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Q67Q63 (GLPK_SYMTH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:STH1195
OrganismSymbiobacterium thermophilum [Complete proteome] [HAMAP]
Taxonomic identifier2734 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiales Family XVIII. Incertae Sedis › Symbiobacterium

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Glycerol kinase HAMAP MF_00186
PRO_1000020806

Regions

Nucleotide binding410 – 4145ATP By similarity

Sites

Binding site131Substrate By similarity
Binding site171ATP By similarity
Binding site831Substrate By similarity
Binding site1351Substrate By similarity
Binding site2441Substrate By similarity
Binding site2661ATP By similarity
Binding site3091ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q67Q63 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: BBB81EB46CD26ACA

FASTA49854,500
        10         20         30         40         50         60 
MNKGYVLALD QGTTSSRAIL FNRDGRLVGQ VNHEFRQIYP QPGWVEHDPR EIWSTQLRAV 

        70         80         90        100        110        120 
QDVLARTGVR LSEVAAIGIT NQRETTVVWD AETGEPVYNA IVWQCRRTAP ICAELAARGW 

       130        140        150        160        170        180 
APRIREKTGL VIDAYFSGTK VKWILDNVPG VREKAEQGRL RFGTIDAWLI WNLTGGRVHA 

       190        200        210        220        230        240 
TDYSNASRTM LFNIHQLAWD EEILHELGIP ASLLPRALPS SHVYGETDPA VLGAAIPIAG 

       250        260        270        280        290        300 
VAGDQQAALF GQACFQPGDA KNTYGTGCFM LMNTGDRAVP SESGLLTTIA WGIGDRVEYA 

       310        320        330        340        350        360 
LEGSIFIGGA AVQWLRDELR FFDRAADSEA LALSVPDSGG VYVVPAFVGL GAPYWDMYAR 

       370        380        390        400        410        420 
GIVVGLTRGT GRAHITRATL ESIAYQTRDV LGAMEKDSGI RLNRLKVDGG AVANNFLMQF 

       430        440        450        460        470        480 
QSDILGVPVE RPKIAETTAL GAAYLAGLAT GFWRSQAELA DKWALDRGFT PALPAEERER 

       490 
LYAGWRRAVE RARGWAAE

« Hide

References

[1]"Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
Nucleic Acids Res. 32:4937-4944(2004) [PubMed: 15383646] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: T / IAM 14863.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006840 Genomic DNA. Translation: BAD40180.1.
RefSeqYP_075024.1. NC_006177.1.

3D structure databases

HSSPHSSP built from PDB template 1GLC based on UniProtKB P0A6F3.
ProteinModelPortalQ67Q63.
SMRQ67Q63. Positions 3-495.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2982322.
GenomeReviewsGene locus STH1195 in contig AP006840_GR.
KEGGsth:STH1195.
NMPDRfig|292459.1.peg.1148.
PATRIC23780544. VBISymThe116959_1193.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG511469.
OMAALYGQLC.

Enzyme and pathway databases

BioCycSTHE292459:STH1195-MONOMER.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_SYMTH
AccessionPrimary (citable) accession number: Q67Q63
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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