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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.UniRule annotation

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase 2 (coaX2), Type III pantothenate kinase 1 (coaX1)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 158ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTHE292459:GJMM-911-MONOMER.
UniPathwayiUPA00241; UER00356.

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinaseUniRule annotation (EC:2.7.1.24UniRule annotation)
Alternative name(s):
Dephosphocoenzyme A kinaseUniRule annotation
Gene namesi
Name:coaEUniRule annotation
Ordered Locus Names:STH851
OrganismiSymbiobacterium thermophilum (strain T / IAM 14863)
Taxonomic identifieri292459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSymbiobacteriaceaeSymbiobacterium
Proteomesi
  • UP000000417 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Dephospho-CoA kinasePRO_0000243350Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi292459.STH851.

Structurei

3D structure databases

ProteinModelPortaliQ67R57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 206204DPCKUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CoaE family.UniRule annotation
Contains 1 DPCK (dephospho-CoA kinase) domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZQD. Bacteria.
COG0237. LUCA.
HOGENOMiHOG000020768.
KOiK00859.
OMAiRGKPAYN.
OrthoDBiEOG6HTP3H.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q67R57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIIGLTGSI ASGKSTVSAM LREPGAAVID ADAIVHHLQL PGTPVFESIV
60 70 80 90 100
REFGPGVVRP DGSLDRQALG RIVFADPGRR RALEAIVHPA VRAEIWRQVE
110 120 130 140 150
QYRREGRPAV VLDVPLLYES GWDRQVDEVW VVWVDAETQK ARLIARSGLS
160 170 180 190 200
PEEAEARIAA QMSLDEKARR ADRIIDNRGS LDRTRAQVEA AWRAACGGEG
210 220 230
GEPAAGSSAH HGAGSVDPGA GPCDGPGAAP EAERRGGDR
Length:239
Mass (Da):25,541
Last modified:October 11, 2004 - v1
Checksum:iEB59D59C66C0FACD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006840 Genomic DNA. Translation: BAD39836.1.
RefSeqiWP_011194983.1. NC_006177.1.

Genome annotation databases

EnsemblBacteriaiBAD39836; BAD39836; STH851.
KEGGisth:STH851.
PATRICi23779820. VBISymThe116959_0840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006840 Genomic DNA. Translation: BAD39836.1.
RefSeqiWP_011194983.1. NC_006177.1.

3D structure databases

ProteinModelPortaliQ67R57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi292459.STH851.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD39836; BAD39836; STH851.
KEGGisth:STH851.
PATRICi23779820. VBISymThe116959_0840.

Phylogenomic databases

eggNOGiENOG4108ZQD. Bacteria.
COG0237. LUCA.
HOGENOMiHOG000020768.
KOiK00859.
OMAiRGKPAYN.
OrthoDBiEOG6HTP3H.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.
BioCyciSTHE292459:GJMM-911-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
    Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
    Nucleic Acids Res. 32:4937-4944(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T / IAM 14863.

Entry informationi

Entry nameiCOAE_SYMTH
AccessioniPrimary (citable) accession number: Q67R57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 11, 2004
Last modified: January 20, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.