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Q67SB4

- SYL_SYMTH

UniProt

Q67SB4 - SYL_SYMTH

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei591 – 5911ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSTHE292459:GJMM-486-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:STH444
    OrganismiSymbiobacterium thermophilum (strain T / IAM 14863)
    Taxonomic identifieri292459 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVIII. Incertae SedisSymbiobacterium
    ProteomesiUP000000417: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 861861Leucine--tRNA ligasePRO_0000152101Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi292459.STH444.

    Structurei

    3D structure databases

    ProteinModelPortaliQ67SB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi588 – 5925"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 2 hits.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q67SB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEERFDFRE AEPRWQRRWD EEGIYKVERD LSRPKYYALA MFPYPSGKLH    50
    MGHVRNYTIV DVIARYRRMK GYNVLHPMGF DSFGMPAENA AIQHGANPAV 100
    WTRENIAEMT AQLKQMGYSY DWSRAVYTYR EDYYRWTQWL FLQFYKKGLA 150
    YKKTAPVNWC PSCQTVLANE QVEDGRCWRC DSVVTKKDLA QWFFRITQYA 200
    DELLEDLKLL EGGWPEQVRI MQQNWIGRSE GARVEFTLEA TGDKIPIFTT 250
    RPDTIYGVTF MVVAPEHPIV EKICTSGLIP EERVAAIRAF QEKMKHLSEI 300
    ARTSTEAEKE GLYTGLDVIN PFNGEKAQLW IANYVLMDYG TGAVMGVPAH 350
    DQRDFEFAQK YGLPVKVVIQ NPEGTLRAEE MTAAYVEPGI MVNSGPFDGT 400
    PNLEGIPKVI AYAEEQGFGQ KTVSYRLRDW LISRQRAWGA PIPIVYCDKC 450
    GTVPVPEKDL PVRLPDDLDF TGEGGSPLAR HEGFVNTTCP QCGGPARRET 500
    DTMDTFVCSS WYFLRYTDPQ NAERPWNRED VDYWMPVDQY VGGIEHAVLH 550
    LLYARFFTKV LRDMGLVKVD EPFARLLTQG MVLKDGSKMS KSKGNTVSPE 600
    EMIAKYGADA VRLFIMFAAP PERDLDWSDA GIEGAARFVN RFYRMVVSAL 650
    PAYQHARSLL PINPADPASV MGALSEAEIA EGLAKAAPNL TAEDRELRRV 700
    IHATVKRITA DLHDRFAFNT AISGLMEMTN AIYAYREKQH AEQNTSALVL 750
    AEAVQKAVLI IAPFCPHLAD ELWSRMGHPR SIHLEPWPAY DEEVAKADTV 800
    EIVVQINGRV RDRLEVPAGI SAAEMEAVAM ASEKVQALVA GKQIVKVVPV 850
    PGKLVNIVVK G 861
    Length:861
    Mass (Da):97,335
    Last modified:October 11, 2004 - v1
    Checksum:iCF32ACCC54E5F2F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006840 Genomic DNA. Translation: BAD39429.1.
    RefSeqiYP_074273.1. NC_006177.1.

    Genome annotation databases

    EnsemblBacteriaiBAD39429; BAD39429; STH444.
    GeneIDi2979842.
    KEGGisth:STH444.
    PATRICi23778962. VBISymThe116959_0428.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006840 Genomic DNA. Translation: BAD39429.1 .
    RefSeqi YP_074273.1. NC_006177.1.

    3D structure databases

    ProteinModelPortali Q67SB4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 292459.STH444.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD39429 ; BAD39429 ; STH444 .
    GeneIDi 2979842.
    KEGGi sth:STH444.
    PATRICi 23778962. VBISymThe116959_0428.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci STHE292459:GJMM-486-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 2 hits.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
      Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
      Nucleic Acids Res. 32:4937-4944(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: T / IAM 14863.

    Entry informationi

    Entry nameiSYL_SYMTH
    AccessioniPrimary (citable) accession number: Q67SB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3