LSTTPVDTST PVTNSTEARS SPTTSEGTSM PTSTPSEGST 2230 2240 2250 2260 2270 2280 PFTSMPVSTM PVVTSEASTL SATPVDTSTP VTTSTEATSS PTTAEGTSIP TSTLSEGTTP 2290 2300 2310 2320 2330 2340 LTSIPVSHTL VANSEVSTLS TTPVDSNTPF TTSTEASSPP PTAEGTSMPT STSSEGNTPL 2350 2360 2370 2380 2390 2400 TRMPVSTTMV ASFETSTLST TPADTSTPVT TYSQAGSSPT TADDTSMPTS TYSEGSTPLT 2410 2420 2430 2440 2450 2460 SVPVSTMPVV SSEASTHSTT PVDTSTPVTT STEASSSPTT AEGTSIPTSP PSEGTTPLAS 2470 2480 2490 2500 2510 2520 MPVSTTPVVS SEAGTLSTTP VDTSTPMTTS TEASSSPTTA EDIVVPISTA SEGSTLLTSI 2530 2540 2550 2560 2570 2580 PVSTTPVASP EASTLSTTPV DSNSPVVTST EISSSATSAE GTSMPTSTYS EGSTPLRSMP 2590 2600 2610 2620 2630 2640 VSTKPLASSE ASTLSTTPVD TSIPVTTSTE TSSSPTTAKD TSMPISTPSE VSTSLTSILV 2650 2660 2670 2680 2690 2700 STMPVASSEA STLSTTPVDT RTLVTTSTGT SSSPTTAEGS SMPTSTPGER STPLTNILVS 2710 2720 2730 2740 2750 2760 TTLLANSEAS TLSTTPVDTS TPVTTSAEAS SSPTTAEGTS MRISTPSDGS TPLTSILVST 2770 2780 2790 2800 2810 2820 LPVASSEAST VSTTAVDTSI PVTTSTEASS SPTTAEVTSM PTSTPSETST PLTSMPVNHT 2830 2840 2850 2860 2870 2880 PVASSEAGTL STTPVDTSTP VTTSTKASSS PTTAEGIVVP ISTASEGSTL LTSIPVSTTP 2890 2900 2910 2920 2930 2940 VASSEASTLS TTPVDTSIPV TTSTEGSSSP TTAEGTSMPI STPSEVSTPL TSILVSTVPV 2950 2960 2970 2980 2990 3000 AGSEASTLST TPVDTRTPVT TSAEASSSPT TAEGTSMPIS TPGERRTPLT SMSVSTMPVA 3010 3020 3030 3040 3050 3060 SSEASTLSRT PADTSTPVTT STEASSSPTT AEGTGIPIST PSEGSTPLTS IPVSTTPVAI 3070 3080 3090 3100 3110 3120 PEASTLSTTP VDSNSPVVTS TEVSSSPTPA EGTSMPISTY SEGSTPLTGV PVSTTPVTSS 3130 3140 3150 3160 3170 3180 AISTLSTTPV DTSTPVTTST EAHSSPTTSE GTSMPTSTPS EGSTPLTYMP VSTMLVVSSE 3190 3200 3210 3220 3230 3240 DSTLSATPVD TSTPVTTSTE ATSSTTAEGT SIPTSTPSEG MTPLTSVPVS NTPVASSEAS 3250 3260 3270 3280 3290 3300 ILSTTPVDSN TPLTTSTEAS SSPPTAEGTS MPTSTPSEGS TPLTSMPVST TTVASSETST 3310 3320 3330 3340 3350 3360 LSTTPADTST PVTTYSQASS SPPIADGTSM PTSTYSEGST PLTNMSFSTT PVVSSEASTL 3370 3380 3390 3400 3410 3420 STTPVDTSTP VTTSTEASLS PTTAEGTSIP TSSPSEGTTP LASMPVSTTP VVSSEVNTLS 3430 3440 3450 3460 3470 3480 TTPVDSNTLV TTSTEASSSP TIAEGTSLPT STTSEGSTPL SIMPLSTTPV ASSEASTLST 3490 3500 3510 3520 3530 3540 TPVDTSTPVT TSSPTNSSPT TAEVTSMPTS TAGEGSTPLT NMPVSTTPVA SSEASTLSTT 3550 3560 3570 3580 3590 3600 PVDSNTFVTS SSQASSSPAT LQVTTMRMST PSEGSSSLTT MLLSSTYVTS SEASTPSTPS 3610 3620 3630 3640 3650 3660 VDRSTPVTTS TQSNSTPTPP EVITLPMSTP SEVSTPLTIM PVSTTSVTIS EAGTASTLPV 3670 3680 3690 3700 3710 3720 DTSTPVITST QVSSSPVTPE GTTMPIWTPS EGSTPLTTMP VSTTRVTSSE GSTLSTPSVV 3730 3740 3750 3760 3770 3780 TSTPVTTSTE AISSSATLDS TTMSVSMPME ISTLGTTILV STTPVTRFPE SSTPSIPSVY 3790 3800 3810 3820 3830 3840 TSMSMTTASE GSSSPTTLEG TTTMPMSTTS ERSTLLTTVL ISPISVMSPS EASTLSTPPG 3850 3860 3870 3880 3890 3900 DTSTPLLTST KAGSFSIPAE VTTIRISITS ERSTPLTTLL VSTTLPTSFP GASIASTPPL 3910 3920 3930 3940 3950 3960 DTSTTFTPST DTASTPTIPV ATTISVSVIT EGSTPGTTIF IPSTPVTSST ADVFPATTGA 3970 3980 3990 4000 4010 4020 VSTPVITSTE LNTPSTSSSS TTTSFSTTKE FTTPAMTTAA PLTYVTMSTA PSTPRTTSRG 4030 4040 4050 4060 4070 4080 CTTSASTLSA TSTPHTSTSV TTRPVTPSSE SSRPSTITSH TIPPTFPPAH SSTPPTTSAS 4090 4100 4110 4120 4130 4140 STTVNPEAVT TMTTRTKPST RTTSFPTVTT TAVPTNTTIK SNPTSTPTVP RTTTCFGDGC 4150 4160 4170 4180 4190 4200 QNTASRCKNG GTWDGLKCQC PNLYYGELCE EVVSSIDIGP PETISAQMEL TVTVTSVKFT 4210 4220 4230 4240 4250 4260 EELKNHSSQE FQEFKQTFTE QMNIVYSGIP EYVGVNITKL RLGSVVVEHD VLLRTKYTPE 4270 4280 4290 4300 4310 4320 YKTVLDNATE VVKEKITKVT TQQIMINDIC SDMMCFNTTG TQVQNITVTQ YDPEEDCRKM 4330 4340 4350 4360 4370 4380 AKEYGDYFVV EYRDQKPYCI SPCEPGFSVS KNCNLGKCQM SLSGPQCLCV TTETHWYSGE 4390 4400 4410 4420 4430 4440 TCNQGTQKSL VYGLVGAGVV LMLIILVALL MLVFRSKREV KRQKYRLSQL YKWQEEDSGP 4450 4460 4470 4480 4490 APGTFQNIGF DICQDDDSIH LESIYSNFQP SLRHIDPETK IRIQRPQVMT TSF
	Isoform 2 (Minor) (s-MUC17) [UniParc]. Checksum: 334BF9C863B8B7F7	FASTA	4,361	436,777
	10 20 30 40 50 60 MPRPGTMALC LLTLVLSLLP PQAAAEQDLS VNRAVWDGGG CISQGDVLNR QCQQLSQHVR 70 80 90 100 110 120 TGSAANTATG TTSTNVVEPR MYLSCSTNPE MTSIESSVTS DTPGVSSTRM TPTESRTTSE 130 140 150 160 170 180 STSDSTTLFP SSTEDTSSPT TPEGTDVPMS TPSEESISST MAFVSTAPLP SFEAYTSLTY 190 200 210 220 230 240 KVDMSTPLTT STQASSSPTT PESTTIPKST NSEGSTPLTS MPASTMKVAS SEAITLLTTP 250 260 270 280 290 300 VEISTPVTIS AQASSSPTTA EGPSLSNSAP SGGSTPLTRM PLSVMLVVSS EASTLSTTPA 310 320 330 340 350 360 ATNIPVITST EASSSPTTAE GTSIPTSTYT EGSTPLTSTP ASTMPVATSE MSTLSITPVD 370 380 390 400 410 420 TSTLVTTSTE PSSLPTTAEA TSMLTSTLSE GSTPLTNMPV STILVASSEA STTSTIPVDS 430 440 450 460 470 480 KTFVTTASEA SSSPTTAEDT SIATSTPSEG STPLTSMPVS TTPVASSEAS NLSTTPVDSK 490 500 510 520 530 540 TQVTTSTEAS SSPPTAEVNS MPTSTPSEGS TPLTSMSVST MPVASSEAST LSTTPVDTST 550 560 570 580 590 600 PVTTSSEASS SSTTPEGTSI PTSTPSEGST PLTNMPVSTR LVVSSEASTT STTPADSNTF 610 620 630 640 650 660 VTTSSEASSS STTAEGTSMP TSTYSERGTT ITSMSVSTTL VASSEASTLS TTPVDSNTPV 670 680 690 700 710 720 TTSTEATSSS TTAEGTSMPT STYTEGSTPL TSMPVNTTLV ASSEASTLST TPVDTSTPVT 730 740 750 760 770 780 TSTEASSSPT TADGASMPTS TPSEGSTPLT SMPVSKTLLT SSEASTLSTT PLDTSTHITT 790 800 810 820 830 840 STEASCSPTT TEGTSMPIST PSEGSPLLTS IPVSITPVTS PEASTLSTTP VDSNSPVTTS 850 860 870 880 890 900 TEVSSSPTPA EGTSMPTSTY SEGRTPLTSM PVSTTLVATS AISTLSTTPV DTSTPVTNST 910 920 930 940 950 960 EARSSPTTSE GTSMPTSTPG EGSTPLTSMP DSTTPVVSSE ARTLSATPVD TSTPVTTSTE 970 980 990 1000 1010 1020 ATSSPTTAEG TSIPTSTPSE GTTPLTSTPV SHTLVANSEA STLSTTPVDS NTPLTTSTEA 1030 1040 1050 1060 1070 1080 SSPPPTAEGT SMPTSTPSEG STPLTRMPVS TTMVASSETS TLSTTPADTS TPVTTYSQAS 1090 1100 1110 1120 1130 1140 SSSTTADGTS MPTSTYSEGS TPLTSVPVST RLVVSSEAST LSTTPVDTSI PVTTSTEASS 1150 1160 1170 1180 1190 1200 SPTTAEGTSI PTSPPSEGTT PLASMPVSTT LVVSSEANTL STTPVDSKTQ VATSTEASSP 1210 1220 1230 1240 1250 1260 PPTAEVTSMP TSTPGERSTP LTSMPVRHTP VASSEASTLS TSPVDTSTPV TTSAETSSSP 1270 1280 1290 1300 1310 1320 TTAEGTSLPT STTSEGSTLL TSIPVSTTLV TSPEASTLLT TPVDTKGPVV TSNEVSSSPT 1330 1340 1350 1360 1370 1380 PAEGTSMPTS TYSEGRTPLT SIPVNTTLVA SSAISILSTT PVDNSTPVTT STEACSSPTT 1390 1400 1410 1420 1430 1440 SEGTSMPNSN PSEGTTPLTS IPVSTTPVVS SEASTLSATP VDTSTPGTTS AEATSSPTTA 1450 1460 1470 1480 1490 1500 EGISIPTSTP SEGKTPLKSI PVSNTPVANS EASTLSTTPV DSNSPVVTST AVSSSPTPAE 1510 1520 1530 1540 1550 1560 GTSIAISTPS EGSTALTSIP VSTTTVASSE INSLSTTPAV TSTPVTTYSQ ASSSPTTADG 1570 1580 1590 1600 1610 1620 TSMQTSTYSE GSTPLTSLPV STMLVVSSEA NTLSTTPIDS KTQVTASTEA SSSTTAEGSS 1630 1640 1650 1660 1670 1680 MTISTPSEGS PLLTSIPVST TPVASPEAST LSTTPVDSNS PVITSTEVSS SPTPAEGTSM 1690 1700 1710 1720 1730 1740 PTSTYTEGRT PLTSITVRTT PVASSAISTL STTPVDNSTP VTTSTEARSS PTTSEGTSMP 1750 1760 1770 1780 1790 1800 NSTPSEGTTP LTSIPVSTTP VLSSEASTLS ATPIDTSTPV TTSTEATSSP TTAEGTSIPT 1810 1820 1830 1840 1850 1860 STLSEGMTPL TSTPVSHTLV ANSEASTLST TPVDSNSPVV TSTAVSSSPT PAEGTSIATS 1870 1880 1890 1900 1910 1920 TPSEGSTALT SIPVSTTTVA SSETNTLSTT PAVTSTPVTT YAQVSSSPTT ADGSSMPTST 1930 1940 1950 1960 1970 1980 PREGRPPLTS IPVSTTTVAS SEINTLSTTL ADTRTPVTTY SQASSSPTTA DGTSMPTPAY 1990 2000 2010 2020 2030 2040 SEGSTPLTSM PLSTTLVVSS EASTLSTTPV DTSTPATTST EGSSSPTTAG GTSIQTSTPS 2050 2060 2070 2080 2090 2100 ERTTPLAGMP VSTTLVVSSE GNTLSTTPVD SKTQVTNSTE ASSSATAEGS SMTISAPSEG 2110 2120 2130 2140 2150 2160 SPLLTSIPLS TTPVASPEAS TLSTTPVDSN SPVITSTEVS SSPIPTEGTS MQTSTYSDRR 2170 2180 2190 2200 2210 2220 TPLTSMPVST TVVASSAIST LSTTPVDTST PVTNSTEARS SPTTSEGTSM PTSTPSEGST 2230 2240 2250 2260 2270 2280 PFTSMPVSTM PVVTSEASTL SATPVDTSTP VTTSTEATSS PTTAEGTSIP TSTLSEGTTP 2290 2300 2310 2320 2330 2340 LTSIPVSHTL VANSEVSTLS TTPVDSNTPF TTSTEASSPP PTAEGTSMPT STSSEGNTPL 2350 2360 2370 2380 2390 2400 TRMPVSTTMV ASFETSTLST TPADTSTPVT TYSQAGSSPT TADDTSMPTS TYSEGSTPLT 2410 2420 2430 2440 2450 2460 SVPVSTMPVV SSEASTHSTT PVDTSTPVTT STEASSSPTT AEGTSIPTSP PSEGTTPLAS 2470 2480 2490 2500 2510 2520 MPVSTTPVVS SEAGTLSTTP VDTSTPMTTS TEASSSPTTA EDIVVPISTA SEGSTLLTSI 2530 2540 2550 2560 2570 2580 PVSTTPVASP EASTLSTTPV DSNSPVVTST EISSSATSAE GTSMPTSTYS EGSTPLRSMP 2590 2600 2610 2620 2630 2640 VSTKPLASSE ASTLSTTPVD TSIPVTTSTE TSSSPTTAKD TSMPISTPSE VSTSLTSILV 2650 2660 2670 2680 2690 2700 STMPVASSEA STLSTTPVDT RTLVTTSTGT SSSPTTAEGS SMPTSTPGER STPLTNILVS 2710 2720 2730 2740 2750 2760 TTLLANSEAS TLSTTPVDTS TPVTTSAEAS SSPTTAEGTS MRISTPSDGS TPLTSILVST 2770 2780 2790 2800 2810 2820 LPVASSEAST VSTTAVDTSI PVTTSTEASS SPTTAEVTSM PTSTPSETST PLTSMPVNHT 2830 2840 2850 2860 2870 2880 PVASSEAGTL STTPVDTSTP VTTSTKASSS PTTAEGIVVP ISTASEGSTL LTSIPVSTTP 2890 2900 2910 2920 2930 2940 VASSEASTLS TTPVDTSIPV TTSTEGSSSP TTAEGTSMPI STPSEVSTPL TSILVSTVPV 2950 2960 2970 2980 2990 3000 AGSEASTLST TPVDTRTPVT TSAEASSSPT TAEGTSMPIS TPGERRTPLT SMSVSTMPVA 3010 3020 3030 3040 3050 3060 SSEASTLSRT PADTSTPVTT STEASSSPTT AEGTGIPIST PSEGSTPLTS IPVSTTPVAI 3070 3080 3090 3100 3110 3120 PEASTLSTTP VDSNSPVVTS TEVSSSPTPA EGTSMPISTY SEGSTPLTGV PVSTTPVTSS 3130 3140 3150 3160 3170 3180 AISTLSTTPV DTSTPVTTST EAHSSPTTSE GTSMPTSTPS EGSTPLTYMP VSTMLVVSSE 3190 3200 3210 3220 3230 3240 DSTLSATPVD TSTPVTTSTE ATSSTTAEGT SIPTSTPSEG MTPLTSVPVS NTPVASSEAS 3250 3260 3270 3280 3290 3300 ILSTTPVDSN TPLTTSTEAS SSPPTAEGTS MPTSTPSEGS TPLTSMPVST TTVASSETST 3310 3320 3330 3340 3350 3360 LSTTPADTST PVTTYSQASS SPPIADGTSM PTSTYSEGST PLTNMSFSTT PVVSSEASTL 3370 3380 3390 3400 3410 3420 STTPVDTSTP VTTSTEASLS PTTAEGTSIP TSSPSEGTTP LASMPVSTTP VVSSEVNTLS 3430 3440 3450 3460 3470 3480 TTPVDSNTLV TTSTEASSSP TIAEGTSLPT STTSEGSTPL SIMPLSTTPV ASSEASTLST 3490 3500 3510 3520 3530 3540 TPVDTSTPVT TSSPTNSSPT TAEVTSMPTS TAGEGSTPLT NMPVSTTPVA SSEASTLSTT 3550 3560 3570 3580 3590 3600 PVDSNTFVTS SSQASSSPAT LQVTTMRMST PSEGSSSLTT MLLSSTYVTS SEASTPSTPS 3610 3620 3630 3640 3650 3660 VDRSTPVTTS TQSNSTPTPP EVITLPMSTP SEVSTPLTIM PVSTTSVTIS EAGTASTLPV 3670 3680 3690 3700 3710 3720 DTSTPVITST QVSSSPVTPE GTTMPIWTPS EGSTPLTTMP VSTTRVTSSE GSTLSTPSVV 3730 3740 3750 3760 3770 3780 TSTPVTTSTE AISSSATLDS TTMSVSMPME ISTLGTTILV STTPVTRFPE SSTPSIPSVY 3790 3800 3810 3820 3830 3840 TSMSMTTASE GSSSPTTLEG TTTMPMSTTS ERSTLLTTVL ISPISVMSPS EASTLSTPPG 3850 3860 3870 3880 3890 3900 DTSTPLLTST KAGSFSIPAE VTTIRISITS ERSTPLTTLL VSTTLPTSFP GASIASTPPL 3910 3920 3930 3940 3950 3960 DTSTTFTPST DTASTPTIPV ATTISVSVIT EGSTPGTTIF IPSTPVTSST ADVFPATTGA 3970 3980 3990 4000 4010 4020 VSTPVITSTE LNTPSTSSSS TTTSFSTTKE FTTPAMTTAA PLTYVTMSTA PSTPRTTSRG 4030 4040 4050 4060 4070 4080 CTTSASTLSA TSTPHTSTSV TTRPVTPSSE SSRPSTITSH TIPPTFPPAH SSTPPTTSAS 4090 4100 4110 4120 4130 4140 STTVNPEAVT TMTTRTKPST RTTSFPTVTT TAVPTNTTIK SNPTSTPTVP RTTTCFGDGC 4150 4160 4170 4180 4190 4200 QNTASRCKNG GTWDGLKCQC PNLYYGELCE EVVSSIDIGP PETISAQMEL TVTVTSVKFT 4210 4220 4230 4240 4250 4260 EELKNHSSQE FQEFKQTFTE QMNIVYSGIP EYVGVNITKL HDVFQHHWHP SAKHYGDPVR 4270 4280 4290 4300 4310 4320 PTVLDNATEV VKEKITKVTT QQIMINDICS DMMCFNTTGT QVQNITVTQY DPEEDCRKMA 4330 4340 4350 4360 KEYGDYFVVE YRDQKPYCIS PCEPGFSVSK NCNLGKCQMS L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of human mucin MUC17. Complete coding sequence and organization." Moniaux N., Junker W.M., Singh A.P., Jones A.M., Batra S.K. J. Biol. Chem. 281:23676-23685(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, TISSUE SPECIFICITY. Tissue: Pancreatic adenocarcinoma.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Molecular cloning of human MUC3 cDNA reveals a novel 59 amino acid tandem repeat region." Van Klinken B.J.-W., Van Dijken T.C., Oussoren E., Buller H.A., Dekker J., Einerhand A.W. Biochem. Biophys. Res. Commun. 238:143-148(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1347-1582, TISSUE SPECIFICITY, VARIANTS PRO-1348; ARG-1375 AND ALA-1480. Tissue: Small intestine.
[4]	"MUC17, a novel membrane-tethered mucin." Gum J.R. Jr., Crawley S.C., Hicks J.W., Szymkowski D.E., Kim Y.S. Biochem. Biophys. Res. Commun. 291:466-475(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3465-4493 (ISOFORM 1), TISSUE SPECIFICITY.
[5]	"N-glycosylation is required for the surface localization of MUC17 mucin." Ho J.J.L., Jaituni R.S., Crawley S.C., Yang S.C., Gum J.R., Kim Y.S. Int. J. Oncol. 23:585-592(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION, SUBCELLULAR LOCATION.
[6]	"The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine." Malmberg E.K., Pelaseyed T., Petersson A.C., Seidler U.E., De Jonge H., Riordan J.R., Hansson G.C. Biochem. J. 410:283-289(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH PDZK1.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Mucin database

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ606307 mRNA. Translation: CAE54435.1. AJ606308 mRNA. Translation: CAE54436.1. AC105446 Genomic DNA. No translation available. AF016693 mRNA. Translation: AAB71686.1. AF430017 mRNA. Translation: AAL89737.1.
IPI	IPI00470673. IPI00886884.
PIR	PC4396.
RefSeq	NP_001035194.1. NM_001040105.1.
UniGene	Hs.271819.
3D structure databases
ProteinModelPortal	Q685J3.
SMR	Q685J3. Positions 4137-4174, 4353-4388, 4464-4490.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000302716.
PTM databases
PhosphoSite	Q685J3.
Polymorphism databases
DMDM	296439228.
Proteomic databases
PaxDb	Q685J3.
PRIDE	Q685J3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000306151; ENSP00000302716; ENSG00000169876.
GeneID	140453.
KEGG	hsa:140453.
UCSC	uc003uxp.1. human.
Organism-specific databases
CTD	140453.
GeneCards	GC07P100663.
H-InvDB	HIX0006940.
HGNC	HGNC:16800. MUC17.
HPA	HPA031634.
MIM	608424. gene.
neXtProt	NX_Q685J3.
PharmGKB	PA31315.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000172388.
InParanoid	Q685J3.
OMA	DENGSTH.
OrthoDB	EOG4ZS931.
Enzyme and pathway databases
Reactome	REACT_17015. Metabolism of proteins.
Gene expression databases
ArrayExpress	Q685J3.
Bgee	Q685J3.
CleanEx	HS_MUC17.
Genevestigator	Q685J3.
Family and domain databases
InterPro	IPR000742. EG-like_dom. IPR013032. EGF-like_CS. IPR000082. SEA. [Graphical view]
Pfam	PF01390. SEA. 1 hit. [Graphical view]
SMART	SM00181. EGF. 1 hit. SM00200. SEA. 1 hit. [Graphical view]
PROSITE	PS00022. EGF_1. 1 hit. PS01186. EGF_2. False negative. PS50026. EGF_3. 1 hit. PS50024. SEA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	140453.
NextBio	84093.
SOURCE	Search...

Entry information

Entry name

MUC17_HUMAN

Accession

Primary (citable) accession number: Q685J3
Secondary accession number(s): O14761, Q685J2, Q8TDH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.