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Q67T48 (HEMH_SYMTH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:STH160
OrganismSymbiobacterium thermophilum [Complete proteome] [HAMAP]
Taxonomic identifier2734 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiales Family XVIII. Incertae Sedis › Symbiobacterium

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Ferrochelatase HAMAP MF_00323
PRO_0000175214

Sites

Metal binding1941Iron By similarity
Metal binding2731Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q67T48 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 0A7886E5D1D5423C

FASTA32036,453
        10         20         30         40         50         60 
MEKTAVLLVN LGTPSAPEPD AVRPYLAEFL GDWWVIDKPR WQWLPILHGI ILRVRPPRVA 

        70         80         90        100        110        120 
KIYQKIWLPE GSPLLHYSRL QQAALQQRLE PEGIRVALGM TYGQPSVKSA LEELRGWGVR 

       130        140        150        160        170        180 
RLLVLPLFPQ YSSTTTAAVW SKVQKALDGW RDLPEQIFIR DFPTHPKYLA FLTERISGYI 

       190        200        210        220        230        240 
AEKGRPDALV LSYHSIPQAY TASGDDYAAQ CESTTDAVRD RFPDLKIVMG YQSKFGNDPW 

       250        260        270        280        290        300 
LEPATDEVLR ELVRTGHRHV AVMAPGFAAD CIETLHELEV EYAEEFVKAG GERYDYLPAA 

       310        320 
NDHPLFIDCL EDLVRRHLPR

« Hide

References

[1]"Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
Nucleic Acids Res. 32:4937-4944(2004) [PubMed: 15383646] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: T / IAM 14863.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006840 Genomic DNA. Translation: BAD39145.1.
RefSeqYP_073989.1. NC_006177.1.

3D structure databases

ProteinModelPortalQ67T48.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2981304.
GenomeReviewsGene locus STH160 in contig AP006840_GR.
KEGGsth:STH160.
NMPDRfig|292459.1.peg.157.
PATRIC23778379. VBISymThe116959_0161.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMATIEEIGM.

Enzyme and pathway databases

BioCycSTHE292459:STH160-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_SYMTH
AccessionPrimary (citable) accession number: Q67T48
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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