Q67N36 (GCST_SYMTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	STH1922

Organism

Symbiobacterium thermophilum [Complete proteome] [HAMAP]

Taxonomic identifier

2734 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiales Family XVIII. Incertae Sedis › Symbiobacterium

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	Aminomethyltransferase HAMAP MF_00259		PRO_0000122605

Sequences

	Sequence		Length	Mass (Da)
	Q67N36 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: EC3FF63B4CDC73DD	FASTA	375	41,243
	10 20 30 40 50 60 MNESLKRTPL YELHLKLGAR MVPFGGWEMP VQYSSVIEEH RAVREAAGLF DVSHMGEFEV 70 80 90 100 110 120 RGPQALDLIQ LVSTNDAAKL AVGRVQYALM CYENGTVVDD ILIYRLDEHR YWLVVNAGNT 130 140 150 160 170 180 QKDWEWINTA RERAGLHNLE LIDRSAEIAL LALQGPKAEE ILQPLATGVV LSQLEPFSLA 190 200 210 220 230 240 KNVTVSGVPT LVLSRTGYTG EDGFEIYVKA EDVAALWEAL LEAGDEQGLL PCGLGARDTL 250 260 270 280 290 300 RFEAKLPLYG HEISDQHNPL EAGLGFAVKL KKGVDFIGRD ALARIKEQGP TRKLVGIEMI 310 320 330 340 350 360 DRGVPRQGYP VAVGGEVVGE VTTGSFSPTL EKNIALAYVP VAHSAVGTEV EVIIRGRALK 370 ARVVETPFYR SPHRR

References

[1]

"Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism." Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T. Nucleic Acids Res. 32:4937-4944(2004) [PubMed: 15383646] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: T / IAM 14863.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006840 Genomic DNA. Translation: BAD40907.1.
RefSeq	YP_075751.1. NC_006177.1.
3D structure databases
ProteinModelPortal	Q67N36.
SMR	Q67N36. Positions 5-368.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2980570.
GenomeReviews	Gene locus STH1922 in contig AP006840_GR.
KEGG	sth:STH1922.
NMPDR	fig|292459.1.peg.1855.
PATRIC	23782015. VBISymThe116959_1927.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG299834.
OMA	GWEMPIS.
Enzyme and pathway databases
BioCyc	STHE292459:STH1922-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_SYMTH

Accession

Primary (citable) accession number: Q67N36

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program