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Q680B9

- PRRP2_ARATH

UniProt

Q680B9 - PRRP2_ARATH

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Protein

Proteinaceous RNase P 2

Gene

PRORP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Endonuclease RNase P responsible for the 5' maturation of tRNA precursors. Also involved in the maturation of mRNA and small nucleolar RNA (snoRNA).1 Publication

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.1 Publication

GO - Molecular functioni

  1. ribonuclease P activity Source: TAIR

GO - Biological processi

  1. mRNA processing Source: TAIR
  2. RNA phosphodiester bond hydrolysis Source: GOC
  3. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
  4. snoRNA processing Source: TAIR
  5. tRNA 5'-leader removal Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Proteinaceous RNase P 2 (EC:3.1.26.5)
Gene namesi
Name:PRORP2
Ordered Locus Names:At2g16650
ORF Names:T24I21.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G16650.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype; due to the redundancy with PRORP3. Prorp2 and prorp3 double mutant is lethal.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi421 – 4222DD → AA: Loss of activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Proteinaceous RNase P 2PRO_0000420273Add
BLAST

Proteomic databases

PaxDbiQ680B9.
PRIDEiQ680B9.

Expressioni

Gene expression databases

GenevestigatoriQ680B9.

Structurei

3D structure databases

ProteinModelPortaliQ680B9.
SMRiQ680B9. Positions 28-514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati29 – 6436PPR 1Add
BLAST
Repeati72 – 10736PPR 2Add
BLAST
Repeati108 – 14235PPR 3Add
BLAST
Repeati145 – 17935PPR 4Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 244Poly-Lys

Sequence similaritiesi

Belongs to the PPR family. P subfamily.Curated
Contains 4 PPR (pentatricopeptide) repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG68490.
HOGENOMiHOG000006117.
InParanoidiQ680B9.
KOiK18213.
OMAiHNKRIAK.
PhylomeDBiQ680B9.

Family and domain databases

InterProiIPR021869. RNase_Zc3h12.
[Graphical view]
PfamiPF11977. RNase_Zc3h12a. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q680B9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAASDQHRSR RHDESSSRPN KKKKVSRNPE TNLLFNLNSC SKSKDLSAAL
60 70 80 90 100
ALYDAAITSS EVRLSQQHFQ TLLYLCSASI TDISLQYLAI DRGFEIFDRM
110 120 130 140 150
VSSGISPNEA SVTSVARLAA AKGNGDYAFK VVKEFVSVGG VSIPRLRTYA
160 170 180 190 200
PALLCFCEKL EAEKGYEVEE HMEAAGIALE EAEISALLKV SAATGRENKV
210 220 230 240 250
YRYLHKLREY VGCVSEETLK IIEEWFCGEK AGEVGDNGIG SDVGMLREAV
260 270 280 290 300
LNNGGGWHGH GWVGEGKWTV KKGNVSSTGR CLSCSEQLAC VDTNEVETQK
310 320 330 340 350
FVDSLVALAM DRKTKMNSCE TNVVFSEFQD WLEKHGDYEA IVDGANIGLY
360 370 380 390 400
QQNFVDGSFS LSQLESVMKE LYRESGNNKW PLILLHKRRV KTLLENPTHR
410 420 430 440 450
NLVEEWISNG VLYATPPGSN DDWYWLYAAA KLKCLLVTND EMRDHIFELL
460 470 480 490 500
GSTFFQKWKE RHQVRYTFVK GNLKLEMPSP FSVVIQESEK GSWHFPVSCE
510 520
NNEESSRTWM CISRQSILDS PKSNGKIP
Length:528
Mass (Da):59,228
Last modified:October 11, 2004 - v1
Checksum:iE9CE36AE22686ABF
GO

Sequence cautioni

The sequence AAD24622.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC005825 Genomic DNA. Translation: AAD24622.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC06522.1.
AK175948 mRNA. Translation: BAD43711.1.
PIRiE84542.
RefSeqiNP_179256.3. NM_127217.3.
UniGeneiAt.29161.

Genome annotation databases

EnsemblPlantsiAT2G16650.1; AT2G16650.1; AT2G16650.
GeneIDi816166.
KEGGiath:AT2G16650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC005825 Genomic DNA. Translation: AAD24622.1 . Sequence problems.
CP002685 Genomic DNA. Translation: AEC06522.1 .
AK175948 mRNA. Translation: BAD43711.1 .
PIRi E84542.
RefSeqi NP_179256.3. NM_127217.3.
UniGenei At.29161.

3D structure databases

ProteinModelPortali Q680B9.
SMRi Q680B9. Positions 28-514.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q680B9.
PRIDEi Q680B9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G16650.1 ; AT2G16650.1 ; AT2G16650 .
GeneIDi 816166.
KEGGi ath:AT2G16650.

Organism-specific databases

TAIRi AT2G16650.

Phylogenomic databases

eggNOGi NOG68490.
HOGENOMi HOG000006117.
InParanoidi Q680B9.
KOi K18213.
OMAi HNKRIAK.
PhylomeDBi Q680B9.

Gene expression databases

Genevestigatori Q680B9.

Family and domain databases

InterProi IPR021869. RNase_Zc3h12.
[Graphical view ]
Pfami PF11977. RNase_Zc3h12a. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. Cited for: IDENTIFICATION, SUBCELLULAR LOCATION.
  5. "PRORP proteins support RNase P activity in both organelles and the nucleus in Arabidopsis."
    Gutmann B., Gobert A., Giege P.
    Genes Dev. 26:1022-1027(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, DISRUPTION PHENOTYPE, MUTAGENESIS OF 421-ASP-ASP-422.

Entry informationi

Entry nameiPRRP2_ARATH
AccessioniPrimary (citable) accession number: Q680B9
Secondary accession number(s): Q9SLF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3