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Q67P77

- PNP_SYMTH

UniProt

Q67P77 - PNP_SYMTH

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, STH1531
Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi502 – 5021Magnesium By similarity
Metal bindingi508 – 5081Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciSTHE292459:GJMM-1600-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:STH1531
OrganismiSymbiobacterium thermophilum (strain T / IAM 14863)
Taxonomic identifieri292459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVIII. Incertae SedisSymbiobacterium
ProteomesiUP000000417: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 762762Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329893Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi292459.STH1531.

Structurei

3D structure databases

ProteinModelPortaliQ67P77.
SMRiQ67P77. Positions 641-713.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini569 – 63365KH
Add
BLAST
Domaini643 – 71169S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q67P77-1 [UniParc]FASTAAdd to Basket

« Hide

MPPGAPDGPG HRRRTNVTAS FSMELGGRTM TLETGRLAKQ ASGSVLVNYG    50
DSVVLCTAVG SATPREGVDF FPLTVDYEER MYSVGRIPGN WFRREGRPTS 100
KAILWARLTD RPIRPLFPEG FRNDVQVVCT VLSVDPDHPV EIMGMIGASA 150
ALTISDIPFE GPIGGVIVGL VDGQFVINPT AEQQERSEMH LVVAGTEHAV 200
LMVEAGAKEV PEQTMLDAIL FGHEVIKNTI IPTIKQMQAE VGKPKREVVL 250
FNPPPELEQA VREAATVRLR EAVRNPDKLA REEAVAAVGE AVQAELAEQF 300
PESEKHIAYL LKKVLKEEVR RAIIEEGIRP DGRSLTEIRP IECAVDLLPR 350
PHGSGLFQRG QTQVLSICTL GTLGDMQKLD DLTLEETKRF MHHYNFPPYS 400
VGETRPLRGP GRREIGHGAL AERALEPVIP PEEEFPYTIR VVSEVLESNG 450
SSSMASVCGS TLALMAAGVP IKAPVAGVAM GLVEDPETGR YAVLTDIQGI 500
EDALGDMDFK VAGTKKGVTA LQMDMKISGT SREILEKALM QAREGRMFIM 550
EKMLACISEP RKELSPWAPR IITMKISPEK IRDVIGKGGS TINKIIEETK 600
VGHTKVEIDI QDDGTIYIAA VNLEAGERAR QMIEALVKDP EPGMIYTGRV 650
TRLMQFGAFV EILPGKEGLV HISELSDKRV ARVEDVVNIG DEVTVKVTEI 700
DRLGRINLSI KDAMPKQAAS QPSGRPEARQ PQPKPGQGKP GPAKAGAGRP 750
GPGKPGPGRH GR 762
Length:762
Mass (Da):82,820
Last modified:October 11, 2004 - v1
Checksum:i09DA829CDDDAF97C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006840 Genomic DNA. Translation: BAD40516.1.
RefSeqiYP_075360.1. NC_006177.1.

Genome annotation databases

EnsemblBacteriaiBAD40516; BAD40516; STH1531.
GeneIDi2980075.
KEGGisth:STH1531.
PATRICi23781215. VBISymThe116959_1528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006840 Genomic DNA. Translation: BAD40516.1 .
RefSeqi YP_075360.1. NC_006177.1.

3D structure databases

ProteinModelPortali Q67P77.
SMRi Q67P77. Positions 641-713.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 292459.STH1531.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD40516 ; BAD40516 ; STH1531 .
GeneIDi 2980075.
KEGGi sth:STH1531.
PATRICi 23781215. VBISymThe116959_1528.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci STHE292459:GJMM-1600-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
    Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
    Nucleic Acids Res. 32:4937-4944(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T / IAM 14863.

Entry informationi

Entry nameiPNP_SYMTH
AccessioniPrimary (citable) accession number: Q67P77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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