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Q67U69 (FDH2_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate dehydrogenase 2, mitochondrial

EC=1.2.1.2
Alternative name(s):
NAD-dependent formate dehydrogenase 2
Short name=FDH 2
Gene names
Ordered Locus Names:Os06g0486900, LOC_Os06g29220
ORF Names:P0404G03.13
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Formate + NAD+ = CO2 + NADH.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to cadmium ion

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Cellular_componentchloroplast

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

mitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

thylakoid

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

formate dehydrogenase (NAD+) activity

Inferred from electronic annotation. Source: UniProtKB-EC

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1818Mitochondrion Potential
Chain19 – 378360Formate dehydrogenase 2, mitochondrial
PRO_0000225339

Regions

Nucleotide binding201 – 2022NAD By similarity
Nucleotide binding282 – 2843NAD By similarity
Nucleotide binding332 – 3354NAD By similarity

Sites

Active site2841 By similarity
Active site3321Proton donor By similarity
Binding site3081NAD By similarity

Experimental info

Sequence conflict411E → K in AK064610. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q67U69 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 7DFE10FAABC0E2EF

FASTA37841,267
        10         20         30         40         50         60 
MAMWRAPSAA GQLLGRALAS TAAQTSAGSK KVVGVFYKGG EYADKNPNFV GCVDSALGIR 

        70         80         90        100        110        120 
GWLESKGHRY IVTDDKEGIN CELEKHIEDA HVLITTPFHP AYITAERIKK AKNLELLLTA 

       130        140        150        160        170        180 
GVGSDHIDLP AAAAAGLTVA EITGSNTVSV AEDQLMRILL LLRNFLPGHH QIVNGEWNVA 

       190        200        210        220        230        240 
GIAHRTYDLE GKTVGTVGAG RIGRLLLQRL KPFNCNLMYH DRVKIDPELE KEIGAKYEED 

       250        260        270        280        290        300 
LDAMLPKCDV VVINMPLTEK TRGMFNKERI AKMKKGVTIV NNARGAIMDT QAVADACASG 

       310        320        330        340        350        360 
HVAGYGGDVW FPQPAPKDHP WRYMPNHAMT PHCSGTTIDG QLRYAAGVKD MLDRYFKGED 

       370 
FPAQNYIVKA GQLASQYQ 

« Hide

References

[1]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
The rice full-length cDNA consortium
Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP005656 Genomic DNA. Translation: BAD38302.1.
AK064610 mRNA. No translation available.
RefSeqNP_001057667.1. NM_001064202.1.
UniGeneOs.14187.

3D structure databases

ProteinModelPortalQ67U69.
SMRQ67U69. Positions 31-372.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ67U69.
PRIDEQ67U69.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsOS06T0486900-01; OS06T0486900-01; OS06G0486900.
GeneID4341070.
KEGGosa:4341070.

Organism-specific databases

GrameneQ67U69.

Phylogenomic databases

eggNOGCOG1052.
HOGENOMHOG000136703.
KOK00122.
OMAANIIIAK.
ProtClustDBPLN03139.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDH2_ORYSJ
AccessionPrimary (citable) accession number: Q67U69
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations