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Protein

Rap1 GTPase-activating protein 2

Gene

RAP1GAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-392517. Rap1 signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
Rap1 GTPase-activating protein 2
Short name:
Rap1GAP2
Alternative name(s):
GTPase-activating Rap/Ran-GAP domain-like protein 4
Gene namesi
Name:RAP1GAP2
Synonyms:GARNL4, KIAA1039, RAP1GA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29176. RAP1GAP2.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cytoplasmperinuclear region 1 Publication

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • neuron projection Source: Ensembl
  • nuclear membrane Source: HPA
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi7S → A: Abolishes phosphorylation by PKG/PRKG1. 1 Publication1
Mutagenesisi357N → A: Abolishes GAP activity. 1 Publication1

Organism-specific databases

DisGeNETi23108.
OpenTargetsiENSG00000132359.
PharmGKBiPA165432528.

Polymorphism and mutation databases

BioMutaiRAP1GAP2.
DMDMi162416269.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003127161 – 730Rap1 GTPase-activating protein 2Add BLAST730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7Phosphoserine; by PKG/PRKG1; in vitro1 Publication1
Modified residuei45PhosphoserineCombined sources1
Modified residuei49PhosphothreonineCombined sources1
Modified residuei507PhosphoserineBy similarity1
Modified residuei544PhosphoserineCombined sources1
Modified residuei558PhosphoserineCombined sources1
Modified residuei564PhosphoserineCombined sources1
Modified residuei612PhosphoserineBy similarity1
Modified residuei613PhosphoserineBy similarity1

Post-translational modificationi

In vitro phosphorylated by cGMP-dependent protein kinase 1 (cGKI) at Ser-7; the phosphorylation probably does not regulate GAP activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ684P5.
MaxQBiQ684P5.
PaxDbiQ684P5.
PeptideAtlasiQ684P5.
PRIDEiQ684P5.

PTM databases

iPTMnetiQ684P5.
PhosphoSitePlusiQ684P5.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are expressed in platelets with isoform 2 being the predominant form. Expressed in lymphocytes, heart, testis and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000132359.
CleanExiHS_GARNL4.
GenevisibleiQ684P5. HS.

Organism-specific databases

HPAiHPA022148.
HPA022896.

Interactioni

Protein-protein interaction databases

BioGridi116732. 3 interactors.
IntActiQ684P5. 4 interactors.
STRINGi9606.ENSP00000254695.

Structurei

3D structure databases

ProteinModelPortaliQ684P5.
SMRiQ684P5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini248 – 464Rap-GAPPROSITE-ProRule annotationAdd BLAST217

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi586 – 726Ser-richAdd BLAST141

Sequence similaritiesi

Contains 1 Rap-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3686. Eukaryota.
ENOG410XTIX. LUCA.
GeneTreeiENSGT00760000119182.
HOGENOMiHOG000231640.
HOVERGENiHBG016371.
InParanoidiQ684P5.
KOiK17708.
OMAiHNSVEVT.
OrthoDBiEOG091G028T.
PhylomeDBiQ684P5.
TreeFamiTF318626.

Family and domain databases

InterProiIPR000331. Rap_GAP_dom.
[Graphical view]
PfamiPF02145. Rap_GAP. 1 hit.
[Graphical view]
SUPFAMiSSF111347. SSF111347. 1 hit.
PROSITEiPS50085. RAPGAP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q684P5-1) [UniParc]FASTAAdd to basket
Also known as: Rap1GAP2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGRKRSVSF GGFGWIDKTM LASLKVKKQE LANSSDATLP DRPLSPPLTA
60 70 80 90 100
PPTMKSSEFF EMLEKMQGIK LEEQKPGPQK NKDDYIPYPS IDEVVEKGGP
110 120 130 140 150
YPQVILPQFG GYWIEDPENV GTPTSLGSSI CEEEEEDNLS PNTFGYKLEC
160 170 180 190 200
KGEARAYRRH FLGKDHLNFY CTGSSLGNLI LSVKCEEAEG IEYLRVILRS
210 220 230 240 250
KLKTVHERIP LAGLSKLPSV PQIAKAFCDD AVGLRFNPVL YPKASQMIVS
260 270 280 290 300
YDEHEVNNTF KFGVIYQKAR QTLEEELFGN NEESPAFKEF LDLLGDTITL
310 320 330 340 350
QDFKGFRGGL DVTHGQTGVE SVYTTFRDRE IMFHVSTKLP FTDGDAQQLQ
360 370 380 390 400
RKRHIGNDIV AIIFQEENTP FVPDMIASNF LHAYIVVQVE TPGTETPSYK
410 420 430 440 450
VSVTAREDVP TFGPPLPSPP VFQKGPEFRE FLLTKLTNAE NACCKSDKFA
460 470 480 490 500
KLEDRTRAAL LDNLHDELHA HTQAMLGLGP EEDKFENGGH GGFLESFKRA
510 520 530 540 550
IRVRSHSMET MVGGQKKSHS GGIPGSLSGG ISHNSMEVTK TTFSPPVVAA
560 570 580 590 600
TVKNQSRSPI KRRSGLFPRL HTGSEGQGDS RARCDSTSST PKTPDGGHSS
610 620 630 640 650
QEIKSETSSN PSSPEICPNK EKPFMKLKEN GRAISRSSSS TSSVSSTAGE
660 670 680 690 700
GEAMEEGDSG GSQPSTTSPF KQEVFVYSPS PSSESPSLGA AATPIIMSRS
710 720 730
PTDAKSRNSP RSNLKFRFDK LSHASSGAGH
Length:730
Mass (Da):80,056
Last modified:December 4, 2007 - v2
Checksum:i8E7584ADC2DA0B08
GO
Isoform 2 (identifier: Q684P5-2) [UniParc]FASTAAdd to basket
Also known as: Rap1GAP2a

The sequence of this isoform differs from the canonical sequence as follows:
     68-82: Missing.

Show »
Length:715
Mass (Da):78,380
Checksum:i3A8175583D2C9C3F
GO
Isoform 3 (identifier: Q684P5-3) [UniParc]FASTAAdd to basket
Also known as: Rap1GAP2c

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:711
Mass (Da):77,897
Checksum:iF90B7B7CBC1F46A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti285P → L in BAC85912 (PubMed:14702039).Curated1
Sequence conflicti304K → N in CAF31652 (PubMed:15632203).Curated1
Sequence conflicti304K → N in CAF31653 (PubMed:15632203).Curated1
Sequence conflicti726S → P in CAH10514 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037553202L → M.Corresponds to variant rs17762452dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0298881 – 19Missing in isoform 3. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_02988968 – 82Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ628446 mRNA. Translation: CAF31652.1.
AJ628447 mRNA. Translation: CAF31653.1.
AK124640 mRNA. Translation: BAC85912.1.
CR627427 mRNA. Translation: CAH10514.1.
BC140870 mRNA. Translation: AAI40871.1.
BC140871 mRNA. Translation: AAI40872.1.
AB028962 mRNA. Translation: BAA82991.1.
CCDSiCCDS45573.1. [Q684P5-1]
CCDS45574.1. [Q684P5-2]
CCDS82035.1. [Q684P5-3]
RefSeqiNP_001093868.1. NM_001100398.1. [Q684P5-2]
NP_001316987.1. NM_001330058.1.
NP_055900.4. NM_015085.4. [Q684P5-1]
XP_011522043.1. XM_011523741.2. [Q684P5-3]
XP_016879859.1. XM_017024370.1. [Q684P5-3]
UniGeneiHs.499659.

Genome annotation databases

EnsembliENST00000254695; ENSP00000254695; ENSG00000132359. [Q684P5-1]
ENST00000366401; ENSP00000389824; ENSG00000132359. [Q684P5-2]
ENST00000540393; ENSP00000439688; ENSG00000132359. [Q684P5-3]
ENST00000542807; ENSP00000444890; ENSG00000132359. [Q684P5-1]
GeneIDi23108.
KEGGihsa:23108.
UCSCiuc010ckd.4. human. [Q684P5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ628446 mRNA. Translation: CAF31652.1.
AJ628447 mRNA. Translation: CAF31653.1.
AK124640 mRNA. Translation: BAC85912.1.
CR627427 mRNA. Translation: CAH10514.1.
BC140870 mRNA. Translation: AAI40871.1.
BC140871 mRNA. Translation: AAI40872.1.
AB028962 mRNA. Translation: BAA82991.1.
CCDSiCCDS45573.1. [Q684P5-1]
CCDS45574.1. [Q684P5-2]
CCDS82035.1. [Q684P5-3]
RefSeqiNP_001093868.1. NM_001100398.1. [Q684P5-2]
NP_001316987.1. NM_001330058.1.
NP_055900.4. NM_015085.4. [Q684P5-1]
XP_011522043.1. XM_011523741.2. [Q684P5-3]
XP_016879859.1. XM_017024370.1. [Q684P5-3]
UniGeneiHs.499659.

3D structure databases

ProteinModelPortaliQ684P5.
SMRiQ684P5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116732. 3 interactors.
IntActiQ684P5. 4 interactors.
STRINGi9606.ENSP00000254695.

PTM databases

iPTMnetiQ684P5.
PhosphoSitePlusiQ684P5.

Polymorphism and mutation databases

BioMutaiRAP1GAP2.
DMDMi162416269.

Proteomic databases

EPDiQ684P5.
MaxQBiQ684P5.
PaxDbiQ684P5.
PeptideAtlasiQ684P5.
PRIDEiQ684P5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254695; ENSP00000254695; ENSG00000132359. [Q684P5-1]
ENST00000366401; ENSP00000389824; ENSG00000132359. [Q684P5-2]
ENST00000540393; ENSP00000439688; ENSG00000132359. [Q684P5-3]
ENST00000542807; ENSP00000444890; ENSG00000132359. [Q684P5-1]
GeneIDi23108.
KEGGihsa:23108.
UCSCiuc010ckd.4. human. [Q684P5-1]

Organism-specific databases

CTDi23108.
DisGeNETi23108.
GeneCardsiRAP1GAP2.
H-InvDBHIX0013424.
HIX0039496.
HGNCiHGNC:29176. RAP1GAP2.
HPAiHPA022148.
HPA022896.
neXtProtiNX_Q684P5.
OpenTargetsiENSG00000132359.
PharmGKBiPA165432528.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3686. Eukaryota.
ENOG410XTIX. LUCA.
GeneTreeiENSGT00760000119182.
HOGENOMiHOG000231640.
HOVERGENiHBG016371.
InParanoidiQ684P5.
KOiK17708.
OMAiHNSVEVT.
OrthoDBiEOG091G028T.
PhylomeDBiQ684P5.
TreeFamiTF318626.

Enzyme and pathway databases

ReactomeiR-HSA-392517. Rap1 signalling.

Miscellaneous databases

ChiTaRSiRAP1GAP2. human.
GeneWikiiRAP1GAP2.
GenomeRNAii23108.
PROiQ684P5.

Gene expression databases

BgeeiENSG00000132359.
CleanExiHS_GARNL4.
GenevisibleiQ684P5. HS.

Family and domain databases

InterProiIPR000331. Rap_GAP_dom.
[Graphical view]
PfamiPF02145. Rap_GAP. 1 hit.
[Graphical view]
SUPFAMiSSF111347. SSF111347. 1 hit.
PROSITEiPS50085. RAPGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPGP2_HUMAN
AccessioniPrimary (citable) accession number: Q684P5
Secondary accession number(s): B2RTY5
, Q684P4, Q6AI00, Q6ZVF0, Q9UPW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 30, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.