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Q67U69

- FDH2_ORYSJ

UniProt

Q67U69 - FDH2_ORYSJ

Protein

Formate dehydrogenase 2, mitochondrial

Gene

Os06g0486900

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Formate + NAD+ = CO2 + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei284 – 2841By similarity
    Binding sitei308 – 3081NADBy similarity
    Active sitei332 – 3321Proton donorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi201 – 2022NADBy similarity
    Nucleotide bindingi282 – 2843NADBy similarity
    Nucleotide bindingi332 – 3354NADBy similarity

    GO - Molecular functioni

    1. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro
    3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro

    GO - Biological processi

    1. response to cadmium ion Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate dehydrogenase 2, mitochondrial (EC:1.2.1.2)
    Alternative name(s):
    NAD-dependent formate dehydrogenase 2
    Short name:
    FDH 2
    Gene namesi
    Ordered Locus Names:Os06g0486900, LOC_Os06g29220
    ORF Names:P0404G03.13
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 6

    Organism-specific databases

    GrameneiQ67U69.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. chloroplast Source: EnsemblPlants/Gramene
    2. mitochondrion Source: UniProtKB-SubCell
    3. thylakoid Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1818MitochondrionSequence AnalysisAdd
    BLAST
    Chaini19 – 378360Formate dehydrogenase 2, mitochondrialPRO_0000225339Add
    BLAST

    Proteomic databases

    PaxDbiQ67U69.
    PRIDEiQ67U69.

    Structurei

    3D structure databases

    ProteinModelPortaliQ67U69.
    SMRiQ67U69. Positions 31-372.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1052.
    HOGENOMiHOG000136703.
    KOiK00122.
    OMAiYITAERI.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view]
    PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
    PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q67U69-1 [UniParc]FASTAAdd to Basket

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    MAMWRAPSAA GQLLGRALAS TAAQTSAGSK KVVGVFYKGG EYADKNPNFV    50
    GCVDSALGIR GWLESKGHRY IVTDDKEGIN CELEKHIEDA HVLITTPFHP 100
    AYITAERIKK AKNLELLLTA GVGSDHIDLP AAAAAGLTVA EITGSNTVSV 150
    AEDQLMRILL LLRNFLPGHH QIVNGEWNVA GIAHRTYDLE GKTVGTVGAG 200
    RIGRLLLQRL KPFNCNLMYH DRVKIDPELE KEIGAKYEED LDAMLPKCDV 250
    VVINMPLTEK TRGMFNKERI AKMKKGVTIV NNARGAIMDT QAVADACASG 300
    HVAGYGGDVW FPQPAPKDHP WRYMPNHAMT PHCSGTTIDG QLRYAAGVKD 350
    MLDRYFKGED FPAQNYIVKA GQLASQYQ 378
    Length:378
    Mass (Da):41,267
    Last modified:October 11, 2004 - v1
    Checksum:i7DFE10FAABC0E2EF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti41 – 411E → K in AK064610. (PubMed:12869764)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP005656 Genomic DNA. Translation: BAD38302.1.
    AK064610 mRNA. No translation available.
    RefSeqiNP_001057667.1. NM_001064202.1.
    UniGeneiOs.14187.

    Genome annotation databases

    EnsemblPlantsiOS06T0486900-01; OS06T0486900-01; OS06G0486900.
    GeneIDi4341070.
    KEGGiosa:4341070.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP005656 Genomic DNA. Translation: BAD38302.1 .
    AK064610 mRNA. No translation available.
    RefSeqi NP_001057667.1. NM_001064202.1.
    UniGenei Os.14187.

    3D structure databases

    ProteinModelPortali Q67U69.
    SMRi Q67U69. Positions 31-372.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q67U69.
    PRIDEi Q67U69.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS06T0486900-01 ; OS06T0486900-01 ; OS06G0486900 .
    GeneIDi 4341070.
    KEGGi osa:4341070.

    Organism-specific databases

    Gramenei Q67U69.

    Phylogenomic databases

    eggNOGi COG1052.
    HOGENOMi HOG000136703.
    KOi K00122.
    OMAi YITAERI.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00065. D_2_HYDROXYACID_DH_1. 1 hit.
    PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiFDH2_ORYSJ
    AccessioniPrimary (citable) accession number: Q67U69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3