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Reviewed, UniProtKB/Swiss-Prot Q67Q47 (MURB2_SYMTH)

Last modified November 3, 2009. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    UDP-N-acetylenolpyruvoylglucosamine reductase 2
    EC=1.1.1.158
Alternative name(s):
    UDP-N-acetylmuramate dehydrogenase 2
Gene names
Name: murB2
Ordered Locus Names: STH1211
OrganismSymbiobacterium thermophilum [Complete proteome] [HAMAP]
Taxonomic identifier2734 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiales Family XVIII. Incertae Sedis › Symbiobacterium

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Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Cell wall formation By similarity.

Catalytic activity

UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037

Cofactor

FAD By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the murB family.

Contains 1 FAD-binding PCMH-type domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308UDP-N-acetylenolpyruvoylglucosamine reductase 2 HAMAP MF_00037
PRO_0000224729

Regions

Domain31 – 197167FAD-binding PCMH-type

Sites

Active site1761 By similarity
Active site2261Proton donor By similarity
Active site2961 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q67Q47-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: AAF85F733C1F4EC2

FASTA30833,219
        10         20         30         40         50         60 
MSPMAERLRS IIRDPGRIRR AEPLKRHTSV RIGGPADYLV EVADRHELSR LLRLAGEEAL 

        70         80         90        100        110        120 
PVYILGSGSN LVVSDEGVRG LVLRLTGEFA RIAVDGSTVR VGGGCSLPKL AHQASRRGLG 

       130        140        150        160        170        180 
GLEFACAIPG TVGAGLVMNA GAHGGDMAQV VAEATVIWGD GRMERLCPGE IGFAYRSTRL 

       190        200        210        220        230        240 
QGTSAIVAEV VMALRPADRA ALEGAMRQHL NRRRATQPLQ YPNAGSVFKN PPGDYAGRLI 

       250        260        270        280        290        300 
EQAGLKGERV GDAQVSEKHA NFIVNLGQAT ARDVLTLMDR VRSTVERRFG VRLEAEVKIW 


GHNPWFPP

« Hide

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References

[1]"Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
Nucleic Acids Res. 32:4937-4944(2004) [PubMed: 15383646] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: T / IAM 14863.

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Cross-references

Sequence databases

AP006840 Genomic DNA. Translation: BAD40196.1.
RefSeqYP_075040.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2981282.
GenomeReviewsGene locus STH1211 in contig AP006840_GR.
KEGGsth:STH1211.
NMPDRfig|292459.1.peg.1164.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ67Q47.
OMAQPIREKT.

Enzyme and pathway databases

BioCycSTHE292459:STH1211-MON.
BRENDA1.1.1.158. 20615.

Family and domain databases

HAMAPMF_00037.
[Tree]
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
Gene3DG3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit.
G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit.
G3DSA:3.90.78.10. MurB_C. 1 hit.
PANTHERPTHR21071. MurB. 1 hit.
PfamPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR00179. murB. 1 hit.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameMURB2_SYMTH
AccessionPrimary (citable) accession number: Q67Q47
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 11, 2004
Last modified: November 3, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents