Reviewed, UniProtKB/Swiss-Prot Q67Q46 (MURA1_SYMTH)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
    EC=2.5.1.7
Alternative name(s):
    Enoylpyruvate transferase 1
    UDP-N-acetylglucosamine enolpyruvyl transferase 1
      Short name=EPT 1

Gene names

Name:	murA1
Ordered Locus Names:	STH1212

Organism

Symbiobacterium thermophilum [Complete proteome] [HAMAP]

Taxonomic identifier

2734 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiales Family XVIII. Incertae Sedis › Symbiobacterium

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity.
Catalytic activity	Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. HAMAP MF_00111
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00111
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family. MurA subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-N-acetylgalactosamine biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 441	441	UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 HAMAP MF_00111		PRO_0000231287
Sites
	Active site	141	1	Proton donor By similarity
	Binding site	141	1	Phosphoenolpyruvate (covalent) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q67Q46-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: A6E5EF105C7FB604	FASTA	441	47,251
	10 20 30 40 50 60 MDRPAGLRLR PREVACIVKP NERYVVAGGC RLQGEVPVSG AKNAALPILA AALLTSGESV 70 80 90 100 110 120 IHNAPMIRDV AVMIEILHKL GARVEEGPEG VSGRTLRIRA DGLNGQEVGA DFTREMRSSI 130 140 150 160 170 180 FLMGPLLARV GKIRISYPGG CAIGPRPIDF HLRGLEALGA RIEERFGYIE ASVPRRLRGT 190 200 210 220 230 240 EIYLDFPSVG ATENLMMAAV LAEGTTVIRN AAREPEIVDL QAFLNKMGAR VRGAGLDVIR 250 260 270 280 290 300 IDGVSKLGSV EHTVIPDRIE AATFLAAAAI TGGEVTVQGV IPEHVDAVTA KLREMGTTIR 310 320 330 340 350 360 EYGTAVTAVG PRRLKAADVK TLPYPGFPTD MQPQMMALAA TADGTSIITE TIFENRFKVA 370 380 390 400 410 420 DELRRMGANI KTEGRTAVVQ GVPSLSGATV VCPALREGMA LILAGLRAEG ETTIEDIYHI 430 440 DRGYQHLEQK LTRLGATISR V

References

[1]

"Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism." Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T. Nucleic Acids Res. 32:4937-4944(2004) [PubMed: 15383646] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: T / IAM 14863.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006840 Genomic DNA. Translation: BAD40197.1.
RefSeq	YP_075041.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2981283.
GenomeReviews	Gene locus STH1212 in contig AP006840_GR.
KEGG	sth:STH1212.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q67Q46.
OMA	MPGGCSI.
Enzyme and pathway databases
BioCyc	STHE292459:STH1212-MON.
BRENDA	2.5.1.7. 20615.
Family and domain databases
HAMAP	MF_00111. [Tree]
InterPro	IPR001986. EPSP_synthase_core. IPR005750. UDP_GlcNAc_COvinyl_MurA. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
PANTHER	PTHR21090:SF4. AcGlu_Tran_MurA. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01072. murA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURA1_SYMTH

Accession

Primary (citable) accession number: Q67Q46

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)