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Q684P5

- RPGP2_HUMAN

UniProt

Q684P5 - RPGP2_HUMAN

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Protein

Rap1 GTPase-activating protein 2

Gene

RAP1GAP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.1 Publication

GO - Molecular functioni

  1. Rap GTPase activator activity Source: Ensembl

GO - Biological processi

  1. negative regulation of neuron projection development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_23898. Rap1 signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
Rap1 GTPase-activating protein 2
Short name:
Rap1GAP2
Alternative name(s):
GTPase-activating Rap/Ran-GAP domain-like protein 4
Gene namesi
Name:RAP1GAP2
Synonyms:GARNL4, KIAA1039, RAP1GA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:29176. RAP1GAP2.

Subcellular locationi

Cytoplasm 1 Publication. Cytoplasmperinuclear region 1 Publication

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: HPA
  3. cytosol Source: Reactome
  4. neuron projection Source: Ensembl
  5. nuclear membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi7 – 71S → A: Abolishes phosphorylation by PKG/PRKG1. 1 Publication
Mutagenesisi357 – 3571N → A: Abolishes GAP activity. 1 Publication

Organism-specific databases

PharmGKBiPA165432528.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 730730Rap1 GTPase-activating protein 2PRO_0000312716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71Phosphoserine; by PKG/PRKG1; in vitro1 Publication
Modified residuei45 – 451Phosphoserine2 Publications
Modified residuei49 – 491Phosphothreonine2 Publications
Modified residuei544 – 5441Phosphoserine2 Publications
Modified residuei558 – 5581Phosphoserine1 Publication
Modified residuei564 – 5641Phosphoserine1 Publication

Post-translational modificationi

In vitro phosphorylated by cGMP-dependent protein kinase 1 (cGKI) at Ser-7; the phosphorylation probably does not regulate GAP activity.5 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ684P5.
PaxDbiQ684P5.
PRIDEiQ684P5.

PTM databases

PhosphoSiteiQ684P5.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are expressed in platelets with isoform 2 being the predominant form. Expressed in lymphocytes, heart, testis and pancreas.1 Publication

Gene expression databases

BgeeiQ684P5.
CleanExiHS_GARNL4.
GenevestigatoriQ684P5.

Organism-specific databases

HPAiHPA022148.
HPA022896.

Interactioni

Protein-protein interaction databases

BioGridi116732. 3 interactions.
IntActiQ684P5. 2 interactions.
STRINGi9606.ENSP00000254695.

Structurei

3D structure databases

ProteinModelPortaliQ684P5.
SMRiQ684P5. Positions 147-479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini248 – 464217Rap-GAPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi586 – 726141Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 Rap-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG292109.
GeneTreeiENSGT00760000119182.
HOGENOMiHOG000231640.
HOVERGENiHBG016371.
InParanoidiQ684P5.
KOiK17708.
OMAiTMVGSQK.
OrthoDBiEOG7WHH8V.
PhylomeDBiQ684P5.
TreeFamiTF318626.

Family and domain databases

InterProiIPR000331. Rap_GAP_dom.
[Graphical view]
PfamiPF02145. Rap_GAP. 1 hit.
[Graphical view]
PROSITEiPS50085. RAPGAP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q684P5-1) [UniParc]FASTAAdd to Basket

Also known as: Rap1GAP2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGRKRSVSF GGFGWIDKTM LASLKVKKQE LANSSDATLP DRPLSPPLTA
60 70 80 90 100
PPTMKSSEFF EMLEKMQGIK LEEQKPGPQK NKDDYIPYPS IDEVVEKGGP
110 120 130 140 150
YPQVILPQFG GYWIEDPENV GTPTSLGSSI CEEEEEDNLS PNTFGYKLEC
160 170 180 190 200
KGEARAYRRH FLGKDHLNFY CTGSSLGNLI LSVKCEEAEG IEYLRVILRS
210 220 230 240 250
KLKTVHERIP LAGLSKLPSV PQIAKAFCDD AVGLRFNPVL YPKASQMIVS
260 270 280 290 300
YDEHEVNNTF KFGVIYQKAR QTLEEELFGN NEESPAFKEF LDLLGDTITL
310 320 330 340 350
QDFKGFRGGL DVTHGQTGVE SVYTTFRDRE IMFHVSTKLP FTDGDAQQLQ
360 370 380 390 400
RKRHIGNDIV AIIFQEENTP FVPDMIASNF LHAYIVVQVE TPGTETPSYK
410 420 430 440 450
VSVTAREDVP TFGPPLPSPP VFQKGPEFRE FLLTKLTNAE NACCKSDKFA
460 470 480 490 500
KLEDRTRAAL LDNLHDELHA HTQAMLGLGP EEDKFENGGH GGFLESFKRA
510 520 530 540 550
IRVRSHSMET MVGGQKKSHS GGIPGSLSGG ISHNSMEVTK TTFSPPVVAA
560 570 580 590 600
TVKNQSRSPI KRRSGLFPRL HTGSEGQGDS RARCDSTSST PKTPDGGHSS
610 620 630 640 650
QEIKSETSSN PSSPEICPNK EKPFMKLKEN GRAISRSSSS TSSVSSTAGE
660 670 680 690 700
GEAMEEGDSG GSQPSTTSPF KQEVFVYSPS PSSESPSLGA AATPIIMSRS
710 720 730
PTDAKSRNSP RSNLKFRFDK LSHASSGAGH
Length:730
Mass (Da):80,056
Last modified:December 4, 2007 - v2
Checksum:i8E7584ADC2DA0B08
GO
Isoform 2 (identifier: Q684P5-2) [UniParc]FASTAAdd to Basket

Also known as: Rap1GAP2a

The sequence of this isoform differs from the canonical sequence as follows:
     68-82: Missing.

Show »
Length:715
Mass (Da):78,380
Checksum:i3A8175583D2C9C3F
GO
Isoform 3 (identifier: Q684P5-3) [UniParc]FASTAAdd to Basket

Also known as: Rap1GAP2c

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:711
Mass (Da):77,897
Checksum:iF90B7B7CBC1F46A6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti285 – 2851P → L in BAC85912. (PubMed:14702039)Curated
Sequence conflicti304 – 3041K → N in CAF31652. (PubMed:15632203)Curated
Sequence conflicti304 – 3041K → N in CAF31653. (PubMed:15632203)Curated
Sequence conflicti726 – 7261S → P in CAH10514. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti202 – 2021L → M.
Corresponds to variant rs17762452 [ dbSNP | Ensembl ].
VAR_037553

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1919Missing in isoform 3. 2 PublicationsVSP_029888Add
BLAST
Alternative sequencei68 – 8215Missing in isoform 2. 1 PublicationVSP_029889Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ628446 mRNA. Translation: CAF31652.1.
AJ628447 mRNA. Translation: CAF31653.1.
AK124640 mRNA. Translation: BAC85912.1.
CR627427 mRNA. Translation: CAH10514.1.
BC140870 mRNA. Translation: AAI40871.1.
BC140871 mRNA. Translation: AAI40872.1.
AB028962 mRNA. Translation: BAA82991.1.
CCDSiCCDS45573.1. [Q684P5-1]
CCDS45574.1. [Q684P5-2]
RefSeqiNP_001093868.1. NM_001100398.1. [Q684P5-2]
NP_055900.4. NM_015085.4. [Q684P5-1]
XP_006721540.1. XM_006721477.1. [Q684P5-3]
UniGeneiHs.499659.

Genome annotation databases

EnsembliENST00000254695; ENSP00000254695; ENSG00000132359. [Q684P5-1]
ENST00000366401; ENSP00000389824; ENSG00000132359. [Q684P5-2]
ENST00000540393; ENSP00000439688; ENSG00000132359. [Q684P5-3]
ENST00000542807; ENSP00000444890; ENSG00000132359. [Q684P5-1]
GeneIDi23108.
KEGGihsa:23108.
UCSCiuc010ckd.3. human. [Q684P5-1]
uc010cke.3. human. [Q684P5-2]

Polymorphism databases

DMDMi162416269.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ628446 mRNA. Translation: CAF31652.1 .
AJ628447 mRNA. Translation: CAF31653.1 .
AK124640 mRNA. Translation: BAC85912.1 .
CR627427 mRNA. Translation: CAH10514.1 .
BC140870 mRNA. Translation: AAI40871.1 .
BC140871 mRNA. Translation: AAI40872.1 .
AB028962 mRNA. Translation: BAA82991.1 .
CCDSi CCDS45573.1. [Q684P5-1 ]
CCDS45574.1. [Q684P5-2 ]
RefSeqi NP_001093868.1. NM_001100398.1. [Q684P5-2 ]
NP_055900.4. NM_015085.4. [Q684P5-1 ]
XP_006721540.1. XM_006721477.1. [Q684P5-3 ]
UniGenei Hs.499659.

3D structure databases

ProteinModelPortali Q684P5.
SMRi Q684P5. Positions 147-479.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116732. 3 interactions.
IntActi Q684P5. 2 interactions.
STRINGi 9606.ENSP00000254695.

PTM databases

PhosphoSitei Q684P5.

Polymorphism databases

DMDMi 162416269.

Proteomic databases

MaxQBi Q684P5.
PaxDbi Q684P5.
PRIDEi Q684P5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254695 ; ENSP00000254695 ; ENSG00000132359 . [Q684P5-1 ]
ENST00000366401 ; ENSP00000389824 ; ENSG00000132359 . [Q684P5-2 ]
ENST00000540393 ; ENSP00000439688 ; ENSG00000132359 . [Q684P5-3 ]
ENST00000542807 ; ENSP00000444890 ; ENSG00000132359 . [Q684P5-1 ]
GeneIDi 23108.
KEGGi hsa:23108.
UCSCi uc010ckd.3. human. [Q684P5-1 ]
uc010cke.3. human. [Q684P5-2 ]

Organism-specific databases

CTDi 23108.
GeneCardsi GC17P002680.
H-InvDB HIX0013424.
HIX0039496.
HGNCi HGNC:29176. RAP1GAP2.
HPAi HPA022148.
HPA022896.
neXtProti NX_Q684P5.
PharmGKBi PA165432528.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG292109.
GeneTreei ENSGT00760000119182.
HOGENOMi HOG000231640.
HOVERGENi HBG016371.
InParanoidi Q684P5.
KOi K17708.
OMAi TMVGSQK.
OrthoDBi EOG7WHH8V.
PhylomeDBi Q684P5.
TreeFami TF318626.

Enzyme and pathway databases

Reactomei REACT_23898. Rap1 signalling.

Miscellaneous databases

ChiTaRSi RAP1GAP2. human.
GeneWikii RAP1GAP2.
GenomeRNAii 23108.
NextBioi 44297.
PROi Q684P5.

Gene expression databases

Bgeei Q684P5.
CleanExi HS_GARNL4.
Genevestigatori Q684P5.

Family and domain databases

InterProi IPR000331. Rap_GAP_dom.
[Graphical view ]
Pfami PF02145. Rap_GAP. 1 hit.
[Graphical view ]
PROSITEi PS50085. RAPGAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets."
    Schultess J., Danielewski O., Smolenski A.P.
    Blood 105:3185-3192(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, PHOSPHORYLATION AT SER-7, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF SER-7 AND ASN-357.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Cerebellum.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Cervix.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 287-730.
    Tissue: Brain.
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-544, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND THR-49, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45; THR-49 AND SER-544, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-558 AND SER-564, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRPGP2_HUMAN
AccessioniPrimary (citable) accession number: Q684P5
Secondary accession number(s): B2RTY5
, Q684P4, Q6AI00, Q6ZVF0, Q9UPW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3