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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (STH838)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateUniRule annotation1
Binding sitei118SubstrateUniRule annotation1
Binding sitei151SubstrateUniRule annotation1
Binding sitei202ATPUniRule annotation1
Binding sitei321ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi347 – 350ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTHE292459:G1G28-250-MONOMER
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:STH242
OrganismiSymbiobacterium thermophilum (strain T / IAM 14863)
Taxonomic identifieri292459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSymbiobacteriaceaeSymbiobacterium
Proteomesi
  • UP000000417 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000580741 – 392Phosphoglycerate kinaseAdd BLAST392

Proteomic databases

PRIDEiQ67SW6

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi292459.STH242

Structurei

3D structure databases

ProteinModelPortaliQ67SW6
SMRiQ67SW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni59 – 62Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227108
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q67SW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALMTVRDID VKGKRVFVRV DFNVPLEDGR ITDDTRIRAA VPTIRYLVEE
60 70 80 90 100
GAVAVLASHL GRPKGQRNEK YSLAPCARRL SELLGREVVF APDCIGEEVE
110 120 130 140 150
RLVAEQPPGS VVLLENVRFY AEEEKNDPEF AAKLARLGEI FVNDAFGTAH
160 170 180 190 200
RAHASTRGVA DHMPVRVAGF LMQKEVDIMG KALSDPDRPF VAIIGGAKVS
210 220 230 240 250
DKIMVIENLL TKVDRLIIGG GMANTFLRAR GFATGKSLVE EDRVDTAREL
260 270 280 290 300
LAKGGDKILL PTDLVVASEF KADAEQKVVP VDAIPEGWMA LDIGPETARA
310 320 330 340 350
FADVIRGAHT VVWNGPMGVF EMEPFARGTF AVAQAMADCE GVTIVGGGDS
360 370 380 390
VAAVEAAGLA DRMTHVSTGG GASLEFLEGK ELPGVACLAV KP
Length:392
Mass (Da):41,999
Last modified:October 11, 2004 - v1
Checksum:i3BC18CE27BB08EAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006840 Genomic DNA Translation: BAD39227.1
RefSeqiWP_011194377.1, NC_006177.1

Genome annotation databases

EnsemblBacteriaiBAD39227; BAD39227; STH242
KEGGisth:STH242

Similar proteinsi

Entry informationi

Entry nameiPGK_SYMTH
AccessioniPrimary (citable) accession number: Q67SW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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