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Q680B9

- PRRP2_ARATH

UniProt

Q680B9 - PRRP2_ARATH

Protein

Proteinaceous RNase P 2

Gene

PRORP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Endonuclease RNase P responsible for the 5' maturation of tRNA precursors. Also involved in the maturation of mRNA and small nucleolar RNA (snoRNA).1 Publication

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.1 Publication

    GO - Molecular functioni

    1. ribonuclease P activity Source: TAIR

    GO - Biological processi

    1. mRNA processing Source: TAIR
    2. RNA phosphodiester bond hydrolysis Source: GOC
    3. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
    4. snoRNA processing Source: TAIR
    5. tRNA 5'-leader removal Source: TAIR

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteinaceous RNase P 2 (EC:3.1.26.5)
    Gene namesi
    Name:PRORP2
    Ordered Locus Names:At2g16650
    ORF Names:T24I21.6
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G16650.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: TAIR

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype; due to the redundancy with PRORP3. Prorp2 and prorp3 double mutant is lethal.1 Publication

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi421 – 4222DD → AA: Loss of activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 528528Proteinaceous RNase P 2PRO_0000420273Add
    BLAST

    Proteomic databases

    PaxDbiQ680B9.
    PRIDEiQ680B9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ680B9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ680B9.
    SMRiQ680B9. Positions 28-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati29 – 6436PPR 1Add
    BLAST
    Repeati72 – 10736PPR 2Add
    BLAST
    Repeati108 – 14235PPR 3Add
    BLAST
    Repeati145 – 17935PPR 4Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi21 – 244Poly-Lys

    Sequence similaritiesi

    Belongs to the PPR family. P subfamily.Curated
    Contains 4 PPR (pentatricopeptide) repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG68490.
    HOGENOMiHOG000006117.
    InParanoidiQ680B9.
    KOiK18213.
    OMAiHNKRIAK.
    PhylomeDBiQ680B9.

    Family and domain databases

    InterProiIPR021869. RNase_Zc3h12.
    [Graphical view]
    PfamiPF11977. RNase_Zc3h12a. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q680B9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASDQHRSR RHDESSSRPN KKKKVSRNPE TNLLFNLNSC SKSKDLSAAL    50
    ALYDAAITSS EVRLSQQHFQ TLLYLCSASI TDISLQYLAI DRGFEIFDRM 100
    VSSGISPNEA SVTSVARLAA AKGNGDYAFK VVKEFVSVGG VSIPRLRTYA 150
    PALLCFCEKL EAEKGYEVEE HMEAAGIALE EAEISALLKV SAATGRENKV 200
    YRYLHKLREY VGCVSEETLK IIEEWFCGEK AGEVGDNGIG SDVGMLREAV 250
    LNNGGGWHGH GWVGEGKWTV KKGNVSSTGR CLSCSEQLAC VDTNEVETQK 300
    FVDSLVALAM DRKTKMNSCE TNVVFSEFQD WLEKHGDYEA IVDGANIGLY 350
    QQNFVDGSFS LSQLESVMKE LYRESGNNKW PLILLHKRRV KTLLENPTHR 400
    NLVEEWISNG VLYATPPGSN DDWYWLYAAA KLKCLLVTND EMRDHIFELL 450
    GSTFFQKWKE RHQVRYTFVK GNLKLEMPSP FSVVIQESEK GSWHFPVSCE 500
    NNEESSRTWM CISRQSILDS PKSNGKIP 528
    Length:528
    Mass (Da):59,228
    Last modified:October 11, 2004 - v1
    Checksum:iE9CE36AE22686ABF
    GO

    Sequence cautioni

    The sequence AAD24622.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005825 Genomic DNA. Translation: AAD24622.1. Sequence problems.
    CP002685 Genomic DNA. Translation: AEC06522.1.
    AK175948 mRNA. Translation: BAD43711.1.
    PIRiE84542.
    RefSeqiNP_179256.3. NM_127217.3.
    UniGeneiAt.29161.

    Genome annotation databases

    EnsemblPlantsiAT2G16650.1; AT2G16650.1; AT2G16650.
    GeneIDi816166.
    KEGGiath:AT2G16650.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005825 Genomic DNA. Translation: AAD24622.1 . Sequence problems.
    CP002685 Genomic DNA. Translation: AEC06522.1 .
    AK175948 mRNA. Translation: BAD43711.1 .
    PIRi E84542.
    RefSeqi NP_179256.3. NM_127217.3.
    UniGenei At.29161.

    3D structure databases

    ProteinModelPortali Q680B9.
    SMRi Q680B9. Positions 28-514.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q680B9.
    PRIDEi Q680B9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G16650.1 ; AT2G16650.1 ; AT2G16650 .
    GeneIDi 816166.
    KEGGi ath:AT2G16650.

    Organism-specific databases

    TAIRi AT2G16650.

    Phylogenomic databases

    eggNOGi NOG68490.
    HOGENOMi HOG000006117.
    InParanoidi Q680B9.
    KOi K18213.
    OMAi HNKRIAK.
    PhylomeDBi Q680B9.

    Gene expression databases

    Genevestigatori Q680B9.

    Family and domain databases

    InterProi IPR021869. RNase_Zc3h12.
    [Graphical view ]
    Pfami PF11977. RNase_Zc3h12a. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. Cited for: IDENTIFICATION, SUBCELLULAR LOCATION.
    5. "PRORP proteins support RNase P activity in both organelles and the nucleus in Arabidopsis."
      Gutmann B., Gobert A., Giege P.
      Genes Dev. 26:1022-1027(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, DISRUPTION PHENOTYPE, MUTAGENESIS OF 421-ASP-ASP-422.

    Entry informationi

    Entry nameiPRRP2_ARATH
    AccessioniPrimary (citable) accession number: Q680B9
    Secondary accession number(s): Q9SLF2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2012
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3