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Protein

Triacylglycerol lipase 2

Gene

LIP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Triacylglycerol (TAG) lipase. May be involved for TAG storage breakdown during seed germination (By similarity).By similarity

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei190NucleophileBy similarity1
Active sitei360Charge relay systemPROSITE-ProRule annotation1
Active sitei393Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

  • lipase activity Source: TAIR
  • triglyceride lipase activity Source: UniProtKB-EC

GO - Biological processi

  • defense response to insect Source: TAIR
  • lipid catabolic process Source: UniProtKB-KW

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciARA:AT5G14180-MONOMER
ReactomeiR-ATH-192456 Digestion of dietary lipid
R-ATH-6809371 Formation of the cornified envelope

Protein family/group databases

ESTHERiarath-LIP2 Acidic_Lipase
MEROPSiS33.A64

Names & Taxonomyi

Protein namesi
Recommended name:
Triacylglycerol lipase 2 (EC:3.1.1.3)
Gene namesi
Name:LIP2
Ordered Locus Names:At5g14180
ORF Names:MUA22.18, MUA22.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G14180
TAIRilocus:2174648 AT5G14180

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000023433732 – 418Triacylglycerol lipase 2Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ67ZU1

Expressioni

Gene expression databases

ExpressionAtlasiQ67ZU1 baseline and differential
GenevisibleiQ67ZU1 AT

Interactioni

Protein-protein interaction databases

BioGridi16546, 1 interactor
STRINGi3702.AT5G14180.1

Structurei

3D structure databases

ProteinModelPortaliQ67ZU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2624 Eukaryota
COG0596 LUCA
HOGENOMiHOG000240694
InParanoidiQ67ZU1
OMAiPEWAHVD
OrthoDBiEOG09360ESD
PhylomeDBiQ67ZU1

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR006693 AB_hydrolase_lipase
IPR025483 Lipase_euk
PfamiView protein in Pfam
PF04083 Abhydro_lipase, 1 hit
PIRSFiPIRSF000862 Steryl_ester_lip, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q67ZU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSVMVPSV SIGLALSVLI FFALSLKTLE ARGTFGRLAG QPPQRTAAGG
60 70 80 90 100
ICASSVHIFG YKCEEHDVVT QDGYILNMQR IPEGRAGAVA GDGGKRQPVL
110 120 130 140 150
IQHGILVDGM SWLLNPADQN LPLILADQGF DVWMGNTRGT RFSRRHKYLN
160 170 180 190 200
PSQRAFWNWT WDELVSYDLP AMFDHIHGLT GQKIHYLGHS LGTLIGFASF
210 220 230 240 250
SEKGLVDQVR SAAMLSPVAY LSHMTTVIGD IAAKTFLAEA TSILGWPEFN
260 270 280 290 300
PKSGLVGDFI KAICLKAGID CYDLVSVITG KNCCLNASTI DLFLANEPQS
310 320 330 340 350
TSTKNMIHLA QTVRDKELRK YNYGSSDRNI KHYGQAIPPA YNISAIPHEL
360 370 380 390 400
PLFFSYGGLD SLADVKDVEF LLDQFKYHDI DKMNVQFVKD YAHADFIMGV
410
TAKDVVYNQV ATFFKRQA
Length:418
Mass (Da):46,048
Last modified:October 11, 2004 - v1
Checksum:i613F11551D34A6D7
GO

Sequence cautioni

The sequence AAK82499 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB08297 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB08298 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191L → Q (PubMed:14593172).Curated1
Sequence conflicti213A → G in AAQ84586 (Ref. 4) Curated1
Sequence conflicti242S → A in AAQ84586 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007650 Genomic DNA Translation: BAB08297.1 Sequence problems.
AB007650 Genomic DNA Translation: BAB08298.1 Sequence problems.
CP002688 Genomic DNA Translation: AED91996.1
AK175707 mRNA Translation: BAD43470.1
AK176026 mRNA Translation: BAD43789.1
AY320231 mRNA Translation: AAQ84586.1
AY048236 mRNA Translation: AAK82499.1 Different initiation.
AY091711 mRNA Translation: AAM10310.1
RefSeqiNP_568295.2, NM_121422.4
UniGeneiAt.6513

Genome annotation databases

EnsemblPlantsiAT5G14180.1; AT5G14180.1; AT5G14180
GeneIDi831268
GrameneiAT5G14180.1; AT5G14180.1; AT5G14180
KEGGiath:AT5G14180

Similar proteinsi

Entry informationi

Entry nameiLIP2_ARATH
AccessioniPrimary (citable) accession number: Q67ZU1
Secondary accession number(s): Q681B0
, Q6VY31, Q94AE7, Q9FMT2, Q9FMT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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