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Q67PZ8 (Q67PZ8_SYMTH) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotate dehydrogenase HAMAP MF_00224
Short name=DHOD HAMAP MF_00224
Short name=DHODase HAMAP MF_00224
Short name=DHOdehase HAMAP MF_00224
EC=1.3.-.- HAMAP MF_00224
Gene names
Name:pyrD HAMAP MF_00224
Ordered Locus Names:STH1260
OrganismSymbiobacterium thermophilum [Complete proteome] [HAMAP]
Taxonomic identifier2734 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiales Family XVIII. Incertae Sedis › Symbiobacterium

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of dihydroorotate to orotate By similarity. HAMAP MF_00224

Catalytic activity

(S)-dihydroorotate + acceptor = orotate + reduced acceptor. HAMAP MF_00224

Cofactor

Binds 1 FMN per subunit By similarity. HAMAP MF_00224 SAAS SAAS012135

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway. HAMAP MF_00224

Subcellular location

Cytoplasm By similarity HAMAP MF_00224.

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. HAMAP MF_00224

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1331Nucleophile By similarity PIRSR PIRSR000164-1

Sequences

Sequence LengthMass (Da)Tools
Q67PZ8 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 26900AB7746A75CA

FASTA30631,665
        10         20         30         40         50         60 
MASDQPDLAV QLFGRTFRTP VWAASGCFGY GREFAGVLDL SRVGAICVKG TSIEPWTGNP 

        70         80         90        100        110        120 
GIRVVETPGG MLNAIGLQNP GVDHFLTVDW PWLQEQGATV IVNIVGRTVE EYVAVARRLE 

       130        140        150        160        170        180 
GTGVAAVELN ISCPNVKEGG MAFGTTPGSA AAVTAAVRKA TTLPLIVKLS PNVADVVAIA 

       190        200        210        220        230        240 
RAVEDAGADG LSVINTLQGM SIDIRRGRPH LGNVFGGLSG PAIKPVALRM VWQVAGAVKV 

       250        260        270        280        290        300 
PVIGVGGIMS GEDAAEFLMA GASAVQVGTA CFIDPRAPLT IAEELARFMG EHGFRNVRAL 


VGAARG

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References

[1]"Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
Nucleic Acids Res. 32:4937-4944(2004) [PubMed: 15383646] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: T / IAM 14863.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006840 Genomic DNA. Translation: BAD40245.1.
RefSeqYP_075089.1. NC_006177.1.

3D structure databases

ProteinModelPortalQ67PZ8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2979457.
GenomeReviewsGene locus STH1260 in contig AP006840_GR.
KEGGsth:STH1260.
NMPDRfig|292459.1.peg.1213.
PATRIC23780682. VBISymThe116959_1262.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG472415.
OMAVALRMVW.

Enzyme and pathway databases

BioCycSTHE292459:STH1260-MONOMER.

Family and domain databases

HAMAPMF_00224. DHO_dh_type1.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005720. Dihydroorotate_DH.
IPR024920. Dihydroorotate_DH_1.
IPR012135. Dihydroorotate_DH_1_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00226.
PfamPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsTIGR01037. PyrD_sub1_fam. 1 hit.
PROSITEPS00912. DHODEHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ67PZ8_SYMTH
AccessionPrimary (citable) accession number: Q67PZ8
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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