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Q67U69

- FDH2_ORYSJ

UniProt

Q67U69 - FDH2_ORYSJ

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Protein

Formate dehydrogenase 2, mitochondrial

Gene

Os06g0486900

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei284 – 2841By similarity
Binding sitei308 – 3081NADBy similarity
Active sitei332 – 3321Proton donorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi201 – 2022NADBy similarity
Nucleotide bindingi282 – 2843NADBy similarity
Nucleotide bindingi332 – 3354NADBy similarity

GO - Molecular functioni

  1. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro
  3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase 2, mitochondrial (EC:1.2.1.2)
Alternative name(s):
NAD-dependent formate dehydrogenase 2
Short name:
FDH 2
Gene namesi
Ordered Locus Names:Os06g0486900, LOC_Os06g29220
ORF Names:P0404G03.13
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 6

Organism-specific databases

GrameneiQ67U69.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1818MitochondrionSequence AnalysisAdd
BLAST
Chaini19 – 378360Formate dehydrogenase 2, mitochondrialPRO_0000225339Add
BLAST

Proteomic databases

PaxDbiQ67U69.
PRIDEiQ67U69.

Expressioni

Gene expression databases

ExpressionAtlasiQ67U69. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ67U69.
SMRiQ67U69. Positions 31-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1052.
HOGENOMiHOG000136703.
InParanoidiQ67U69.
KOiK00122.
OMAiYITAERI.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q67U69-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAMWRAPSAA GQLLGRALAS TAAQTSAGSK KVVGVFYKGG EYADKNPNFV
60 70 80 90 100
GCVDSALGIR GWLESKGHRY IVTDDKEGIN CELEKHIEDA HVLITTPFHP
110 120 130 140 150
AYITAERIKK AKNLELLLTA GVGSDHIDLP AAAAAGLTVA EITGSNTVSV
160 170 180 190 200
AEDQLMRILL LLRNFLPGHH QIVNGEWNVA GIAHRTYDLE GKTVGTVGAG
210 220 230 240 250
RIGRLLLQRL KPFNCNLMYH DRVKIDPELE KEIGAKYEED LDAMLPKCDV
260 270 280 290 300
VVINMPLTEK TRGMFNKERI AKMKKGVTIV NNARGAIMDT QAVADACASG
310 320 330 340 350
HVAGYGGDVW FPQPAPKDHP WRYMPNHAMT PHCSGTTIDG QLRYAAGVKD
360 370
MLDRYFKGED FPAQNYIVKA GQLASQYQ
Length:378
Mass (Da):41,267
Last modified:October 11, 2004 - v1
Checksum:i7DFE10FAABC0E2EF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411E → K in AK064610. (PubMed:12869764)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP005656 Genomic DNA. Translation: BAD38302.1.
AK064610 mRNA. No translation available.
RefSeqiNP_001057667.1. NM_001064202.1.
UniGeneiOs.14187.

Genome annotation databases

EnsemblPlantsiOS06T0486900-01; OS06T0486900-01; OS06G0486900.
GeneIDi4341070.
KEGGiosa:4341070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP005656 Genomic DNA. Translation: BAD38302.1 .
AK064610 mRNA. No translation available.
RefSeqi NP_001057667.1. NM_001064202.1.
UniGenei Os.14187.

3D structure databases

ProteinModelPortali Q67U69.
SMRi Q67U69. Positions 31-372.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q67U69.
PRIDEi Q67U69.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS06T0486900-01 ; OS06T0486900-01 ; OS06G0486900 .
GeneIDi 4341070.
KEGGi osa:4341070.

Organism-specific databases

Gramenei Q67U69.

Phylogenomic databases

eggNOGi COG1052.
HOGENOMi HOG000136703.
InParanoidi Q67U69.
KOi K00122.
OMAi YITAERI.

Gene expression databases

ExpressionAtlasi Q67U69. baseline.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view ]
PROSITEi PS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiFDH2_ORYSJ
AccessioniPrimary (citable) accession number: Q67U69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3