Q67R27 (Q67R27_SYMTH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123

Gene names

Name:	acsA HAMAP MF_01123
Ordered Locus Names:	STH881

Organism

Symbiobacterium thermophilum [Complete proteome] [HAMAP]

Taxonomic identifier

2734 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiales Family XVIII. Incertae Sedis › Symbiobacterium

Protein attributes

Sequence length	654 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	522	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	614	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	Q67R27 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 4E62FEE8F0CCBDC8	FASTA	654	73,396
	10 20 30 40 50 60 MDSKQFAALL NEDRRFPPPA EFAARANVAD ESLYEQAARD REGFWAAQAE RLHWFRRWDK 70 80 90 100 110 120 VLEWNPPFAQ WFLGGKLNVA YNCLDRHLQT HTRTKAAIIW EGEPGDERVL TYLDLHREVC 130 140 150 160 170 180 RFANVLRQMG VGKGDRVTIY LPMIPEAAVA MLACTRIGAI HSVVFGGFSA ESLRDRINDS 190 200 210 220 230 240 RSKVVVTADG GWRRGNIIRM KQIVNEAVVD CASVEKVIVV KRIGHESLVE HGWHPGRDHW 250 260 270 280 290 300 YHTLMRNAPV TCPVEEMDAE DPLFILYTSG STGKPKGVLH TTGGYLTQVA ATTKYVFDLK 310 320 330 340 350 360 DEDVYWCSAD IGWITGHSYV IYGPLANGAT TLMYEGAPDY PDRGRIWEII QKYRVNIFYT 370 380 390 400 410 420 APTLIRSFMR WGEGWPSKYD LSSLRLLGTV GEPINPEAWM WYHKHIGGER CPIVDTWWQT 430 440 450 460 470 480 ETGAIMATPL PGVVHTKPGS TTRPFPGIEM AVVNEEGQEV PPGAGGYLVV KSPWPSMLRT 490 500 510 520 530 540 VWGDPDRYVS TYFGRFGHQV YFTGDGAKRD EDGYYWIIGR VDDVINVSGH RIGTMEVESA 550 560 570 580 590 600 LVDHPLVAEA AVIGRSHAVK GQAITAFVTL KEGRRGTPDL VDELKQHVVT KIGALARPEE 610 620 630 640 650 IYFAADLPKT RSGKIMRRLL RDIAEGRALG DTTTLADPNV VAQLRQQYES QEAG

References

[1]

"Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism." Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T. Nucleic Acids Res. 32:4937-4944(2004) [PubMed: 15383646] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: T / IAM 14863.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006840 Genomic DNA. Translation: BAD39866.1.
RefSeq	YP_074710.1. NC_006177.1.
3D structure databases
ProteinModelPortal	Q67R27.
SMR	Q67R27. Positions 15-650.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2980978.
GenomeReviews	Gene locus STH881 in contig AP006840_GR.
KEGG	sth:STH881.
NMPDR	fig|292459.1.peg.845.
PATRIC	23779880. VBISymThe116959_0870.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG547964.
OMA	VISVSGH.
Enzyme and pathway databases
BioCyc	STHE292459:STH881-MONOMER.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q67R27_SYMTH

Accession

Primary (citable) accession number: Q67R27

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)