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Protein

DUF21 domain-containing protein At4g14240

Gene

CBSDUF1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
DUF21 domain-containing protein At4g14240
Alternative name(s):
CBS domain-containing protein CBSDUF1
Gene namesi
Name:CBSDUF1
Ordered Locus Names:At4g14240
ORF Names:dl3160c, FCAALL.149
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G14240.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Topological domaini65 – 93CytoplasmicSequence analysisAdd BLAST29
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 121ExtracellularSequence analysis7
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 159CytoplasmicSequence analysisAdd BLAST17
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 494ExtracellularSequence analysisAdd BLAST314

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004116781 – 494DUF21 domain-containing protein At4g14240Add BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi350N-linked (GlcNAc...)Sequence analysis1
Glycosylationi385N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ67XQ0.

PTM databases

iPTMnetiQ67XQ0.

Expressioni

Gene expression databases

GenevisibleiQ67XQ0. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G14240.1.

Structurei

3D structure databases

ProteinModelPortaliQ67XQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 203DUF21Add BLAST165
Domaini232 – 292CBS 1PROSITE-ProRule annotationAdd BLAST61
Domaini297 – 352CBS 2PROSITE-ProRule annotationAdd BLAST56
Domaini364 – 425CBS 3PROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi439 – 444Poly-Ala6

Sequence similaritiesi

Contains 3 CBS domains.PROSITE-ProRule annotation
Contains 1 DUF21 domain.Curated

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2118. Eukaryota.
COG1253. LUCA.
HOGENOMiHOG000183089.
InParanoidiQ67XQ0.
KOiK16302.
OMAiPSKHQVN.
OrthoDBiEOG09360B6N.
PhylomeDBiQ67XQ0.

Family and domain databases

InterProiIPR000644. CBS_dom.
IPR002550. DUF21.
[Graphical view]
PfamiPF01595. DUF21. 1 hit.
[Graphical view]
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q67XQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHLINAVAAA RILSGIGQSN GNNGGEAIPF GSFEWITYAG ISCFLVLFAG
60 70 80 90 100
IMSGLTLGLM SLGLVELEIL QRSGTPNEKK QAAAIFPVVQ KQHQLLVTLL
110 120 130 140 150
LCNAMAMEGL PIYLDKLFNE YVAIILSVTF VLAFGEVIPQ AICTRYGLAV
160 170 180 190 200
GANFVWLVRI LMTLCYPIAF PIGKILDLVL GHNDALFRRA QLKALVSIHS
210 220 230 240 250
QEAGKGGELT HDETTIISGA LDLTEKTAQE AMTPIESTFS LDVNSKLDWE
260 270 280 290 300
AMGKILARGH SRVPVYSGNP KNVIGLLLVK SLLTVRPETE TLVSAVCIRR
310 320 330 340 350
IPRVPADMPL YDILNEFQKG SSHMAAVVKV KGKSKVPPST LLEEHTDESN
360 370 380 390 400
DSDLTAPLLL KREGNHDNVI VTIDKANGQS FFQNNESGPH GFSHTSEAIE
410 420 430 440 450
DGEVIGIITL EDVFEELLQE EIVDETDEYV DVHKRIRVAA AAAASSIARA
460 470 480 490
PSSRKLLAQK GTGGQNKQGQ TNKVPGQEQD KMLGTITEPI RRNN
Length:494
Mass (Da):53,582
Last modified:October 11, 2004 - v1
Checksum:iBE6A0EF1936654B2
GO
Isoform 2 (identifier: Q67XQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-82: Missing.

Show »
Length:485
Mass (Da):52,628
Checksum:i39E9CAAB89335C30
GO

Sequence cautioni

The sequence CAB10203 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB78466 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134F → Y in CAB10203 (PubMed:9461215).Curated1
Sequence conflicti134F → Y in CAB78466 (PubMed:9461215).Curated1
Sequence conflicti134F → Y in AAU05525 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04162774 – 82Missing in isoform 2. 2 Publications9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97335 Genomic DNA. Translation: CAB10203.1. Sequence problems.
AL161538 Genomic DNA. Translation: CAB78466.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE83399.1.
CP002687 Genomic DNA. Translation: AEE83400.1.
BT015402 mRNA. Translation: AAU05525.1.
AK176768 mRNA. Translation: BAD44531.1.
AK175696 mRNA. Translation: BAD43459.1.
AK175756 mRNA. Translation: BAD43519.1.
AK176131 mRNA. Translation: BAD43894.1.
PIRiA71404.
RefSeqiNP_001031633.2. NM_001036556.2. [Q67XQ0-2]
NP_193160.3. NM_117501.5. [Q67XQ0-1]
UniGeneiAt.50339.

Genome annotation databases

EnsemblPlantsiAT4G14240.1; AT4G14240.1; AT4G14240. [Q67XQ0-1]
GeneIDi827065.
GrameneiAT4G14240.1; AT4G14240.1; AT4G14240.
KEGGiath:AT4G14240.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97335 Genomic DNA. Translation: CAB10203.1. Sequence problems.
AL161538 Genomic DNA. Translation: CAB78466.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE83399.1.
CP002687 Genomic DNA. Translation: AEE83400.1.
BT015402 mRNA. Translation: AAU05525.1.
AK176768 mRNA. Translation: BAD44531.1.
AK175696 mRNA. Translation: BAD43459.1.
AK175756 mRNA. Translation: BAD43519.1.
AK176131 mRNA. Translation: BAD43894.1.
PIRiA71404.
RefSeqiNP_001031633.2. NM_001036556.2. [Q67XQ0-2]
NP_193160.3. NM_117501.5. [Q67XQ0-1]
UniGeneiAt.50339.

3D structure databases

ProteinModelPortaliQ67XQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G14240.1.

PTM databases

iPTMnetiQ67XQ0.

Proteomic databases

PaxDbiQ67XQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G14240.1; AT4G14240.1; AT4G14240. [Q67XQ0-1]
GeneIDi827065.
GrameneiAT4G14240.1; AT4G14240.1; AT4G14240.
KEGGiath:AT4G14240.

Organism-specific databases

TAIRiAT4G14240.

Phylogenomic databases

eggNOGiKOG2118. Eukaryota.
COG1253. LUCA.
HOGENOMiHOG000183089.
InParanoidiQ67XQ0.
KOiK16302.
OMAiPSKHQVN.
OrthoDBiEOG09360B6N.
PhylomeDBiQ67XQ0.

Miscellaneous databases

PROiQ67XQ0.

Gene expression databases

GenevisibleiQ67XQ0. AT.

Family and domain databases

InterProiIPR000644. CBS_dom.
IPR002550. DUF21.
[Graphical view]
PfamiPF01595. DUF21. 1 hit.
[Graphical view]
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiY4424_ARATH
AccessioniPrimary (citable) accession number: Q67XQ0
Secondary accession number(s): O23282, Q66GK0, Q680W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.