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Q680B9 (PRRP2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteinaceous RNase P 2

EC=3.1.26.5
Gene names
Name:PRORP2
Ordered Locus Names:At2g16650
ORF Names:T24I21.6
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Endonuclease RNase P responsible for the 5' maturation of tRNA precursors. Also involved in the maturation of mRNA and small nucleolar RNA (snoRNA). Ref.5

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. Ref.5

Subcellular location

Nucleus Ref.4.

Disruption phenotype

No visible phenotype; due to the redundancy with PRORP3. Prorp2 and prorp3 double mutant is lethal. Ref.5

Sequence similarities

Belongs to the PPR family. P subfamily.

Contains 4 PPR (pentatricopeptide) repeats.

Sequence caution

The sequence AAD24622.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 528528Proteinaceous RNase P 2
PRO_0000420273

Regions

Repeat29 – 6436PPR 1
Repeat72 – 10736PPR 2
Repeat108 – 14235PPR 3
Repeat145 – 17935PPR 4
Compositional bias21 – 244Poly-Lys

Experimental info

Mutagenesis421 – 4222DD → AA: Loss of activity. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q680B9 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: E9CE36AE22686ABF

FASTA52859,228
        10         20         30         40         50         60 
MAASDQHRSR RHDESSSRPN KKKKVSRNPE TNLLFNLNSC SKSKDLSAAL ALYDAAITSS 

        70         80         90        100        110        120 
EVRLSQQHFQ TLLYLCSASI TDISLQYLAI DRGFEIFDRM VSSGISPNEA SVTSVARLAA 

       130        140        150        160        170        180 
AKGNGDYAFK VVKEFVSVGG VSIPRLRTYA PALLCFCEKL EAEKGYEVEE HMEAAGIALE 

       190        200        210        220        230        240 
EAEISALLKV SAATGRENKV YRYLHKLREY VGCVSEETLK IIEEWFCGEK AGEVGDNGIG 

       250        260        270        280        290        300 
SDVGMLREAV LNNGGGWHGH GWVGEGKWTV KKGNVSSTGR CLSCSEQLAC VDTNEVETQK 

       310        320        330        340        350        360 
FVDSLVALAM DRKTKMNSCE TNVVFSEFQD WLEKHGDYEA IVDGANIGLY QQNFVDGSFS 

       370        380        390        400        410        420 
LSQLESVMKE LYRESGNNKW PLILLHKRRV KTLLENPTHR NLVEEWISNG VLYATPPGSN 

       430        440        450        460        470        480 
DDWYWLYAAA KLKCLLVTND EMRDHIFELL GSTFFQKWKE RHQVRYTFVK GNLKLEMPSP 

       490        500        510        520 
FSVVIQESEK GSWHFPVSCE NNEESSRTWM CISRQSILDS PKSNGKIP 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. expand/collapse author list , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"A single Arabidopsis organellar protein has RNase P activity."
Gobert A., Gutmann B., Taschner A., Goessringer M., Holzmann J., Hartmann R.K., Rossmanith W., Giege P.
Nat. Struct. Mol. Biol. 17:740-744(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, SUBCELLULAR LOCATION.
[5]"PRORP proteins support RNase P activity in both organelles and the nucleus in Arabidopsis."
Gutmann B., Gobert A., Giege P.
Genes Dev. 26:1022-1027(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, CATALYTIC ACTIVITY, DISRUPTION PHENOTYPE, MUTAGENESIS OF 421-ASP-ASP-422.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC005825 Genomic DNA. Translation: AAD24622.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC06522.1.
AK175948 mRNA. Translation: BAD43711.1.
PIRE84542.
RefSeqNP_179256.3. NM_127217.3.
UniGeneAt.29161.

3D structure databases

ProteinModelPortalQ680B9.
SMRQ680B9. Positions 28-514.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ680B9.
PRIDEQ680B9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G16650.1; AT2G16650.1; AT2G16650.
GeneID816166.
KEGGath:AT2G16650.

Organism-specific databases

TAIRAT2G16650.

Phylogenomic databases

eggNOGNOG68490.
HOGENOMHOG000006117.
InParanoidQ680B9.
KOK18213.
OMAHNKRIAK.
PhylomeDBQ680B9.

Gene expression databases

GenevestigatorQ680B9.

Family and domain databases

InterProIPR021869. RNase_Zc3h12.
[Graphical view]
PfamPF11977. RNase_Zc3h12a. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePRRP2_ARATH
AccessionPrimary (citable) accession number: Q680B9
Secondary accession number(s): Q9SLF2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names