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Protein

5'-nucleotidase SurE

Gene

surE

Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.UniRule annotation

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91Divalent metal cationUniRule annotation
Metal bindingi10 – 101Divalent metal cationUniRule annotation
Metal bindingi42 – 421Divalent metal cationUniRule annotation
Metal bindingi99 – 991Divalent metal cationUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTHE292459:GJMM-1783-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
5'-nucleotidase SurEUniRule annotation (EC:3.1.3.5UniRule annotation)
Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolaseUniRule annotation
Gene namesi
Name:surEUniRule annotation
Ordered Locus Names:STH1714
OrganismiSymbiobacterium thermophilum (strain T / IAM 14863)
Taxonomic identifieri292459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSymbiobacteriaceaeSymbiobacterium
Proteomesi
  • UP000000417 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2562565'-nucleotidase SurEPRO_0000235654Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi292459.STH1714.

Structurei

3D structure databases

ProteinModelPortaliQ67NP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SurE nucleotidase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CV2. Bacteria.
COG0496. LUCA.
HOGENOMiHOG000122501.
KOiK03787.
OMAiKICRQAK.
OrthoDBiEOG68WR45.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
HAMAPiMF_00060. SurE.
InterProiIPR030048. SurE.
IPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q67NP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALVLLTNDD GIFAPGINAL RARMEQIPGL EVWAVAPDRE RSASGHAITT
60 70 80 90 100
YRPLFPVRVE IPGAVAPCIS VTGTPADSAK LAIEAILPRR PDLVISGINR
110 120 130 140 150
GANLGTDIFY SGTVAAALEG PILGIPALAV SLDSMTSSDY SAAADFAAQL
160 170 180 190 200
ALKVLEEGLP EGTLLNVNVP ALPREAIKGV RVTKVGRRIY RDQWVRRMHP
210 220 230 240 250
RGQEYYWLAG ELAEIHNDRE SDVSAVEAGY ISVTPVHLDL TRYDQMDRLR

QWNLTF
Length:256
Mass (Da):27,853
Last modified:October 11, 2004 - v1
Checksum:i186882E40B26A795
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006840 Genomic DNA. Translation: BAD40699.1.
RefSeqiWP_011195842.1. NC_006177.1.

Genome annotation databases

EnsemblBacteriaiBAD40699; BAD40699; STH1714.
KEGGisth:STH1714.
PATRICi23781585. VBISymThe116959_1713.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006840 Genomic DNA. Translation: BAD40699.1.
RefSeqiWP_011195842.1. NC_006177.1.

3D structure databases

ProteinModelPortaliQ67NP4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi292459.STH1714.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD40699; BAD40699; STH1714.
KEGGisth:STH1714.
PATRICi23781585. VBISymThe116959_1713.

Phylogenomic databases

eggNOGiENOG4105CV2. Bacteria.
COG0496. LUCA.
HOGENOMiHOG000122501.
KOiK03787.
OMAiKICRQAK.
OrthoDBiEOG68WR45.

Enzyme and pathway databases

BioCyciSTHE292459:GJMM-1783-MONOMER.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
HAMAPiMF_00060. SurE.
InterProiIPR030048. SurE.
IPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
    Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
    Nucleic Acids Res. 32:4937-4944(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T / IAM 14863.

Entry informationi

Entry nameiSURE_SYMTH
AccessioniPrimary (citable) accession number: Q67NP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 11, 2004
Last modified: January 20, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.