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Protein

Triacylglycerol lipase 2

Gene

LIP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Triacylglycerol (TAG) lipase. May be involved for TAG storage breakdown during seed germination (By similarity).By similarity

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei190NucleophileBy similarity1
Active sitei360Charge relay systemPROSITE-ProRule annotation1
Active sitei393Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

  • lipase activity Source: TAIR
  • triglyceride lipase activity Source: UniProtKB-EC

GO - Biological processi

  • defense response to insect Source: TAIR
  • lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciARA:AT5G14180-MONOMER.
ReactomeiR-ATH-192456. Digestion of dietary lipid.

Protein family/group databases

ESTHERiarath-LIP2. Acidic_Lipase.
MEROPSiS33.A64.

Names & Taxonomyi

Protein namesi
Recommended name:
Triacylglycerol lipase 2 (EC:3.1.1.3)
Gene namesi
Name:LIP2
Ordered Locus Names:At5g14180
ORF Names:MUA22.18, MUA22.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G14180.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000023433732 – 418Triacylglycerol lipase 2Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi158N-linked (GlcNAc...)Sequence analysis1
Glycosylationi286N-linked (GlcNAc...)Sequence analysis1
Glycosylationi342N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ67ZU1.

Expressioni

Gene expression databases

GenevisibleiQ67ZU1. AT.

Interactioni

Protein-protein interaction databases

BioGridi16546. 1 interactor.
STRINGi3702.AT5G14180.1.

Structurei

3D structure databases

ProteinModelPortaliQ67ZU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
HOGENOMiHOG000240694.
InParanoidiQ67ZU1.
OMAiFLANEPQ.
OrthoDBiEOG09360ESD.
PhylomeDBiQ67ZU1.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR006693. AB_hydrolase_lipase.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF04083. Abhydro_lipase. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q67ZU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSVMVPSV SIGLALSVLI FFALSLKTLE ARGTFGRLAG QPPQRTAAGG
60 70 80 90 100
ICASSVHIFG YKCEEHDVVT QDGYILNMQR IPEGRAGAVA GDGGKRQPVL
110 120 130 140 150
IQHGILVDGM SWLLNPADQN LPLILADQGF DVWMGNTRGT RFSRRHKYLN
160 170 180 190 200
PSQRAFWNWT WDELVSYDLP AMFDHIHGLT GQKIHYLGHS LGTLIGFASF
210 220 230 240 250
SEKGLVDQVR SAAMLSPVAY LSHMTTVIGD IAAKTFLAEA TSILGWPEFN
260 270 280 290 300
PKSGLVGDFI KAICLKAGID CYDLVSVITG KNCCLNASTI DLFLANEPQS
310 320 330 340 350
TSTKNMIHLA QTVRDKELRK YNYGSSDRNI KHYGQAIPPA YNISAIPHEL
360 370 380 390 400
PLFFSYGGLD SLADVKDVEF LLDQFKYHDI DKMNVQFVKD YAHADFIMGV
410
TAKDVVYNQV ATFFKRQA
Length:418
Mass (Da):46,048
Last modified:October 11, 2004 - v1
Checksum:i613F11551D34A6D7
GO

Sequence cautioni

The sequence AAK82499 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB08297 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB08298 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191L → Q (PubMed:14593172).Curated1
Sequence conflicti213A → G in AAQ84586 (Ref. 4) Curated1
Sequence conflicti242S → A in AAQ84586 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007650 Genomic DNA. Translation: BAB08297.1. Sequence problems.
AB007650 Genomic DNA. Translation: BAB08298.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED91996.1.
AK175707 mRNA. Translation: BAD43470.1.
AK176026 mRNA. Translation: BAD43789.1.
AY320231 mRNA. Translation: AAQ84586.1.
AY048236 mRNA. Translation: AAK82499.1. Different initiation.
AY091711 mRNA. Translation: AAM10310.1.
RefSeqiNP_568295.2. NM_121422.4.
UniGeneiAt.6513.

Genome annotation databases

EnsemblPlantsiAT5G14180.1; AT5G14180.1; AT5G14180.
GeneIDi831268.
GrameneiAT5G14180.1; AT5G14180.1; AT5G14180.
KEGGiath:AT5G14180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007650 Genomic DNA. Translation: BAB08297.1. Sequence problems.
AB007650 Genomic DNA. Translation: BAB08298.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED91996.1.
AK175707 mRNA. Translation: BAD43470.1.
AK176026 mRNA. Translation: BAD43789.1.
AY320231 mRNA. Translation: AAQ84586.1.
AY048236 mRNA. Translation: AAK82499.1. Different initiation.
AY091711 mRNA. Translation: AAM10310.1.
RefSeqiNP_568295.2. NM_121422.4.
UniGeneiAt.6513.

3D structure databases

ProteinModelPortaliQ67ZU1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16546. 1 interactor.
STRINGi3702.AT5G14180.1.

Protein family/group databases

ESTHERiarath-LIP2. Acidic_Lipase.
MEROPSiS33.A64.

Proteomic databases

PaxDbiQ67ZU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G14180.1; AT5G14180.1; AT5G14180.
GeneIDi831268.
GrameneiAT5G14180.1; AT5G14180.1; AT5G14180.
KEGGiath:AT5G14180.

Organism-specific databases

TAIRiAT5G14180.

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
HOGENOMiHOG000240694.
InParanoidiQ67ZU1.
OMAiFLANEPQ.
OrthoDBiEOG09360ESD.
PhylomeDBiQ67ZU1.

Enzyme and pathway databases

BioCyciARA:AT5G14180-MONOMER.
ReactomeiR-ATH-192456. Digestion of dietary lipid.

Miscellaneous databases

PROiQ67ZU1.

Gene expression databases

GenevisibleiQ67ZU1. AT.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR006693. AB_hydrolase_lipase.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF04083. Abhydro_lipase. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIP2_ARATH
AccessioniPrimary (citable) accession number: Q67ZU1
Secondary accession number(s): Q681B0
, Q6VY31, Q94AE7, Q9FMT2, Q9FMT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.