UniProtKB - Q67PR5 (DEF_SYMTH)
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Protein
Peptide deformylase
Gene
def
Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Functioni
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation
Catalytic activityi
Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation
Cofactori
Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 91 | IronUniRule annotation | 1 | |
Metal bindingi | 133 | IronUniRule annotation | 1 | |
Active sitei | 134 | UniRule annotation | 1 | |
Metal bindingi | 137 | IronUniRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- peptide deformylase activity Source: UniProtKB-EC
GO - Biological processi
- translation Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Protein biosynthesis |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
BioCyci | STHE292459:G1G28-1368-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)Short name: PDFUniRule annotation Alternative name(s): Polypeptide deformylaseUniRule annotation |
Gene namesi | Name:defUniRule annotation Ordered Locus Names:STH1343 |
Organismi | Symbiobacterium thermophilum (strain T / IAM 14863) |
Taxonomic identifieri | 292459 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Clostridia › Clostridiales › Symbiobacteriaceae › Symbiobacterium › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000301114 | 1 – 217 | Peptide deformylaseAdd BLAST | 217 |
Structurei
3D structure databases
ProteinModelPortali | Q67PR5. |
SMRi | Q67PR5. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the polypeptide deformylase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4108Z02. Bacteria. COG0242. LUCA. |
HOGENOMi | HOG000243508. |
KOi | K01462. |
OMAi | VCIQHEI. |
OrthoDBi | POG091H02B0. |
Family and domain databases
CDDi | cd00487. Pep_deformylase. 1 hit. |
Gene3Di | 3.90.45.10. 1 hit. |
HAMAPi | MF_00163. Pep_deformylase. 1 hit. |
InterProi | View protein in InterPro IPR023635. Peptide_deformylase. IPR036821. Peptide_deformylase_sf. |
PANTHERi | PTHR10458. PTHR10458. 1 hit. |
Pfami | View protein in Pfam PF01327. Pep_deformylase. 1 hit. |
PIRSFi | PIRSF004749. Pep_def. 1 hit. |
PRINTSi | PR01576. PDEFORMYLASE. |
SUPFAMi | SSF56420. SSF56420. 1 hit. |
TIGRFAMsi | TIGR00079. pept_deformyl. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q67PR5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAILEIVKEP AEVLRKKAKP VTKINASIRK LLDDMTETMY AAPGVGLAAP
60 70 80 90 100
QVGVSKRLIV VDPQDGSGQL YQLINPEIVK AEGWVKGTEG CLSIPGMVGD
110 120 130 140 150
VWRYEKVQVV ALDRTGKKVW IDAEGYLARI FQHEIDHLDG ILYTDKCTNL
160 170 180 190 200
RPVSEDGEEE EEAEVAEVMP EPEAEGAGEP SAEGAGQAAA EAGAEEGEQV
210
TTGVSGERRG SAAAKEE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP006840 Genomic DNA. Translation: BAD40328.1. |
RefSeqi | WP_011195474.1. NC_006177.1. |
Genome annotation databases
EnsemblBacteriai | BAD40328; BAD40328; STH1343. |
KEGGi | sth:STH1343. |
Similar proteinsi
Entry informationi
Entry namei | DEF_SYMTH | |
Accessioni | Q67PR5Primary (citable) accession number: Q67PR5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | October 11, 2004 | |
Last modified: | February 28, 2018 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |