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Q67Q00 (Q67Q00_SYMTH) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase RuleBase RU003441
EC=3.5.2.3 RuleBase RU003441
Gene names
Ordered Locus Names:STH1258
OrganismSymbiobacterium thermophilum [Complete proteome] [HAMAP]
Taxonomic identifier2734 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiales Family XVIII. Incertae Sedis › Symbiobacterium

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. RuleBase RU003441 SAAS SAAS002195

Cofactor

Binds 2 zinc ions per subunit By similarity. RuleBase RU003441 SAAS SAAS002195

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. RuleBase RU003441 SAAS SAAS002195

Subunit structure

Homodimer By similarity. SAAS SAAS002195

Sequence similarities

Belongs to the DHOase family. Type 2 subfamily. RuleBase RU003441

Sequences

Sequence LengthMass (Da)Tools
Q67Q00 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: B89383947402155E

FASTA43446,290
        10         20         30         40         50         60 
MSSLLIRGGR LLDPANGVDR VADVLVADGR IRAIGEGLPV PPGATVIEAS GKVVAPGFID 

        70         80         90        100        110        120 
VHVHLRVPGQ EYKEDMRTGT AAAVRGGFVG VVCMPNTRPV IDSAPLVAHV LDLAGREGLC 

       130        140        150        160        170        180 
RVWPAGAITK GSQGEELAEI GEMARAGAVA VTDDGKPVDR AETMRQAMIY ARQFDLPVMD 

       190        200        210        220        230        240 
HCEDRSLSAG GAMHEGRVSS LLGLKGIPAA AEEVHVARDI LLALETGARV HLQHLSSRRS 

       250        260        270        280        290        300 
VELVRWGKAQ GARVTAEATP HHFTLTDQAV ADMAYSPNTK MNPPLREEAD RQAILEGLAD 

       310        320        330        340        350        360 
GTIDVIATDH APHHVDEKDV EYPLAAFGIT GLETAVGLAL DRLVRPGLIR LEQLILMLST 

       370        380        390        400        410        420 
RPARLINRTP PALREGAEAD ITVLDLDRTW TVSADEMASK SRNSPFIGWT LTGAPYATVV 

       430 
GGRLRMLEMK VIAG

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References

[1]"Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
Nucleic Acids Res. 32:4937-4944(2004) [PubMed: 15383646] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: T / IAM 14863.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006840 Genomic DNA. Translation: BAD40243.1.
RefSeqYP_075087.1. NC_006177.1.

3D structure databases

ProteinModelPortalQ67Q00.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2981836.
GenomeReviewsGene locus STH1258 in contig AP006840_GR.
KEGGsth:STH1258.
NMPDRfig|292459.1.peg.1211.
PATRIC23780678. VBISymThe116959_1260.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG724623.
OMACDVHPVG.

Enzyme and pathway databases

BioCycSTHE292459:STH1258-MONOMER.

Family and domain databases

HAMAPMF_00220_B. PyrC_type2_B.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004722. DHOase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR00857. PyrC_multi. 1 hit.
PROSITEPS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ67Q00_SYMTH
AccessionPrimary (citable) accession number: Q67Q00
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: December 14, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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