def

Functionⁱ

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityⁱ

Formyl-L-methionyl peptide + H₂O = formate + methionyl peptide.UniRule annotation

Cofactorⁱ

Fe²⁺UniRule annotationNote: Binds 1 Fe²⁺ ion.UniRule annotation

Sites

Feature key	Position(s)	Length	Description
Metal bindingⁱ	91 – 91	1	IronUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00163
Metal bindingⁱ	133 – 133	1	IronUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00163
Active siteⁱ	134 – 134	1	UniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00163
Metal bindingⁱ	137 – 137	1	IronUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00163

GO - Molecular functionⁱ

iron ion binding Source: InterPro
peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processⁱ

translation Source: UniProtKB-HAMAP

Complete GO annotation...

Enzyme and pathway databases

BioCycⁱ	STHE292459:GJMM-1412-MONOMER.

BioCycⁱ

STHE292459:GJMM-1412-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peptide deformylaseUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00163 (EC:3.5.1.88UniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00163 ) Short name: PDFUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00163 Alternative name(s): Polypeptide deformylaseUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00163
Gene namesⁱ	Name:defUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00163 Ordered Locus Names:STH1343
Organismⁱ	Symbiobacterium thermophilum (strain T / IAM 14863)
Taxonomic identifierⁱ	292459 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Clostridia › Clostridiales › Symbiobacteriaceae › Symbiobacterium › Symbiobacterium thermophilum
Proteomesⁱ	UP000000417 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 217	217	Peptide deformylase		PRO_0000301114	Add BLAST

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	292459.STH1343.

STRINGⁱ

292459.STH1343.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q67PR5.
SMRⁱ	Q67PR5. Positions 1-149.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4108Z02. Bacteria. COG0242. LUCA.
HOGENOMⁱ	HOG000243508.
KOⁱ	K01462.
OMAⁱ	HMAILNI.
OrthoDBⁱ	POG091H02B0.

Family and domain databases

CDDⁱ	cd00487. Pep_deformylase. 1 hit.
Gene3Dⁱ	3.90.45.10. 1 hit.
HAMAPⁱ	MF_00163. Pep_deformylase. 1 hit.
InterProⁱ	IPR023635. Peptide_deformylase. [Graphical view]
PANTHERⁱ	PTHR10458. PTHR10458. 1 hit.
Pfamⁱ	PF01327. Pep_deformylase. 1 hit. [Graphical view]
PRINTSⁱ	PR01576. PDEFORMYLASE.
SUPFAMⁱ	SSF56420. SSF56420. 1 hit.
TIGRFAMsⁱ	TIGR00079. pept_deformyl. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q67PR5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAILEIVKEP AEVLRKKAKP VTKINASIRK LLDDMTETMY AAPGVGLAAP 
        60         70         80         90        100
QVGVSKRLIV VDPQDGSGQL YQLINPEIVK AEGWVKGTEG CLSIPGMVGD 
       110        120        130        140        150
VWRYEKVQVV ALDRTGKKVW IDAEGYLARI FQHEIDHLDG ILYTDKCTNL 
       160        170        180        190        200
RPVSEDGEEE EEAEVAEVMP EPEAEGAGEP SAEGAGQAAA EAGAEEGEQV 
       210 
TTGVSGERRG SAAAKEE

Length:217

Mass (Da):23,242

Last modified:October 11, 2004 - v1

Checksum:ⁱDAA0BEF5C915026C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP006840 Genomic DNA. Translation: BAD40328.1.
RefSeqⁱ	WP_011195474.1. NC_006177.1.

Genome annotation databases

EnsemblBacteriaⁱ	BAD40328; BAD40328; STH1343.
KEGGⁱ	sth:STH1343.
PATRICⁱ	23780837. VBISymThe116959_1339.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP006840 Genomic DNA. Translation: BAD40328.1.
RefSeqⁱ	WP_011195474.1. NC_006177.1.

3D structure databases

ProteinModelPortalⁱ	Q67PR5.
SMRⁱ	Q67PR5. Positions 1-149.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	292459.STH1343.

STRINGⁱ

292459.STH1343.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	BAD40328; BAD40328; STH1343.
KEGGⁱ	sth:STH1343.
PATRICⁱ	23780837. VBISymThe116959_1339.

Phylogenomic databases

eggNOGⁱ	ENOG4108Z02. Bacteria. COG0242. LUCA.
HOGENOMⁱ	HOG000243508.
KOⁱ	K01462.
OMAⁱ	HMAILNI.
OrthoDBⁱ	POG091H02B0.

Enzyme and pathway databases

BioCycⁱ	STHE292459:GJMM-1412-MONOMER.

BioCycⁱ

STHE292459:GJMM-1412-MONOMER.

Family and domain databases

CDDⁱ	cd00487. Pep_deformylase. 1 hit.
Gene3Dⁱ	3.90.45.10. 1 hit.
HAMAPⁱ	MF_00163. Pep_deformylase. 1 hit.
InterProⁱ	IPR023635. Peptide_deformylase. [Graphical view]
PANTHERⁱ	PTHR10458. PTHR10458. 1 hit.
Pfamⁱ	PF01327. Pep_deformylase. 1 hit. [Graphical view]
PRINTSⁱ	PR01576. PDEFORMYLASE.
SUPFAMⁱ	SSF56420. SSF56420. 1 hit.
TIGRFAMsⁱ	TIGR00079. pept_deformyl. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

DEF_SYMTH

Accessionⁱ

Primary (citable) accession number: Q67PR5

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	October 11, 2004
Last modified:	September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q67PR5 (DEF_SYMTH)

UniProt

Q67PR5 - DEF_SYMTH

Your basket is currently empty.

Peptide deformylase

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ