true
2005-03-15
2023-06-28
78
LUXS_SERMA
luxS mutants of Serratia defective in autoinducer-2-dependent 'quorum sensing' show strain-dependent impacts on virulence, carbapenem and prodigiosin production.
Coulthurst S.J.
Kurz C.L.
Salmond G.P.C.
doi:10.1099/mic.0.26946-0
2004
Microbiology
150
1901-1910
NUCLEOTIDE SEQUENCE [GENOMIC DNA]
ATCC 274 / NCDO 740 / NCIB 1377 / NCTC 1377
S-ribosylhomocysteinase (LuxS)
LuxS
LuxS_sf
Metalloenz_LuxS/M16
S-ribosylhomocysteinase
S-RIBOSYLHOMOCYSTEINE LYASE
S-RIBOSYLHOMOCYSTEINE LYASE
LuxS
AI2
LUXSPROTEIN
LuxS/MPP-like metallohydrolase
S-ribosylhomocysteine lyase
4.4.1.21
AI-2 synthesis protein
Autoinducer-2 production protein LuxS
luxS
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
Binds 1 Fe cation per subunit.
Homodimer.
Belongs to the LuxS family.
S-ribosylhomocysteine lyase
19355
1
171
54
58
128
2004-10-11
1
19355
feef3505b467a8493d83282fb2388bf9
MPLLDSFTVDHTRMAAPAVRVAKTMKTPHGDTITVFDLRFCRPNLEVMPERGIHTLEHLFAGFMRDHLNGQGVEIIDISPMGCRTGFYMSLIGVPEEQRVADAWKAAMADVLKVTDQRKIPELNEYQCGTYHMHSLEEAQEIAKHILDNGVVVNHNDELALPKEKLQELHI
true
true