Q67QQ0 (G6PI_SYMTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	STH1008

Organism

Symbiobacterium thermophilum [Complete proteome] [HAMAP]

Taxonomic identifier

2734 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiales Family XVIII. Incertae Sedis › Symbiobacterium

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180751
Sites
	Active site	291	1	Proton donor By similarity
	Active site	312	1	By similarity
	Active site	425	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q67QQ0 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 209CF6D33C30A27E	FASTA	448	49,188
	10 20 30 40 50 60 MSSSLRFTVS PSLLGPHPHE LTYQAEAIRI AHRMLHERTG PGAGFTGWLD LPERYDREEF 70 80 90 100 110 120 RRIQEAAARI RGDSDVLVVI GIGGSYLGAR ATVEALGHAF HNLLPPERRG APQIFFAGTD 130 140 150 160 170 180 LSPRYLTELL DVLEDREVSL NVVSKSGTTT EPAIAFRLLR NWMERRYGKE GARRRIYATT 190 200 210 220 230 240 DAARGALKQL ADAEGYTRFV IPDDVGGRYS VLTAVGLLPI AAAGIDIDAL MAGAAAAAAA 250 260 270 280 290 300 YSDPDLERNP CYQYAAARNA LYRKGMTTEV LVTYEPALKA TAEWWKQLFG ESEGKDGKGI 310 320 330 340 350 360 FPAAAAFTTD LHSLGQYIQE GMRNLFETVV HVERPSVDIP LPPGDEGDGL GFLGGQTLHH 370 380 390 400 410 420 VNHTAFLATR LAHTEGGVPN LTLTLPELTP YHYGYMLYFF MKACAISGYL LGVNPFDQPG 430 440 VEAYKQNMYA LLGKPGFEAR RAEIEERL

References

[1]

"Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism." Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T. Nucleic Acids Res. 32:4937-4944(2004) [PubMed: 15383646] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: T / IAM 14863.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006840 Genomic DNA. Translation: BAD39993.1.
RefSeq	YP_074837.1. NC_006177.1.
3D structure databases
ProteinModelPortal	Q67QQ0.
SMR	Q67QQ0. Positions 4-448.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2981041.
GenomeReviews	Gene locus STH1008 in contig AP006840_GR.
KEGG	sth:STH1008.
NMPDR	fig|292459.1.peg.966.
PATRIC	23780156. VBISymThe116959_1008.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG615843.
OMA	RINDKNS.
ProtClustDB	PRK14097.
Enzyme and pathway databases
BioCyc	STHE292459:STH1008-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_SYMTH

Accession

Primary (citable) accession number: Q67QQ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program