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Q67SB4

- SYL_SYMTH

UniProt

Q67SB4 - SYL_SYMTH

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei591 – 5911ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTHE292459:GJMM-486-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:STH444
OrganismiSymbiobacterium thermophilum (strain T / IAM 14863)
Taxonomic identifieri292459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVIII. Incertae SedisSymbiobacterium
ProteomesiUP000000417: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 861861Leucine--tRNA ligasePRO_0000152101Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi292459.STH444.

Structurei

3D structure databases

ProteinModelPortaliQ67SB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi588 – 5925"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 2 hits.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q67SB4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEERFDFRE AEPRWQRRWD EEGIYKVERD LSRPKYYALA MFPYPSGKLH
60 70 80 90 100
MGHVRNYTIV DVIARYRRMK GYNVLHPMGF DSFGMPAENA AIQHGANPAV
110 120 130 140 150
WTRENIAEMT AQLKQMGYSY DWSRAVYTYR EDYYRWTQWL FLQFYKKGLA
160 170 180 190 200
YKKTAPVNWC PSCQTVLANE QVEDGRCWRC DSVVTKKDLA QWFFRITQYA
210 220 230 240 250
DELLEDLKLL EGGWPEQVRI MQQNWIGRSE GARVEFTLEA TGDKIPIFTT
260 270 280 290 300
RPDTIYGVTF MVVAPEHPIV EKICTSGLIP EERVAAIRAF QEKMKHLSEI
310 320 330 340 350
ARTSTEAEKE GLYTGLDVIN PFNGEKAQLW IANYVLMDYG TGAVMGVPAH
360 370 380 390 400
DQRDFEFAQK YGLPVKVVIQ NPEGTLRAEE MTAAYVEPGI MVNSGPFDGT
410 420 430 440 450
PNLEGIPKVI AYAEEQGFGQ KTVSYRLRDW LISRQRAWGA PIPIVYCDKC
460 470 480 490 500
GTVPVPEKDL PVRLPDDLDF TGEGGSPLAR HEGFVNTTCP QCGGPARRET
510 520 530 540 550
DTMDTFVCSS WYFLRYTDPQ NAERPWNRED VDYWMPVDQY VGGIEHAVLH
560 570 580 590 600
LLYARFFTKV LRDMGLVKVD EPFARLLTQG MVLKDGSKMS KSKGNTVSPE
610 620 630 640 650
EMIAKYGADA VRLFIMFAAP PERDLDWSDA GIEGAARFVN RFYRMVVSAL
660 670 680 690 700
PAYQHARSLL PINPADPASV MGALSEAEIA EGLAKAAPNL TAEDRELRRV
710 720 730 740 750
IHATVKRITA DLHDRFAFNT AISGLMEMTN AIYAYREKQH AEQNTSALVL
760 770 780 790 800
AEAVQKAVLI IAPFCPHLAD ELWSRMGHPR SIHLEPWPAY DEEVAKADTV
810 820 830 840 850
EIVVQINGRV RDRLEVPAGI SAAEMEAVAM ASEKVQALVA GKQIVKVVPV
860
PGKLVNIVVK G
Length:861
Mass (Da):97,335
Last modified:October 11, 2004 - v1
Checksum:iCF32ACCC54E5F2F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006840 Genomic DNA. Translation: BAD39429.1.
RefSeqiWP_011194578.1. NC_006177.1.
YP_074273.1. NC_006177.1.

Genome annotation databases

EnsemblBacteriaiBAD39429; BAD39429; STH444.
GeneIDi2979842.
KEGGisth:STH444.
PATRICi23778962. VBISymThe116959_0428.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006840 Genomic DNA. Translation: BAD39429.1 .
RefSeqi WP_011194578.1. NC_006177.1.
YP_074273.1. NC_006177.1.

3D structure databases

ProteinModelPortali Q67SB4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 292459.STH444.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD39429 ; BAD39429 ; STH444 .
GeneIDi 2979842.
KEGGi sth:STH444.
PATRICi 23778962. VBISymThe116959_0428.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci STHE292459:GJMM-486-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 2 hits.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
    Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
    Nucleic Acids Res. 32:4937-4944(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T / IAM 14863.

Entry informationi

Entry nameiSYL_SYMTH
AccessioniPrimary (citable) accession number: Q67SB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3