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Q67P59 (DAPA_SYMTH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydrodipicolinate synthase
Short name=DHDPS
EC=4.2.1.52
Gene names
Name:dapA
Ordered Locus Names:STH1549
OrganismSymbiobacterium thermophilum [Complete proteome] [HAMAP]
Taxonomic identifier2734 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiales Family XVIII. Incertae Sedis › Symbiobacterium

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418

Subunit structure

Homotetramer By similarity. HAMAP MF_00418

Subcellular location

Cytoplasm By similarity HAMAP MF_00418.

Sequence similarities

Belongs to the DHDPS family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrodipicolinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 293293Dihydrodipicolinate synthase HAMAP MF_00418
PRO_0000103170

Regions

Region50 – 512Pyruvate binding By similarity

Sites

Active site1641Schiff-base intermediate with substrate By similarity
Binding site1081Pyruvate By similarity
Site1351Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
Q67P59 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 220526EFBDEEFDCA

FASTA29331,202
        10         20         30         40         50         60 
MPTFGRLLTA MVTPMTPDGA VDYQRAGELA KHLVAAGSEG LVVSGTTGES PTLSHEEKLR 

        70         80         90        100        110        120 
LFETVVDAVG GQVSVIAGTG SNNTAESIRF SREAARTGVH GLLLVTPYYN KPPQEGLYRH 

       130        140        150        160        170        180 
FRAVAEAVDL PCILYNVPSR TSVNMLPATT LRLARDVPNI VGIKECADVG QLADILSGAP 

       190        200        210        220        230        240 
EGFRVWSGDD ANLLPYLTVG AYGIISVASH VVGPQMRELI DAFLAGDTAR AAAWHRRLLP 

       250        260        270        280        290 
VFRGLFAVTN PILVKAALRL TGFPVGPVRL PLVDATEEQE EALREVLAEA GVL

« Hide

References

[1]"Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
Nucleic Acids Res. 32:4937-4944(2004) [PubMed: 15383646] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: T / IAM 14863.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006840 Genomic DNA. Translation: BAD40534.1.
RefSeqYP_075378.1. NC_006177.1.

3D structure databases

ProteinModelPortalQ67P59.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2980744.
GenomeReviewsGene locus STH1549 in contig AP006840_GR.
KEGGsth:STH1549.
NMPDRfig|292459.1.peg.1490.
PATRIC23781251. VBISymThe116959_1546.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG358848.
OMACEMEDSN.

Enzyme and pathway databases

BioCycSTHE292459:STH1549-MONOMER.

Family and domain databases

HAMAPMF_00418. DapA.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
IPR020624. Dihydrodipicolinate_synth_CS.
IPR005263. Dihydrodipicolinate_synth_DapA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01714.
PANTHERPTHR12128. DHDPS. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
TIGRFAMsTIGR00674. DapA. 1 hit.
PROSITEPS00665. DHDPS_1. 1 hit.
PS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPA_SYMTH
AccessionPrimary (citable) accession number: Q67P59
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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