Q67TK7 (DNAA_SYMTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	STH1

Organism

Symbiobacterium thermophilum [Complete proteome] [HAMAP]

Taxonomic identifier

2734 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiales Family XVIII. Incertae Sedis › Symbiobacterium

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 458	458	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_0000114282
Regions
	Nucleotide binding	161 – 168	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q67TK7 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: E3F6990A94B40074	FASTA	458	51,597
	10 20 30 40 50 60 MKTELSEVWQ QCIDHLERHT SKTAIENWVR STRPVAVVED TIIVGVQGEF AKHRMESRYA 70 80 90 100 110 120 PLLRQALRDL TKRNMQLKFV ANPNVIEDPA AEPVDAPNVA DLPAGTSAPA AEQNARLLGY 130 140 150 160 170 180 INPKYTFETF VVGNSNRFAH AAALAVAETP ARTYNPLFIY GGVGLGKTHL MHAIGHYVLQ 190 200 210 220 230 240 HNPTAKVAYV STETFTNEFI MAIQKGSTTA FQNRYRKVDV LLIDDIQFLA GKEATQEEFY 250 260 270 280 290 300 HTFNAIREAN KQIVISSDRP PKEIPTLEDR LRSRFEWGLI CDIQPPDLET RTAILRKKAQ 310 320 330 340 350 360 SEGIQVPDEV TNYIATNIET NIRELEGALT RVVAYANMLK CPLTYDLAVQ ALKDILPPVR 370 380 390 400 410 420 PKQITIATIK QVVAEHYNIR MQDFEVRNRS RAVAYPRQIA MYLARELTDS SLPKIGEEFG 430 440 450 GRDHTTVIHA CEKIAKDIQS DPAFAHTIEQ LIARIRAE

References

[1]

"Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism." Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T. Nucleic Acids Res. 32:4937-4944(2004) [PubMed: 15383646] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: T / IAM 14863.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006840 Genomic DNA. Translation: BAD38986.1.
RefSeq	YP_073830.1. NC_006177.1.
3D structure databases
ProteinModelPortal	Q67TK7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2980229.
GenomeReviews	Gene locus STH1 in contig AP006840_GR.
KEGG	sth:STH1.
NMPDR	fig|292459.1.peg.1.
PATRIC	23778028. VBISymThe116959_0001.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG695666.
OMA	CHTLNAL.
ProtClustDB	PRK00149.
Enzyme and pathway databases
BioCyc	STHE292459:STH1-MONOMER.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_SYMTH

Accession

Primary (citable) accession number: Q67TK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program