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Protein

Ubiquitin carboxyl-terminal hydrolase 18

Gene

UBP18

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei177NucleophilePROSITE-ProRule annotation1
Active sitei433Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri61 – 98MYND-typePROSITE-ProRule annotationAdd BLAST38

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiC19.A08

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 18 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 18
Short name:
AtUBP18
Ubiquitin thioesterase 18
Ubiquitin-specific-processing protease 18
Gene namesi
Name:UBP18
Ordered Locus Names:At4g31670
ORF Names:F28M20.140
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G31670
TAIRilocus:2124809 AT4G31670

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130441 – 631Ubiquitin carboxyl-terminal hydrolase 18Add BLAST631

Proteomic databases

PaxDbiQ67XW5
PRIDEiQ67XW5

Expressioni

Gene expression databases

ExpressionAtlasiQ67XW5 baseline and differential
GenevisibleiQ67XW5 AT

Interactioni

Protein-protein interaction databases

BioGridi14581, 1 interactor
STRINGi3702.AT4G31670.1

Structurei

3D structure databases

ProteinModelPortaliQ67XW5
SMRiQ67XW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 474USPAdd BLAST307

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri61 – 98MYND-typePROSITE-ProRule annotationAdd BLAST38

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1865 Eukaryota
ENOG410XQ92 LUCA
HOGENOMiHOG000097839
InParanoidiQ67XW5
KOiK11855
OMAiSATDHQE
OrthoDBiEOG09360CKB
PhylomeDBiQ67XW5

Family and domain databases

InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
IPR002893 Znf_MYND
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PF01753 zf-MYND, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS50235 USP_3, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q67XW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHEVGFPLDL SVFTRLIATL FFLAVGVFYF LKNTAAKYFD IGAAAAGGFD
60 70 80 90 100
RDFMAVDAED CSVCGNFSTK KCSRCKSVRY CSAECQRSDW SSGHQRNCRD
110 120 130 140 150
YGITTLTPSA KNGLRFRASP FGDSSASSIA LISERGQNKS SLKPREVLFP
160 170 180 190 200
YEEFVEYFNW DNPELAPCGL MNCGNSCFAN VILQCLSWTR PLVAYLLEKG
210 220 230 240 250
HKRECMRNDW CFLCEFQTHV ERASQSRFPF SPMNIISRLT NIGGTLGYGR
260 270 280 290 300
QEDAHEFMRY AIDMMQSVCL DEFGGEKIVP PRSQETTLIQ YIFGGLLQSQ
310 320 330 340 350
VQCTVCNHVS DQYENMMDLI VEMHGDAGSL EECLDQFTAE EWLHGDNMYK
360 370 380 390 400
CDRCSDYVKA CKRLTIRRAP NILTIALKRY QGGRYGKLNK RISFPETLDL
410 420 430 440 450
NPYMSEGGDG SDVYKLYAVI VHLDMLNASF FGHYICYIKD FCGNWYRIDD
460 470 480 490 500
SEIESVELED VLSQRAYMLL YSRIQARSSS SCLRSEVKDE KKTDTLDTES
510 520 530 540 550
CVKELVESSM VGAIESRSST HATIEDPVCE QSPSPSPSPS PSPSPSPSPS
560 570 580 590 600
VLASECCSEV ERIDTLDSES NSSIDDSATD HQEDVANGNK DPEVKYQAAD
610 620 630
SWSDPTTSTP LVCTKSKPPV RDMDTKMIDA Q
Length:631
Mass (Da):70,753
Last modified:January 15, 2008 - v2
Checksum:i4C875C228588A0BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti432G → S in BAD43230 (Ref. 4) Curated1
Sequence conflicti550S → P in BAD44466 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031004 Genomic DNA Translation: CAA19756.1
AL161579 Genomic DNA Translation: CAB79885.1
CP002687 Genomic DNA Translation: AEE85943.1
AY142532 mRNA Translation: AAN13075.1
AK175467 mRNA Translation: BAD43230.1
AK176703 mRNA Translation: BAD44466.1
PIRiT05103
RefSeqiNP_194895.1, NM_119316.5
UniGeneiAt.31726

Genome annotation databases

EnsemblPlantsiAT4G31670.1; AT4G31670.1; AT4G31670
GeneIDi829295
GrameneiAT4G31670.1; AT4G31670.1; AT4G31670
KEGGiath:AT4G31670

Similar proteinsi

Entry informationi

Entry nameiUBP18_ARATH
AccessioniPrimary (citable) accession number: Q67XW5
Secondary accession number(s): O81780, Q682A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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