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Q67QF3

- SYFA_SYMTH

UniProt

Q67QF3 - SYFA_SYMTH

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Protein
Phenylalanine--tRNA ligase alpha subunit
Gene
pheS, pheSA, STH1105
Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotation

Cofactori

Binds 2 magnesium ions per tetramer By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi258 – 2581Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
  4. tRNA binding Source: InterPro

GO - Biological processi

  1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTHE292459:GJMM-1166-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase alpha subunit (EC:6.1.1.20)
Alternative name(s):
Phenylalanyl-tRNA synthetase alpha subunit
Short name:
PheRS
Gene namesi
Name:pheS
Synonyms:pheSA
Ordered Locus Names:STH1105
OrganismiSymbiobacterium thermophilum (strain T / IAM 14863)
Taxonomic identifieri292459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVIII. Incertae SedisSymbiobacterium
ProteomesiUP000000417: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Phenylalanine--tRNA ligase alpha subunitUniRule annotation
PRO_0000126779Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

STRINGi292459.STH1105.

Structurei

3D structure databases

ProteinModelPortaliQ67QF3.
SMRiQ67QF3. Positions 83-343.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0016.
HOGENOMiHOG000242675.
KOiK01889.
OMAiQIRTMEH.
OrthoDBiEOG6WX4QN.

Family and domain databases

HAMAPiMF_00281. Phe_tRNA_synth_alpha1.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004529. Phe-tRNA-synth_IIc_asu.
IPR004188. Phe-tRNA_ligase_II_N.
IPR022911. Phe_tRNA_ligase_alpha1_bac.
IPR002319. Phenylalanyl-tRNA_Synthase.
IPR010978. tRNA-bd_arm.
[Graphical view]
PfamiPF02912. Phe_tRNA-synt_N. 1 hit.
PF01409. tRNA-synt_2d. 1 hit.
[Graphical view]
SUPFAMiSSF46589. SSF46589. 1 hit.
TIGRFAMsiTIGR00468. pheS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q67QF3-1 [UniParc]FASTAAdd to Basket

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MKDQLLKLRD EALAAIAAAA DVGAIQEMRV RYLGKKSELS QVLGGLGRLP    50
TVEERKAMGA LGNEIKQAIT AALDAREAEL AAAALQARLA SERIDVTLPG 100
APVRRGHLHI LNQVIHRIEE IFIAMGYEVA ESRQVETDWY NFEALNIPKG 150
HPARDAQDSL FLSEEVLLRT HTSNTQIRYM LEVARGRTPV KIICPGRVFR 200
RDFEDATHAM MFHQVEGLVI DKGITMASLK GALTEMARAL FGPDVGIRLR 250
PSYFPFTEPS AEMDISCIFC GGKGCRTCKG SGWIEIGGSG MVHPNVLRAG 300
GYDPEEVSGW AFGYGPERVA MLMYGIEDIR HFVNNDMRFL RQF 343
Length:343
Mass (Da):37,988
Last modified:October 11, 2004 - v1
Checksum:i920E073E177DCE5E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006840 Genomic DNA. Translation: BAD40090.1.
RefSeqiYP_074934.1. NC_006177.1.

Genome annotation databases

EnsemblBacteriaiBAD40090; BAD40090; STH1105.
GeneIDi2979552.
KEGGisth:STH1105.
PATRICi23780354. VBISymThe116959_1106.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006840 Genomic DNA. Translation: BAD40090.1 .
RefSeqi YP_074934.1. NC_006177.1.

3D structure databases

ProteinModelPortali Q67QF3.
SMRi Q67QF3. Positions 83-343.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 292459.STH1105.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD40090 ; BAD40090 ; STH1105 .
GeneIDi 2979552.
KEGGi sth:STH1105.
PATRICi 23780354. VBISymThe116959_1106.

Phylogenomic databases

eggNOGi COG0016.
HOGENOMi HOG000242675.
KOi K01889.
OMAi QIRTMEH.
OrthoDBi EOG6WX4QN.

Enzyme and pathway databases

BioCyci STHE292459:GJMM-1166-MONOMER.

Family and domain databases

HAMAPi MF_00281. Phe_tRNA_synth_alpha1.
InterProi IPR006195. aa-tRNA-synth_II.
IPR004529. Phe-tRNA-synth_IIc_asu.
IPR004188. Phe-tRNA_ligase_II_N.
IPR022911. Phe_tRNA_ligase_alpha1_bac.
IPR002319. Phenylalanyl-tRNA_Synthase.
IPR010978. tRNA-bd_arm.
[Graphical view ]
Pfami PF02912. Phe_tRNA-synt_N. 1 hit.
PF01409. tRNA-synt_2d. 1 hit.
[Graphical view ]
SUPFAMi SSF46589. SSF46589. 1 hit.
TIGRFAMsi TIGR00468. pheS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
    Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
    Nucleic Acids Res. 32:4937-4944(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T / IAM 14863.

Entry informationi

Entry nameiSYFA_SYMTH
AccessioniPrimary (citable) accession number: Q67QF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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